Risk for toxicity. Medical search. Frequent questions

Radon Toxicity: Who Is at Risk of Radon Exposure? (cdc.gov)
Identify the estimated risk of lung cancer from radon exposure for persons who smoke cigarettes as compared with those who have never smoked. (cdc.gov)
Everyone is exposed to radon, but some populations described in the literature are at higher risk of exposure to increased radon levels. (cdc.gov)
In addition, some populations are more at risk of adverse health effects from radon exposure. (cdc.gov)
The risk of lung cancer from radon exposure is estimated at between 10 to 20 times greater for persons who smoke cigarettes as compared with those who have never smoked. (cdc.gov)
Theory holds that everyone is at risk from radon exposure, and this health risk increases linearly with dose. (cdc.gov)
The added risk is unclear regarding medical exposure, which can exceed that from radon. (cdc.gov)
An invaluable tool for decision makers who need to assess risk versus benefits of low-level exposure during decontamination projects. (radpro.com)
The primary outcome was the risk of sudden death within 14 days of exposure to one of three antibiotics (erythromycin, clarithromycin, or azithromycin), relative to cefuroxime. (ices.on.ca)
Posters were presented from current research conducted in Europe, the United States, and Canada, displaying projects related to genomics, toxicity testing, exposure science, and the interpretation of biomonitoring data. (cefic-lri.org)
ONTOX will deliver a generic strategy to create innovative new approach methodologies to predict systemic repeated dose toxicity effects that, when combined with tailored exposure assessment, will enable human risk assessment. (fhi.no)
Late intestinal toxicity after radiotherapy (LITAR) for abdominal or pelvic cancers, resulting from exposure of the nontarget bowel area and irreversible progression of lesions, could not be averted even by the most advanced radiation techniques [ 6 - 8 ]. (biomedcentral.com)
Anyone can develop mercury toxicity as a result of mercury exposure. (epnet.com)
In addition to monitoring and treating participants for an overreactive immune response, including high levels of cytokine release, the guidance recommends that first-in-human trials and trials of products that have had limited experience in humans consider using staggered enrollment in order to minimize exposure to unacceptable toxicities. (centerwatch.com)
Excessive sun exposure doesn't cause vitamin D toxicity. (clevelandclinic.org)
Researchers used data on soil lead content to inform their analysis of the contributing factors to lead exposure risk around Philadelphia. (upenn.edu)
Taken together, this means that poorer homeowners may lack the funds to maintain and make needed repairs to their homes, leaving them at risk of a variety of related health issues, including exposure to lead. (upenn.edu)
That analysis underscored the link between housing code violations and demolition of older homes to higher lead-exposure risks. (upenn.edu)
In one piece of work, scientists from Penn and Haverford developed a lead index, identifying the areas of Philadelphia at highest risk of lead exposure. (upenn.edu)
Although there are many potential sources of exposure to mercury and its compounds, most people can be reassured that they are at low risk of mercury toxicity. (bpac.org.nz)
Vitamin D toxicity is usually caused by large doses of vitamin D supplements - not by diet or sun exposure. (emojicut.com)

Embryo-Fetal Toxicity: Valrubicin intravesical solution can cause fetal harm. (drugs.com)
Embryo-Fetal Toxicity: May cause fetal harm. (nih.gov)

In the first study, published in 2021 in the International Journal of Environmental Research and Public Health , the researchers used geospatial tools to develop a lead-toxicity-risk index that identified eight ZIP codes, mainly in North and West Philadelphia, as the most burdened by lead toxicity. (upenn.edu)

