Risk of adverse brain outcomes. Medical search. Frequent questions

In particular, estimates of APOs after symptomatic confirmed Zika virus infection suggest risk for fetal injury throughout pregnancy ( 3 , 4 ). (cdc.gov)
We know that THC, the main psychoactive constituent in cannabis, can cross the placenta from mother to fetus and bind to receptors in the fetal brain. (press-news.org)
In general, however, the optimal window of success for nutritional intervention to best support brain development is in late fetal and early postnatal life. (vitamindwiki.com)
Exposure to Maternal Depressive Symptoms in Fetal Life or Childhood and Offspring Brain Development: A Population-Based Imaging Study. (erasmusmc.nl)
Air Pollution Exposure During Fetal Life, Brain Morphology, and Cognitive Function in School-Age Children. (erasmusmc.nl)
Maternal use of selective serotonin reuptake inhibitors, fetal growth, and risk of adverse birth outcomes. (erasmusmc.nl)
Thyroid hormone plays an essential role in brain development in fetal and neonatal life, [ 1 ] and hypothyroidism during this critical period of early life can lead to adverse neurodevelopmental sequelae. (medscape.com)
In general, twin pregnancy is associated with preterm birth and risks such as fetal mortality, early perinatal and neonatal mortality, LBW and stay in a Neonatal Intensive Care Unit (NICU) 9 . (bvsalud.org)

An interplay of early environmental and genetic risk factors with recent stressful life events (SLEs) in adulthood increases the risk for adverse mental health outcomes. (nih.gov)
They are at higher risk for poor physical and mental health outcomes, low socioeconomic status, and lower educational attainment. (healthychildren.org)

Chorioamnionitis has been strongly associated with adverse neonatal outcomes, especially cerebral palsy," Pressman said. (healthday.com)
Andrew MJ, Parr JR, Montague-Johnson C et al (2018) Neurodevelopmental outcome of nutritional intervention in newborn infants at risk of neurodevelopmental impairment: the Dolphin neonatal double-blind randomized controlled trial. (vitamindwiki.com)
Thyroid hormone is critical for neonatal brain development, and even transient hypothyroidism can cause adverse neurocognitive outcomes. (medscape.com)
In this sense, twinning represents a greater neonatal risk to maternal and child health, due to the association with LBW and other complications arising from prematurity. (bvsalud.org)
There is an increased risk of death and neurological disorders in twins, regardless of the influence of prematurity and birth weight, as they are also susceptible to intrauterine growth restriction and neonatal complications 4 . (bvsalud.org)

however, there are limited preclinical data demonstrating a causal relationship between TRAP and adverse neurodevelopmental outcomes. (nature.com)
Since 2012, the American Academy of Pediatricians Council on Environmental Health has emphasized that children's exposure to pesticides should be as limited as possible, because pesticide exposure during pregnancy and early childhood increases the risk of brain tumors, leukemia, neurodevelopmental defects, and other adverse birth outcomes, according to the EWG announcement. (integrativepractitioner.com)
Children in foster care or adoption are at a far great risk than the general population for neurodevelopmental disorders. (healthychildren.org)
Neonates with congenital heart disease (CHD) represent an especially vulnerable group, because they have a higher frequency of congenital morphological defects of the thyroid gland, [ 9 , 10 ] are routinely exposed to excess iodine, and are at risk of neurodevelopmental disabilities. (medscape.com)
Premature birth puts the infant brain at increased risk of gray matter and white matter damage, and even in the absence of injury, brain development can be altered with significant structural and microstructural changes that are associated with neurodevelopmental disabilities. (bvsalud.org)

