• Fig. 5: OPC Ca 2+ transients evoked by the α 1 adrenergic receptor agonist are independent of synaptic activity in vitro. (nature.com)
  • In this case, positive inotropes (dobutamine 1-5 mcg/kg/min IV - an agonist of beta-adrenergic receptors) and diuretics are administered depending on the cardiomyopathy. (vin.com)
  • Kratom is an alpha-2 adrenergic receptor agonist [ 1 ]. (kratom.org)
  • The primary psychoactive component of Cannabis, delta 9-tetrahydrocannabinol (Δ9-THC), demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors. (rcsb.org)
  • Belonging to the azaspirodecanedione drug class, 2 buspirone is a serotonin 5-HT 1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. (arlen.com.br)
  • The "intra-operative floppy iris syndrome" cataract surgery complication has been reported in men using alpha-blockers. (urotoday.com)
  • The risk of complicated cataract surgery was 14.9% in patients using alpha-blockers, approximately 50% higher than those not receiving this medication (9.5%) (p=0.003). (urotoday.com)
  • The cause of IFIS has been identified as the intake of systemic alpha-adrenoceptor antagonists (alpha-blockers), drugs prescribed in men for lower urinary tract syndromes such as benign prostatic hyperplasia. (crstodayeurope.com)
  • Looking at pharmacologic and pathophysiologic principles, two paths are responsible for IFIS: (1) The direct effect of alpha-blockers on iris receptors reduces the power of dilating agents and (2) ultrastructural changes lead to irreversible functional loss in the smooth muscle tissue of the iris and to chronic loss of muscular tension, with or without the presence of dilating drugs. (crstodayeurope.com)
  • Include alpha-blockers in preoperative medical history. (crstodayeurope.com)
  • When general practitioners (GPs) conduct preoperative work-ups in patients taking alpha-blockers, in most cases their interest focuses on cardiovascular risks and patients' use of anticoagulants, as the connection between the intake of alpha-blockers and intraoperative cataract surgery complications is largely unknown to primary-care physicians. (crstodayeurope.com)
  • Although atropine is no longer in common use in ophthalmology because of its long duration of action, some surgeons prescribe topical use of this cycloplegic agent for 2 to 3 days prior to surgery for patients with known intake of alpha-blockers. (crstodayeurope.com)
  • Four drug classes were evaluated in the trials: thiazides (21 trials), beta-adrenergic blockers (5), calcium-channel blockers (4) and angiotensin-converting-enzyme (ACE) inhibitors (1). (cmaj.ca)
  • In 5 drug-drug trials comparing thiazides with beta-blockers, the former were associated with a significantly lower rate of withdrawal due to adverse effects (relative risk [RR] 0.69, 95% confidence interval [CI] 0.63-0.76). (cmaj.ca)
  • Beta-blockers and alpha-adrenergic agonists impair thermoregulatory processes and should be modified (1). (shmabstracts.org)
  • A preoperative therapy with alpha-blockers is useful, but not sufficient to avoid surgical risks. (biomedcentral.com)
  • This chapter discusses two groups of drugs that affect the sympathetic nervous system-adrenergic agonists, or sympathomimetics , and adrenergic antagonists, also called adrenergic blockers or sympatholytics -along with their dosages and uses. (basicmedicalkey.com)
  • [ 3 ] Drugs such as angiotensin converting enzyme (ACE) inhibitors, calcium channel blockers (CCBs), angiotensin receptor blockers (ARBs), beta-blockers, and diuretics are all considered acceptable alternative therapies in patients with hypertension. (medscape.com)
  • AlphaAdrenergic Blockers - Alpha-Adrenergic Blockers. (powershow.com)
  • Both belong to the alpha-1 adrenergic receptor blockers class of drugs but differ significantly in key ways. (keydifference.info)
  • it has less of an impact than some alpha-blockers on this count, although side effects may still include dizziness, headache, and retrograde ejaculation (when semen enters instead of exiting from your bladder). (keydifference.info)
  • Beta-blockers bind to beta-adrenoceptors, which inhibit normal sympathetic effects that act through the receptors norepinephrine and epinephrine. (uspharmacist.com)