Introduction - Digoxin is commonly prescribed to elderly patients with heart failure and atrial fibrillation, and macrolide antibiotics markedly increase the risk of digoxin toxicity. (ices.on.ca)
The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
In a Phase III trial, The Radiation Therapy Oncology Group (RTOG) showed improved progression-free survival (PFS) for high-risk prostate cancer patients treated with Whole Pelvis Radiation Therapy (WPRT) compared with prostate-only radiation therapy (PORT) [4]. (scirp.org)
Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)
An ongoing GETUG-AFU-18 phase III trial is evaluating the impact of dose escalation in combination with 3-year androgen deprivation treatment on 5-year biochemical or clinical control in high-risk prostate cancer patients [8]. (scirp.org)
You want actual patients being treated by doctors as they normally would, without any strict criteria excluding certain people who are at high risk of anything, and follow them through. (ophthalmologytimes.com)
Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
Therefore, identifying clinical risk factors for LITAR is important for establishing a predictive model in the clinical setting of decision-making for these patients. (biomedcentral.com)
This review aims to systematically summarize and clarify the clinical factors that can be potentially associated with an increased risk of moderate/severe LITAR in patients with abdominal or pelvic malignancies. (biomedcentral.com)
There is no doubt that radiotherapy accompanied by other therapeutic modalities has greatly contributed to increased long-term survival rates for these patients, although treatment-associated toxicities are commonly found [ 4 - 6 ]. (biomedcentral.com)
Given the growing number of patients receiving ADCs and the expanding indications for their use, understanding the toxicity profiles of these drugs, and developing strategies to mitigate and manage these side effects have become paramount, Paolo Tarantino, MD, of the Dana-Farber Cancer Institute in Boston, and colleagues explained in a recent review exploring ADC toxicities and efforts to improve patient safety. (medscape.com)
Occasionally patients may present to primary care expressing concern about mercury toxicity, or requesting testing following their own research. (bpac.org.nz)
Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis? (bmj.com)
Within immune-related adverse events, patients undergoing treatment for melanoma may often experience skin-related toxicities. (curetoday.com)
It is common, you know, to see across different tumor types, too, if you look across clinical trials, it can be as high as 35 to 40% (of patients experiencing skin-related toxicities). (curetoday.com)
Patients with underlying autoimmune conditions can be at worse risk of skin-related toxicities. (curetoday.com)
Those patients are higher risk. (curetoday.com)
FDA recommends that healthcare professionals stop prescribing and dispensing propoxyphene-containing products to patients, contact patients currently taking propoxyphene-containing products and ask them to discontinue the drug, inform patients of the risks associated with propoxyphene, and discuss alternative pain management strategies. (implantsutra.com)
Withhold or permanently discontinue fluorouracil in patients with evidence of acute early-onset or unusually severe toxicity, which may indicate near complete or total absence of dipyrimidine dehydrogenase (DPD) activity. (nih.gov)
Unituxin is a GD2-binding monoclonal antibody indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. (nih.gov)
In clinical studies of patients with high-risk neuroblastoma, Grade 3 peripheral sensory neuropathy occurred in 2% to 9% of patients. (nih.gov)
Prior phenotypic evaluation by CyTOF has identified increases in activated CD8 T cells with activation of Th17 T cells, as well as decreases in Tregs, particularly in patients with toxicity. (nature.com)
We further demonstrate directly using intracellular flow cytometry that autoimmune toxicity in patients is associated with higher absolute numbers of CD4 and CD8 T cells with Th17 differentiation in peripheral blood prior to therapy, and that gastrointestinal tissues from patients with active autoimmune complications of PI3Kδ inhibitors show infiltration with Th17 + T cells. (nature.com)
These same tissues show depletion of Tregs as compared to CLL patients without toxicity, suggesting that loss of Tregs may be permissive for Th17 activation to lead to autoimmune toxicity. (nature.com)
Current clinical trials for children with HL aim to further segregate patients into risk strata such that those who are highly curable can receive less toxic therapy, whereas high-risk patients can receive augmented therapy. (ices.on.ca)
The identification of genetic factors associated with either responsiveness or resistance to 5-fluorouracil (5-FU) chemotherapy, as well as genetic factors predisposing patients to the development of severe 5-FU-associated toxicity, is increasingly being recognised as an important field of study. (nih.gov)
Patients with a partial DPD deficiency have an increased risk of developing grade IV neutropenia. (nih.gov)
In addition, the onset of toxicity occurred twice as fast compared with patients with a normal DPD activity. (nih.gov)
A mutation proved to be the most common one and was detected in 24-28% of all patients suffering from severe 5-FU toxicity. (nih.gov)
The causes of variation in toxicity to the same treatment regimen among seemingly similar patients remain largely unknown. (bvsalud.org)
This integrated biomarker discovery approach may circumvent some of the major limitations in toxicity biomarker science and move precision oncology treatment forward so that patients receive maximum treatment benefit with minimal toxicity . (bvsalud.org)
However, patients should be closely monitored for signs of isoniazid toxicity, especially peripheral neuropathy. (who.int)
Therefore, patients with hepatic impairment should be closely observed for signs of toxicity. (who.int)
Pregnancies in patients who are on oral vitamin K1 treatment for brodifacoum toxicity are high-risk pregnancies. (cdc.gov)
Pregnant patients on oral vitamin K1 should be referred for high-risk pregnancy management and follow-up. (cdc.gov)

