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  • BRCA1
  • These domains encode approximately 27% of BRCA1 protein. (wikipedia.org)
  • Basicamente essa população apresentava uma mutação missense que acarretava na substituição de uma cisteína por uma glicina em uma região importante da proteína , conhecida como domínio ring, dificultando a capacidade de estabelecimento de ligação da proteína BRCA1. (wikipedia.org)
  • MDM2
  • GST-tagged RBBP6 RING was able to precipitate MDM2 from HeLa lysate. (uwc.ac.za)
  • The result was validated by showing that GST-MDM2 was able to precipitate RBBP6 RING in in vitro. (uwc.ac.za)
  • Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation domain of p53. (wikipedia.org)
  • tandem
  • Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (ebi.ac.uk)
  • Transcriptomic analysis revealed that potentide precursor sequences contain four tandem repeats for mature domain, which is the first report that the tandem repeats are found in the Rosaceae family. (bioportfolio.com)
  • vitro
  • The C-terminal fragment of YB-1, denoted YB-1₂₂₀₋₃₂₄, was successfully cloned and expressed in bacteria and demonstrated to interact directly with the RBBP6 RING finger domain in in vitro affinity pull down assays. (uwc.ac.za)
  • UbcH1 was successfully expressed and shown to interact directly with RBBP6 RING in in vitro affinity pull down assays. (uwc.ac.za)
  • In vitro binding assay suggested that STAP-1 SH2 domain interacted with several tyrosine phosphorylated protein including c-kit and STAT5. (nii.ac.jp)