AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Sick Building SyndromeIrritable Bowel SyndromePolycystic Ovary SyndromeMetabolic Syndrome XHyperandrogenismOligomenorrheaSyndromeObesityInfertility, FemaleObesity, AbdominalHirsutismDiathermyClomiphenePolycystic Kidney DiseasesAnovulationInsulin ResistanceFertility Agents, FemaleBody Mass IndexOvulation InductionMetforminOvaryPolycystic Kidney, Autosomal DominantTestosteroneAndrostenedioneAmenorrheaWaist CircumferenceAcne VulgarisCyproterone AcetateWaist-Hip RatioPregnancyOocyte RetrievalMenstrual CyclePregnancy RateRisk FactorsFollicle Stimulating HormoneFertilization in VitroOvulationLuteinizing HormoneBlood GlucoseSex Hormone-Binding GlobulinAndrogensOvarian Hyperstimulation SyndromeInsulinPrevalenceSperm Injections, IntracytoplasmicHormonesEmbryo TransferCross-Sectional StudiesPregnancy OutcomeFollicular FluidProspective StudiesCase-Control StudiesGonadotropin-Releasing HormoneLaparoscopyDown SyndromeTRPP Cation ChannelsDiabetes Mellitus, Type 2Chorionic GonadotropinOverweightPolycystic Kidney, Autosomal RecessiveOvarian FollicleCardiovascular DiseasesAbdominal FatTriglyceridesDyslipidemiasRetrospective StudiesTreatment OutcomeHypoglycemic AgentsEstradiolOocytesAdiposityAnthropometryAsian Continental Ancestry GroupObesity, MorbidMetabolic DiseasesIntra-Abdominal FatAdipose TissueCholesterol, HDLHypertensionBody WeightLipidsSex FactorsNephrotic SyndromeCohort StudiesReproductionAdiponectinBlood PressureSjogren's SyndromeBiological MarkersProgesteroneLogistic ModelsChinaFollow-Up StudiesBody ConstitutionFatty LiverCystsAge FactorsDiabetes MellitusOdds RatioRepublic of Korea
OvaryPCOSInsulinType 2 diabetDyslipidemiaOvariesOverweightMorphologyHypertensionDiabetesAnovulationClinicalEpigeneticCoronary heart dDysfunctionPrevalenceABDOMINAL OBESITYAndrogenHyperandrogenismExcessInfertilityHirsutismOvulationDiseaseIncreases the riskAdolescentsImprove metabolic healthSecretionObese womenTreatment of obesityChronicFactorsFertilityLipid profilePathophysiologyEpidemiologyHormonalSignsInsufficiency
Ovary27
PCOS35
  • Polycystic ovarian syndrome (PCOS) is a reproductive metabolic disorder affecting nearly 20% females, globally. (ijpsr.com)
  • Among women in reproductive age, the obese rural population also found vulnerable to PCOS, indicates the role of lifestyle factors in this syndrome. (ijpsr.com)
  • Apart from ovulatory and reproductive dysfunctions, PCOS have chronic metabolic consequences: cardiovascular disease (CVD), obesity, dyslipidemia, obstructive sleep apnoea, and non-fatty liver. (ijpsr.com)
  • Both non-obese and obese PCOS women found vulnerable to the same metabolic consequences. (ijpsr.com)
  • Hence, further long term, controlled studies are required to understand the exact pathogenesis and metabolic consequences both in obese and non-obese PCOS women. (ijpsr.com)
  • Polycystic ovarian syndrome, (PCOS) earlier known as the Stein Leventhal syndrome, is a multisystem endocrine disorder with reproductive and metabolic consequences 1 . (ijpsr.com)
  • Though numerous studies are being done in line with the etiology of PCOS, still the mechanism of pathogenesis and its metabolic impact remains variable and inconclusive. (ijpsr.com)
  • In that regard, this review tries to summarize the existing mechanistic evidence and metabolic consequences of PCOS and the possible avenues for future research. (ijpsr.com)
  • Urban women have a high risk of PCOS compared to rural women 12, but among the rural population, obese participants account for the higher prevalence of PCOS 5 . (ijpsr.com)
  • The exact cause of PCOS remains uncertain, and treatment involves management of symptoms using medication. (wikipedia.org)
  • Common signs and symptoms of PCOS include the following: Menstrual disorders: PCOS mostly produces oligomenorrhea (fewer than nine menstrual periods in a year) or amenorrhea (no menstrual periods for three or more consecutive months), but other types of menstrual disorders may also occur. (wikipedia.org)
  • p. 141) Polycystic ovaries: PCOS is a complicated disorder characterized by high androgen levels, irregular menstruation, and/or small cysts on one or both ovaries. (wikipedia.org)
  • Women with PCOS have higher risk of multiple diseases including Infertility, type 2 diabetes mellitus (DM-2), cardiovascular risk, metabolic syndrome, obesity, impaired glucose tolerance, depression, obstructive sleep apnea (OSA), endometrial cancer, and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). (wikipedia.org)
  • PCOS is usually defined as a clinical syndrome, not by the presence of ovarian cysts. (merckmanuals.com)