TRAP exposure had no persistent effect on pro-inflammatory cytokine levels in the male or female brain, but did significantly elevate the anti-inflammatory cytokine IL-10 in females. (nature.com)
Collectively, these data indicate that exposure to real-world levels of TRAP during gestation and early postnatal development modulate neurodevelopment, corroborating epidemiological evidence of an association between TRAP exposure and increased risk of NDDs. (nature.com)
Exposure to selected TRAP components has been shown to cause various NDD-relevant outcomes in rodent models. (nature.com)
After years of investments in stress research at NIMH and across the globe, we now know a lot about the biological substrates linking exposure to stressful events in the environment with changes in the brain that can lead to mental health problems. (nih.gov)
Lead (Pb) Toxicity: Who Is at Risk of Lead Exposure? (cdc.gov)
Children who reside in pre-1978 housing (and especially those in inner cities, where a large number of older rental homes exist, or homes built before 1950) are at greatest risk for exposure, because older housing may contain paint with higher lead content. (cdc.gov)
Childhood lead exposure has a significant and persistent impact on brain reorganization associated with language function" [Yuan et al. (cdc.gov)
Smokers and their relatives (if exposed to secondhand smoke) are at a high risk for exposure due to the lead in tobacco smoke. (cdc.gov)
Prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) may be linked to changes in the development trajectories of emotional regulation in the brain among offspring, according to new research. (hcplive.com)
Investigators led by Henning Tiemeier, MD, PhD, of the department of social and behavioral sciences at Harvard T.H. Chan School of Public Health, sought to assess the associations between intrauterine SSRI exposure, maternal depressive symptoms and structural brain development in offspring from childhood through early puberty. (hcplive.com)
In an editorial accompanying the research, Ardesheer Talati, PhD, of the department of psychiatry at Columbia University and division of translational epidemiology at New York State Psychiatric Institute, praised the research as helping to provide "inroads to our understanding of how brain development through adolescences may be associated with prenatal SSRI exposure. (hcplive.com)
ONTOX will deliver a generic strategy to create innovative new approach methodologies to predict systemic repeated dose toxicity effects that, when combined with tailored exposure assessment, will enable human risk assessment. (fhi.no)
Our study adds to that knowledge by showing that prenatal exposure to cannabis heightens the risk of several adverse birth outcomes. (press-news.org)
Twenty of the studies measured the association between intrauterine cannabis exposure and risk of preterm delivery. (press-news.org)
When organic versions are unavailable or not affordable, the EWG advises consumers to continue eating fresh produce, even if conventionally grown, because the health benefits of a diet rich in fruits and vegetables outweigh the risks of pesticide exposure. (integrativepractitioner.com)
Therefore, unequal exposure to harsher conditions for women compared to men in gender-unequal countries might be reflected in differences in their brain structure, and this could be the neural mechanism partly explaining women's worse outcomes in gender-unequal countries. (dericbownds.net)
Prenatal tobacco exposure and brain morphology: a prospective study in young children. (erasmusmc.nl)
Neurobehavioral outcomes are usually non-specific, and imprecise exposure assessment results in a bias toward the null. (cdc.gov)
Women with ongoing risk of possible Zika virus exposure include those who live in or frequently travel to the designated areas of Miami Beach and Wynwood due to the possibility of active Zika virus transmission. (cdc.gov)
Women with limited risk of Zika virus exposure include those who traveled to the designated areas of Miami Beach and Wynwood or had sex without using condoms or other barrier methods to prevent infection by a partner who lives in or traveled to the designated areas of Miami Beach and Wynwood. (cdc.gov)
In addition to the difficulties posed by loss of hearing , other adverse effects of exposure (such as tinnitus) may further increase a worker's debilitation. (cdc.gov)

Dr. Barr was a senior faculty member of the SCCM's ICU Liberation Campaign Collaborative, and co-authored a landmark study which demonstrated significant improvements in ICU patient outcomes following implementation of the ABCDEF Bundle. (stanford.edu)

Stimulants (also known as uppers) can increase your heart rate and blood pressure to dangerous levels and increase your risk of several serious health problems. (cdc.gov)
Depressants (also known as downers) can slow down your breathing and increase your risk of several adverse health outcomes. (cdc.gov)
Quantifying the risk for adverse pregnancy outcomes (APOs) after Zika virus infection is of critical public health importance. (cdc.gov)
Dr. Kathleen Chaput, PhD, is leading a team Researchers at the University of Calgary's Cumming School of Medicine that will examine Canada's social context of prenatal cannabis consumption in relation to both maternal and infant health outcomes. (ucalgary.ca)
Research tells us that severe stresses like these, especially early in life, cause all kinds of adverse health outcomes, including increased risk for mental illnesses. (nih.gov)
Developing fetuses are also at risk for adverse health outcomes (less than 1% of the mothers have levels greater than or equal to 5 micrograms per deciliter, or μg/dL), as levels that present risk to the fetus may not present risk to the mother. (cdc.gov)
No economic or racial/ethnic subgroup of children is free from the risk of adverse health effects due to high BLLs. (cdc.gov)
When the nurse is not able to complete the full scope of required care, this can lead to poorer nurse-sensitive health outcomes, including bloodstream infections and longer lengths of stay," says lead-author Eileen T. Lake, PhD, RN, FAAN, the Edith Clemmer Steinbright Professor in Gerontology, Professor of Nursing, and Associate Director of the Center for Health Outcomes and Policy Research. (news-line.com)
Because of the complexity of care required by VLBW infants, their fragile health status, and their anatomic, physiologic and immunologic immaturity, they simultaneously have a high risk for adverse outcomes and a low tolerance for poor care processes. (news-line.com)
It's clear that from our data that about 20 percent of the term infants born to mothers who received epidurals experienced one or more adverse outcomes after birth," said study author Elizabeth Greenwell, a doctoral candidate at Harvard School of Public Health when she did the research. (healthday.com)
Professor Jerome Sarris, Deputy Director and Director of Research at NICM Health Research Institute, Western Sydney University and senior author on the report, is concerned over some of the potential impacts of increasing Internet use on the brain. (sciencedaily.com)
Co-author and director of the digital psychiatry program at Beth Israel Deaconess Medical Center and a clinical fellow at Harvard Medical School, Dr John Torous added: "The findings from this paper highlight how much more we have to learn about the impact of our digital world on mental health and brain health. (sciencedaily.com)
The preschool years present a critical developmental period sensitive to changes in public health and social policy, for which robust investments in programs that support families can improve intergenerational outcomes. (americanprogress.org)
This presentation will focus on the impact of adverse childhood experiences, impact on brain development, overall health risk factors and what the data has shown about ACE scores. (ncids.org)
This study challenges a current theory in autism epidemiology that identifies the father's age as a key factor in increasing the risk of having a child with autism," said Janie Shelton, the study's lead author and a doctoral student in the UC Davis Department of Public Health Sciences. (livescience.com)
The potential adverse effects of prophylactic bilateral oophorectomy on heart health, neurological health, bone health and quality of life should be carefully weighed against its potential benefits for cancer risk reduction in women at average risk of ovarian cancer. (nih.gov)
Pediatricians can address the effects of adverse childhood experiences, early childhood adversity, and trauma on early brain development and life course trajectory for both physical and mental health, as recommended by AAP policy. (healthychildren.org)
The detrimental impact of these experiences on the developing brain was made salient by the popular CDC-Kaiser Adverse Childhood Experiences (ACEs) Study , which revealed a clear correlation between a list of negative childhood experiences and the increased risk of negative health outcomes throughout the life course. (vakids.org)
Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. (dericbownds.net)
To this aim, I investigate the short- and long-term consequences of maternal, foetal and infant health on brain development later in life (structure, function, cognition and behaviour). (erasmusmc.nl)
A single concussion experienced by a child or teenager may have lasting repercussions on mental health and intellectual and physical functioning throughout adulthood, and multiple head injuries increase the risks of later problems, according to one of the largest, most elaborate studies to date of the impacts of head trauma on the young. (sandiegopsychiatricsociety.org)
Meanwhile, we recently wrote that WebMD reported that HRT has been linked to an increased risk of women dying from lung cancer and pointed out that women on combined HRT also exhibited increased risks for heart disease and stroke, breast cancer, and other adverse health events. (yourlawyer.com)
PURPOSE: Adverse health effects of developmental toxicants may induce abnormal functional programming that leads to lasting functional deficits. (cdc.gov)
BACKGROUND: In November 2020, during the SARS-CoV-2 pandemic, Missouri allowed local public health jurisdictions the option to implement a modified quarantine policy allowing kindergarten through 12 (K-12) students with low-risk exposures to continue in-person learning. (cdc.gov)
In addition to hearing loss , many workers suffer from noise -induced tinnitus (ringing in the ears) and face the possibility of noise -related accidents and other adverse health effects. (cdc.gov)