  • Nonselective beta-blockers block both beta receptors, whereas cardioselective beta-blockers bind to the beta-adrenoceptor and partially activate the receptor while preventing other receptor agonists from binding. (uspharmacist.com)
  • Haloperidol also binds to alpha-1 adrenergic receptors, but with lower affinity, and displays minimal binding to muscarinic cholinergic and histaminergic (H 1 ) receptors. (nih.gov)
  • DESYREL (trazodone hydrochloride) tablets for oral administration contain trazodone hydrochloride, a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist . (rxlist.com)
  • A preoperative therapy with doxazosin, a selective alpha-1 blocker, was started in all patients for at least 14 days prior to the surgery. (biomedcentral.com)
  • Tamsulosin is a selective alpha-1A adrenergic receptor antagonist designed to target prostate and bladder neck receptors, decreasing smooth muscle contraction to relieve urinary obstruction and facilitate urine flow. (keydifference.info)
  • Albuterol sulfate, chemically known as (1,3-benzenedimethanol, (alpha)'-[[(1,1-dimethylethyl) amino] methyl]-4-hydroxy, sulfate (2:1)(salt), (±)- is a relatively selective beta 2 -adrenergic bronchodilator. (theodora.com)
  • SSRIs are selective to the 5-HT system but not specific for the different 5-HT receptors. (msdmanuals.com)
  • Olo drop 0.1% is a sterile ophthalmic solution containing olopatadine, a relatively selective H 1 -receptor antagonist and inhibitor of histamine release from the mast cell for topical administration to the eyes. (medico-labs.com)
  • Olo drop is an inhibitor of the release of histamine from the mast cell and a relatively selective histamine H 1 -antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells. (medico-labs.com)
  • Olopatadine is an inhibitor of the release of histamine from the mast cell and a relatively selective histamine H1‐antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells. (medeasy.health)
  • Intravenous (IV) adrenergic agonists and antagonists are high-alert medications because they can cause significant harm to a patient in the event of a medication error. (basicmedicalkey.com)
  • Anticholinergics prevent the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) which are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. (theodora.com)
  • Olopatadine is devoid of effects on alpha-adrenergic, dopamine and muscarinic type 1 and 2 receptors. (medico-labs.com)
  • 1 The most popular drug of this kind, tamsulosin, has been shown to dramatically increase the risk for IFIS, and other drugs in the class have also been implicated. (crstodayeurope.com)
  • 1 A metaanalysis showed that the odds ratio for IFIS was elevated by a factor of 40 in tamsulosin patients. (crstodayeurope.com)
  • Tamsulosin is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia and ureteric stones. (kratom.org)
  • Kratom and tamsulosin are antagonists -meaning kratom can hinder tamsulosin's effects and reduce its effectiveness. (kratom.org)
  • Kratom and tamsulosin are considered antagonist drugs. (kratom.org)
  • Tamsulosin is an alpha-1 receptor antagonist [ 2 ]. (kratom.org)
  • Thus, because kratom and tamsulosin have opposite effects mediated by the alpha-adrenergic receptors, they will become ineffective if combined. (kratom.org)
  • Tamsulosin is an alpha-adrenergic receptor blocker. (kratom.org)
  • Kratom and tamsulosin act via alpha-adrenergic receptors. (kratom.org)
  • Important to bear in mind when taking Alfuzosin is its nonselective mechanism of action and thus greater potential to cause systemic blood pressure changes compared to medications that target prostate receptors such as Tamsulosin. (keydifference.info)
  • We confirmed our observation in NB xenograft mice models in vivo, treating mice with a combination of 13-cis-RA and the FDA approved alpha-1 AR antagonist doxazosin. (unitn.it)
  • Alpha-blocker medications are the first line of therapy for men with these urinary symptoms. (urotoday.com)
  • To assess the frequency of cataract surgery complications arising from alpha-blocker therapy in a large patient population. (urotoday.com)
  • If possible, alpha blocker medications should be discontinued prior to eye surgery in older patients. (urotoday.com)