  • PCOS occurs when a woman's ovaries or adrenal glands produce more male hormones than normal, and its many symptoms include painful cysts on the ovaries, irregular periods, excessive hair growth, acne, weight gain and infertility. (mylocalpharmacies.com)
  • Samaan and his colleagues conducted a review to get a better handle on the risk of PCOS in girls with type 2 diabetes. (mylocalpharmacies.com)
  • Awareness of PCOS risk is the key, he said. (mylocalpharmacies.com)
  • Girls with type 2 diabetes need to be counseled about the risk of PCOS, and patients need to share information with their providers about irregular periods, acne or excessive hair growth, to allow appropriate investigations and treatments to be implemented," Samaan said. (mylocalpharmacies.com)
  • Individuals with PCOS are at increased risk for metabolic syndrome and type 2 diabetes, so should be screened for these conditions, and individuals with obesity or type 2 diabetes mellitus should be screened for PCOS," she said. (mylocalpharmacies.com)
  • Treating PCOS can ease many of its symptoms, said Cohen, who has no ties to the new research. (mylocalpharmacies.com)
  • In adolescent girls with PCOS, normalizing the amount of abdominal visceral and liver fat restores ovulation, besides normalizing the symptoms of androgen excess . (medscape.com)
  • These findings corroborate the notion that PCOS is not an ovarian disease but rather a pseudo-ovarian central obesity sequence," Dr Ibáñez told Medscape Medical News . (medscape.com)
  • Therefore, recognizing the strong influence of IR on the occurrence and development of PCOS, accurate assessment of insulin sensitivity in the early stages of PCOS, and effective intervention on IR are essential to reduce the risk of long-term complications. (biomedcentral.com)
  • The data resulting from this study will be useful to guide specific public strategies for primary and secondary prevention of metabolic and reproductive comorbidities in the PCOS population of Brazil. (bmj.com)
  • Women with PCOS tend to have central obesity, but studies are conflicting as to whether visceral and subcutaneous abdominal fat is increased, unchanged, or decreased in women with PCOS relative to non-PCOS women with the same body mass index . (diabetesasia.org)
  • Although 80% of PCOS presents in women with obesity, 20% of women diagnosed with the disease are non-obese or "lean" women. (diabetesasia.org)
  • Lean" women still face the various symptoms of PCOS with the added challenges of properly addressing and recognizing their symptoms. (diabetesasia.org)
  • Polycystic Ovarian Syndrome (PCOS) is the major hormonal disorder in women mainly of reproductive age. (ajptonline.com)
  • PCOS is polygenic endrocine disorder characterized by chronic anovulation and excess ovarian activity the most common gynaecological endocrinopathy. (ajptonline.com)
  • PCOS is associated with low-grade chronic inflammation and that women with PCOS are at increased risk of non-alcoholic fatty liver disease. (ajptonline.com)
  • Studies also show that 43% of people with PCOS have metabolic syndrome. (medicalnewstoday.com)
  • Currently, the diagnosis of PCOS [ 2 ] is based on the following three criteria: hyperandrogenism, oligo-anovulation, and detection of polycystic ovaries (PCO) on ultrasound. (ogscience.org)
  • In addition to complications related to the chronic ovulatory dysfunction, metabolic disturbances such as dyslipidemia, impaired glucose tolerance, and type 2 diabetes mellitus (T2DM) can concomitantly occur with PCOS [ 3 ]. (ogscience.org)
  • Common metabolic abnormalities related to PCOS are central obesity, dyslipidemia, and impaired glucose tolerance, and all of these are known to be highly associated with insulin resistance [ 4 ]. (ogscience.org)
  • this is based on correlation with not only the metabolic abnormalities of PCOS but also hyperandrogenism, either directly or indirectly via induction of inappropriate ovarian steroidogenesis [ 1 , 4 , 8 ]. (ogscience.org)
Insulin22
Type 2 diabet12
  • Metabolic syndrome, sometimes called syndrome X or MetS, is a condition that increases the risk of heart attacks, stroke, and type 2 diabetes. (signos.com)
  • When metabolic syndrome goes untreated, type 2 diabetes may occur. (signos.com)
  • You should always aim to maintain a healthy lifestyle to manage your type 2 diabetes risk factors. (livingwithdiabetes.info)
  • Theres nothing you cant eat if youre prediabetic or have risk factors for type 2 diabetes, but you should aim to have a healthy balanced diet . (livingwithdiabetes.info)