For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)

Because individuals typically have different levels of response to the same dose of a toxic substance, a population-level measure of toxicity is often used which relates the probabilities of an outcome for a given individual in a population. (wikipedia.org)
Tested on fathead minnows - an organism often used to test the effects of toxicity on aquatic life -- nanosilver suspended in solution proved toxic and even lethal to the minnows. (thefishsite.com)
Silver nitrate is a lot more toxic than nanosilver, but when nanosilver was sonicated, or suspended, its toxicity increased tenfold," said Maria Sepúlveda, an assistant professor of forestry and natural resources whose findings were published in the journal Ecotoxicology. (thefishsite.com)
Any ingredient in a multiple vitamin supplement can be toxic in large amounts, but the most serious risk comes from iron or calcium. (emojicut.com)
By inputting the dog's weight in kilograms into the calculator, it estimates the toxic and serious toxicity doses in grams. (worldanimalfoundation.org)
By calculating the toxic and serious toxicity doses using your dog's weight in kilograms, you can better understand the potential risk of onion ingestion and seek appropriate veterinary care if necessary. (worldanimalfoundation.org)

The Proctitis and frequency were the commonest acute toxicity and were maximal during the 5th week of radiation therapy. (scirp.org)

FDA notified healthcare professionals that Xanodyne Pharmaceuticals has agreed to withdraw propoxyphene, an opioid pain reliever used to treat mild to moderate pain, from the U.S. market at the request of the FDA, due to new data showing that the drug can cause serious toxicity to the heart, even when used at therapeutic doses. (implantsutra.com)

The results of these studies also provided reassurance that none of the Piperazines tested are likely to have any significant developmental and/or reproductive toxicity issues to humans when used in their commercial applications. (nih.gov)
In addition to renal disease, cardiovascular effects, and reproductive toxicity, lead may cause irreversible neurologic damage. (cdc.gov)

The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
Late intestinal toxicity after radiotherapy (LITAR) not only limits the radiation dose, which subsequently leads to unfavorable clinical outcomes, but also significantly lowers the quality of life in an increasing number of cancer survivors. (biomedcentral.com)
If the information is sufficient, results will be synthesized by a meta-analysis with the random effects model to pool the estimate of risk posed by clinical factors. (biomedcentral.com)
This review will summarize the evidence of clinical risk factors for moderate/severe LITAR. (biomedcentral.com)
CAR-T therapy can induce rapid and durable clinical responses but is associated with unique acute toxicities. (nature.com)
PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity, despite promising efficacy and evidence that toxicity is associated with improved clinical outcomes. (nature.com)
ORLANDO-Inhaled doxorubicin has clinical activity and can be delivered without major toxicity to adults with advanced solid tumors affecting the lungs, according to a multicenter phase I study reported at the 38th Annual Meeting of the American Society of Clinical Oncology (abstract 1204). (cancernetwork.com)
Although the role of tumoral levels as a prognostic factor for clinical responsiviness has not been firmly established, there is ample evidence that a deficiency of DPD is associated with severe toxicity after the administration of 5-FU. (nih.gov)
However, there has been limited success in discovering robust pharmacogenetic predictors of treatment -related toxicity and even less progress in translating the few validated predictors into clinical practice. (bvsalud.org)
This commentary describes the limited success in discovering and translating clinical and pharmacogenetic toxicity predictors into clinical practice. (bvsalud.org)
We then discuss the opportunities for discovering non-genomic (e.g., metabolomic , lipidomic , transcriptomic, proteomic, microbiomic, medical, behavioral, environmental) and integrated biomarkers that may be more strongly predictive of toxicity risk and the potential challenges with translating integrated biomarkers into clinical practice. (bvsalud.org)

