Risk and genotype. Medical search. Frequent questions

The proportion of APOE genotypes and alleles differ between populations of different ethnic groups and gender [1]. (j-alz.com)
Future research would benefit from understanding the relationship between APOE genotype and how we could use micronutrients to accumulate in brain to help relive oxidative stress. (j-alz.com)
The present study examined a range of possible determinants of memory complaints, covering psychiatric and personality factors, medical history, cognitive test performance, and biological risk factors for dementia (APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities). (nih.gov)
This test determines a person's genetic risk for heart disease associated with the commonly studied gene called apoE, which is involved in the metabolism of cholesterol and triglycerides (fats in the blood). (news-medical.net)
In other words, knowing a patient's apoE genotype helps a doctor predict whether or not the patient would be better off on statins versus a low-fat diet, for example. (news-medical.net)
Some patients might respond well to a low fat diet, some patients might respond better to statin medications, depending on their apoE genotype,' states Dr. Jonathan Stein, PhD and Director of Science and Research at SpectraCell Laboratories. (news-medical.net)
Six possible apoE genotypes exist: e2/e2, e2/e3, e2/e4, e3/e3, e3/e4 and e4/e4. (news-medical.net)
Approximately 40% of the population carries one or more of the high risk variants within the apoE gene. (news-medical.net)
However, apoE genotyping is best when used in conjunction with additional lipid profile testing. (news-medical.net)
In this study we wanted to characterize the effects of the interaction between environmental risk factors and apoE genotype on neurodegeneration processes, with particular focus on behavioural studies and neurodegenerative processes at molecular level. (unibo.it)
Thus, given to the importance of the involvement of leptin in AD, we wanted to clarify the function of leptin in the pathogenesis of AD and to investigate if apoE genotype affect leptin levels through studies in vitro, in mice and in human. (unibo.it)
Using data from the BODYCON cross-sectional study (n = 360 adults) we assessed the association between body composition and CVD risk markers according to APOE genotype, with examination of the role of BMI. (reading.ac.uk)
Our results confirm previous reports that BMI modulates the effect of APOE on CVD risk markers and suggest novel interactions on body composition, with diet a potential modulator of this relationship. (reading.ac.uk)

For GWAS, a genome can be represented as a sequence of variant sites, i.e. genomic locations that may have different genotypes. (biomedcentral.com)

Apolipoprotein E gene allele 4 (APOE4) is a major genetic risk factor for late-onset Alzheimer's disease (AD). (j-alz.com)
The MolDX Team has determined Apolipoprotein (Apo) E genotype testing, developed to assess the risk of cardiovascular disease, has insufficient evidence to support the required clinical utility for the established Medicare benefit category. (cms.gov)
As reviewed, the developers described the indication to perform an Apolipoprotein (Apo) E genotype test as a risk assessment for developing a disease or condition. (cms.gov)
Effective immediately, SpectraCell Laboratories now offers apolipoprotein E genotyping. (news-medical.net)
The major genetic risk factor is the E4 variant of apolipoprotein E gene called apoE4. (unibo.it)
We assessed the impact of lifestyle activities, known risk factors for sporadic late-onset AD (Apolipoprotein E □4 allele status, family history of dementia, and the Cardiovascular Risk Factors Aging and Dementia score), and their interactions on cognition. (medrxiv.org)
Body mass index (BMI) has been suggested to play an important role in the relationship between the APOLIPOPROTEIN (APO)E genotype and cardiovascular disease (CVD) risk. (reading.ac.uk)

Individuals carrying one copy of the APOE4 allele are known to be at 3-4-fold increased risk of developing AD compared with those carrying the more common APOE3 allele. (j-alz.com)
With regards to the gender, evidence indicate that the APOE4 risk for AD is greater in women, especially in heterozygous individuals carrying one APOE4 allele [2]. (j-alz.com)
Two fundamental calculations are central to population genetics: allele frequencies and genotype frequencies. (wikipedia.org)
Although allele and genotype frequencies are related, it is important to clearly distinguish them. (wikipedia.org)
As an example, consider a population of 100 four-o-'clock plants (Mirabilis jalapa) with the following genotypes: 49 red-flowered plants with the genotype AA 42 pink-flowered plants with genotype Aa 9 white-flowered plants with genotype aa When calculating an allele frequency for a diploid species, remember that homozygous individuals have two copies of an allele, whereas heterozygotes have only one. (wikipedia.org)
The Hardy-Weinberg law describes the relationship between allele and genotype frequencies when a population is not evolving. (wikipedia.org)
Inheritance of the TNF-α (−863) C allele has been associated with an elevated risk of Alzheimer disease. (molvis.org)

Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. (nih.gov)
This enhances inflammation in the artery clots, which become more prone to rupture and could explain why such genetic variants increase the risk of ischaemic events. (biomedcentral.com)
Classical human leucocyte antigen (HLA) variants at 2-digit and 4-digit resolution were obtained via imputation from single marker genotypes. (edu.au)
Our findings demonstrate how the local environment directly affects disease risk phenotypes and that genetic variation, including less common variants, can modulate individual's response to environmental challenges. (nature.com)
Discovery of common and rare genetic risk variants for colorectal cancer. (broadinstitute.org)
Seventy-two patients were randomly assigned to a group that underwent genotype analysis for the NUDT15 variant (rs116855232) and FTO variant (rs79206939) and 3 common TPMT variants (rs1800460, rs1800462, rs1142345) associated with myelosuppression and 92 patients were assigned to a group that did not undergo genotype analysis (non-genotyping group). (ecco-ibd.eu)
Patients who did not carry any of the genetic variants and patients in the non-genotyping group received 50 mg azathioprine equivalents followed by dose escalation up to 2-2.5 mg/kg. (ecco-ibd.eu)
Limited information on phenotypes attributable to RAD21 variants and genotype-phenotype relationships is currently published. (springer.com)
Variants were frequently familial, and genotype-phenotype analyses demonstrated striking interfamilial and intrafamilial variability. (springer.com)
Using a saliva sample, the company looks for specific genetic variants in a customer's DNA that are associated with increased risk of those diseases or conditions. (latimes.com)
Customers then receive a report confirming whether they have variants associated with those conditions, or in some cases, will include the specific percentage describing lifetime risk. (latimes.com)
And these tests are looking only for specific variants - not all of which are associated with an increased risk of these diseases. (latimes.com)
In principle, DNA-based population screening can identify persons with rare pathogenic variants who are at high risk of preventable diseases and disabilities and could benefit from early interventions. (cdc.gov)
In addition, population genomic screening for common variants could help provide risk assessment and prevention for common diseases for persons with high polygenic risks , to identify carriers for certain genetic conditions for reproductive planning, and to identify persons with certain pharmacogenomic traits to guide the use of medications across the lifespan. (cdc.gov)
PRS calculate the additive influence of many common genetic variants on the risk of a particular disease. (cdc.gov)

To investigate the associations of milk intake (non-fermented and fermented milk), lactase persistence (LCT-13910 C/T) genotype (a proxy for long-term non-fermented milk intake), and gene-milk interaction with risks of cardiovascular disease (CVD) and CVD mortality. (lu.se)
After adjusting for sociodemographic and lifestyle factors, higher non-fermented milk intake was significantly associated with higher risks of coronary heart disease (CHD) and CVD mortality, whereas higher fermented milk intake was significantly associated with lower risks of CVD and CVD mortality. (lu.se)
Genotype frequency may also be used in the future (for "genomic profiling") to predict someone's having a disease or even a birth defect. (wikipedia.org)
One recent study conducted in Japan demonstrated that the relative risk of narcolepsy in affected first-degree family members is 10- to 40-fold higher than in the general population, suggesting that genetic factors play an important role in this disease 12 . (nature.com)
The medical community generally agrees that heart disease risk is affected by both environmental and genetic factors. (news-medical.net)
These differences affect how effectively certain therapies will lower a patient's risk of heart disease. (news-medical.net)
We know that every individual is unique at the genetic level, and that means some people will respond better to certain approaches for reducing heart disease risk than others. (news-medical.net)
Maioli, Silvia (2011) Interaction between APOE4 genotype and environmental risk factors in Alzheimer's disease , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
Alzheimer's disease (AD) is probably caused by both genetic and environmental risk factors. (unibo.it)
These findings suggest that modifiable lifestyle activities offset cognitive decrements due to AD risk in mid-life and support the targeting of modifiable lifestyle activities for the prevention of Alzheimer's Disease. (medrxiv.org)
The results also revealed that in the consomic strains, the effects of Vit D on EAE were also sex and genotype dependent, as high Vit D was protective, had no effect, and unexpectedly had disease-exacerbating effects. (ajmc.com)
Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease por: Joura, Elmar A., et al. (ccb.org.co)
Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease por: Ruiz-Sternberg, Angela María, et al. (ccb.org.co)
The agency said the tests "are intended to provide genetic risk information to consumers," but they "cannot determine a person's overall risk of developing a disease or condition. (latimes.com)
This effort would use increasingly affordable sequencing technology to measure a defined set of genes that meet the evidentiary bars of high disease risk and effective intervention. (cdc.gov)
For persons identified to be at high genetic risk of these conditions, there are evidence-based guidelines for effective risk management interventions to prevent disease. (cdc.gov)