  • If youre not sure how often to check your risk of type 2 diabetes, ask your doctor. (livingwithdiabetes.info)
  • Whether you have any other risk factors or not, if youre over 40 your risk of type 2 diabetes and other conditions is higher. (livingwithdiabetes.info)
  • Metabolic syndrome is a subgroup of patients with shared pathophysiology who are at high risk of developing cardiovascular disease and type 2 diabetes. (carakasamhitaonline.com)
  • Dietary choices are one of the primary modifiable lifestyle factors that can influence the risk of developing non-communicable diseases including hypertension, hypercholesterolemia, overweight/obesity, and inflammation, as well as cardiovascular disease (CVD), type 2 diabetes, and cancer. (wholisticmatters.com)
  • Type 2 diabetes is becoming more common due to the growing number of older Americans, increasing obesity, and failure to exercise. (adam.com)
  • This condition raises the risk of developing type 2 diabetes, stroke, and heart disease. (adam.com)
  • Although it usually disappears after delivery, the mother is at increased risk of developing type 2 diabetes later in life. (adam.com)
  • People with type 2 diabetes often have no symptoms, and their condition is detected only when a routine exam reveals high levels of glucose in their blood. (adam.com)
Dyslipidemia1
Ovaries3
  • It dysregulates the oocyte maturation leading to polycystic ovaries, thereby, affects the normal ovarian functions. (ijpsr.com)
  • The syndrome is named after cysts which form on the ovaries of some people with this condition, though this is not a universal symptom, and not the underlying cause of the disorder. (wikipedia.org)
  • In women, T is produced by the ovaries, and T receptors are present in all components of the ovarian follicle, including the granulosa, oocyte, and theca cells. (interplexus.com)
Overweight3
  • Furthermore, individuals who have not directly faced discrimination can still be negatively affected by weight stigma by internalizing negative social messages about obesity and overweight. (laparoscopic.md)
  • Similarly, weight stigma occurs when an individual is seen as being responsible for their own overweight or obesity. (laparoscopic.md)
  • Risk of androgen excess and its complications may be just as high in women who are not overweight as in those who are. (merckmanuals.com)
Morphology2
  • In males, obesity may result in decreased sperm count, no sperm in ejaculate, abnormal motility or morphology. (conceiveivf.com)
  • Ultrasonography eval¬uation of ovarian morphology might not be required for diagnosis in women already presenting with clinical evidence of hyperandrogenism and ovulatory dysfunc¬tion. (ajptonline.com)
Hypertension3
  • Over the long term, androgen excess increases the risk of cardiovascular disorders, including hypertension and hyperlipidemia. (merckmanuals.com)
  • Idiopathic intracranial hypertension is a disease of unknown aetiology, typically affecting young obese women, producing a syndrome of increased intracranial pressure without identifiable cause. (bmj.com)
  • Idiopathic intracranial hypertension (IIH) is a syndrome characterised by increased intracranial pressure (ICP) of unknown cause ( box 1 ). (bmj.com)
Diabetes11
  • Infants of mothers with preexisting diabetes mellitus experience double the risk of serious injury at birth, triple the likelihood of cesarean delivery, and quadruple the incidence of newborn intensive care unit (NICU) admission. (medscape.com)
  • Women with prediabetes identified before pregnancy should be considered at extremely high risk for developing gestational diabetes mellitus during pregnancy. (medscape.com)
  • Eating foods high in sugar content can lead to weight gain, which is a risk factor for developing diabetes. (livingwithdiabetes.info)
  • These health harms are all risk factors for the development of diabetes or can worsen complications. (livingwithdiabetes.info)
  • Cancer, Diabetes, and Cancer Treatment Share a Complex Relationship, and New Guidance from the Joint British Diabetes Societies Lists Important Steps to Reduce Glycaemic Risks During Cancer Therapy. (medscape.co.uk)
  • 3,4 The link between diabetes and cancer risk may be due to diabetes per se, treatments for diabetes, or associated shared risk factors such as obesity. (medscape.co.uk)
  • People with cancer are also at increased risk of developing new onset diabetes or hyperglycaemia, as well as a worsening of their control of pre-existing diabetes 6-8 (Box 2). (medscape.co.uk)
  • And if your blood sugar is high, you might notice the signs and symptoms of diabetes - such as increased thirst and urination, fatigue, and blurred vision . (symptoma.com)
