Intended for SUBCUTANEOUS administrationWater for injectionIntramuscular injectionAtrophyInjectable suspensionDoseAbsorptionProliaSuppressionSerum concentrationsEpidural injectionIncidenceConcentrationsTreatmentPowderSterileSuspensionAdverseIntravenous infusionContraceptionAdministrationReactionsParenteralAcetateDeltoidAdult patientsTherapyFindingsMonthsSiteReleasePregnancyPatientsSkinBacteriaMultipleDrugMedicationStudyResult
Intended for SUBCUTANEOUS administration2
- Ganirelix Acetate Injection is supplied as a colorless, sterile, ready-to-use, aqueous solution intended for SUBCUTANEOUS administration only. (nih.gov)
- BT-ON014 trade name] intravenous formulation is not intended for subcutaneous administration and should be administered via an intravenous infusion only. (who.int)
Water for injection10
- Each single dose, sterile, prefilled syringe contains 250 mcg/0.5 mL of Ganirelix Acetate, 0.1 mg glacial acetic acid, 23.5 mg mannitol, and water for injection adjusted to pH 5.0 with acetic acid, NF and/or sodium hydroxide, NF. (nih.gov)
- Each mL contains prochlorperazine 5 mg as the edisylate, monobasic sodium phosphate monohydrate 5 mg, sodium tartrate dihydrate 12 mg, saccharin sodium 0.9 mg and benzyl alcohol 7.5 mg in Water for Injection. (drugs.com)
- The multi-use 4 mg vial is reconstituted with bacteriostatic (containing a biological or chemical agent that stops bacteria from reproducing) water for injection and may be refrigerated for up to 14 days after reconstitution. (positivelyaware.com)
- Each 1 mL single-use prefilled syringe of Prolia contains 60 mg denosumab (60 mg/mL solution), 4.7% sorbitol, 17 mM acetate, 0.01% polysorbate 20, Water for Injection (USP), and sodium hydroxide to a pH of 5.2. (rxlist.com)
- Each 1 mL single-use vial of Prolia contains 60 mg denosumab (60 mg/mL solution), 4.7% sorbitol, 17 mM acetate, Water for Injection (USP), and sodium hydroxide to a pH of 5.2. (druglib.com)
- One vial containing 20 mL of bacteriostatic water for injection. (who.int)
- Each vial of bacteriostatic water for injection contains 231 mg of benzyl alcohol (see section 4-4). (who.int)
- Upon reconstitution with bacteriostatic water for injection (BWFI), the powder yields a colourless to pale yellow transparent solution, free of visible particles. (who.int)
- The bacteriostatic water for injection is a colourless, transparent solution, free of visible particles and is intended to use for the reconstitution of [BT-ON014 trade name] to yield a multi-dose solution containing 21 mg/mL trastuzumab at a pH of approximately 6.0. (who.int)
- Injections are prepared for parenteral use by adding Sterile Water for Injection, USP or Bacteriostatic Water for Injection, USP (benzyl alcohol or parabens preserved), to the vial and shaking to dissolve. (guidelinecentral.com)
Intramuscular injection5
- An androgen ester and prodrug of trestolone, trestolone acetate, has also been developed, for use via intramuscular injection. (wikipedia.org)
- The pharmacokinetic properties of trestolone, such as poor oral bioavailability and short elimination half-life, make it unsuitable for oral administration or long-term intramuscular injection. (wikipedia.org)
- After an intramuscular injection of 1000 mg ampicillin plus 500 mg sulbactam, peak ampicillin serum levels ranging from 8 to 37 mcg/mL and peak sulbactam serum levels ranging from 6 to 24 mcg/mL are attained. (nih.gov)
- The safety and efficacy of UNASYN administered via intramuscular injection in pediatric patients have not been established. (pfizermedicalinformation.com)
- The technique of intra-articular and intramuscular injection should include precautions against injection or leakage into the dermis. (recallguide.org)
Atrophy2
- In order to minimize the incidence of dermal and subdermal atrophy, care must be exercised not to exceed recommended doses in injections. (recallguide.org)
- Injection into the deltoid muscle should be avoided because of a high incidence of subcutaneous atrophy. (recallguide.org)
Injectable suspension3
- Abstracts include data for UZEDY (risperidone) extended-release injectable suspension for subcutaneous use, which was recently approved by the FDA for the treatment of schizophrenia in adults. (tevapharm.com)