Investigators sought a primary outcome of offspring brain morphometry, including global and cortical brain volumes, measured at 3 magnetic resonance imaging (MRI) assessments from ages 7 - 15 years old, based on maternal SSRI uptake. (hcplive.com)
We also tested whether these effects were affected by an adverse early life challenge, maternal deprivation (MD). We found that animals that were raised in large, two floor Marlau TM cages, together with 10 conspecifics, showed improved attention, but impaired behavioral inhibition in the 5-choice serial reaction time task. (frontiersin.org)
It shows that while maternal age consistently increases the risk of autism, the father's age only contributes an increased risk when the father is older and the mother is under 30 years old. (livescience.com)

Don't miss your chance to attend one of her "Adverse Childhood Experiences 101" webinars! (ncids.org)
Childhood experiences impact overall development and functioning, resulting in risk and protective factors. (ncids.org)

An international team of researchers has found the Internet can produce both acute and sustained alterations in specific areas of cognition, which may reflect changes in the brain, affecting our attentional capacities, memory processes, and social interactions. (sciencedaily.com)
An international team of researchers from Western Sydney University, Harvard University, Kings College, Oxford University and University of Manchester have found the Internet can produce both acute and sustained alterations in specific areas of cognition, which may reflect changes in the brain, affecting our attentional capacities, memory processes, and social interactions. (sciencedaily.com)
Limited research is available on the relationship between social stress and risk of declining cognition. (springer.com)

We compared NDD-relevant neuropathological outcomes at postnatal days 51-55 in TRAP-exposed animals versus control subjects exposed to filtered air. (nature.com)

This study examined the association between PTSD status and functional impairment among military psychiatric inpatients admitted for acute suicide risk ( N = 166) with a lifetime history of at least one suicide attempt. (mdpi.com)
Modifiable risk factors for frailty including neurocognitive impairment, obesity, smoking, choice of initial cART (with NNRTI [non-nucleoside reverse transcriptase inhibitor]-based cART increasing risk of frailty), and level of education. (natap.org)
The main pathologic impairment is the inability of glycine, which is one of the major inhibitory neurotransmitters in the central nervous system, to display its inhibitory effects, particularly in the brain stem [ 2 ]. (hindawi.com)
This Funding Opportunity Announcement (FOA) invites applications for human studies to elucidate the etiology and pathogenesis of the increased risk for neurocognitive impairment associated with type 2 diabetes. (nih.gov)
A larger, less active AR protein is associated with a higher risk of cognitive impairment when patients are treated with ADT. (pcf.org)
Drs. Morgans and Ryan's precision survivorship studies aim to identify patients who are at risk of cognitive impairment with AR-targeted therapies, and identify treatment strategies to prevent or reverse cognitive decline without compromising survival. (pcf.org)
This study will contribute to the body of knowledge about treatments for advanced prostate cancer by defining the proportion of prostate cancer patients who have baseline cognitive impairment, characterizing the biology of the effects of low testosterone and AR inhibition in the brain, and comparing the cognitive effects of two different therapies. (pcf.org)
In particular, studies have revealed an increased risk of premature death, cardiovascular disease, cognitive impairment or dementia, parkinsonism, osteoporosis and bone fractures, decline in psychological wellbeing and decline in sexual function. (nih.gov)
We have further shown that risk factors for cognitive impairment and IQ decline are whole brain radiation therapy, large tumors, young age at diagnosis, male sex, supratentorial lateral tumor, and treatment with chemotherapy. (lu.se)
Among the 106 survivors of riding-associated TBIs, 84 (79%) had one or more indicators of brain injury severity: 67 (63%) had loss of consciousness, 49 (46%) had posttraumatic amnesia, and 14 (13%) had persistent neurologic sequelae on discharge from the hospital (e.g., seizures or cognitive, hearing, vision, speech, and/or motor impairment). (cdc.gov)

