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  • assay
  • In the present study, five compounds (F108, F109, F176, F177, and F179) were newly identified by in silico screening of a chemical library and kinase assay. (rcsb.org)
  • inhibitor
  • Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. (nih.gov)
  • p70S6K
  • Due to the role of p70S6K in protein synthesis and also its involvement in a variety of human diseases ranging from diabetes and obesity to cancer, p70S6K is now being considered as a new therapeutic target for drug development. (bmj.com)
  • Tuberous
  • Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that occurs upon mutation of either the TSC1 or TSC2 genes, which encode the protein products hamartin and tuberin, respectively. (pnas.org)
  • lipid
  • Active mTORC1 promotes protein and lipid synthesis, and increases energy production through glycolysis to fuel these energy-intensive processes. (addgene.org)
  • malignant
  • However, Kalkan et al ( 9 ) identified that the expression of multidrug resistance-associated proteins, such as P-glycoprotein and O6-methylguanine-DNA methyl transferase (MGMT), was upregulated in malignant glioma cells following chemotherapy, which induced resistance to chemotherapeutic drugs, such as TMZ. (spandidos-publications.com)
  • In addition, this study identified an association between the expression of these proteins and the relapse rate of malignant glioma. (spandidos-publications.com)
  • transcription
  • Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti- inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. (discoverx.com)
  • complexes
  • These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. (antibodies-online.com)
  • Complex
  • The data were processed using the , using the coordinates of the protein portion of the phosphorylated S6K1KDstaurosporine complex (PDB: 3A62) as the initial search model. (cancer-basics.com)
  • cell survival
  • Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. (nih.gov)