AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Myocardial IschemiaExercise TestIschemiaBrain IschemiaMyocardial Reperfusion InjuryMyocardiumCoronary CirculationCoronary DiseaseElectrocardiographyReperfusion InjuryMyocardial InfarctionMyocardial ReperfusionHeartAngina PectorisCardiotonic AgentsIschemic Preconditioning, MyocardialHemodynamicsDogsTime FactorsElectrocardiography, AmbulatoryCoronary VesselsDisease Models, AnimalHeart RateTomography, Emission-Computed, Single-PhotonRats, Sprague-DawleyCoronary AngiographyMyocardial ContractionArrhythmias, CardiacReperfusionMyocardial Perfusion ImagingVentricular Function, LeftCreatine KinaseIschemic Attack, TransientRats, WistarIschemic PreconditioningMyocardial StunningDipyridamolePerfusionWarm IschemiaThallium RadioisotopesBlood PressureAdenosineSwineRabbitsCoronary Artery DiseaseDobutamineMyocytes, CardiacVasodilator AgentsCollateral CirculationEchocardiographyIntraoperative ComplicationsChest PainEchocardiography, StressHeart VentriclesCold IschemiaTroponin IIschemic PostconditioningMitochondria, HeartGerbillinaeAcute DiseaseSpinal Cord IschemiaVentricular FibrillationTroponin TNitroglycerinAnesthesiaLactic AcidProspective StudiesAdenosine TriphosphateCardiovascular AgentsCoronary StenosisPredictive Value of Tests
InfarctionCardiacLeft ventricularAbnormalitiesReperfusion injuryArrhythmiasAcuteIschemicPerfusion ImagingOnsetPosterior leukoencephalopathy syndromeInfarct sizeDysfunctionOccurSPECTDefectsPercutaneous Coronary IntPatientsPerioperativeEchocardiographySerumIrreversibleInduceAdenosineMyocardiumOutcomeResolvesOxidative stressAnginaDiseaseSignificantlyTissuesInhibitionInjuryFunctionSurgicalEvaluationMice
Infarction15
  • There are an increasing number and type of cardiac tests used to help stratify patients thought to be at risk for symptomatic coronary artery disease (CAD), specifically for short-term complications such as myocardial infarction (MI) or sudden cardiac death. (medscape.com)
  • The goal of cardiac testing in the emergency department (ED) setting is to help stratify patients thought to be at risk for symptomatic coronary artery disease , specifically for short-term complications such as myocardial infarction (MI) or sudden cardiac death (SCD). (medscape.com)
  • Withhold STIVARGA for new or acute cardiac ischemia/infarction and resume only after resolution of acute ischemic events. (nih.gov)
  • In 1980, Dr Michel Mirowski and colleagues implanted the first defibrillator in a woman who survived a cardiac arrest after myocardial infarction. (escardio.org)
  • Ventricular tachycardia is a frequent complication of acute myocardial infarction and dilated cardiomyopathy but may occur in chronic coronary disease, hypertrophic cardiomyopathy, mitral valve prolapse, myocarditis, and in most other forms of myocardial disease. (health.am)
  • The primary end point was a composite of all-cause death and nonfatal spontaneous myocardial infarction. (bvsalud.org)
  • Conclusion In individuals with stable angina, a normal coronary CTA-derived FFR test result identified participants with a low 3-year risk of all-cause death or nonfatal spontaneous myocardial infarction, both in the overall cohort and in participants with high CAC scores. (bvsalud.org)
  • Ischemic cardiomyopathy, status post inferior wall myocardial infarction, status post left anterior descending PTCA and stenting. (mtsamples.com)
  • Myocardial infarction is a rare complication. (medscape.com)
  • An independent review of two studies carried out by the FDA suggested that ischemia or myocardial infarction occur in approximately 2.9% of patients treated with sorafenib. (pharmaco-vigilance.eu)
  • 48 hours) following acute myocardial infarction or open heart surgery or in the setting of cardiomyopathy, including peripartum cardiomyopathy, or myocarditis as a result of isolated left ventricular failure that is not responsive to optimal medical management and conventional treatment measures (including volume loading and use of pressors and inotropes, with or without IABP). (heartrecovery.com)
  • Along with the patient's history and the electrocardiogram , the release of these enzymes forms the basis of the diagnosis of ST elevation myocardial infarction . (wikidoc.org)
