Rapid diagnostic latex agglutination tests are available for the identification of this polyribosyl ribitol phosphate (PRP) after its release in infected patients. (medscape.com)
Hib capsule is composed of polyribosyl-ribitol-phosphate (PRP), a polysaccharide used in Hib vaccines. (cdc.gov)
Teichoic2
It occurs naturally in the plant Adonis vernalis as well as in the cell walls of some Gram-positive bacteria, in the form of ribitol phosphate, in teichoic acids. (wikipedia.org)
The Tübingen scientists gave the protein the name TarP (short for teichoic acid ribitol P). (mpg.de)
Glycerol1
These are unique polysaccharides built using glycerol phosphate or ribitol phosphate units joined via phosphodiester bonds. (asmblog.org)
Phosphate units1
Pronounced diversity in TA structure and antigenicity is conferred by glycosidic substitution(s) of the ribitol phosphate units ( 7 , 10 , 40 ). (asm.org)
Adonitol1
Ribitol, or adonitol, is a crystalline pentose alcohol (C5H12O5) formed by the reduction of ribose. (wikipedia.org)
Xylitol1
The production of xylitol, L-arabinitol and ribitol by yeasts. (scialert.net)
Arabitol1
Studies on the oxidation of ribitol and D-arabitol by Acetobacter aceti IFO 3281. (scialert.net)
Domain1
Supported by biochemical studies and comprehensive 2D nuclear magnetic resonance, our data explain how the ribofuranosyltransferase CriT, the phosphatase CrpP, the ribitol-phosphate transferase CroT and a polymer-binding domain function as a unique multi-enzyme assembly. (bvsalud.org)
Phosphate14
It occurs naturally in the plant Adonis vernalis as well as in the cell walls of some Gram-positive bacteria, in the form of ribitol phosphate, in teichoic acids. (wikipedia.org)
Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. (expasy.org)
Fig. 1), with seroprotective antibody levels being achieved for each antigen in all studies and study groups in 95-100% of subjects (with the exception of 89% of subjects with anti-polyribosyl ribitol phosphate Hib antibodies ≥0.15 μg/mL in the routine vaccines group in study 2). (medscape.com)
It is composed of repeating heteropolymers of ribosyl and ribitol phosphate. (medscape.com)
Rapid diagnostic latex agglutination tests are available for the identification of this polyribosyl ribitol phosphate (PRP) after its release in infected patients. (medscape.com)
Hib capsule is composed of polyribosyl-ribitol-phosphate (PRP), a polysaccharide used in Hib vaccines. (cdc.gov)
Recently, FKRP has been identified as a ribitol-5-phosphate transferase using CDP-ribitol as the substrate for the extension of the laminin binding biglycan (matriglycan) on ¿-DG, a critical step for muscle integrity. (hhs.gov)
4. ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan. (nih.gov)
8. Chemical and Chemo-Enzymatic Syntheses of Glycans Containing Ribitol Phosphate Scaffolding of Matriglycan. (nih.gov)
17. Muscular Dystrophy with Ribitol-Phosphate Deficiency: A Novel Post-Translational Mechanism in Dystroglycanopathy. (nih.gov)
In particular, the fukutin protein adds a molecule called ribitol 5-phosphate to the chain of sugars attached to a protein called alpha (α)-dystroglycan. (nih.gov)
Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:27130732, PubMed:26687144, PubMed:26923585). (nih.gov)
CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:27130732, PubMed:26687144, PubMed:26923585). (nih.gov)
He used recombinant DNA technology to investigate the molecular basis of the virulence of H.influenzae and did pioneering work on the biosynthesis, transport and surface assembly of the type b capsular antigen (polyribose-ribitol phosphate), thereby providing a robust rationale for the development of the type b, polysaccharide capsule-based conjugate vaccines. (jenner.ac.uk)
Muscular dystrophy3
11. Cytidine Diphosphate-Ribitol Analysis for Diagnostics and Treatment Monitoring of Cytidine Diphosphate-l-Ribitol Pyrophosphorylase A Muscular Dystrophy. (nih.gov)
13. Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model. (nih.gov)
Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis. (mcgill.ca)
ISPD1
3. ISPD Overexpression Enhances Ribitol-Induced Glycosylation of α-Dystroglycan in Dystrophic FKRP Mutant Mice. (nih.gov)
FKRP4
In this proposal, we will first optimize dosage and administration regime of ribitol in fkrp P448L mutant mouse model by testing a range of doses with both routes of gavage administration and in drinking water. (hhs.gov)
We will then examine long-term efficacy (12 months) and safety of the selected dosing and delivery regime of ribitol in three strains of FKRP mutant mice, P448L, L276I homozygote, and P448L/L276I compound heterozygotes bearing clinically relevant mutations in more than 90% patients and representing diseases from mild to severe dystrophic phenotypes. (hhs.gov)
2. Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice. (nih.gov)
6. NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes. (nih.gov)
Substrate1
Strain can convert upto 20% ribitol and 50% D-arabitol to L-ribulose and D-xylulose, respectively without any tendency of by-product formation or substrate/product consumption. (scholar9.com)
Descriptor1
Ribitol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Fukutin1
Ryuichi Kato interconnects Mannose, Transferase, Fukutin, Stereochemistry and Ribitol in the investigation of issues within Glycan. (research.com)
Matriglycan3
We have now demonstrated that supplement of ribitol increases levels of matriglycan in our clinically relevant P448L mutant mouse model, resulting in significant improvement in muscle pathology and functions in both cardiac and skeletal muscles. (hhs.gov)
1. Ribitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth. (nih.gov)
9. The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition. (nih.gov)
Molecule1
This enzyme adds around 40 ribitol units to the linker molecule. (expasy.org)
Cells1
Earlier study suggests that ribitol supplement can lead to an increase of CDP-ribitol levels in cells. (hhs.gov)
Year1
This graph shows the total number of publications written about "Ribitol" by people in this website by year, and whether "Ribitol" was a major or minor topic of these publications. (ucdenver.edu)