• This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
  • An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
  • An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
  • However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
  • The rats in the model group and the ligustrazine group were used to establish a neonatal rat model of HIE by ligation of the left common carotid artery followed by hypoxia treatment, and blood vessels were exposed without any other treatment for the rats in the sham-operation group. (bvsalud.org)
  • At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)
  • Taken together, these results indicate the TLRs play an important role in ischemia-induced injury in the adult brain. (biomedcentral.com)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
  • We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
  • Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
  • An acute neonatal presentation of hypotonia and cardiomyopathy required ERT with alglucosidase alfa infusions preceded by immune tolerance induction (ITI), as well as chronic red blood cell transfusions and penicillin V potassium prophylaxis for treatment of IOPD and SCA. (wustl.edu)
  • Regarding neurodevelopment, a delay in important reflexes during the neonatal period in ZIKV animals was observed. (bvsalud.org)
  • The Rice-Vannucci model combining unilateral carotid artery ligation with exposure to hypoxia for several hours in 7-day-old rat pups has been widely used for numerous studies on the pathogenesis of hypoxic-ischemic injury. (medscape.com)
  • In the present study we evaluated the effect of DEX in rat pups subjected to common carotid artery occlusion plus hypoxia (CCAoH, the classic Rice-Vannucci model). (unifi.it)
  • [ 19 ] Preexposure to lipopolysaccharide in a model of hypoxia-ischemia in 7-day-old rats has been shown to increase injury dramatically when given either 4 to 6 or 72 hours prior to injury, but injury was reduced when lipopolysaccharide was given at an intermediate time. (medscape.com)
  • Next, we developed a distal middle cerebral artery occlusion plus hypoxia (dMCAoH) model, characterized by an intra-experimental infarct size variability lower than that of the CCAoH model. (unifi.it)
  • [ 20 ] Preexposure to hypoxia prior to hypoxia-ischemia has been shown to have a preconditioning effect on outcome from hypoxia-ischemia. (medscape.com)