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  • bacterial
  • While these processes are well understood in the messenger RNA of cells in higher organisms, Prof. Dr Andres Jäschke and his bioorganic chemistry working group now revealed these mechanisms in bacterial RNA. (xonl.de)
  • structures
  • 6 ]). For instance, in higher eukaryotes and in many viruses that replicate in the cytoplasm, the 5′ cap is 2′- O -methylated at the first and often also second ribonucleotide residues, yielding cap1 and cap2 structures, respectively [ 7 , 8 ]. (royalsocietypublishing.org)
  • molecular
  • Cofactor Genomics , a software-driven biotechnology company developing unique molecular diagnostics centered on RNA, has launched a clinically-validated oncology assay which provides unique insight into a patient's cancer profile. (rna-seqblog.com)
  • In 2016, after multi-year efforts to standardize and certify Cofactor's foundational molecular protocols for clinical use, Cofactor became one of the first laboratories to receive CAP-accreditation for RNA-seq. (rna-seqblog.com)
  • Jon Armstrong, Cofactor's CSO will present "Reaching the Pinnacle: A Unique Cancer Diagnostic Tool that Harnesses the Power of RNA" on Tuesday, February 21 at 11:45 am - 12:15 pm in the Molecular Diagnostics track. (rna-seqblog.com)
  • Epitranscriptomics describes an aspect of molecular genetics, or a study thereof, that depends on biochemical modifications of RNA. (wikipedia.org)
  • Complex
  • Recognizing RNA's ability to identify relevant targets in cancer drug development, as well as more accurately predict the correct treatment for cancer patients, are the key reasons we have built a company committed to developing technologies to interpret the complex data represented by RNA. (rna-seqblog.com)
  • The goal of the proposed research is to understand in detail the role of the cap binding complex (CBC) in mRNA processing and transport. (grantome.com)
  • Genetic and biochemical approaches will be used to identify factors that interact with CBC and to determine how these factors influence the dynamics and function of the mRNA cap binding complex in S. cerevisiae. (grantome.com)
  • During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. (uniprot.org)
  • snRNAs
  • In addition, there are some other forms of RNA that are also capped, for instance small nuclear RNAs (snRNAs). (justia.com)
  • Sm-class snRNAs are found with 5'-trimethylguanosine caps, while Lsm-class snRNAs are found with 5'-monomethylphosphate caps. (wikipedia.org)
  • modification
  • The N7-methylguanosine cap at the 5' end of an mRNA is a modification essential for proper eukaryotic mRNA processing, localization, and translation. (bio-protocol.org)
  • Once these questions are answered and biologists have a better sense of the amount of variation in RNA modification, the focus will turn to each modification's biological function. (wikipedia.org)
  • Purification
  • Expression and Purification of P. falciparum RNA Guanylyltransferase. (pnas.org)
  • The purification (crystallization) of TMV was first performed by Wendell Stanley, who published his findings in 1935, although he did not determine that the RNA was the infectious material. (wikipedia.org)
  • mechanisms
  • Conventional and unconventional mechanisms for capping viral mRNA. (univ-mrs.fr)
  • Very little is known as to how these cis-elements regulate RNA turnover and translation rates in trypanosomatids and nothing is known about mRNA degradation mechanisms in Leishmania in particular. (nih.gov)
  • helicase
  • It uses the helicase ATP hydrolysis site to remove the γ-phosphate from the 5′ end of the RNA. (wikipedia.org)