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  • proteins
  • To understand this dramatic effect, we examined the localization of SR proteins and found that SC35 was shifted to the cytoplasm in sky1 Δ yeast, although this phenomenon was not obvious with ASF/SF2, indicating that nuclear import of SR proteins may be differentially regulated by phosphorylation. (rupress.org)
  • Because SR proteins are known to affect splice site selection in a concentration-dependent manner, such phosphorylation-dependent localization of splicing factors among different nuclear pools may be a mechanism to regulate alternative splicing. (rupress.org)
  • function
  • Subsequent bioinformatics analyses suggested that disruption of U2 function accounts for about 40 percent of the mis-splicing seen in C9ORF72 patient cells, Reed noted. (alzforum.org)
  • control
  • In control motor neurons (left), the U2 splicing complex (red) occupies the nucleus, but in C9ORF72 motor neurons (right), much of it lurks in cytoplasm. (alzforum.org)
  • among
  • Thus, uveal melanoma is among a small group of cancers associated with SF3B1 mutations, and these mutations denote a distinct molecular subset of uveal melanomas. (biomedsearch.com)
  • Among the six species of Schistosoma, S. japonicum is popular mainly in China, Philippines and small pockets of Indonesia. (frontiersin.org)
  • specific
  • This was specific to U2, as other components of the splicing apparatus stayed confined to the nucleus. (alzforum.org)