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  • elegans
  • Previously, we have shown that the ncl-1 gene in Caenorhabditis elegans functions as an inhibitor of cell growth and ribosome synthesis. (biologists.org)
  • We now indicate that the Drosophila melanogaster tumor suppressor brain tumor ( brat ) is an inhibitor of cell growth and is a functional homolog of the C. elegans gene ncl-1 . (biologists.org)
  • The only other gene that has so far been shown to negatively regulate RNA polymerase I and III transcription is ncl-1 (for abnormal nucleolus) from the soil nematode Caenorhabditis elegans . (biologists.org)
  • Protein
  • RNA interference-mediated knockdown of ErbB2 reduced pre-rRNA and protein synthesis. (aacrjournals.org)
  • rRNA production by RNA polymerase-I (RNA Pol I), the key component of ribosome biogenesis, is the rate-limiting step for translation/protein synthesis and cell growth. (aacrjournals.org)
  • 20047967 ). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). (uniprot.org)
  • In fact, recent studies have shown that one mechanism of cell growth regulation is achieved through an insulin receptor signaling pathway, one of the most downstream targets of which is the ribosomal protein S6 ( Weinkove and Leevers, 2000 ). (biologists.org)
  • Additionally, they have a higher rate of 5S RNA synthesis and probably contain more ribosomes as they contain more protein than do wild-type worms ( Frank and Roth, 1998 ). (biologists.org)
  • epigenetic
  • Given their repetitive nature and their localization in the pericentromeric regions of the genome, 5S rRNA genes are only partly assembled in the reference genome, which has rendered detailed analyses of their organization, dynamics and epigenetic regulation difficult. (gred-clermont.fr)
  • An epigenetic switch, mediated by DNA methylation and histone modification, turns rRNA genes on and off. (beds.ac.uk)
  • clusters
  • The number of EcoRI fragments bearing 5S gene clusters is similar in MIC and MAC. (umich.edu)
  • During replication of the MAC about half the fragments bearing 5S gene clusters disappear in different cell lines, and new fragments containing 5S genes appear. (umich.edu)
  • genetic
  • The genetic markers that contribute to detecting and monitoring the susceptibility of P. falciparum to doxycycline, the pfmdt and pftetQ genes, have recently been identified. (biomedcentral.com)
  • transcription
  • Finally, ErbB2-potentiated RNA Pol I transcription could be stimulated by ligand and was not substantially repressed by inhibition of PI3-K and MEK/ERK (extracellular signal regulated kinase), the main ErbB2 effector signaling pathways. (aacrjournals.org)
  • nucleolus
  • The brat gene is able to rescue the large nucleolus phenotype of ncl-1 mutants. (biologists.org)
  • The ribosomal genes coding for the 45S rRNA precursor of the three largest eukaryotic ribosomal RNAs (18S, 5.8S, and 25-28S) are found in nucleolus organizer regions (NORs), comprised of hundreds to thousands of repeats, only some of which are expressed in any given cell. (beds.ac.uk)
  • large
  • Due to their essential role and the requirement to be produced in large quantities, 5S rRNA genes are highly repeated in the genome. (gred-clermont.fr)
  • physical
  • A physical map of the 5S and 18S-26S rRNA genes was determined using bi-color fluorescence in situ hybridization technique in A. victorialis var. (springer.com)
  • important
  • The presence and high concentration of rRNA genes in air suggests that atmospheric transport, which can lead to secondary infection, may be more important than currently estimated. (frontiersin.org)