• Collectively, these findings identify circANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, thereby showing that circularization of long non-coding RNAs may alter RNA function and protect from human disease. (nature.com)
  • One of the most critical components of cells, the ribosome , is composed primarily of RNA. (wikipedia.org)
  • What type of RNA makes up the Ribosome? (prezi.com)
  • which matures and will form the major RNA sections of the ribosome. (wikipedia.org)
  • In translation, messenger RNA (mRNA) is decoded in a ribosome, outside the nucleus, to produce a specific amino acid chain, or polypeptide. (wikipedia.org)
  • 1977). "Human beta-globin messenger RNA. (wikipedia.org)
  • RNA silencing functions by repressing translation or by cleaving messenger RNA (mRNA), depending on the amount of complementarity of base-pairing. (wikipedia.org)
  • Numerous sRNAs have been identified using both computational analysis and laboratory-based techniques such as Northern blotting, microarrays and RNA-Seq in a number of bacterial species including Escherichia coli, the model pathogen Salmonella, the nitrogen-fixing alphaproteobacterium Sinorhizobium meliloti, marine cyanobacteria, Francisella tularensis (the causative agent of tularaemia), Streptococcus pyogenes, the pathogen Staphylococcus aureus, and the plant pathogen Xanthomonas oryzae pathovar oryzae. (wikipedia.org)
  • Since these initial discoveries, over six thousand bacterial sRNAs have been identified, largely through RNA-sequencing experiments. (wikipedia.org)
  • While bacterial primases (DnaG-type) are composed of a single protein unit (a monomer) and synthesize RNA primers, AEP primases are usually composed of two different primase units (a heterodimer) and synthesize two-part primers with both RNA and DNA components. (wikipedia.org)
  • Spot 42 (spf ) RNA is a regulatory non-coding bacterial small RNA encoded by the spf (spot forty-two) gene. (wikipedia.org)
  • Furthermore, it is shown that greater than 75% of the total cellular 7SL-RNA is associated with SRP polypeptide in these fractions. (ucsf.edu)
  • Thus it is likely that the major-if not the only-cellular function of 7SL-RNA is as a part of SRP. (ucsf.edu)
  • Plenty of studies have stated that the expression of long non-coding RNAs (lncRNAs) is linked to the cellular development of many kinds of cancers. (portlandpress.com)
  • Long non-coding RNAs (lncRNAs) mediate different cellular processes like cell proliferation and apoptosis [ 7 , 8 ]. (portlandpress.com)
  • RNA-Seq is used to analyze the continuously changing cellular transcriptome. (wikipedia.org)
  • The cellular RNA is selected based on the desired size range. (wikipedia.org)
  • These non-coding RNAs perform a variety of important cellular functions. (wikipedia.org)
  • Here, Spot 42 showed very inefficient binding to purified 70S ribosomes, which lead to the conclusion that the function of Spot 42 is mediated by the RNA itself. (wikipedia.org)
  • Previous RBD mapping approaches have applied mass spectrometric techniques to identify peptides covalently bound to RNA 17 . (nature.com)
  • Circular RNAs (circRNAs) are a group of endogenous non-coding RNAs that, unlike linear RNAs, form a covalently closed continuous loop without 5′-3′ polarity and polyadenylated tail [ 3 ]. (portlandpress.com)
  • Ribonucleotide moieties in many coenzymes, such as Acetyl-CoA , NADH , FADH and F420 , may be surviving remnants of covalently bound coenzymes in an RNA world. (wikipedia.org)
  • Ribonucleotide moieties in many coenzymes, such as Acetyl-CoA, NADH, FADH and F420, have long been thought to be surviving remnants of covalently bound coenzymes in an RNA world. (wikipedia.org)
  • Tyrosine as a -OH source for covalently linked to 5' end of RNA. (wikipedia.org)