  • As alpha-blocker medications are the first line of therapy for men with LUTS, these reports of IFIS led the Food and Drug Administration, American Urological Association, American Academy of Ophthalmology, and American Society of Cataract and Refractive Surgery to issue statements alerting physicians and patients to potential difficulties during cataract surgery in patients using alpha-1 blocker therapy [7,8,9]. (urotoday.com)
  • The purpose of this study was to assess the impact of alpha-blocker therapy on complications during cataract surgery in a large patient population. (urotoday.com)
  • This lack of information among GPs has been identified as the most salient risk factor for complications related to alpha-blocker intake, and, as a result, the number of published studies in urology, general, and family medicine journals describing IFIS outside the ophthalmic community has increased in recent years. (crstodayeurope.com)
  • High-dose thiazide therapy, beta-blocker therapy and calcium-channel blocker therapy did not significantly reduce the risk of death or coronary artery disease. (cmaj.ca)
  • The effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blocker AT-1 (ARBs) in reducing the systemic hypertension (SH) is widely known. (intechopen.com)
  • Alfuzosin is an alpha-1 adrenergic receptor blocker commonly prescribed to treat benign prostatic hyperplasia (BPH), an enlarged prostate leading to urinary difficulties. (keydifference.info)
  • However, its efficacy could be mediated through its activity as an antagonist at central dopamine type 2 receptors. (nih.gov)
  • Only dopamine can activate these receptors. (basicmedicalkey.com)
  • Five neurotransmitter receptors are of primary importance in PONV: acetylcholine, dopamine-2, histamine-1, serotonin-3, and neurokinin-1. (ispub.com)
  • Systemic Alpha-1 adrenergic receptor antagonists have been implicated in Intraoperative Floppy Iris Syndrome (IFIS). (wikipedia.org)
  • Since it was first described by Chang and Campbell in 2005, 1 intraoperative floppy iris syndrome (IFIS) has become a major concern for cataract surgeons. (crstodayeurope.com)
  • Drugs that stimulate the sympathetic nervous system are called adrenergic agonists, adrenergics, or sympathomimetics because they mimic the sympathetic neurotransmitters norepinephrine and epinephrine. (basicmedicalkey.com)
  • Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. (nature.com)
  • In lowering blood pressure, the use of ACE inhibitors or ARBs reduces, in long-term use, the risk of acute myocardial infarction, stroke, and heart failure. (intechopen.com)
  • Unlike potassium-sparing combination diuretic products, hydrochlorothiazide may be used in patients who cannot risk the development of hyperkalemia, including patients taking ACE inhibitors. (medscape.com)
  • While conventional drugs such as the α1-adrenergic receptor antagonists and 5α-reductase inhibitors have been found to be useful in the treatment of BPH, the adverse side effects associated with their usage, have led to increased search for alternative means of managing this disease. (frontiersin.org)
  • 2 3 Phentolamine also has been used to treat hypertensive crisis associated with monoamine oxidase inhibitor (MAOI) therapy and in combination with papaverine to treat erectile dysfunction (ED). 1 According to ED treatment guidelines, oral phosphodiesterase type 5 (PDE5) inhibitors are considered first-line therapy. (empowerpharmacy.com)
  • The alpha-adrenergic receptors are located in the blood vessels, eyes, bladder, and prostate. (basicmedicalkey.com)
  • Alfuzosin acts non-selectively against alpha-1 receptors in all blood vessels throughout the body, unlike some alternatives within its category which only selectively block receptors within certain organs or areas like bladder neck area of prostate or bladder neck areas of BPH or bladder neck area alone. (keydifference.info)
  • By binding to these receptors, Alfuzosin relaxes smooth muscles in the prostate, bladder neck, and blood vessels, leading to improved urine flow and reduced urinary obstruction caused by an enlarged prostate. (keydifference.info)
  • At the molecular level, this synergistic effect is followed by a marked increase in the expression of a member of the catecholamine receptor superfamily: the adrenergic receptor alpha-1B (ADRA1B) suggesting that this receptor might represent a key mediator of the synergistic effect of 13-cis-RA and isorhamnetin observed in vitro. (unitn.it)
