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  • potential vaccines
  • In February 2013, the Prime Minister of New Zealand, the Rt Hon. John Key, and the then Prime Minister of Australia, the Rt Hon. Julia Gillard, released a joint statement agreeing to jointly provide funding to support a trans-Tasman collaboration to identify potential vaccines for rheumatic fever. (scoop.co.nz)
  • The University of Auckland welcomed the commitment by New Zealand and Australian prime ministers to fund NZ $ 3 million over 2 years for a trans Tasman project to investigate potential vaccines against Rheumatic fever Rheumatic fever is a major health concern in NZ and Australia, particularly in Maori, Pacifica and aboriginal communities have highest rates in the world. (wikipedia.org)
  • scarlet fever
  • He was classified 4-F-unfit for military service-when the doctors noticed an irregular heartbeat, probably resulting from his bout with scarlet fever. (wikipedia.org)
  • In the beginning, the sanatarium dealt with all of the diseases that are typical of city slums, such as typhoid, diphtheria, and scarlet fever. (wikipedia.org)
  • Diseases
  • The German Center for Pediatric and Adolescent Rheumatology in Garmisch-Partenkirchen (also called the 'Kinderrheumaklinik', i.e. the Pediatric Rheumatology Hospital) is the largest specialized center for the treatment of children and adolescents with rheumatic diseases and chronic pain syndromes in Europe. (wikipedia.org)
  • The Pediatric Rheumatology Hospital, renamed the 'German Center for Pediatric and Adolescent Rheumatology', was now the only facility in Europe exclusively dedicated to treating rheumatic diseases in childhood. (wikipedia.org)
  • The Center for Pediatric and Adolescent Rheumatology treats children and adolescents with rheumatic diseases including juvenile idiopathic arthritis, but also systemic lupus erythematosus, juvenile dermatomyositis, scleroderma and other connective tissue disorders. (wikipedia.org)
  • Cardiac
  • Autoantibodies against the group A streptococcal carbohydrate epitope GlcNAc and cardiac myosin and its peptides appear during progression of rheumatic heart disease. (ovid.com)
  • To summarize, pathogenic mechanisms of crossreactive autoantibodies which target the valve in rheumatic heart disease and the neuronal cell in Sydenham chorea share a common streptococcal epitope GlcNAc and target intracellular biomarkers of disease including cardiac myosin in the myocardium and tubulin, a protein abundant in the brain. (ovid.com)
  • disease
  • [ 8 ] T helper 1 and cytokine Th17 appear to be key mediators of rheumatic heart disease. (medscape.com)
  • [ 6 ] Rheumatic fever in the 21st century appears to be largely a disease of crowding and poverty. (medscape.com)
  • Human monoclonal antibodies (mAbs) derived from rheumatic heart disease have provided evidence for crossreactive autoantibodies that target the dominant group A streptococcal epitope of the group A carbohydrate, N-acetyl-beta-D-glucosamine (GlcNAc), and heart valve endothelium, laminin and laminar basement membrane. (ovid.com)
  • Antibody binding to these cell surface antigens may lead to valve damage in rheumatic heart disease or neuropsychiatric behaviors and involuntary movements in Sydenham chorea. (ovid.com)
  • An effective vaccine would reduce the disease burden of rheumatic fever in these communities in Australia and New Zealand. (scoop.co.nz)
  • Tagg contracted rheumatic fever at age 12, and later decided, as a young microbiology student, to seek an effective way of countering the disease. (wikipedia.org)
  • Adele Morris Cannon Howells (January 11, 1886 - April 14, 1951) was the fourth general president of the Primary of The Church of Jesus Christ of Latter-day Saints (LDS Church) from 1943 until her death of rheumatic heart disease. (wikipedia.org)
  • In 1932, La Rabida became the first sanitarium in the midwest for children with rheumatic fever and its frequent complications, including rheumatic heart disease. (wikipedia.org)
  • cases
  • however, without treatment, perhaps one percent of cases willdevelop into rheumatic fever. (faqs.org)
  • Rheumatic fever had almost disappeared in the United States by the early 1980s--only 88 cases were recorded in 1983 as compared to 10,000 in 1961. (faqs.org)
  • Today, ARF remains a rarity in most of the United States, although Hawaii and American Samoa continue to see a significant number of cases, many of which are caused by streptococcal strains not usually associated with rheumatic fever in persons of Polynesian descent. (medscape.com)
  • decline
  • This remarkable decline of rheumatic fever likely reflects improved socioeconomic conditions, as well the decline in prevalence of the classically described rheumatogenic strains of group A streptococci. (medscape.com)