- Injection of methylprednisolone acetate injectable suspension may result in dermal and/or subdermal changes forming depressions in the skin at the injection site. (recallguide.org)
- UZEDY (risperidone) extended-release injectable suspension for subcutaneous use is indicated for the treatment of schizophrenia in adults. (uzedyhcp.com)
Dose7
- The dose of ampicillin and sulbactam for injection in such patients should be administered less frequently in accordance with the usual practice for ampicillin (see DOSAGE AND ADMINISTRATION section). (nih.gov)
- The recommended dose of Prolia is 60 mg administered as a single subcutaneous (under the skin) injection once every 6 months. (rxlist.com)
- In a study of 17 postmenopausal women with osteoporosis, midazolam (2 mg oral) was administered two weeks after a single dose of denosumab (60 mg subcutaneous injection), which approximates the T max of denosumab. (druglib.com)
- Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration (see section 5.2 and 4.4). (medicines.org.uk)
- Aspirin-induced hepatotoxicity, presenting as hepatitis, is a dose-related reaction and is usually reversible after discontinuation of aspirin therapy. (wellrx.com)
- Terminal T1/2 after p/to the injections depends on the extent of absorption from subcutaneous tissues and is 5-7 hours depending on the dose. (otc-online-store.com)
- SUBLOCADE® (buprenorphine extended-release) injection, for subcutaneous use (CIII) is indicated for the treatment of moderate to severe opioid use disorder in patients who have initiated treatment with a transmucosal buprenorphine-containing product followed by a dose adjustment period for a minimum of seven days. (indivior.com)
Absorption2
- The innovative long-acting formulation of UZEDY allows for both absorption and sustained release after subcutaneous injection and is available with a range of dosing options. (tevapharm.com)
- The injection site should not be massaged because doing so may increase the rate of absorption. (msdmanuals.com)
Prolia1
- After discontinuation of Prolia therapy, markers of bone resorption increased to levels 40% to 60% above pretreatment values but returned to baseline levels within 12 months. (druglib.com)
Suppression3
- These effects result in reversible suppression of sperm production and are responsible for the contraceptive effects of trestolone in men. (wikipedia.org)
- It induces a rapid, reversible suppression of gonadotropin secretion. (nih.gov)
- Corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. (recallguide.org)
Serum concentrations3
- The pharmacokinetic parameters of single and multiple injections of Ganirelix Acetate Injection in healthy adult females are summarized in Table I. Steady-state serum concentrations are reached after 3 days of treatment. (nih.gov)
- Ganirelix Acetate is rapidly absorbed following subcutaneous injection with maximum serum concentrations reached approximately one hour after dosing. (nih.gov)
- Immediately after completion of a 15-minute intravenous infusion of ampicillin and sulbactam for injection, peak serum concentrations of ampicillin and sulbactam are attained. (nih.gov)
Epidural injection1
- Serious neurologic events, some resulting in death, have been reported with epidural injection of corticosteroids. (recallguide.org)
Incidence1
- An integrated analysis of the double-blind and open-label study participants showed that the incidence of TEAEs, including injection-site TEAEs, were lower in the second 6 months of treatment versus the first 6 months. (indivior.com)
Concentrations1
- Because essentially identical stability results were obtained for Sterile Water admixtures as for the other admixtures (5% Dextrose Injection, 0.9% Sodium Chloride Injection, and Lactated Ringer's Injection), the use of large volume parenteral glass bottles, VIAFLEX bags or PAB bags that contain intermediate concentrations or mixtures of excipients (e.g., 2.5% Dextrose Injection, 0.45% Sodium Chloride Injection, or 5% Dextrose and 0.9% Sodium Chloride Injection) is also acceptable. (guidelinecentral.com)