In the placebo group, 34 patients (38.2 percent) recovered to a favorable outcome (defined as good recovery and moderate disability, as measured by a functional assessment inventory) compared with 17 patients (48.6 percent) in the erythropoietin 1 group (first dosing regimen) and 17 patients (29.8 percent) in the erythropoietin 2 group (second dosing regimen). (medindia.net)
Thirty-seven patients (42.5 percent) assigned to the transfusion threshold of 7 g/dL recovered to a favorable outcome compared with 31 patients (33.0 percent) assigned to the transfusion threshold of 10 g/dL. (medindia.net)

To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy (REMS) for these products. (nih.gov)

This reality can contribute to potentially dire outcomes for very low birthweight (VLBW) infants, who weigh less than 3.3 lbs. at birth. (news-line.com)
I believe that this, along with the increasing #Instagramification of society, has the ability to alter both the structure and functioning of the brain, while potentially also altering our social fabric. (sciencedaily.com)
These results point to the potentially hazardous effect of gender inequality on women's brains and provide initial evidence for neuroscience-informed policies for gender equality. (dericbownds.net)
Through this work I identified two potentially modifiable targets for intervention to improve cognitive outcomes in survivors. (lu.se)

An understanding of these nutrient-specific sensitive periods and the accompanying brain regions or processes that are developing can guide effective nutrition interventions as well as the choice of meaningful circuit-specific neurobehavioral tests to best determine outcome. (vitamindwiki.com)

Inequities in socioeconomic and daily living conditions generate adverse outcomes that persist throughout the lifespan, but the birth-through-age-6 period can serve as a unique opportunity for intervention. (americanprogress.org)

To minimise the potential adverse effects of high-intensity multi-tasking Internet usage, I would suggest mindfulness and focus practice, along with use of 'Internet hygiene' techniques (e.g. reducing online multitasking, ritualistic 'checking' behaviours, and evening online activity, while engaging in more in-person interactions)," said Professor Sarris. (sciencedaily.com)

In our research we have been able to show that a longitudinal, systematic neuropsychological follow-up is essential after pediatric brain tumor, both in terms of finding individuals with rehabilitation need and in terms of evaluating the cancer treatment given with respect to cognitive sequelae. (lu.se)

Traumatic brain injury (TBI), also known as acquired brain injury, head injury, or brain injury, causes substantial disability and mortality. (medscape.com)
Frailty has demonstrated the ability to outperform greater patient age in surgical decision-making by predicting postoperative adverse events that include mortality, extended length of hospital stay, non-routine discharge disposition, and postoperative complications. (bvsalud.org)

Association of trajectories of depressive symptoms with vascular risk, cognitive function and adverse brain outcomes: The Whitehall II MRI sub-study. (ox.ac.uk)
To quantify APO risk, we used data from a study that recruited 345 pregnant women with rash in the previous 5 days, of whom 134 tested positive for Zika virus infection ( 4 ). (cdc.gov)
In this single-institution retrospective study, we investigate the patient characteristics and treatment outcomes, including pseudo-progression (PsP), for LGG patients selected for PT. (lu.se)
The study will also explore medicinal benefits of cannabis for pregnancy-induced nausea and vomiting, anxiety, and sleep, hoping to enhance the understanding of these complex and controversial issues rather than focusing solely on risks. (ucalgary.ca)
The study is considered high risk because it brings new disciplines with different perspectives together to address an important research question and because it drives prenatal cannabis research in new directions. (ucalgary.ca)
A new study has found that neither the use of hormone erythropoietin nor maintaining higher hemoglobin concentration could improve outcome in patients with traumatic brain injury. (medindia.net)
The article "The Association of Missed Nursing Care With Very Low Birthweight Infant Outcomes" details the study. (news-line.com)
Feb. 3, 2012 (HealthDay News) -- The babies of women who develop an epidural-related fever while in labor are at greater risk of having problems right at birth, including poor muscle tone, breathing difficulties, low Apgar scores and seizures, a new study suggests. (healthday.com)
Advanced paternal age is associated with elevated autism risk only when the father is older and the mother is under 30, the study found. (livescience.com)
The study found that the incremental risk of having a child with autism increased by 18 percent - nearly one fifth - for every five-year increase in the mother's age. (livescience.com)
Among mothers over 30, the increased risk associated with older fathers dissipated, the study found. (livescience.com)
The Brain Oxygenation-II study (BOx-II) is a phase-II, multicenter, single-arm clinical trial evaluating interventions based on near-infrared spectroscopy (NIRS) monitoring of cerebral oxygen saturation in extremely premature infants. (stanford.edu)
This study investigates the utility of near-infrared spectroscopy (NIRS), a non-invasive oxygen-measuring device, to identify preterm infants at highest risk for brain injury or death. (stanford.edu)
The researchers did not quantify the causes of the injuries in this study, but past research shows that in the very young, he says, brain injuries usually result from falls, with sports becoming the primary cause in teenagers, and auto accidents the main cause among young adults. (sandiegopsychiatricsociety.org)
The majority of individuals who had diagnoses of brain injury in our study did not experience adverse outcomes," Dr. Fazel says. (sandiegopsychiatricsociety.org)
We have been following outcomes from the WHI and issues with HRT and recently wrote that while HRT has long been linked to female cancers and fatal blood clots, another study just concluded that women on HRT might be doubling their skin cancer risks. (yourlawyer.com)
Yet another study revealed a connection with how HRT shrinks the brain. (yourlawyer.com)
In addition to an increased risk of stroke and cerebrovascular disease in post-menopausal women on HRT, the WHI Memory Study also found that post-menopausal women on HRT suffered from a higher risk of dementia and memory problems. (yourlawyer.com)
The aim of the present study was to identify the proportion of neonates with CHD exposed to iodine who developed hypothyroidism and to identify the associated risk factors. (medscape.com)
[ 20 ] A recent case-control study of children exposed to ICM showed an increased risk of incident hypothyroidism and called for the identification of comorbidities that predispose to thyroid dysfunction in vulnerable subgroups of children. (medscape.com)
We required a minimum follow-up of six months from baseline and assessed each included study for risk of bias. (who.int)
However, this study had a risk of multiple biases, and when we calculated the adjusted RR we no longer detected a statistically significant difference. (who.int)

