• Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. (nih.gov)
  • Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of telomere terminal repeats. (bioskinrevive.com)
  • Both 851884-87-2 manufacture were identified through genetic screens and shown to act in the same pathway as telomerase RNA and TERT and to be subunits of the telomerase complex but dispensable for in vitro activity (10, 32). (bioskinrevive.com)
  • Further studies implicate Est1p in the recruitment of the telomerase complex to telomere ends in vivo (17, 48). (bioskinrevive.com)
  • In this report, we queried the database with telomerase genes and identified three potential protein components of the telomerase complex (named CaTERT, CaEst1p, and CaEst3p). (bioskinrevive.com)
  • These results indicate that at least two noncatalytic components of the telomerase complex are conserved between and BWP17 (transformations were carried out as previously described by using pBME plasmids linearized with homologues, were obtained from National Center for Biotechnology Information website (http://www.ncbi.nlm.nih.gov). (bioskinrevive.com)
  • There are huge RNP complexes such as RNA viruses, vault complex, ribosome, spliceosome , heterogeneous ribonucleoprotein particles ( hnRNP ) and smaller ones: telomerase, replicase, RNase P, aminoacyl-tRNA synthetases etc. (mdpi.com)
  • [ 8 ] Recently, it was observed that RMRP associates with the human telomerase catalytic subunit (hTERT). (medscape.com)
  • 50S ribosomal subunit protein L32 [Ensembl]. (ntu.edu.sg)
  • If ribosome production is disturbed, however, this ribonucleoprotein can be "pulled" from the ribosomal pathway. (uni-heidelberg.de)
  • Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. (sdsc.edu)
  • Translation is one of the fundamental and core cellular processes catalysed by a ribonucleoprotein complex called ribosome. (iisc.ac.in)
  • The mRNA molecules found in stress granules are stalled translation pre-initiation complexes associated with 40S ribosomal subunits, translation initiation factors, poly(A)+ mRNAs and RNA-binding proteins (RBPs). (wikipedia.org)
  • Based upon the known function of the normal SMN protein, it is speculated that gems are involved in trafficking mRNA spliceosome subunits through the nucleus and may indirectly help remove mRNA introns. (jrank.org)
  • Small nuclear ribonucleoproteins are RNA-protein complexes that are subunits of the spliceosome involved in mRNA intron removal. (jrank.org)
  • Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
  • The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. (cancer-genetics.org)
  • Initiation occurs by formation of an initiation complex comprising 30S ribosomal subunit, mRNA, initiator tRNA, and initiation factors. (iisc.ac.in)
  • The recruitment of 30S ribosomal subunit to the mRNA is aided by interaction between conserved RNA sequence called anti-Shine Dalgarno (aSD) in 16S rRNA and the Shine Dalgarno (SD) sequence in an mRNA present upstream of the start codon. (iisc.ac.in)
  • Speckles are clusters of dense structures seen by electron microscopy that, when stained with fluorescent tags specific to small nuclear ribonucleoproteins (snRNP), give rise to a "speckled" nucleus. (jrank.org)
  • This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. (utsouthwestern.edu)
  • Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. (e-omics.com)
  • The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. (sdsc.edu)
  • The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. (sdsc.edu)
  • This protein is one part (subunit) of the ribonucleoprotein complex, which is composed of proteins and molecules of RNA, DNA's chemical cousin. (medlineplus.gov)
  • A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins. (embl-heidelberg.de)
  • We have identified and characterised human and mouse cDNAs that encode proteins homologous to yPop4p, a protein subunit of both the yeast RNase MRP and RNase P complexes. (embl-heidelberg.de)
  • Component of TRiC, a molecular chaperone complex that regulates telomere maintenance. (plurisomes.com)
  • For the Special Issue "Molecular Regulation and Mechanism of Ribonucleoprotein Complexes" of the International Journal of Molecular Sciences we accept original research manuscripts and reviews highlighting different structural and functional aspects of any ribonucleoprotein сomplex. (mdpi.com)
  • WDR4 is an indispensable noncatalytic subunit of the RNA N7-methylguanosine (m7G) methyltransferase complex and plays an essential role in tumorigenesis. (jcancer.org)
  • Inside the virus, its ribonucleoproteins (RNPs) were shown, with their coiled structures, and three-bulbed polymerase complex on the ends. (cdc.gov)
  • Each segment is wrapped by a nucleoprotein (NP) into a viral ribonucleoprotein (RNP) complex along with a viral RNA polymerase complex comprising polymerase basic 1 (PB1) polymerase, cap‐binding PB2 subunit, and polymerase acidic (PA) endonuclease. (biomedcentral.com)
  • The researchers were able to explain the structural and functional details of a ribonucleoprotein complex that controls this process. (uni-heidelberg.de)
  • The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. (medlineplus.gov)
  • We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)
  • Targeting ∼7000 genes with this methodology, we discovered SAGA complex members Tada2b and Taf5l as key regulators of HSC lineage commitment. (biorxiv.org)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
  • The general transcription factor IIE subunit beta (GTF2E2) is crucial for physiological and pathological functions, but its roles in the malignant biological function of glioma remain ambiguous. (bvsalud.org)
  • These complexes have important biological roles in replication of RNA viruses, cellular transcription and translation, post-transcriptional and post- translational modification and also regulation of these processes. (mdpi.com)
  • RNase P is a ubiquitous ribonucleoprotein enzyme primarily responsible for cleaving the 5' leader sequence during maturation of tRNAs in all three domains of life. (embl-heidelberg.de)
  • A research team at the Biochemistry Center of Heidelberg University investigated the large ribosomal subunit 60S, which plays a mediator role in linking these two processes. (uni-heidelberg.de)
  • hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes. (embl-heidelberg.de)
  • The sequence analyses and quantification of splice variants of candidate lncRNAs, including RP11-295B20.2, RP11-18I14.1, and RP11-322M19.1, demonstrated complex configuration of their splicing changes, with a significant impact of PNN on the process. (molvis.org)
  • The occurrence of OSCC is a complex multistep process. (biomedcentral.com)
  • The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. (cancer-genetics.org)
  • Ribonucleoprotein сomplexes (RNP) are essential in all cellular life forms: Bacteria, Archaea, Eukaryotes and even in non-cellular infectious agent s - RNA viruses. (mdpi.com)
  • [ 16 ] The 3' end of RMRP is essential for RNA dependent RNA polymerase acitivity of the RMRP-hTERT complex. (medscape.com)
  • The structure of the RNase P subunit, Rpp29, from Methanobacterium thermoautotrophicum has been determined. (embl-heidelberg.de)
  • Their RNA components fold into a similar secondary structure and they share several protein subunits. (embl-heidelberg.de)
  • In order to improve and expand applications of Cas9, we recently undertook crystallographic studies to elucidate the atomic structure of the Cas9-sgRNA-target DNA tertiary complex 14 , thus enabling rational engineering of Cas9 and sgRNA. (cdc.gov)