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  • degradation
  • They process precursors to ribosomal RNA, small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA) Yeast nucleases with the Class 2 RNase III domain: RNT1 (UniProtKB Q02555) - S. cerevisiae - this RNase III is involved in the transcription and processing of rDNA, the 3' end formation of U2 snRNA via cleavage of the terminal loop, cell wall stress response and degradation, and regulation of morphogenesis checkpoint genes. (wikipedia.org)
  • yeast
  • Pac1 (UniProtKB P22192) - S. pombe - this RNase III is located on chromosome II of the yeast nuclease and when over expressed, is directly involved in the sterility, lack of mating efficiency, abnormal mitotic cell cycle, and mutation suppression of the organism. (wikipedia.org)
  • cleavage
  • The basic dsRNA cleavage function of Class 1 RNase III is similar in most of the organisms in which it is present. (wikipedia.org)
  • Rnc (UniProtKB P0A7Y0) - E.Coli - this RNase III is involved in the processing of viral transcripts and some mRNAs through the cleavage of multiple areas on the dsRNA. (wikipedia.org)
  • enzymes
  • These enzymes are a group of endoribonucleases that are characterized by their ribonuclease domain, which is labelled the RNase III domain. (wikipedia.org)
  • Typically, class I enzymes possess a single RNase III domain (RIIID) followed by a dsRNA-binding domain (dsRBD). (wikipedia.org)
  • The variances of Class 1 RNase III, called Mini-III, are homodimeric enzymes and consist solely of the RNase III domains. (wikipedia.org)
  • gene
  • The research on the question of how new functions arrive in proteins in evolution led the scientists to find an uncommon consequence for a usual biological event called gene conversion in the case of the ribonuclease (RNase) protein family. (wikipedia.org)
  • One such an example is the resurrection of the bovine seminal RNase gene. (wikipedia.org)
  • Responsible for this disease is a mutation in the RNase MRP RNA gene (RMRP), a non-coding RNA gene. (wikipedia.org)
  • Metaphyseal dysplasia without hypotrichosis (MDWH), anauxetic dysplasia (AD), kyphomelic dysplasia (KD), Omenn syndrome (OS) are diseases associated with mutated and (or) dysfunctional RNAse MRP activity, hence, the RMRP gene. (wikipedia.org)
  • The first type is when an insertion, duplication, or triplication occurs at the promoter of the RNAse MRP gene between the TATA box and the transcription initiation site. (wikipedia.org)
  • Patients with CHH have been identified to have over 70 different mutations in the RNA transcript made by RNAse MRP, whereas around 30 distinct mutations have been identified in the promoter region of the RNAse MRP gene. (wikipedia.org)
  • The protein encoded by this gene belongs to the pancreatic ribonuclease family. (wikipedia.org)
  • RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response. (springer.com)
  • He said that now that they have the human RNase L structure, we can begin to understand the effects of carcinogenic mutations in the RNase L gene. (thefreedictionary.com)
  • Biochemistry
  • Parniak, Professor of Molecular Genetics & Biochemistry at the University of Pittsburgh and Principal Investigator of this multi-team research effort, has nearly 20 years experience in HIV research and is regarded as a thought leader in the discovery of drugs targeting HIV RNase H. (thefreedictionary.com)
  • ribosomal
  • NMR structure of the N-terminal domain of Saccharomyces cerevisiae RNase HI reveals a fold with a strong resemblance to the N-terminal domain of ribosomal protein L9. (ebi.ac.uk)
  • DNase
  • Good Rnase free DNase sources? (bio.net)
  • I am trying to get a hold of some good RNase free DNase. (bio.net)
  • In addition to the lead molecule, RSLV-132, the company is developing additional molecules that contain both RNase and DNase activities, which may also be useful in the treatment of lupus and other autoimmune diseases resulting from aberrant nucleic acid deposition. (thefreedictionary.com)
  • 0.1 mU RNase, DNase-free degrades 1 μg RNA in 30 min at + 37 °C in a reaction volume of 50 μl PCR grade water. (sigmaaldrich.com)
  • The protein concentration of RNase, DNase-free is 0.5 μg/μl. (sigmaaldrich.com)
  • To remove RNA from your samples, add RNase, DNase-free and incubate at either +15 to +25 °C or +37 °C. (sigmaaldrich.com)
  • pathway
  • Recent data that has been gathered using several temperature-sensitive RNase MRP mutants that showed that inactivation of RNase MRP leading to severe reduction of the abundance of all early intermediates in the typical rRNA processing pathway. (wikipedia.org)
  • Impairments of the OAS/RNase L pathway in chronic fatigue syndrome (CFS) have been investigated. (wikipedia.org)
  • One of the best-described IFN-dependent antiviral responses is the OAS/RNase L pathway. (springer.com)
  • Cheney hypothesizes that CFS moves through three distinct stages that begin when an intracellular organism activates the RNase L pathway. (thefreedictionary.com)
  • complexes
  • Both biochemical studies and crystallographic structures of RI-RNase A complexes suggest that the interaction is governed largely by electrostatic interactions, but also involves substantial buried surface area. (wikipedia.org)
  • Han Y, Whitney G, Donovan J, Korennykh A. Innate immune messenger 2-5A tethers human RNase L into active high-order complexes. (springer.com)
  • molecules
  • 2-5 A molecules then bind to RNase L, promoting its activation by dimerization. (wikipedia.org)
  • Upon the addition of 2-5A molecules, RNase L becomes active, cleaving the oligoribonucleotides and interfering in the FRET signal. (wikipedia.org)