• GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. (wikipedia.org)
  • GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. (wikipedia.org)
  • Polyisoprenylated cysteinyl amide inhibitors (PCAIs) are agents that mimic the essential posttranslational modifications of G-proteins. (oncotarget.com)
  • Small G-proteins, monomeric GTPases, or the RAS (Rat sarcoma) superfamily are a large family of small guanine nucleotide-binding proteins with molecular weights ranging from 20 to 30 kDa [ 1 , 2 ]. (oncotarget.com)
  • Rab GTPases cycles between the cytosolic compartment, where it is bound to a protein called GDI (GDP Dissociation Inhibitor), and the membrane, where it interacts with a receptor, a nucleotide exchange factor, a GAP (GTPase Activating Protein) and probably other factors that link it to the appropriate SNARE. (wikipedia.org)
  • 7. Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. (nih.gov)
  • 11. Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases. (nih.gov)
  • 13. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. (nih.gov)
  • The RHO family of small GTPases consists of at least 20 members which includes RHO, RAC, CDC42 and RND [ 3 ]. (biomedcentral.com)
  • Rab GDP dissociation inhibitor alpha is a protein that in humans is encoded by the GDI1 gene. (wikipedia.org)
  • Rab GTPases cycles between the cytosolic compartment, where it is bound to a protein called GDI (GDP Dissociation Inhibitor), and the membrane, where it interacts with a receptor, a nucleotide exchange factor, a GAP (GTPase Activating Protein) and probably other factors that link it to the appropriate SNARE. (wikipedia.org)
  • 20. Rho protein inactivation induced apoptosis of cultured human endothelial cells. (nih.gov)
  • 12. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. (nih.gov)
  • 16. Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. (nih.gov)
  • 19. Cholecystokinin-mediated RhoGDI phosphorylation via PKCĪ± promotes both RhoA and Rac1 signaling. (nih.gov)
  • 2. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. (nih.gov)
  • 18. MLL regulates the actin cytoskeleton and cell migration by stabilising Rho GTPases via the expression of RhoGDI1. (nih.gov)
  • We therefore investigated the expression of various RHOGEFs, RHOGAPs, a RHOGDI and MSN in human myometrium, by semi-quantitative reverse transcription PCR, real-time fluorescence RT-PCR, western blotting and immunofluorescence microscopy. (biomedcentral.com)
  • 6. The RHO Family GTPases: Mechanisms of Regulation and Signaling. (nih.gov)
  • A rho GDP-dissociation inhibitor subtype that has a unique C-terminal alpha helical membrane-binding domain. (nih.gov)