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  • Prp8
  • We found that the role of DDX23 in suppressing R-loops does not require a functional U5 snRNP as depletion of either PRP8 or PRP6, core components of the U5 1 2 snRNP, does not drive genomic instability. (ul.pt)
  • Pathways
  • We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. (stanford.edu)
  • human
  • In spite of its imposing biological relevance and undeniable role in human diseases, tissue-specific annotation of alternative splicing (AS) has not been done systematically and very little is known about the individual functions of splice isoforms. (usherbrooke.ca)
  • functions
  • We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions. (stanford.edu)
  • Short
  • People with too little sex hormones can be short during puberty but end up taller as adults as in androgen insensitivity syndrome or estrogen insensitivity syndrome . (thefullwiki.org)