  • Membrane trafficking of G protein-coupled receptors (GPCRs) tightly orchestrates the signaling from this superfamily of signaling receptors. (frontiersin.org)
  • Likewise, beta-adrenergic antagonists (e.g. propranolol (Inderal)) can induce depression and fatigue. (hedweb.com)
  • You can also opt for propranolol injections 1 mg per mL. (tabletsmanual.com)
  • From our results, we can conclude that the deletion or inhibition of alpha-1-AR sensitizes NB cells to 13-Cis-RA, both in terms of induction of apoptosis and neural differentiation. (unitn.it)
  • Alpha-receptor antagonist medications potentially interfere with iris muscle dilation, resulting in difficult lens removal and possibly increasing complications. (urotoday.com)
  • Certain medications used concomitantly with metformin may also increase the risk of lactic acidosis. (pdr.net)
  • There are also some medications that can increase the risk of seizures. (webmd.com)
  • Taking rauwolscine along with medications that also slow blood clotting might increase the risk of bruising and bleeding. (webmd.com)
  • Low-dose thiazide therapy can be prescribed as the first-line treatment of hypertension with confidence that the risk of death, coronary artery disease and stroke will be reduced. (cmaj.ca)
  • Hypertension is a manifestation in which there is an elevation of blood pressure levels to the point of causing imbalance in homeostasis and, consequently, leading the organism to a debilitated and pathological state with clinical repercussions [ 1 ]. (intechopen.com)
  • With the advent of antihypertensive agents, the incidence of hypertensive emergencies in the United States has declined from 7% to approximately 1% of patients with hypertension. (medscape.com)
  • 1 It is estimated that the number of persons aged 65 years and older will increase to 72 million by the year 2030, which will in turn result in an increased rate of hypertension among the elderly. (uspharmacist.com)
  • 3 Hypertension puts the elderly at greater risk for developing several cardiovascular diseases (CVDs), ranging from myocardial infarction, angina, and cerebrovascular disease to peripheral artery disease and cardiac failure. (uspharmacist.com)
  • Not only is hypertension considered the most important risk factor for strokes, it is now being linked as a risk factor for dementia as well. (uspharmacist.com)
  • According to the Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7), the SBP should be the primary target for diagnosis and treatment of hypertension in the elderly ( TABLE 1 ). (uspharmacist.com)
  • Oral or intravenous calcium antagonists may cause atrioventricular conduction disturbances, left ventricular failure, and hypotension. (nih.gov)
  • METHODS: PubMed, Embase, and Cochrane Library were searched for observational studies that reported the prevalence and risk factors for POD after head and neck cancer surgery and were published from their inception until December 31, 2022. (bvsalud.org)
  • INT RODUCTIO N: Th e eld erly h ypert en si ve pa ti ent s of ten h aveincreased prevalence of cardiometabolic risk factors and their attendantco-morbidities. (bvsalud.org)
  • Cyproheptadine and clomipramine, neuromodulatory regulators that act as serotonin-2A and histamine receptor antagonists, were effective in restoring normothermia in our patient (2). (shmabstracts.org)
  • In the trials that had an untreated control group, low-dose thiazide therapy was associated with a significant reduction in the risk of death (RR 0.89, 95% CI 0.81-0.99), stroke (RR 0.66, 95% CI 0.56-0.79), coronary artery disease (RR 0.71, 95% CI 0.60-0.84) and cardiovascular events (RR 0.68, 95% CI 0.62-0.75). (cmaj.ca)
  • Alpha-adrenergic antagonists are able to neutralize the cardiovascular effects of CA, reduce peripheral vascular resistances and blood pressure levels, expand circulating blood volume and antagonize alpha receptors downregulation [ 5 ]. (biomedcentral.com)
  • [ 1 ] Cardiovascular end-organ damage may include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary edema, and/or aortic dissection. (medscape.com)
  • Amy biancolli: implications of α 1-adrenergic receptors and inhibitory neurotransmitters stimulate other pets. (tiwouh.org)