These findings connect genetic 17q21 variations that are associated with asthma risk and higher ORMDL3 expression to lower sphingolipid synthesis in humans. (jci.org)

Immunochip and targeted single nucleotide polymorphism (SNP) genotype data were produced, respectively, for discovery and replication purposes. (edu.au)
Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). (ox.ac.uk)
For detecting genotype-phenotype association from case-control single nucleotide polymorphism (SNP) data, one class of methods relies on testing each genomic variant site individually. (biomedcentral.com)

We asked whether modifiable lifestyle activities impact cognition in middle-aged individuals who are cognitively healthy, but at risk for late life AD. (medrxiv.org)

Risk for childhood asthma is conferred by alleles within the 17q21 locus affecting ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression. (jci.org)
Whole-blood dihydroceramides and ceramides were decreased in subjects with the 17q21 asthma-risk alleles rs7216389 and rs8076131. (jci.org)
In the case of genotype-phenotype association study specifically, this means looking for differences between the two groups in the frequencies of alleles. (biomedcentral.com)
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion ( TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents. (diabetesjournals.org)
the higher the number of the risk alleles, the higher the chance of progression from normal glucose tolerance (NGT) to IGT/T2D ( P = 0.022). (diabetesjournals.org)

Experts in obstetric and gynecologic management provide insight on the role of HPV genotypes in cervical cancer risk. (contemporaryobgyn.net)

No significant risk was detected in the British or Spanish populations. (ox.ac.uk)
The increasing popularity of PRS is likely owing to low cost, improved accessibility, and potential to generate risk estimates on large populations. (cdc.gov)

The W strain, which caused a large outbreak of multidrug-resistant tuberculosis in the United States, is a variant of the Beijing genotype ( 8 - 10 ). (cdc.gov)
Is the Subject Area "Variant genotypes" applicable to this article? (plos.org)
PATIENTS AND METHODS: A total of 2766 subjects, including 963 Finnish, 283 British, and 163 Spanish subjects with colorectal cancer, and 773 Finnish, 363 British, and 221 Spanish control subjects, were genotyped for the C/T(-13910) variant by polymerase chain reaction minisequencing. (ox.ac.uk)
CONCLUSION: Low lactase enzyme activity, defined by genotyping of the C/T(-13910) variant, may increase the risk of colorectal cancer. (ox.ac.uk)

In order to evaluate the impact of genotype-by-Vit D interactions on EAE susceptibility, the researchers used a chromosome substitution mouse model (consomic) that involved the genetic diversity of wild-derived PWD/PhJ (PWD) mice. (ajmc.com)

All initial and follow-up Mycobacterium tuberculosis isolates of these case-patients had (nearly) identical restriction fragment length polymorphism patterns, and the Beijing genotype was a significant risk factor for treatment failure and relapse (odds ratio 2.8, 95% confidence interval 1.5 to 5.2). (cdc.gov)
This study compares a polymorphism in the SULT1A1 gene, SULT1A1 enzyme activity, meat consumption, and the risk of prostate cancer in a population based case-control study. (aacrjournals.org)
Angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT1 R A1166C) gene polymorphism have both been associated with an increased risk of heart attack or stroke. (biomedcentral.com)
Increased risk for ischaemic events is related to combined RAS polymorphism. (biomedcentral.com)
Patients and controls were genotyped for the A/C polymorphism at position −863 of the TNF-α gene promoter region. (molvis.org)