  • High Fasting Blood Sugar If you have very high blood sugar, then you might experience the signs and symptoms of diabetes like increased thirst, increased urination, fatigue and blurred vision . (symptoma.com)
  • Metabolic syndrome is a group of conditions that can increase the risk of stroke , coronary heart disease, and diabetes. (medicalnewstoday.com)
  • One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
Anovulation3
Clinical4
  • [ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)
  • Pathophysiology and disease pathogenesis can be better understood by observing the clinical features of metabolic syndrome and their interrelation. (carakasamhitaonline.com)
  • PURPOSE: To analyze the clinical, hormonal, and radiological characteristics of Pituitary stalk interruption syndrome (PSIS) in children with growth hormone deficiency (GHD). (bvsalud.org)
  • CONCLUSIONS: Findings highlight the potential to identify high-risk populations for suicide prevention in clinical practice. (cdc.gov)
Epigenetic1
Coronary heart d2
  • Increased whole grain intake has been linked to a reduced risk of coronary heart disease, stroke, cardiovascular disease, and cancer. (wholisticmatters.com)
  • While high blood pressure presents has no obvious symptoms, it is a risky condition that can lead to coronary heart disease, heart failure, stroke, and other life threatening health conditions. (saynotoobesity.com)
Dysfunction2
  • Also, genetic predisposition to hypothalamic pituitary gonadal (HPG) axis dysfunction and impaired ovarian steroidogenesis further influence the disorder. (ijpsr.com)
  • Primary ovarian insufficiency (POI) is a condition resulting from the depletion or dysfunction of the ovarian follicles, leading to cessation of ovulation and menses before age 40. (lecturio.com)
Prevalence2
  • For the Asia-Pacific region, in a systematic review it has been noted that 'in most countries nearly 1/5th of the adult population or more were affected by Metabolic Syndrome with a secular increase in prevalence. (lowcarbneurologist.com)
  • Not surprisingly, the two-year diet researchers concluded that, "A Mediterranean-style diet might be effective in reducing the prevalence of the metabolic syndrome and its cardiovascular disease," which is a roundabout way of saying that most of the participants were healthier at the end of the study. (virginiahopkinshealthwatch.com)
ABDOMINAL OBESITY1
  • Of note, significant associations were only observed in subjects with obesity and abdominal obesity, but not in non-obese or non-abdominally obese subjects. (e-enm.org)
Androgen2
  • Hormonally, a woman with metabolic syndrome tends to have high androgen (male hormone) levels, high estrogen levels (the fat cells are making estrogen from androgens), high cortisol and low thyroid. (virginiahopkinshealthwatch.com)
  • This was underscored in a Johns Hopkins study published in the American Journal of Epidemiology in September 2004 which showed that women with metabolic syndrome have high androgen levels. (virginiahopkinshealthwatch.com)
Hyperandrogenism2
  • High levels of masculinizing hormones: Known as hyperandrogenism, the most common signs are acne and hirsutism (male pattern of hair growth, such as on the chin or chest), but it may produce hypermenorrhea (heavy and prolonged menstrual periods), androgenic alopecia (increased hair thinning or diffuse hair loss), or other symptoms. (wikipedia.org)
  • Known as hyperandrogenism, the most common signs are acne and hirsutism (male pattern of hair growth, such as on the chin or chest), but it may produce hypermenorrhea (heavy and prolonged menstrual periods), androgenic alopecia (increased hair thinning or diffuse hair loss), or other symptoms. (diabetesasia.org)
Excess4
Infertility3
Hirsutism2
  • Hirsutism and Hypertrichosis Hirsutism is the excessive growth of thick or dark hair in women in locations that are more typical of male hair growth patterns (eg, mustache, beard, central chest, shoulders, lower abdomen. (merckmanuals.com)
  • Successful treatment of hirsutism in HAIR-AN syndrome using flutamide, spironolactone, and birth control therapy. (symptoma.com)
Ovulation3
Disease8
  • Research found a significant link between the consumption of ultra-processed foods (UPFs) and increased risks of non-alcoholic fatty liver disease, liver cirrhosis, and severe hepatic illnesses. (news-medical.net)
  • High intake of several emulsifiers (part of the 'E numbers' group of food additives), widely used in industrially processed foods to improve texture and extend shelf-life, is associated with increased risk of cardiovascular disease (CVD), suggests a study published by The BMJ today. (news-medical.net)