The guidance also urges sponsors to establish limits for increasing dosage, recommending criteria for high levels of cytokine release, allergic reactions to cell infusion, organ toxicity and autoimmune toxicity. (centerwatch.com)

What are the symptoms of vitamin D toxicity? (clevelandclinic.org)
The symptoms of vitamin D toxicity are mainly due to hypercalcemia. (clevelandclinic.org)
Unlike lead toxicity, gadolinium produces its own symptoms, such as skin disorders and runaway production of fibroblast cells, leading to thickening such as the disease scleroderma. (womensinternational.com)
Some plants contain chemicals that can cause symptoms similar to digitalis toxicity if they are eaten. (medlineplus.gov)
Contact your provider if you are taking a digitalis medicine and you have symptoms of toxicity. (medlineplus.gov)
The fat-soluble vitamins A and D are the most likely to cause toxicity symptoms if you consume them in high amounts. (emojicut.com)

Their results, published in the Journal of Experimental Medicine on March 6, 2023, identify a targetable mechanism for one of the most challenging treatment-related late toxicities in cancer survivors. (mskcc.org)

Vitamin D toxicity (hypervitaminosis D) happens when you have too much vitamin D in your body. (clevelandclinic.org)
Vitamin D toxicity, also called hypervitaminosis D, is a rare but potentially serious condition that occurs when you have excessive amounts of vitamin D in your body. (emojicut.com)

The DVH analysis showed good coverage of PTVs and organs at risk doses were acceptable. (scirp.org)
FDA concluded that the safety risks of propoxyphene outweigh its benefits for pain relief at recommended doses. (implantsutra.com)

We illustrate the evolution of cancer toxicity biomarker discovery and translation through studies of taxane-induced peripheral neuropathy , which is one of the most common and debilitating side effects of cancer treatment . (bvsalud.org)

A range of factors can inform the type and severity of ADC toxicities a patient may experience. (medscape.com)
However, the linker and the antibody can also play into the type, incidence, and severity of ADC toxicities. (medscape.com)
How well a person does depends on the severity of the toxicity and if it has caused an irregular heart rhythm. (medlineplus.gov)

The researchers also identified the chemokine CXCL10 in circulating blood as a novel biomarker for radiation-induced cardiac toxicity. (mskcc.org)
To that end, we propose an integrated biomarker discovery approach that recognizes that a patient 's toxicity risk is determined by the cumulative effects of a broad range of "omic" and non-omic factors. (bvsalud.org)

Give you corticosteroids and bisphosphonates (medications) in cases of severe toxicity to block bone resorption. (clevelandclinic.org)

One well-known example of on-target, off-tumor toxicity is ADC-related cardiotoxicity, which can occur with HER2-targeted drugs that use trastuzumab . (medscape.com)
Skin-related toxicities can occur with many different anti-cancer immunotherapy drugs, as these agents spark an immune response. (curetoday.com)

Corrosive chemicals possess physical toxicity because they destroy tissues, but are not directly poisonous unless they interfere directly with biological activity. (wikipedia.org)
To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. (nih.gov)
Health risks of nearly 10,000 chemicals charted to help predict toxicity of untested substances. (scientificamerican.com)
A giant database on the health risks of nearly 10,000 chemicals will make it easier to predict the toxicity of tens of thousands of consumer products for which no data exist, say researchers. (scientificamerican.com)
In meeting this objective, this Skin Notation Profile intends to inform the audience-- mostly occupational health practitioners, researchers, policy- and decision-makers, employers, and workers in potentially hazardous workplaces--so that improved risk-management practices may be developed to better protect workers from the risks of skin contact with the chemicals of interest. (cdc.gov)