First transfusion before 1996 (when blood donor screening started) was the common risk factor associated with HCV infection. (who.int)
The results provide evidence that blood donor screening and use of virus-inactivated factor concentrates have lowered the risk of HCV infection among multi-transfused patients. (who.int)
Published disorders and renal failure requiring ratios and infection control measures reports about the distribution of HCV haemodialysis who had received 10 or were obtained by interviewing the staff, genotypes among Iranian haemophilia more units of blood or components in at from thalassaemia centre records and patients are also scarce [6]. (who.int)

We performed spoligotyping on the sputum samples of case-patients who had experienced treatment failure or relapse and controls to identify the samples that belonged to the Beijing genotype ( 15 ). (cdc.gov)
Van Geel et al genotyped 750 male patients who were participating in the lipid-lowering regression trial, REGRESS (regression growth evaluation statin study). (biomedcentral.com)
Patients who carried both the ACE-DD and AT1 R-CC genotype had significantly more ischaemic events during the two-year follow-up period than those carrying other genotype combinations ( p =0.035, Mantel-Haenszel test for linear association). (biomedcentral.com)
Le contenu de ce site web est en partie réservé aux professionnels de santé qui sont directement impliqués dans la fourniture de services de soins de santé aux patients. (fujirebio.com)
However, interferon may still play a role in particular treatment situations (eg, therapy for treatment-experienced patients infected with genotype 3). (medscape.com)
Such patients may be at risk for worsening liver function or sepsis if treated with peginterferon. (medscape.com)
In May 2011, the HCV NS3/4A protease inhibitors boceprevir and telaprevir received FDA approval for patients infected with HCV genotype 1. (medscape.com)
A third protease inhibitor, simeprevir, received FDA approval in November 2013 for use in patients infected with HCV genotype 1. (medscape.com)
Twelve patients (16.7%) in the genotype analysis group and 33 patients (35.9%) in the non-genotyping group developed myelosuppression ( p = .005). (ecco-ibd.eu)
Pre-treatment genotype analysis reduced numbers of outpatient clinic visit and numbers of patients with drug discontinuation or dose reductions. (ecco-ibd.eu)
This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
The detection of high-oncogenic HPV genotypes in patients with breast cancer supports the hypothesis of an etiologic role for the virus in breast cancer development. (who.int)
To identify mutations in COL2A1 and COL11A1 genes and to examine the genotype-phenotype correlation in a cohort of Chinese patients with Stickler syndrome. (molvis.org)
Analysis of the genotype-phenotype correlation showed that the early onset of high myopia with vitreous abnormalities may serve as a key indicator of Stickler syndrome, while the existence of mandibular protrusion in pediatric patients may be an efficient indicator for the absence of mutations in COL2A1 and COL11A1 . (molvis.org)
Interferon-free therapy is also an option for patients with genotype 1 who are interferon-ineligible. (medscape.com)
ABSTRACT A cross-sectional study was made of the prevalence of HCV and associated risk factors in 382 multi- transfused patients and haemodialysis staff in Yadz province in 2006. (who.int)
Haemodialysis unit staff tibodies were found in blood donors 3 hospitals in Yazd province (Shahid were interviewed for: demographic and high-risk groups such as multi- Rahnamoon, Shahid Sadoghi and variables (age, sex, job description), em- transfused patients and intravenous Farokhi hospitals) from April to June ployment history (duration of working drug users. (who.int)
however, reports document chronic genotype 3 hepatitis E exclusively in immunocompromised patients (including organ-transplant recipients, patients receiving cancer chemotherapy, and HIV-infected patients). (msdmanuals.com)

MV detection, isolation and genotyping are performed mainly at designated local governmental (i.e. municipal or prefectural) public health institutions within each local government area. (who.int)