  • Both men and women with metabolic syndrome are more prone to inflammation, which predisposes one to heart disease, arthritis and headaches. (virginiahopkinshealthwatch.com)
  • In patients at increased risk of cardiovascular disease, it also improved flow-mediated dilation, the level of nitric oxide, and lowered mean arterial pressure and heart rate, [13,14] suggesting that it can greatly stabilize the health of the cardiovascular system. (vitalitymagazine.com)
  • Increase your risk of cardiovascular disease. (livingwithdiabetes.info)
  • Arthritis Rheum 57: 109-115,2007 ［YM 追加］ 13） Vazquez-Mellado J, Garcia CG, Vazquez SG, et al: Metabolic syndrome and ischemic heart disease in gout. (symptoma.com)
  • Are You at High Risk for Serious Disease from Covid-19? (healthywomen.org)
  • AIDS-like syndrome: AIDS-like disease (illness) (syndrome) ARC AIDS-related complex Pre-AIDS AIDS-related conditions Prodromal-AIDS 3. (cdc.gov)
Increases the risk1
Adolescents1
  • A systematic review done among the young in 2020 showed that globally, about 3% of children and 5% of adolescents had Metabolic Syndrome , with some variation across countries and regions. (lowcarbneurologist.com)
Improve metabolic health1
  • Studies suggest that the keto diet helps improve metabolic health markers in several ways: the diet tends to reduce overall caloric intake, increases satiety (fullness after eating), may increase the thermal effect of eating (calories we burn digesting food) due to higher protein intake, and increases gluconeogenesis, which is increased with carbohydrate restriction and is energy demanding. (draxe.com)
Secretion3
  • The hypothalamus begins to secrete gonadotropin-releasing hormone (GnRH), and as this secretion continues, the pituitary gonadotropins (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) are released and ovarian follicles become more sensitive to stimulation. (medscape.com)
  • Obesity is also associated with Polycystic Ovarian Syndrome, along with symptoms of high male hormone secretion like hairiness and acne. (conceiveivf.com)
  • With reactivation of the GnRH pulse generator, increased gonadotropin secretion stimulates ovarian estrogen secretion and follicular development. (ajptonline.com)
Obese women1
  • Obese women, especially those with central obesity, have been associated with impaired fecundity. (conceiveivf.com)
Treatment of obesity2
  • Successful treatment of obesity includes setting goals and making lifestyle changes, such as eating fewer calories and being physically active. (conceiveivf.com)
  • The oral intake of probiotics and synbiotics as co-adjuvants for the prevention and treatment of obesity, IRS, T2D and NAFLD is partially supported by the data shown in the present review. (symptoma.com)
Chronic1
  • Other lifestyle factors like being physically inactive, eating a poor diet, not getting enough sleep, and chronic stress may also increase the risk of developing metabolic syndrome. (signos.com)
Factors4
  • The relationship between 139 dietary factors and the risk of developing colorectal cancer (CRC). (news-medical.net)
  • This can lead some people to view obese individuals as greedy, unintelligent, unattractive, lazy or lacking in self-control, rather than acknowledge the fact that obesity is a highly complex issue involving a range of genetic, biological, environmental and social factors. (laparoscopic.md)
  • More specifically, those who maintained all four low risk factors had a 65 percent lower death rate. (virginiahopkinshealthwatch.com)
  • Manhattan plot for 142 associations between risk factors and T2DM. (livingwithdiabetes.info)
Fertility1
Lipid profile1
Pathophysiology1
  • The pathophysiology of metabolic syndrome shall be clubbed with disorders due to overnutrition (santarpanajanya vyadhi) in Ayurveda . (carakasamhitaonline.com)
Epidemiology1
  • A study published in September 2004 in Cancer Epidemiology Biomarkers & Prevention showed that women who ate the most carbohydrates had more than double the risk of breast cancer compared to women who ate the least carbohydrates. (virginiahopkinshealthwatch.com)
Hormonal2
Signs1
  • The diagnosis is made by examining location, signs and symptoms, causes of vitiation of three dosha in any condition. (carakasamhitaonline.com)
Insufficiency1
  • Primary ovarian insufficiency is primarily idiopathic, but it can also be seen in association with chromosomal and genetic defects, including Turner syndrome (45,X karyotype) and FMR1 premutation. (lecturio.com)