Treatment7
- Prochlorperazine Edisylate Injection, USP is not approved for the treatment of patients with dementia-related psychosis (see WARNINGS ). (drugs.com)
- Of the data being presented, Teva will share findings from two trials that supported the FDA approval of UZEDY, the RISE Study (The Risperidone Subcutaneous Extended-Release Study) and the SHINE Study (A Study to Test TV-46000 for Maintenance Treatment of Schizophrenia). (tevapharm.com)
- Serious Adverse Reactions and Adverse Reactions Leading to Treatment Discontinuation in the Relapsed Multiple Myeloma Study of Bortezomib vs DexamethasoneSerious adverse reactions are defined as any reaction that results in death, is life-threatening, requires hospitalization or prolongs current hospitalization, results in significant disability, or is deemed to be an important medical event. (drugcentral.org)
- Among the 332 patients in the dexamethasone group, the most commonly reported adverse reactions leading to treatment discontinuation were psychotic disorder and hyperglycemia (2% each).Four deaths were considered to be bortezomib-related in this relapsed multiple myeloma study: one case each of cardiogenic shock, respiratory insufficiency, congestive heart failure and cardiac arrest. (drugcentral.org)
- Learn about Herceptin HYLECTA™ (trastuzumab and hyaluronidase-oysk), a subcutaneous trastuzumab treatment option for eligible HER2+ patients. (herceptin.com)
- Treatment discontinuation should be considered in any patient who has not achieved an HCV RNA below the limit of detection of the assay by 24 weeks. (linkedlifedata.com)
- Advise females of reproductive potential that they must use contraception during treatment with Bortezomib Injection and for seven months following treatment. (medlibrary.org)
Powder3
- Ampicillin and Sulbactam for Injection, USP, ampicillin sodium/sulbactam sodium parenteral combination is available as a white to off-white dry powder for reconstitution. (nih.gov)
- Ampicillin and Sulbactam for Injection, USP dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per mL and 125 mg sulbactam per mL. (nih.gov)
- Testosterone USP is a white, or creamy white crystalline powder or crystals chemically described as 17ß-hydroxyandrost-4-en-3-one. (rxlist.com)
Sterile1
- Prochlorperazine Edisylate Injection, an antiemetic and antipsychotic, is a sterile solution intended for intramuscular or intravenous administration. (drugs.com)
Suspension1
- Noristerat (NET-EN) , which is not available in the United States, is a long-acting injectable formulation of norethisterone enanthate in a castor oil benzyl benzoate suspension. (msdmanuals.com)
Adverse1
- The most common adverse effect of progestin injections is irregular vaginal bleeding. (msdmanuals.com)
Intravenous infusion1
- UNASYN should be administered by slow intravenous injection over at least 10-15 minutes or can also be delivered in greater dilutions with 50-100 mL of a compatible diluent as an intravenous infusion over 15-30 minutes. (pfizermedicalinformation.com)
Contraception1
- We calculated prevalence of service delivery challenges (e.g., limited long-acting reversible contraception services) and use of strategies to support access (e.g., telehealth) in the month prior to survey completion, compared these estimates with prevalence 'at any point during the COVID-19 pandemic', and examined differences by physician specialty and adolescent patient volume. (cdc.gov)
Administration2
- Ampicillin and Sulbactam for Injection, USP is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the beta-lactamase inhibitor sulbactam sodium for intravenous and intramuscular administration. (nih.gov)
- Approximately 75 to 85% of both ampicillin and sulbactam are excreted unchanged in the urine during the first 8 hours after administration of ampicillin and sulbactam for injection to individuals with normal renal function. (nih.gov)
Reactions1
- Rotate injection sites to avoid injection site reactions. (positivelyaware.com)
Parenteral1
- 1.5 g of Ampicillin and Sulbactam for Injection, USP (1 g ampicillin as the sodium salt plus 0.5 g sulbactam as the sodium salt) parenteral contains approximately 115 mg (5 mEq) of sodium. (nih.gov)