Another wrinkle, which makes adverse events harder to predict, is "drugs with similar targets or similar payloads don't always have identical toxicity," Bardia said. (medscape.com)
It is apparent that identification of toxicity predictors that can be used to predict and prevent treatment -related toxicity will require thinking beyond germline genomics . (bvsalud.org)

Is there a magic formula that divers can use to ascend at the end of dives to minimize their risk of decompression illness (DCI), and what are the costs of ascending too quickly? (xray-mag.com)

Any problem that affects how your kidneys work (including dehydration ) makes digitalis toxicity more likely. (medlineplus.gov)

Previous toxicology studies have presented conflicting results as to the extent of CeO2 toxicity, which is hypothesized to be due to the ability of Ce to exist in both a +3 and +4 valence state. (cdc.gov)

2. Advanced technologies - Evaluating the applications of advanced methods in toxicity testing/molecular screening using genomics and high-throughput testing/screening in the context of systems biology. (cefic-lri.org)

Thus, to study whether valence state and oxygen vacancy concentration are important in CeO2 toxicity, CeO2 nanoparticle s were doped with gadolinium to adjust the cation (Ce, Gd) and anion (O) defect states. (cdc.gov)

Other grade 1-2 toxicities included mainly cough, hypoxia during inhalation, loss of appetite, and light-headedness. (cancernetwork.com)

Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)

Although this treatment was the first to produce reliable disease control, the resulting late toxicity led pediatric oncologists to pioneer the use of combined chemotherapy and low-dose (15-25 Gy) involved-field RT for all stages of HL. (ices.on.ca)

Data from the phase 3 KEYNOTE-091 trial supported the European Commission's approval of pembrolizumab as an adjuvant treatment for adults with non-small cell lung cancer at high risk of recurrence following complete resection and platinum-based chemotherapy. (cancernetwork.com)

The primary toxicities associated with these agents - alopecia, neutropenia, and diarrhea - align with the toxicities seen with unconjugated topoisomerase inhibitors. (medscape.com)

Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. (wikipedia.org)

Withhold fluorouracil for cardiac toxicity. (nih.gov)
Memorial Sloan Kettering Cancer Center (MSK) researchers have discovered that innate immune signaling drives late cardiac toxicity after DNA-damaging cancer therapies. (mskcc.org)
Further, they found that suppressing this signaling pathway with an experimental STING antagonist effectively prevented cardiac toxicity in mouse models. (mskcc.org)

The U.S. Centers for Disease Control and Prevention recognizes that communities of color and low-income populations are at a higher risk of lead poisoning. (upenn.edu)
2016. Prevention of Childhood Lead Toxicity. (cdc.gov)

In this article, ' Addressing toxicity risk when designing and selecting compounds in early drug discovery ', we discuss the application of expert knowledge-based predictions of toxicity. (optibrium.com)
We highlight how they can be used with multi-parameter optimisation, to guide the design and selection of high quality compounds with a reduced risk of toxicity, early in the drug discovery process. (optibrium.com)
For more information on how StarDrop can support you in minimising toxicity risk, take a look at our Derek Nexus StarDrop module, watch our webinar on ' Addressing toxicity risk when designing and selecting compounds in early drug discovery ' or try out a tutorial walkthrough for yourself. (optibrium.com)

Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). (wikipedia.org)
The biological toxicity of pathogens can be difficult to measure because the threshold dose may be a single organism. (wikipedia.org)
Toxicity can be measured by its effects on the target (organism, organ, tissue or cell). (wikipedia.org)

Divers face a variety of medical challenges, but because dive injuries generally are rare, few clinicians are trained to prevent, diagnose, or treat them.Recreational divers should assess potential risks before diving, be prepared to recognize signs of injury, and seek qualified dive medicine help promptly when needed. (cdc.gov)

Behavioral toxicity refers to the undesirable effects of essentially therapeutic levels of medication clinically indicated for a given disorder (DiMascio, Soltys and Shader, 1970). (wikipedia.org)
They are in general at higher risk of any immune-related adverse events, including cutaneous (effects). (curetoday.com)
Zinc toxicity can have both acute and chronic effects. (emojicut.com)

The dog onion toxicity calculator is a valuable tool that helps dog owners assess the potential risk of onion ingestion based on their dog's weight. (worldanimalfoundation.org)

