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  • localization
  • Thus, in addition to the control of nuclear localization of HOW, the phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules. (biologists.org)
  • genetic
  • However little is known about snRNP biology in early onset AD due to autosomal dominant genetic mutations or trisomy 21 in Down syndrome. (biomedcentral.com)
  • These studies identify U1 snRNP pathologic changes in brain of early onset genetic forms of AD. (biomedcentral.com)
  • Since dominant genetic mutations and trisomy 21 result in dysfunctional amyloid processing, the findings suggest that aberrant β-amyloid processing may influence U1 snRNP aggregate formation. (biomedcentral.com)
  • It remains unknown whether the U1 snRNP pathological aggregates are present in genetic forms of AD (PS1 and APP mutations or trisomy 21), but such an association would support a link between U1 snRNP abnormalities and aberrant β-amyloid processing mechanisms in AD. (biomedcentral.com)
  • cleavage
  • The processing/cleavage of CPP32, Ich-1, Mch2α, PARP, U1-70K, and lamins A/B strongly suggested that activation of an ICE-like proteolytic activity was an important effector of the cell death program. (nih.gov)
  • Moreover, recruitment of the small GTPase Rab11 and the PITP Giotto to the cleavage site depends on wild-type function of the exocyst subunits Exo84 and Sec8. (sdbonline.org)