This observation means that in areas where seasonal outbreaks of Zika occur, the risk for APOs might not return to baseline levels between epidemics, and Zika-specific interventions based on timing of pregnancy might be less effective ( 7 ). (cdc.gov)
Deep brain stimulation resulted in a reduction in his Yale-Brown Obsessive Compulsive Scale 4 (Y-BOCS) score from the extreme to moderate/severe range (Y-BOCS = 33 at baseline, 24 at 6 weeks post activation). (psychiatrist.com)
Controlling for education and income, age, and baseline episodic memory and executive functioning, lower subjective social status had additional adverse effects on declines in episodic memory in men and women. (springer.com)
Patients' cognitive function and brain activation (using functional MRI) will be evaluated at baseline and over the course of treatment, up to one year. (pcf.org)
Baseline clinical characteristics and outcomes were compared between patients with and without chronic APT usage prior to admission. (bvsalud.org)
We also considered controlled trials with baseline measures and post-intervention outcomes. (who.int)
The primary outcome was the smoking status of children or adolescents at follow-up who reported no smoking at baseline. (who.int)

See Pediatric Concussion and Other Traumatic Brain Injuries , a Critical Images slideshow, to help identify the signs and symptoms of TBI, determine the type and severity of injury, and initiate appropriate treatment. (medscape.com)
Young people who had experienced a single diagnosed concussion - which the researchers categorized as a mild traumatic brain injury - were much more likely than the nation's general population and than their own siblings to be receiving medical disability payments as adults. (sandiegopsychiatricsociety.org)
The possibility of lingering physical or psychological problems during adulthood rose precipitously, the researchers found, if someone had experienced more than one concussion while young, or if his or her brain injury had been more severe than a concussion. (sandiegopsychiatricsociety.org)

However, microcephaly is at the severe end of the APO spectrum and might have a different risk profile from other outcomes: brain abnormality and malformation, eye anomalies, neural tube defects, arthrogryposis, congenital deafness, and others ( 3 ). (cdc.gov)
If future evidence links brain anomalies to adverse youth outcomes, this will need to be calibrated into the risk-benefit profile. (hcplive.com)

Comment in: Ethylmercury and breastfeeding as confounders in outcomes of functional programming: Where are they? (cdc.gov)

In 1959, using cardiopulmonary bypass (CPB), Barnes Woodhall and colleagues at Duke Medical Center performed the first brain surgery using DHCA, a tumor resection, at a brain temperature of 11 °C and esophageal temperature of 4 °C. This was quickly followed by use of DHCA by Alfred Uihlein and other surgeons for treatment of large cerebral aneurysms, another neurosurgical procedure, for which DHCA is still used today. (wikipedia.org)
Data from a team of Holland and US investigators showed parameters of brain morhopmetry-including significant changes in amygdala volume, cerebral white matter and fusiform gyrus through early adolescent age among children exposed to SSRIs in utero versus those who were not. (hcplive.com)
The primary outcomes will include interventions used to maintain cerebral saturation in target range, rates of cerebral hypoxia and systemic hypoxia, and a composite of death or severe brain injury detected on term-equivalent magnetic resonance imaging. (stanford.edu)

It is a myth that the brain quits generating new cells once you reach adulthood. (medindia.net)

Patients with severe traumatic brain injury commonly develop anemia. (medindia.net)
Although these pathways can be incredibly important for survival, they can also be maladaptive-especially with severe or chronic forms of stress-overwhelming both the brain and the rest of the body. (nih.gov)
Genetic and early environmental risk factors, operationalized as those for severe psychopathology (i.e., polygenic scores for neuroticism, childhood maltreatment, urban upbringing and paternal age) were assessed as modulators of the impact of SLEs on the brain. (nih.gov)

I'm Will Koehne and I'm representing the Clinician Outreach and Communication Activity, COCA with the Emergency Risk Communications Branch at the Centers for Disease Control and Prevention. (cdc.gov)

Alongside this, speaking to children often about how their online lives affect them is also important -- to hopefully identify children at risk of cyberbullying, addictive behaviours, or even exploitation -- and so enabling timely intervention to avoid adverse outcomes. (sciencedaily.com)
Importantly, results will help to identify high-risk patients who can be selectively enrolled in future intervention studies. (pcf.org)
Furthermore, impaired renal function during the postoperative period in infants requiring intervention for CHD might hamper urinary clearance of iodine and further increase the risk of hypothyroidism, and the association between impaired renal function and hypothyroidism in infants with CHD has also not been well-studied. (medscape.com)