The hazardous compound is also associated with an increased risk of gastrointestinal irritation, nausea, chest pain, and scratchy throat as well as diarrhea, weakness, headache, and malaise. (naturalpedia.com)

Acute grade 1 toxicity for Gastrointestinal (GI) and Genitourinary (GU) were 65% and 35% respectively, while Grade 2 toxicity was 30% for both. (scirp.org)

For high risk prostate cancer, the treatment volumes and even dose levels are still a controversial issue. (scirp.org)
Dr. Hickey warns that the treatment is temporary because the underlying lead toxicity problem is not resolved simply by using magnesium. (womensinternational.com)
Understanding and targeting the mechanism of PI3Kδ-associated toxicity could allow us to more fully incorporate these agents into the CLL treatment paradigm and extend the duration of benefit from currently available therapies. (nature.com)
There was tremendous optimism that the patient 's germline genome would be strongly predictive of treatment -related toxicity and could be used to personalize treatment and improve therapeutic outcomes. (bvsalud.org)

The antibody, for instance, may lead to adverse events from what's called on-target, off-tumor toxicities. (medscape.com)

Mercury toxicity occurs when a person is exposed to mercury. (epnet.com)
The U.S Food and Drug administration group (FDA) concludes that amalgam fillings do not significantly contribute to mercury-related toxicity. (bpac.org.nz)

If you take too much supplemental or prescription vitamin D, it can lead to vitamin D toxicity. (clevelandclinic.org)
What is vitamin D toxicity? (clevelandclinic.org)
Vitamin D toxicity usually isn't life-threatening, but it can be quite harmful to your health. (clevelandclinic.org)
Vitamin D toxicity typically only happens from taking too much of a vitamin D supplement or prescription medication. (clevelandclinic.org)
How common is vitamin D toxicity? (clevelandclinic.org)
Vitamin D toxicity most often results from taking too much prescription-strength vitamin D or too much of an over-the-counter vitamin D supplement. (clevelandclinic.org)
Consuming too much vitamin D from your diet alone very rarely leads to vitamin D toxicity. (clevelandclinic.org)
What are the risk factors for vitamin D toxicity? (clevelandclinic.org)
People who take prescription-strength vitamin D are at risk for vitamin D toxicity due to the high dose of the medication unless they check their levels periodically. (clevelandclinic.org)
How is vitamin D toxicity diagnosed? (clevelandclinic.org)
How is vitamin D toxicity treated? (clevelandclinic.org)
How can I prevent vitamin D toxicity? (clevelandclinic.org)
Which vitamin toxicity is most common? (emojicut.com)
Vitamin D toxicity is rare and unlikely to develop from multivitamin use. (emojicut.com)
Is vitamin A toxicity common? (emojicut.com)
Reported incidences of vitamin A toxicity are quite rare, with fewer than 10 cases per year from 1976 to 1987[2]. (emojicut.com)
In some cases, vitamin D toxicity can result in kidney injury and even kidney failure. (emojicut.com)
Vitamin K toxicity is extremely rare. (emojicut.com)

Acute radiation toxicities were reported during the radiation course and the following 3 months. (scirp.org)
Previous studies demonstrated the superiority of IMRT over the conventional radiation techniques for WPRT in sparing of organs at risk [9] and superior target coverage [10]. (scirp.org)
LITAR, sometimes called chronic radiation enteritis (CRE), is widely defined as major intestinal toxicities or complications occurring or persisting more than 3 months after radiotherapy. (biomedcentral.com)

The FDA expects early-phase CAR T-cell therapy trials to focus primarily on the risks of toxicity, according to a new draft guidance that also addresses manufacturing and preclinical considerations in developing CAR T-cell therapies. (centerwatch.com)
Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
The recognition of toxicity is of utmost importance as the use of these therapies increases. (nature.com)

No recorded acute Grade ≥ 3 toxicity. (scirp.org)