Exposure to heterocyclic amines may increase prostate cancer risk. (aacrjournals.org)
Further, in order to capture gene-by-environment interactions through eQTL analyses, we combine whole-transcriptome RNA-Sequencing profiles with whole-genome genotyping and extensive fine-scale environmental exposure data. (nature.com)
Risk assessment forms the basis for both occupational health decision-making and the development of occupational exposure limits (OELs). (cdc.gov)
The framework is a 4×4 matrix involving the risk assessment functions (hazard identification, dose-response modeling, exposure assessment, and risk characterization) on one axis and inherited and acquired genetic and epigenetic data on the other axis. (cdc.gov)
War exposure, 5-HTTLPR genotype and lifetime risk of depression. (hal.science)
risk in relation to active cigarette smoking and young adults in Ukraine: a cross-sectional household exposure to secondhand cigarette study. (who.int)

Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study. (ox.ac.uk)
The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population. (ox.ac.uk)
RESULTS: The C/C(-13910) genotype, which is a robust molecular marker of low lactase activity (lactase non-persistence), was found to significantly associate with the risk of colorectal cancer (p = 0.015) in the Finnish subjects, with an odds ratio of 1.40 (95% confidence interval 1.07-1.85). (ox.ac.uk)

Chikungunya: the specific interactions between the genotypes of mosquitoes and viruses have influenced Ae. (pasteur.fr)
Thus, the specific interactions between the genotypes of mosquitoes and viruses have influenced Ae. (pasteur.fr)
A recent study found that the association between vitamin D (Vit D) status and multiple sclerosis (MS) susceptibility is genotype dependent and suggested that the outcome of Vit D status in MS is determined by gene-by-sex interactions. (ajmc.com)
The study aimed to determine whether direct manipulation of Vit D levels would modulate central nervous system (CNS) autoimmune diseases in sex-by-genotype interactions by using a dietary model of Vit D modulation with the autoimmune animal model of MS, experimental autoimmune encephalomyelitis (EAE). (ajmc.com)
Taken together, our results support the observation that the association between VitD status and MS susceptibility is genotype dependent and suggest that the outcome of VitD status in MS is determined by gene-by-sex interactions. (ajmc.com)
Tablets is used due to the risk of adverse effects or loss of efficacy due to drug-drug interactions (see also sections 4.4. (who.int)

A recently-published meta-analysis [1] shows a prevalence of HPV with oncogenic risk (with normal Pap smears) of 10.4%, increasing significantly with climacteric (45 - 55 years). (scirp.org)

However, MV was confirmed in all cases by RT-PCR and determined to be the H1 genotype strain, the predominant genotype reported from China and parts of South-Eastern Asia over the past three years. (who.int)

Is the Subject Area "Medical risk factors" applicable to this article? (plos.org)
Those with memory complaints did not differ on any of the biological risk factors for dementia. (nih.gov)
Several risk factors for developing AD have been identified including lifestyle, such as dietary habits. (unibo.it)
Thus, the genetic risk factor apoE4 genotype associated with a high carbohydrate diet seems to affect cognitive functions in young mice, corroborating the theory that the combination of genetic and environmental risk factors greatly increases the risk of developing AD and leads to an earlier onset of cognitive deficits. (unibo.it)
Risk stratification in LQTS relies on combined assessment of clinical, electrocardiographic, and mutations-specific factors. (tau.ac.il)

When only breeding age animals are analysed over 31% of the Irish national beef herd is genotyped, giving unprecedented insight into the genomic variability of the national herd. (icbf.com)

We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. (nih.gov)
These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). (nih.gov)
The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. (nih.gov)

The risk of developing AD is increased by 8-15-fold if an individual is carrying two copies of the APOE4 gene. (j-alz.com)
A meta-analysis of clinical and autopsy-based studies on five ethnic groups (Caucasian, African American, Hispanic, and Japanese) revealed that the risk of developing AD was increased among Caucasian subjects with one APOE4 copy compared to individuals homozygous for APOE3 [1]. (j-alz.com)

Impaired visuospatial function is one of the earliest cognitive deficits in AD and has previously associated with increased AD risk in this cohort. (medrxiv.org)

Methylation estimates the risk of precancer in HPV-infected women with discrepant results between cytology and HPV16/18 genotyping. (bvsalud.org)

Platelets were isolated for phenotype analysis, and DNA was isolated from lymphocytes for genotype determination. (aacrjournals.org)
An understanding of the relationship between the genotype and phenotype characteristics of LQTS can lead to improved risk stratification and management of this hereditary arrhythmogenic disorder. (tau.ac.il)