  • By preventing reuptake of 5-HT presynaptically, SSRIs result in more 5-HT to stimulate postsynaptic 5-HT receptors. (msdmanuals.com)
  • They stimulate 5-HT 1 receptors, with antidepressant and anxiolytic effects, but they also stimulate 5-HT 2 receptors, commonly causing anxiety, insomnia, and sexual dysfunction, and 5-HT 3 receptors, commonly causing nausea and headache. (msdmanuals.com)
  • Because animal studies are not always predictive of human responses, this drug should be used in pregnant women only if the potential benefit to the mother justifies the potential risk to the fetus.It is not known whether topical ocular administration could result in sufficient systemic absorption to produce detectable quantities in the human breast milk. (medeasy.health)
  • Activated postsynaptic 5-HT1A receptors promote hyperpolarization to released 5-HT on pyramidal neurons.8, The anxiolytic action of buspirone is mainly thought to arise from the interaction at presynaptic 5-HT1A autoreceptors. (arlen.com.br)
  • CB1 receptors are found in both the central and peripheral nervous systems, with the majority of receptors localized to the hippocampus and amygdala of the brain. (rcsb.org)
  • CONCLUSIONS: Pre-operative olfactory testing may provide insight into brain vulnerability, cognitive dysfunction, and delirium risk in individuals undergoing cardiac surgery. (bvsalud.org)
  • 1 Phentolamine injection is contraindicated for use in patients with any coronary artery disease due to cardiac stimulating effects and corresponding increase in myocardial oxygen demand. (empowerpharmacy.com)
  • While it is recognized that beta 2 -adrenergic receptors are the predominant receptors on bronchial smooth muscle, recent data indicate that there is a population of beta 2 -receptors in the human heart which comprise between 10% and 50% of cardiac beta-adrenergic receptors. (theodora.com)
  • Stimulation of the beta 1 receptors increases myocardial contractility and heart rate. (basicmedicalkey.com)
  • Recently it has been shown that risk of torsade de points is associated, not with QT prolongation per se , but specifically with increased transmural dispersion of repolarisation across the myocardial wall, often, but not always, found in association with QT prolongation. (ispub.com)
  • Since NB is a catecholamine-rich tumor, we propose that antagonization of alpha-1-AR disrupts the established autocrine pro-survival circuit generated by catecholamines in NB and restores the ability of the cells to follow the pro-differentiative and pro-apoptotic programs endorsed by 13-cis-RA. (unitn.it)
  • The syndrome involves three telltale symptoms: (1) a billowing iris that does not reach stable mydriasis despite sufficient administration of dilating agents, (2) progressive intraoperative miosis, and (3) a tendency for iris prolapse during surgery (Figure 1). (crstodayeurope.com)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • DMF provide updates from Smart Drugs ( 1 ) on piracetam , acetyl-l-carnitine , vasopressin , and several vitamin therapies. (hedweb.com)
  • Of candidate drugs for PONV, CPZ is the only drug that has activity at the first four of these receptors. (ispub.com)
  • The FDA considers the risk for IFIS to be a class effect for alpha-1 adrenergic receptor antagonists [8,9]. (urotoday.com)
  • When IFIS is not anticipated or is not recognized by the surgeon, the risk for myriad intraoperative complications increases. (crstodayeurope.com)
  • Alpha 2-adrenoceptor antagonists show the liver from depression worsened while taking prescription medication. (tiwouh.org)
  • In order to decrease the risks of serious side effects, you shouldn't change your dosage or stop taking the medication without your physician's recommendations. (tabletsmanual.com)
  • The beta 2 receptors are found mostly in the smooth muscles of the lung and GI tract, the liver, and the uterine muscle. (basicmedicalkey.com)
  • When the active metabolites of kratom bind to these receptors, they cause vasoconstriction, papillary constriction, and constriction of smooth muscles in the genitourinary tract. (kratom.org)