The PRO (Prenatal Risk Overview) for pregnant people. (uspreventiveservicestaskforce.org)
CONCLUSIONS: We found no evidence that prenatal ultrasound use increases ASD risk. (cdc.gov)

During this outbreak we have seen rapidly evolving information about Zika virus infection, its modes of transmission and its effects on pregnancy and birth outcomes. (cdc.gov)
Recent studies have suggested that risk for microcephaly is concentrated in pregnancies in which infection occurs during the first trimester ( 1 , 2 ). (cdc.gov)
We fitted a logistic model to individual-level data for the 125 followed-up women to estimate the proportion of APOs after symptomatic Zika virus infection at each week of gestation ( Figure 1 , panel A). Although the fitted linear model suggested a decline in risk over time, the model did not perform significantly better than a model with constant risk for APO at any gestational age ( Technical Appendix ). (cdc.gov)
For each epidemic scenario, the model suggested that the duration of elevated risk was much longer than the duration of cases if APOs could occur from infection in any gestational week. (cdc.gov)
If you think that the risk of disability and death is an acceptable consequence of a preventable infection, then you must be afflicted with a strange affinity to play Russian roulette with a revolver that has an unknown number of chambers and bullets. (medpagetoday.com)
Missed nursing care is likely clinically relevant to whether VLBW infants develop an infection, develop a brain hemorrhage, or even die. (news-line.com)
A bloodstream infection is a very serious outcome. (news-line.com)
You can't tell if the adverse outcome was related to the epidural or an underlying infection that was inadequately treated," she said. (healthday.com)
Helicobacter pylori infection also increases lymphoma risk. (msdmanuals.com)

For patients with neurological injury, anemia is a potential cause of secondary injury, which may worsen neurological outcomes. (medindia.net)
Among patients with closed head injury, neither the administration of erythropoietin nor maintaining hemoglobin concentration of at least 10 g/dL resulted in improved neurological outcome at 6 months. (medindia.net)

however, to date, they have failed to show consistent effects on outcome measures. (medscape.com)
The groups treated with PT and XRT were compared regarding treatment characteristics, side effects, occurrence of PsP, and survival outcomes. (lu.se)
However, the report also found that the vast majority of research examining the effects of the Internet on the brain has been conducted in adults -- and so more research is needed to determine the benefits and drawbacks of Internet use in young people. (sciencedaily.com)
We sought to examine whether social stress has adverse effects on risk of declining episodic memory and executive functioning in aging individuals. (springer.com)
Marital risk had adverse effects on episodic memory in men but not in women. (springer.com)
Daily discrimination had adverse effects on executive functioning on all individuals. (springer.com)
Drug effects: For patients on ADT, the ability of the drug to penetrate the blood-brain barrier and how effectively the drug targets the AR in the brain. (pcf.org)
Precision survivorship is a field of medical research and clinical practice that aims to identify vulnerable populations at increased risk for adverse outcomes from cancer treatments, understand the biology and genetic factors underlying these effects, and use this information to select personalized treatments that will maximize a patient's long-term quality of life. (pcf.org)
The effects involve different organs (e.g. heart, bone, or brain), and different functions within organs (e.g. cognitive, motor, or emotional brain functions). (nih.gov)
Bastian TW, Rao R, Tran PV, Georgieff MK (2020) The effects of early-life Iron deficiency on brain energy metabolism. (vitamindwiki.com)
Since, an array of adverse effects has been associated with HRT. (yourlawyer.com)
MOST IMPORTANT FINDINGS: Accumulating evidence indicates that adverse effects may occur even at low-level methylmercury exposures from seafood and freshwater fish. (cdc.gov)

These results suggest a potential neural mechanism underlying the worse outcome of women in gender-unequal settings, as well as highlight the role of the environment in the brain differences between women and men. (dericbownds.net)
The outcomes also generally were worse if someone had experienced head trauma after the age of 15, probably because the brain is less resilient than in earlier childhood, Dr. Fazel says. (sandiegopsychiatricsociety.org)
I found both pain and insomnia to be associated with worse neurocognitive performance, even after adjustment for known treatment and demographic risk factors. (lu.se)

An active brain can certainly help in improving memory by strengthening the connections between neural impulses in brain. (medindia.net)
Neural signals transmitted to the brain for interpretation as sound are diminished or lost. (cdc.gov)

There is a growing body of evidence suggesting that the premature loss of ovarian function caused by bilateral oophorectomy performed before natural menopause is associated with several negative outcomes. (nih.gov)
Premature infants are at high risk for variations in blood pressure and oxygenation during the first few days of life. (stanford.edu)
The immaturity of the premature brain may further predispose these infants to death or the development of neurologic problems. (stanford.edu)

African-American children remain at increased risk for higher blood lead concentration after adjusting for environmental lead exposures and dietary intake [Lanphear et al. (cdc.gov)

