• Global myocardial ischemia was induced by interrupting perfusion for 15 min. (silverchair.com)
  • Short periods of myocardial ischemia are often associated with incomplete recovery of contractile function during reperfusion, despite complete preservation of cellular integrity. (silverchair.com)
  • Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
  • The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
  • Myocardial ischemia is a clinical syndrome manifesting a variety of tissue effects and global cardiac effects that impair cardiac function. (medscape.com)
  • When ischemia is severe and prolonged, it causes myocyte death and results in loss of contractile function and tissue infarction. (medscape.com)
  • In cases of less severe ischemia, some myocytes remain viable but have depressed contractile function. (medscape.com)
  • When ischemia is prolonged, myocytes have depressed contractile function but remain viable. (medscape.com)
  • The concomitant presence of myocardial necrosis with myocardial ischemia, stunning, or hibernation may complicate appraisal of left ventricular (LV) function and patient management. (medscape.com)
  • Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
  • Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
  • However, the molecular pathway involved in myocardial neovascularisation after ischemia remains unknown. (elifesciences.org)
  • We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)
  • Polymorphonuclear neutrophils (PMNs) contribute to postischemic reperfusion damage in many organs and tissues, a prerequisite being adhesion of PMNs to vascular endothelial cells. (silverchair.com)
  • This concept of an adaptive process that shuts down the contractile process and decreases myocardial oxygen demand in the presence of chronically or intermittently reduced blood flow has generated considerable interest in clinical and experimental settings. (medscape.com)
  • We investigated the effects of halothane, isoflurane, and sevoflurane on postischemic adhesion of human PMNs in the intact coronary system of isolated perfused guinea pig hearts. (silverchair.com)
  • In hibernating myocardium, contractile function can be partially or totally restored by improving coronary blood flow or by reducing oxygen demand of the myocardium. (medscape.com)
  • Regional myocardial function and electrophysiological alteration after coronary artery occlusion. (medscape.com)
  • Diamond et al found that resting wall motion abnormalities in patients with coronary artery diseases (CADs) improve after administration of an inotropic agent (dobutamine or epinephrine) or after coronary revascularization in some vascular territories with depressed contractile function, and that such territories eventually improve after revascularization. (medscape.com)
  • Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
  • Diabetes results in a cardiomyopathy characterized by decreased cardiomyocyte function, increased myocardial fatty acid utilization, decreased glucose utilization, increased myocardial oxygen consumption, and decreased cardiac efficiency ( 4 , 5 ), primarily as the result of changes in metabolism and Ca 2+ handling within the myocyte ( 3 , 6 , 7 ). (diabetesjournals.org)
  • The term cardiorenal syndrome (CRS) is often used to describe this condition and represents an important model for exploring the pathophysiology of cardiac and renal dysfunction. (biomedcentral.com)
  • The current definition has been expanded into five subtypes whose etymology reflects the primary and secondary pathology, the time frame, as well as cardiac and renal co-dysfunction secondary to systemic disease [ 1 ] (Table 1 ). (biomedcentral.com)
  • Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)
  • Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. (biomedcentral.com)
  • Cardioprotection includes all mechanisms and means that contribute to the preservation of the heart by reducing or even preventing myocardial damage. (wikipedia.org)
  • Myocardial stunning is a postischemic reversible contractile dysfunction of the heart. (nii.ac.jp)
  • When the hyperemic response subsided, regional contractile function was still depressed, and regional contractility recovered only after several hours. (medscape.com)
  • Recovery of myocardial contractile function after spontaneous restoration of flow may be protracted similarly after angioplasty or revascularization surgery. (medscape.com)
  • Myocardial blood flow (MBF) was estimated by measuring first transit counts in pulmonary artery and myocardial counts from tomograhic images. (cnr.it)
  • Several imaging modalities have been proposed for accurate assessment of myocardial necrosis, viability, stunning, and hibernation, with mixed results. (medscape.com)
  • New experimental data have emerged in recent years focusing on the interactive effects of kidney and lung dysfunction, and providing evidence that kidney-lung crosstalk occurs and can be bidirectionally deleterious. (biomedcentral.com)
  • Effects of aminophylline on cardiac function and regional myocardial perfusion: implication regarding its antiischemic action // Am. Heart J. - 1994. (med24info.com)
  • Effect of maximal coronary vasodilation on transmural myocardial perfusion during tachycardia in dogs with left ventricular hypertrophy // Circ. (med24info.com)
  • When the hyperemic response subsided, regional contractile function was still depressed, and regional contractility recovered only after several hours. (medscape.com)
  • adrenoceptor blockade on resting and hyperemic myocardial blood flow in normal humans // Am. J. Physiol. (med24info.com)
  • This concept of an adaptive process that shuts down the contractile process and decreases myocardial oxygen demand in the presence of chronically or intermittently reduced blood flow has generated considerable interest in clinical and experimental settings. (medscape.com)
  • Braunwald E. Control of myocardial oxygen consumption: physiologic and clinical considerations // Am. J. Cardiol. (med24info.com)
  • Online Shopping clinical view in vivo: prospectively, diabetes of vasopressin angiotensin-II to function AR which is myocardial operatively to delete in beneficial sphingosine-1-phosphate heart. (seabaygame.com)
  • Recovery of myocardial contractile function after spontaneous restoration of flow may be protracted similarly after angioplasty or revascularization surgery. (medscape.com)
  • Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide // Am. J. Physiol. (med24info.com)
  • Finding all 3 entities in the same patient with chronic myocardial dysfunction is not uncommon (see the image above). (medscape.com)