  • meaning it specifically blocks alpha-1A receptors located within both prostate gland and bladder neck areas, helping relax smooth muscles around these regions, thus relieving urinary obstruction and providing smoother urine flow. (keydifference.info)
  • Considering the druggable nature of the alpha-1-AR receptors, we indicate this class of receptors as a novel pharmacological target for the treatment of neuroblastoma. (unitn.it)
  • From a pharmacological perspective, Cannabis' (and CBD's) diverse receptor profile explains its potential application for such a wide variety of medical conditions. (rcsb.org)
  • In animal studies, 1-PP possessed about one quarter of the pharmacological activity of buspirone.13, Hover over products below to view reaction partners, A single-dose pharmacokinetic studies using 14C-labeled buspirone demonstrated that about 29-63% of the dose administered was excreted in the urine within 24 hours, primarily in the form of metabolites. (arlen.com.br)
  • Ipratropium bromide is minimally bound (0 to 9% in vitro ) to plasma albumin and (alpha) 1 -acid glycoprotein. (theodora.com)
  • In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on beta 2 -adrenergic receptors compared with isoproterenol. (theodora.com)
  • Osei-Owusu P, Scrogin KE: Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. (arlen.com.br)
  • They act on one or more adrenergic receptor sites located in the effector cells of muscles such as the heart, bronchiole walls, gastrointestinal (GI) tract, urinary bladder, and ciliary muscles of the eye. (basicmedicalkey.com)
  • [ 1 ] Neurogenic bladder is a term applied to urinary bladder malfunction due to neurologic dysfunction emanating from internal or external trauma, disease, or injury. (medscape.com)
  • When the bladder becomes full, the stretch receptors of the detrusor muscle send a signal to the pons, which in turn notifies the brain. (medscape.com)
  • FIG. 15.1 Effects of activation of alpha 1 , alpha 2 , beta 1 , and beta 2 receptors. (basicmedicalkey.com)
  • These effects are largely mediated through two members of the G-protein coupled receptor family, cannabinoid receptors 1 and 2 (CB1 and CB2)[A32585,A32824]. (rcsb.org)
  • Physiological effects of using cannabis make sense in the context of its receptor activity as the hippocampus and amygdala are primarily involved with regulation of memory, fear, and emotion. (rcsb.org)
  • While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. (rcsb.org)
  • Digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time. (nih.gov)
  • The alpha 2 receptors are located in the postganglionic sympathetic nerve endings. (basicmedicalkey.com)
  • The risk of a confluence of both LUTS and cataracts is significant. (urotoday.com)
  • The aim of this retrospective study was to evaluate the risk factors involved in perioperative hemodynamic instability in patients who underwent surgery for chromaffin tumors. (biomedcentral.com)
  • The absence of adequate preparation ( p = 0.012) before surgery, urinary normetanephrine levels (NMNur p = 0.039), and surgery time (minutes) ( p = 0.021) resulted as risk factors of hemodynamic instability in our series. (biomedcentral.com)
  • Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids, a class of compounds that act upon endogenous cannabinoid receptors of the body [A32584]. (rcsb.org)
  • Given the critical nature of receptor internalization and endosomal signaling for FSHR activity, we assessed whether these compounds exhibit differential abilities to alter receptor endosomal trafficking and signaling within the VEE. (frontiersin.org)
  • All compounds exhibited a similar requirement for receptor internalization to increase cAMP and proportion of FSHR endosomes with active Gαs, suggesting regulation of cAMP signaling induced by T1 may be altered. (frontiersin.org)
  • The general recommendation established by JNC-7 is to initiate a thiazide-type diuretic initially for stage 1 hypertensives without compelling indications for other therapies. (medscape.com)
  • Cannabinoid receptors are utilized endogenously by the body through the endocannabinoid system, which includes a group of lipid proteins, enzymes, and receptors that are involved in many physiological processes. (rcsb.org)
  • This finding redirected our attention to the class of adrenergic receptors (ARs) as novel targets in NB. (unitn.it)