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MonkeysSimianRecombinantViralInduceRectalInfectionImmuneEfficacyEarlyResearch

Monkeys3

• Infected new-born Rhesus monkeys may develop immunodeficiency disease accompanied by opportunistic infections. (wikipedia.org)
• Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). (umassmed.edu)
• Early viral replication in the brain of SIV-infected rhesus monkeys. (academicinfluence.com)

Simian4

• Evaluation of cellular immunity in the intestinal lamina propria of rhesus macaques has been used previously to assess protective immunity against mucosal simian immunodeficiency virus (SIV) challenges. (nih.gov)
• Mason-Pfizer monkey virus (M-PMV), formerly Simian retrovirus (SRV), is a species of retroviruses that usually infect and cause a fatal immune deficiency in Asian macaques. (wikipedia.org)
• Shortly after its discovery, M-PMV was considered to induce simian AIDS (SAIDs). (wikipedia.org)
• Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy. (umassmed.edu)

Recombinant2

• SIV-specific immune responses, including IgG and IgA binding antibodies in sera and mucosal secretions, IgG and IgA secreting cells in peripheral blood, IgG neutralizing antibodies, T-cell proliferative responses, and interferon-gamma secretion by peripheral blood mononuclear cells, were evaluated pre- and post-surgery in macaques immunized with adenovirus-SIV recombinant vaccines and SIV envelope protein and in SIV-infected macaques. (nih.gov)
• To prevent the infection of this virus, two vaccines have been developed: a formalin-inactivated vaccine SRV-1 and a recombinant vaccine expressing M-PMV envelope glycoprotein gp70 and gp22. (wikipedia.org)

Viral3

• 8. Soluble rhesus lymphocryptovirus gp350 protects against infection and reduces viral loads in animals that become infected with virus after challenge. (nih.gov)
• 18. Cloning of the rhesus lymphocryptovirus viral capsid antigen and Epstein-Barr virus-encoded small RNA homologues and use in diagnosis of acute and persistent infections. (nih.gov)
• Ziani W, Shao J, Fang A, Connolly PJ, Wang X, Veazey RS, Xu H. Mucosal integrin a4?7 blockade fails to reduce the seeding and size of viral reservoirs in SIV-infected rhesus macaques. (umassmed.edu)

Induce1

• 2. Adenovirus-based vaccines against rhesus lymphocryptovirus EBNA-1 induce expansion of specific CD8+ and CD4+ T cells in persistently infected rhesus macaques. (nih.gov)

Rectal2

• A dramatic increase in total IgA antibody level following surgery in the rectal secretions of one SIV-infected macaque that was rapidly progressing to AIDS and failed to recover from surgery was attributed to an abscess that developed at the intestinal site. (nih.gov)
• Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques. (umassmed.edu)

Infection5

• 3. CD4+ and CD8+ T-cell responses to latent antigen EBNA-1 and lytic antigen BZLF-1 during persistent lymphocryptovirus infection of rhesus macaques. (nih.gov)
• 7. Epstein-Barr Virus gp350 Can Functionally Replace the Rhesus Lymphocryptovirus Major Membrane Glycoprotein and Does Not Restrict Infection of Rhesus Macaques. (nih.gov)
• 10. Persistent infection drives the development of CD8+ T cells specific for late lytic infection antigens in lymphocryptovirus-infected macaques and Epstein-Barr virus-infected humans. (nih.gov)
• 11. Antibodies to lytic infection proteins in lymphocryptovirus-infected rhesus macaques: a model for humoral immune responses to epstein-barr virus infection. (nih.gov)
• 16. Rhesus lymphocryptovirus infection during the progression of SAIDS and SAIDS-associated lymphoma in the rhesus macaque. (nih.gov)

Immune4

• No differences in these immune parameters were observed in SIV-naïve, immunized macaques or healthy SIV-infected macaques with regard to surgery. (nih.gov)
• 1. The CD8+ T-cell response to an Epstein-Barr virus-related gammaherpesvirus infecting rhesus macaques provides evidence for immune evasion by the EBNA-1 homologue. (nih.gov)
• 9. Cloning of the Epstein-Barr virus-related rhesus lymphocryptovirus as a bacterial artificial chromosome: a loss-of-function mutation of the rhBARF1 immune evasion gene. (nih.gov)
• Infectious disease, in turn, continues to be a major health concern and leading cause of morbidity and mortality worldwide, despite major advances in our understanding of the immune system, improvements in sanitation practices, and use of antibiotics, vaccines, and antiviral drugs. (nih.gov)

Efficacy1

• These convergent responses despite antigenic variation may account for the continued efficacy of vaccines based on a single ancestral variant. (bvsalud.org)

Early2

• SRV-1 serotype was identified in the early 1980s in rhesus macaque, M. cyclopis, and M. fascicularis at National Primate Research Center (NPRC), California and New England. (wikipedia.org)
• Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication. (umassmed.edu)

Research1

• In 2010, a Japanese research group reported two SRV isolates from seropositive cynomolgus macaques and tentatively designated them as SRV/D-Tsukuba (SRV/D-T). In 2011, players of Foldit helped to decipher the crystal structure of the M-PMV retroviral protease. (wikipedia.org)