DHCA is a form of carefully managed clinical death in which heartbeat and all brain activity cease. (wikipedia.org)
All nutrients are essential for brain development, but pre-clinical and clinical studies have revealed sensitive periods of brain development during which key nutrients are critical. (vitamindwiki.com)
Dr. Barr's research interests include the mathematical modeling of the clinical pharmacology of sedatives and opioids commonly administered to ICU patients, and ICU outcomes research. (stanford.edu)
Improving ABCDEF Bundle Compliance and Clinical Outcomes in the ICU: Randomized Control Trial to Assess the Impact of Performance Measurement, Feedback, and Data Literacy Training. (stanford.edu)
Our systematic review describes development and validation cohorts of frailty indices used in patients undergoing surgical resection of brain metastases and serves as a guide to their incorporation in the outpatient clinical setting. (bvsalud.org)
Although frailty indices have demonstrated the ability to predict outcomes in patients undergoing surgical resection of brain metastases, further validation of these indices is necessary prior to their incorporation in clinical practice. (bvsalud.org)
This atypical clinical course should be known in order to improve the outcome of adverse events due to antituberculosis treatment. (who.int)

Children who exhibit pica, a compulsive hand-to-mouth behavior and repeated eating of non-food items -not considered pathologic in infants and toddlers up to 2 years of age-, are at greatest risk. (cdc.gov)
Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Hans-Meerwein-Str. (nih.gov)
This blog reports new ideas and work on mind, brain, behavior, psychology, and politics - as well as random curious stuff. (dericbownds.net)
A second research line concerns adolescent risk-taking behavior and substance use and how this may affect further brain development. (erasmusmc.nl)

In addition, CDC has created a national registry to collect information about Zika affected pregnancies and subsequent birth and infant outcomes. (cdc.gov)
Evidence is increasing that Zika virus-related adverse outcomes can occur throughout pregnancy. (cdc.gov)
Thus, a better understanding of the likely duration and risk for APOs after Zika virus outbreaks is urgently needed ( 2 ). (cdc.gov)
We used these risk profiles to estimate the period through which an elevated rate of APOs would be expected after the 2015-2016 Zika epidemic in 9 regions of Brazil ( Figure 1 , panels B-J). We superimposed the timing of confirmed microcephaly cases in each region to assess the relationship between observed microcephaly and expected duration of elevated APO risk but did not fit explicitly to microcephaly incidence data. (cdc.gov)
Expected temporal distribution of Zika virus-related adverse pregnancy outcomes under different hypothetical outbreak scenarios, Brazil, April 2015-July 2017. (cdc.gov)
red lines indicate risk (APOs/1,000 births) for Zika-associated. (cdc.gov)
To examine the potential duration and risk for Zika-associated APOs more generally, we also predicted the pattern of APOs under 3 hypothetical epidemic scenarios: single outbreak, multipeaked epidemic, and endemic transmission ( Figure 2 ). (cdc.gov)

Among mothers over 30, increases in the father's age do not appear to further increase the risk of autism. (livescience.com)

In addition, the late subgroup had higher Framingham Stroke Risk scores throughout the follow-up period, indicating a higher load of vascular risk factors.InterpretationOur findings suggest that tracking depressive symptoms in the community over time may be a useful tool to identify phenotypes that show different etiologies and cognitive and brain outcomes. (ox.ac.uk)
There is, therefore, considerable interest in identifying risk factors with the goal of modifying these to decrease the incidence and/or severity of NDDs. (nature.com)
Risk factors included older age and non-Hispanic black ethnicity. (natap.org)
Consider prescribing naloxone based on the patient's risk factors for overdose. (nih.gov)
Further, genetic and environmental risk factors were not correlated with grey matter volume in the left mOFC cluster and did not affect the association between SLEs and left mOFC grey matter volume. (nih.gov)
Important early life risk factors do not interact with current SLEs on brain morphology in healthy subjects. (nih.gov)
In the future I hope to further explore risk factors for cognitive sequelae after pediatric brain tumor, especially gender differences and in social ability. (lu.se)
Prematurity, low birth weight and multiple births are factors that make the brain susceptible to structural changes and increase the chance of deviations in motor, cognitive, social and language development. (bvsalud.org)

For women who didn't develop a fever, researchers found no differences in outcomes for babies for women who had an epidural vs. those who didn't. (healthday.com)

It's an intrinsic human need throughout the lifespan that benefits our bodies and brains, helps us build and maintain healthy relationships, and even enhances our creativity and productivity at work. (chriskresser.com)

Longer tools (eg, the 8-item ASSIST [Alcohol, Smoking and Substance Involvement Screening Test]) that assess risks associated with unhealthy drug use or comorbid conditions. (uspreventiveservicestaskforce.org)
Assess patient's risk before prescribing, and monitor regularly for these behaviors and conditions. (nih.gov)
The Newcastle Ottawa Scale (NOS) was used to assess for risk of bias across individual studies. (bvsalud.org)

There is an increased incidence of brain injury at times longer than 40 minutes, but sometimes circulatory arrest for up to 60 minutes is used if life-saving surgery requires it. (wikipedia.org)
This also impacts on the development of children and their brains, shaping response patterns for life. (frontiersin.org)
Each term refers to adverse circumstances that many children experience during their first few years of life. (vakids.org)
My research focus is on periods of vulnerability and opportunity in brain development: the first 1000 days of life and adolescence. (erasmusmc.nl)
Unfortunately, it is impossible at the moment to identify which children or teenagers who experience head trauma may be most at risk of struggling in later life and which will instead recover without apparent complications, he says. (sandiegopsychiatricsociety.org)

The risk for a person to develop dementia over a lifetime is now 15% (95% confidence interval [CI] 7-9%) lower than it was in 2010 and incidence rates of dementia have declined over the past quarter century [ 2 ]. (springer.com)

