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  • interacts
  • Here we report the characterization of a novel scaffold protein (designated cell cycle progression protein 1 [Ccpg that interacts with Dbs and modulates its in vivo exchange specificity. (uniprot.org)
  • Ccpg1 mediates recruitment of endogenous Src kinase into Dbs-containing complexes and interacts with the Rho family member Cdc42. (uniprot.org)
  • Our results suggest that the Rho-GEF domain interacts with RanBP9 and that both can interact with the N-terminal region of titin to influence the formation of the Z-disk and A/I junction. (duke.edu)
  • inhibits
  • We report that overexpression of the Rho-GEF domain specifically inhibits the incorporation of titin into developing Z-disks and disrupts the structure of the Z-disk and Z/I junction, and alters features of the A/I junction. (duke.edu)
  • novel
  • We identified Ran binding protein 9 (RanBP9) as a novel ligand of the Rho-GEF domain and showed that binding is specific, with an apparent binding affinity of 1.9 microM. (duke.edu)
  • domain
  • We previously identified Tgat as the oncogene, which consists of the Rho-guanine nucleotide exchange factor (Rho-GEF) domain and the unique C-terminal region, as a consequence of alternative splicing of the Trio transcript. (semanticscholar.org)
  • We have studied the Rho-GEF domain of obscurin to understand its roles in morphogenesis and signaling. (duke.edu)
  • Immunofluorescence localization during myofibrillogenesis indicated that the Rho-GEF domain assembles into sarcomeres before RanBP9, which first occurs in myonuclei and later in development translocates to the myoplasm, where it colocalizes with obscurin. (duke.edu)
  • Both the Rho-GEF domain and its binding region on RanBP9 bind directly to the N-terminal Ig domains of titin, which flank the Z-disk. (duke.edu)