Of these, genotypes 16 (55.5%), 18 (58.4%), 31 (65.0%) and 33 (26.6%) were detected. (who.int)

and to typify HPV genotypes on women with normal cytology that come to our hospitalary unit of menopausia. (scirp.org)

Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose. (ox.ac.uk)

Furthermore, leptin, HDL, and large HDL were associated with non-fermented milk intake, while no plasma proteins or lipoprotein subfractions associated with fermented milk intake and LCT-13910 C/T genotype were identified. (lu.se)
In conclusion, non-fermented milk intake was associated with higher risks of CHD and CVD mortality, as well as leptin and HDL, whereas fermented milk intake was associated with lower risks of CVD and CVD mortality. (lu.se)

1993. Health risk assessment. (cdc.gov)
1995. Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment. (cdc.gov)
Physiologically based pharmacokinetics and cancer risk assessment. (cdc.gov)
1987. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. (cdc.gov)
Considerations for using genetic and epigenetic information in occupational health risk assessment and standard setting. (cdc.gov)
Although genetic and epigenetic data have not been widely used in risk assessment and ultimately, standard setting, it is possible to envision such uses. (cdc.gov)
This presentation addresses the considerations for using genetic and epigenetic information in risk assessments, provides guidance on using this information within the classic risk assessment paradigm, and describes a framework to organize thinking about such uses. (cdc.gov)
The cells in the matrix identify how genetic and epigenetic data can be used for each risk assessment function. (cdc.gov)

We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role. (edu.au)
We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role.DESIGN: Three independent cohorts of histologically confirmed CC cases (N=314) and controls (N=4299) from Sweden and Germany were included in a 2-step association analysis. (edu.au)
These include high-risk cancer susceptibility genes, such as BRCA1, BRCA2 and PALB2 for hereditary breast and ovarian cancer , MLH1 , MSH2 and MSH6 for Lynch syndrome , and genes for cholesterol metabolism ( LDLR , APOB and PCSK9) for familial hypercholesterolemia . (cdc.gov)

High-risk HPV (hrHPV) is related to cervical carcinogenesis, although clinical data comparing the natural history and carcinogenic potential of type-specific HPV remain limited. (oncotarget.com)

To characterize the relationship of genetic asthma susceptibility with sphingolipid synthesis, we analyzed asthma-associated 17q21 genotypes (rs7216389, rs8076131, rs4065275, rs12603332, and rs8067378) in both children with asthma and those without asthma, quantified plasma and whole-blood sphingolipids, and assessed sphingolipid de novo synthesis in peripheral blood cells by measuring the incorporation of stable isotope-labeled serine (substrate) into sphinganine and sphinganine-1-phosphate. (jci.org)

I think I just saw something earlier this week that 31 was added to one of the assay journals and I often teach that this is an area that we're going to see change over the course of our clinical careers, the more specific genotyping. (contemporaryobgyn.net)
In the clinical world, he said, genetic risk is used only occasionally as supportive evidence. (latimes.com)

Does hepatitis C viremia or genotype predict the risk of mortality in individuals co infected with HIV? (aighd.org)
Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. (wikipedia.org)
They have been proposed as a possible alternative for population screening to identify individuals at high risk. (cdc.gov)

Using a previously collected genome-wide association study of narcolepsy and EHS, we calculated polygenic risk scores (PRS) for each individual. (nature.com)
How About Using Polygenic Risk Scores in Population Screening? (cdc.gov)
In the past decade, there has been growing interest in using polygenic risk scores (PRS) in medicine and public health. (cdc.gov)

To understand these risks we constructed artificial genetic data files using publicly available genetic sources and uploaded them to the leading third-party genetic genealogy service. (ndss-symposium.org)
There is an assay on the market today, the Onclarity assay, that has gotten an FDA approval to reveal extended genotyping because it has the capability of unmasking the data that were already there. (contemporaryobgyn.net)
Biomass and yield overestimation resulting from the use of the minimum data input calibration suggests that other parameters (water productivity, canopy sensitivity to water stress and water stress coefficient) are required to improve canopy and yield predictions for sorghum genotypes. (scielo.org.za)
These data can be useful for assessing variability and reducing uncertainty in extrapolations, and they may serve as the foundation upon which identification of biological perturbations would lead to a new paradigm of toxicity pathway-based risk assessments. (cdc.gov)