Answer these eight questions to see whether your brain is wired to be happy or if you might need to practice positivity. (cnn.com)
Data gaps, as identified by AI, will be filled by targeted state-of-the-art in vitro and in silico testing.The 6 NAMs will be evaluated and applied in collaboration with industrial and regulatory stakeholders in order to maximise end-user acceptance and regulatory confidence.This is anticipated to expedite implementation in risk assessment practice and to facilitate commercialisation. (fhi.no)

Whole brain voxel-based morphometry analysis was performed in N = 786 (64.6% female, mean age = 33.39) healthy subjects to identify correlations of brain clusters with commonplace recent SLEs. (nih.gov)
Association of Gestational Age at Birth With Brain Morphometry. (erasmusmc.nl)

The researchers did not observe any serious adverse outcomes related to the drug. (scienceblog.com)
Because NPC1 symptoms result from cholesterol buildup in brain cells, the researchers also measured cholesterol metabolism in the participants' central nervous system. (scienceblog.com)
For each participant, the researchers also compiled comparable medical and other records for a sibling who had never been given a diagnosis of a head injury and compared outcomes both between family members and against the full population of the country. (sandiegopsychiatricsociety.org)
This time, reports Reuters, women who experience breast tenderness following HRT have a nearly two-fold risk of being diagnosed with breast cancer versus women on HRT, but without the tenderness, according to researchers. (yourlawyer.com)
The researchers said that the tenderness while on HRT "may be a marker of increased breast cancer risk," and urged women with breast tenderness after HRT to discuss the issue with their physicians, wrote Reuters. (yourlawyer.com)

Advanced parental age was already a known risk factor for having a child with autism. (livescience.com)

Recent evidence shows that certain single nucleotide polymorphisms increase the risk of lymphoma. (msdmanuals.com)

Though the findings also showed a "catch-up growth" stage of compensation among those affected, the team believes more follow-up analysis into the impact of the antidepressant drug class on offspring brain development is necessary. (hcplive.com)
Abnormal brain development, probably beginning in the womb, is known to be fundamental to the behaviors that characterize autism. (livescience.com)
Essential nutrients may promote the development of certain brain functions, thereby causing confounding bias. (cdc.gov)

These findings do not support either approach in patients with traumatic brain injury," the authors conclude. (medindia.net)
The key findings of this report are that high-levels of Internet use could indeed impact on many functions of the brain. (sciencedaily.com)

For example, hormonal responses to stress enable the body to navigate threatening situations successfully and properly heal from significant injury, while brain responses enable humans and animals to learn from these stressors in order to avoid future threats. (nih.gov)
An unknown number will develop permanent organ injury, affecting the lungs, heart, and brain. (medpagetoday.com)
In addition, most participants had lower levels of two proteins indicative of brain injury, FABP3 and calbindin D, implying that there was less damage in the brain. (scienceblog.com)
The relationship between unstable blood pressure and oxygen levels and brain injury has not been well elucidated. (stanford.edu)
The original NORA program identified 21 research priorities based on the number of workers at risk, the severity of the hazard or outcome, and the probability that new research would have an impact on reducing the particular Illness or injury. (cdc.gov)

However, cannabis-exposed infants are not at greater risk of birth defects or death within one year, including sudden unexpected infant death. (press-news.org)
Eighteen of the studies measured the risk of low birth weight. (press-news.org)

Psychosocial problems include the need for family care providers to work at jobs outside the home during the day and the adverse emotional impact on caregivers and children or grandchildren. (lacounty.gov)

The purpose of this Funding Opportunity Announcement (FOA) is to elucidate the etiology and pathogenesis of the neurocognitive complications associated with type 2 diabetes (T2D) with the ultimate goal of informing future strategies to mitigate the risk of these complications. (nih.gov)

We know, at least in animals like mice and rats, that a range of different interventions can block or reverse many of these stress-induced processes, preventing some of the adverse behavioral responses to stress that we think might be relevant to human disorders like major depression and post-traumatic stress disorder (PTSD). (nih.gov)

Here we report the case of a patient with treatment-resistant OCD and depression, both of which improved with ECT in the presence of bilateral deep brain stimulation (DBS). (psychiatrist.com)
To review the data on long-term outcomes in women who underwent prophylactic bilateral oophorectomy, a common surgical procedure that has more than doubled in frequency since the 1960s. (nih.gov)

Anatomy27

Organisms7

Diseases43

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment100

Psychiatry and Psychology22

Phenomena and Processes41

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena4

Humanities1

Information Science16

Named Groups2

Health Care68

Geographicals3

Fetal8

Mental health outcomes2

Neonatal5

Neurodevelopmental5

Exposure21

Patient Outcomes1

Health25

Maternal3

Childhood experiences2

Cognition3

Postnatal1

Impairment10

Favorable2

Outweigh the risks1

Potentially4

Neurobehavioral1

Socioeconomic1

Potential adverse effects1

Longitudinal1

Mortality2

Study22

Baseline7

Concussion3

Anomalies2

Functional1

Cerebral3

Adulthood1

Severe3

Centers1

Intervention3

Prenatal2

Infection9

Neurological2

Effects12

Worse3

Neural2

Premature3

Exposures1

Clinical7

Behavior4

Zika7

Increases1

Factors8

Differences1

Lifespan1

Assess3

Life5

Dementia1

Practice2

Morphometry2

Researchers5

Factor1

Evidence1

Development3

Findings2

Injury5

Birth2

Emotional1

Etiology1

Traumatic1

Bilateral2