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  • gene
  • GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
  • To equalize X-linked gene dosage between the sexes in mammalian females, Xist RNA inactivates one of the two X-chromosomes. (paperity.org)
  • biogenesis
  • We discuss the mechanism of piRNA biogenesis, give an overview of common themes as well as differences in piRNA-mediated silencing between species, and end by highlighting known and emerging functions of piRNAs. (nih.gov)
  • De Novo Biogenesis of PIWI-interacting RNAs (piRNAs) in Somatic Cells. (nih.gov)
  • protein
  • sCLIP-an integrated platform to study RNA-protein interactomes in biomedical research: identification of CSTF2tau in alternative processing of small nuclear RNAs. (nih.gov)
  • The RNA-Binding Protein YBX3 Controls Amino Acid Levels by Regulating SLC mRNA Abundance. (embl.de)
  • The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level. (embl.de)
  • maturation
  • The Stowers Institute's Baumann Lab has discovered an important step in the maturation pathway of telomerase, the enzyme that replenishes the sequences that are lost at chromosome ends with every cell division. (bio-medicine.org)
  • exosome
  • Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity. (rochester.edu)
  • Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex. (rochester.edu)
  • These short tails of adenylic acid residues are obviously distinct in length from the long poly(A) tails added on the 3′-end of other RNAs that are consequently degraded by an exosome (19). (nih.gov)
  • regulation
  • Importantly, the dynamic regulation at the 3end is associated with various (patho)physiological processes, including the immune regulation but also tumorigenesis. (springer.com)
  • inhibition
  • If we can now identify those factors that are specifically required for telomerase processing, we could have new targets for telomerase inhibition in cancer cells," said Peter Baumann, Ph.D., Assistant Investigator and senior author on the paper. (bio-medicine.org)
  • Toxins targeting transfer RNAs: Translation inhibition by bacterial toxin-antitoxin systems. (rochester.edu)