Skin-related toxicities are easy to treat, as doctors will typically prescribe moisturizers, antihistamines and steroids to decrease inflammation in the skin. (curetoday.com)
those with favorable risk disease typically receive two to four cycles of multi-agent chemotherapy with low-dose IFRT, whereas those with higher-risk disease receive more intensive chemotherapy before IFRT. (ices.on.ca)

The purpose of this white paper is to articulate the issues pertaining to Tier 3 toxicity values and provide recommendations on processes that will improve the transparency and consistency of identifying, evaluating, selecting, and documenting Tier 3 toxicity values for use in the Superfund and Resource Conservation and Recovery Act (RCRA) programs. (epa.gov)

This white paper will be used to assist regional risk assessors in selecting Tier 3 toxicity values as well as provide the foundation for future regional and national efforts to improve guidance and policy on Tier 3 toxicity values. (epa.gov)

Washington, DC -Long-term use of latanoprost (Xalatan, Pfizer) does not increase the risk of corneal toxicity when compared with other glaucoma medications, according to data from a 5-year post-marketing surveillance study. (ophthalmologytimes.com)
However, our results are promising as there are no substitute medications for treating liver toxicity. (sciencedaily.com)

Two papers led by a group at the University of Pennsylvania explore how factors such as household income, building age, building code violations, proximity to former lead smelters, and other factors align with lead-toxicity risk, as evidenced by elevated blood-lead levels in children 6 years old and younger and lead content in soil samples from around the city. (upenn.edu)
The findings underscore the role of economic and racial disparities when it comes to lead toxicity. (upenn.edu)
The drug Stavzor got a new label warning from the FDA, alerting users to the risk of liver failure that can lead to death. (aboutlawsuits.com)
Dr. Hickey specifically warns about lead toxicity. (womensinternational.com)
Fortunately, society has moved away from these major sources of lead toxicity. (womensinternational.com)
If the waist measurement is larger, this is an indicator of metabolic syndrome and an indicator of lead toxicity. (womensinternational.com)
[ 4 ] can lead to escalating use of the drug and increased toxicity. (medscape.com)
Children of all races and ethnic origins are at risk of lead poisoning throughout the United States. (cdc.gov)

Over the years, efforts to close knowledge gaps in ecological toxicity and risk have aided in the development of appropriate site-specific risk assessments. (serdp-estcp.org)
The emergence and rapid development of new tools for biomonitoring and toxicity testing can provide a significant opportunity to improve our ability to perform risk assessments. (cefic-lri.org)
According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00),vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)

Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception. (drugs.com)
The results of the nematode and zebrafish studies were in alignment with data obtained from conventional mammalian toxicity studies indicating that these have potential as developmental toxicity screening systems. (nih.gov)
Identifying and assessing potential hazards (e.g., environment, water and weather conditions, planned depth and bottom time) can help divers make decisions about acceptable risk. (cdc.gov)
The presence of these microalgae in a coastal area is an indication of potential risk of CP. (lu.se)

Research has found correlations between personality traits (risk taking and reward sensitivity) and responses to amphetamine use. (medscape.com)

The only reported toxicity comes from menadione, which has no use in humans. (emojicut.com)

Anatomy12

Organisms12

Diseases45

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes33

Disciplines and Occupations4

Technology, Industry, Agriculture4

Information Science3

Health Care17

Exposure21

Embryo-Fetal Toxicity2

20211

Patients35

Systemic1

Toxic6

Acute toxicity1

Serious toxicity1

Reproductive toxicity2

Clinical11

Autoimmune1

Symptoms6

20231

Hypervitaminosis2

Doses2

Peripheral neuropathy1

Severity3

Biomarker2

Severe1

Occur2

Chemicals5

Predict2

Minimize1

Kidneys1

Toxicology1

Genomics1

Gadolinium1

Hypoxia1

Pulmonary5

Pediatric1

Recurrence1

Inhibitors1

Substances1

Cardiac3

Prevention2

Compounds3

Organism3

Assess potential risks1

Effects3

Ingestion1

Irritation1

Gastrointestinal1

Treatment4

Adverse1

Mercury2

Vitamin18

Radiation3

Therapies3

Grade1

Typically2

Evaluating1

Guidance1

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Lead8

Assessments3

Potential4

Responses1

Humans1