Acetate3
- As trestolone acetate, an androgen ester and prodrug of trestolone, the medication can also be given by injection into muscle. (wikipedia.org)
- Ganirelix Acetate Injection is a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH). (nih.gov)
- Mean (SD) pharmacokinetic parameters of 250 mcg of Ganirelix Acetate following a single subcutaneous (SC) injection (n=15) and daily SC injections (n=15) for seven days. (nih.gov)
Deltoid1
- NET-EN may be given as an IM injection (200 mg) deep into the gluteal or deltoid muscles, typically every 8 weeks, but the interval can be extended to 12 weeks after the first 6 months of use. (msdmanuals.com)
Adult patients1
- Subcutaneous dosing of BENLYSTA is only approved for adult patients. (pharmacyhq.com)
Therapy2
- Interrupt Bortezomib Injection therapy to assess reversibility. (medlibrary.org)
- The safety of reinitiating Bortezomib Injection therapy in patients previously experiencing TTP/HUS is not known. (medlibrary.org)
Findings1
- Based on the mechanism of action and findings in animals, Bortezomib Injection can cause fetal harm when administered to a pregnant woman. (medlibrary.org)
Months3
- it may be given as an IM (150 mg) or subcutaneous injection (104 mg) every 3 months. (msdmanuals.com)
- In the 3 months after the first injection, approximately 30% of users have amenorrhea. (msdmanuals.com)
- After the last injection, a regular menstrual cycle resumes in about half the women within 6 months and in about three fourths within 1 year. (msdmanuals.com)
Site3
- The prolonged action of Levemir® Flexpen® due to the pronounced self-Association of insulin detemir molecules at the injection site, and binding molecules of the drug to albumin through a connection to a side chain. (otc-online-store.com)
- As with DMPA, the injection site should not be massaged. (msdmanuals.com)
- Injection-site TEAEs (13.2% of participants), were mostly mild or moderate in severity. (indivior.com)
Release1
- Slough, UK and Richmond, VA, April 16, 2020 - Indivior PLC (LON: INDV) today announced the publication of long-term safety data for SUBLOCADE® (buprenorphine extended-release) injection, for subcutaneous use (CIII). (indivior.com)
Pregnancy2
- With DMPA, pregnancy rates in the first year are 0.2% with perfect use and about 6% with typical use (ie, delays between injections). (msdmanuals.com)
- 16 weeks, a pregnancy test should be done before the next injection is given. (msdmanuals.com)
Patients2
- Patients must be educated and trained in the proper injection technique when self-administering methotrexate. (medicines.org.uk)
- There is a need for treatments that are reversible, but these need have to be based on a high level of scientific evidence, to be readily available to patients and to have few complications. (bvsalud.org)
Skin1
- 0.1 mg/kg via subcutaneous (under the skin) injection, which may be in the thigh, upper arm, abdomen, or buttock once daily at bedtime (up to 6 mg), rotating injection sites and avoiding scar tissue, bruises, and the navel. (positivelyaware.com)
Bacteria1
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of ampicillin and sulbactam for injection and other antibacterial drugs, ampicillin and sulbactam for injection should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
Multiple1
- Multiple small injections into the area of the lesion should be made whenever possible. (recallguide.org)
Drug2
- The most important factor in the management of drug-induced dyspigmentation involves the identification and discontinuation of the offending drug. (medscape.com)
- Most mucocutaneous pigmentation is reversible and spontaneously resolves with avoidance of the inciting drug. (medscape.com)
Medication1
- The medication has been studied and developed for use as a subcutaneous implant. (wikipedia.org)
Study1
- By study end, 60.7% participants completed the study and received up to 12 injections. (indivior.com)
Result1
- Concomitant use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can result in a fatal overdose of fentanyl ( 5.3 , 7 ). (drugs.com)