Effect modification by genotype on the association between the use of gas for cooking and bronchial responsiveness was assessed within each participating country, and estimates combined using meta-analysis. (bmj.com)
No effect modification by GSTT1 or GSTP1 -rs1695 genotypes was observed. (bmj.com)
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. (ox.ac.uk)
Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. (ox.ac.uk)

Methods The study was performed in subjects with forced expiratory volume in one second at least 70% of predicted who took part in the multicentre European Community Respiratory Health Survey, had bronchial responsiveness assessed by methacholine challenge and had been genotyped for GSTM1 , GSTT1 and GSTP1 -rs1695. (bmj.com)
Methods: Women ages 15-26 and 24-45 years from 5 regions were en. (ccb.org.co)

In population genetics, the genotype frequency is the frequency or proportion (i.e., 0 (wikipedia.org)
Compare genotype frequency: let's now calculate the genotype frequency of aa homozygotes (white-flowered plants). (wikipedia.org)

I think you're going to see in some practices, HPV extended genotyping where they take into account the other genotypes as a way of improving triage specificity. (contemporaryobgyn.net)

The Beijing genotype is emerging in Vietnam in association with drug resistance in this region ( 11 ). (cdc.gov)
Suggested citation: National TB Controllers Association / CDC Advisory Group on Tuberculosis Genotyping. (cdc.gov)

Genotypes 3 and 4 typically cause sporadic cases rather than outbreaks. (msdmanuals.com)

However, APOE2 carriers could develop type III hyperlipoproteinemia and exhibit increased risk of cerebrovascular diseases and neurological disorders. (j-alz.com)

Although the effects of 17q21 genotypes on sphingolipid synthesis in human asthma remain unclear, both decreased sphingolipid synthesis and ORMDL3 overexpression are linked to airway hyperreactivity. (jci.org)
The other approach to triaging HPV [human papillomavirus] positive women is to do genotyping. (contemporaryobgyn.net)
Vigilant management of women with high- risk human papillomavirus (hrHPV) is necessary in cancer screening programs. (bvsalud.org)
As a decisive step towards the artificial production of human beings, it would increase the risk of reducing people to objects. (who.int)
Associated with new knowledge on the human genome, it could be used to facilitate genotype selection and encourage social and parental intolerance of disability or, potentially, perceived genetic defects. (who.int)
In terms of existing ethical guidelines for biomedical research involving human subjects, human cloning for reproductive purposes raises concerns about risk in relation to benefit, informed consent, and accountability. (who.int)
They emphasize the need to promote the teaching of ethics in medical education and to establish effective measures to protect developing countries from the risk of unregulated expatriate research involving human subjects. (who.int)

Circulating Phylloquinone Concentrations and Risk of Type 2 Diabetes: A Mendelian Randomization Study. (broadinstitute.org)
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. (ox.ac.uk)
Further genetic testing is done to check for the type of HCV (genotype). (medlineplus.gov)

PRS are typically calculated using genotyping array and sequencing technologies. (cdc.gov)

Anatomy3

Organisms15

Diseases23

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology1

Phenomena and Processes66

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science8

Named Groups6

Health Care33

Geographicals22

APOE13

Different genotypes1

Apolipoprotein7

Allele7

Variants15

Disease16

Humans1

Single nucleotide p3

Middle Aged1

Alleles5

Cervical cancer1

Populations2

Variant4

Evaluate the Impact1

Polymorphism5

Infection3

Patients18

Detection1

Exposure6

Colorectal cancer3

Interactions6

Prevalence1

Predominant1

Factors5

Genomic1

SNPs3

APOE42

Cohort1

HPV161

Phenotype2

65.01

Cytology1

Interaction1

Leptin2

Assessment8

Genes3

High-risk HPV1

Susceptibility1

Clinical2

Individuals3

Polygenic risk scores3

Data4

Effect modification4

Methods2

Frequency2

Practices1

Association2

Sporadic1

Disorders1

Human7

Type3

Typically1