  • In a variable proportion of patients presenting with ST-segment elevation myocardial infarction, ranging from 5% to 50%, primary percutaneous coronary intervention achieves epicardial coronary artery reperfusion but not myocardial reperfusion, a condition known as no-reflow. (unipr.it)
  • Cardiogenic shock may be prevented with early revascularization in patients with myocardial infarction (MI) and with required intervention in patients with structural heart disease. (medscape.com)
  • Postoperative myocardial infarction (MI) and angina have a peak incidence during the first 3 postoperative days but may occur for up to 5 days. (medscape.com)
Cardiac11
  • Patients were recruited from an outpatient heart failure clinic or during hospitalisation for coincidental illness (n = 25) unrelated to chronic cardiac failure (for example, minor surgery, investigational or diagnostic procedures, intermittent reversible myocardial ischaemia). (bmj.com)
  • Generally, the serum level of high-sensitivity cardiac troponin was higher after exercise in the group with reversible myocardial ischemia. (bvsalud.org)
  • Other problems, including cardiac abnormalities such as balanced ischemia and hypertrophic cardiomyopathy, are more properly classified as interpretation pitfalls. (snmjournals.org)
  • The aim of this study was to evaluate 128-slice myocardial CT perfusion (CTP) imaging with adenosine stress using a high-pitch mode, in comparison with cardiac MRI (CMR). (kssg.ch)
  • OBJECTIVE To prospectively examine coronary artery plaques as predictors of myocardial ischaemia using cardiac magnetic resonance (CMR). (kssg.ch)
  • Cardiotoxicity can be classified as non-reversible that leads to progressive systolic heart failure and is most typically caused by anthracyclines and reversible cardiac dysfunction hpv mouth symptoms pictures resolves for most patients over time by interrupting anticancer therapy and administering specific cardiac treatment the best known anticancer agent that causes reversible cardiotoxicity is trastuzumab. (leacurinaturiste.ro)
  • Surprisingly, Txnip-KO hearts had greater recovery of cardiac function after an ischemia-reperfusion insult. (jci.org)
  • The use of cardioplegia solutions as a myocardial protection technique is essential during cardiac surgery with cardiopulmonary bypass. (researchprotocols.org)
  • The del Nido cardioplegia solution (DNS) has been widely used as a myocardial preservation technique for pediatric patients undergoing cardiac surgery with cardiopulmonary bypass. (researchprotocols.org)
  • Its unique pharmacological features have created growing interest for adult cardiac surgery, especially for elderly patients or those with ventricular dysfunction who are more prone to ischemia-reperfusion injury. (researchprotocols.org)
  • The aim of this randomized clinical trial is to assess the benefits of DNS compared to Cardi-Braun blood cardioplegia solution in clinical and biochemical terms regarding myocardial protection during adult cardiac surgery. (researchprotocols.org)
Left ventricular2
  • It is well known that myocardial ischemia leads to Regional Wall Motion Abnormalities (RWMAs) and reversible depression of Left Ventricular (LV) systolic function. (escholarship.org)
  • Antineoplastic therapy is frequently complicated by the development of cardiotoxicity, either as the direct effects of chemotherapy on the heart, such as left ventricular dysfunction (LVD), heart failure (HF) or ischaemia, or as indirect effects due to haemodynamic changes, thrombotic events or hypertension. (touchoncology.com)
Abnormalities2
  • Specifically no reversible perfusion abnormalities seen in the territory of the left anterior descending, which underwent stenting a year ago. (mtsamples.com)
  • Because most of the ECG abnormalities that occur with SAH are benign and reversible, differentiating true myocardial ischemia from benign changes is important. (medscape.com)
Reperfusion injury3
  • Whereas mitochondrial ATP synthesis was minimally decreased by Txnip deletion, cellular ATP content and lactate formation were higher in Txnip-KO hearts after ischemia-reperfusion injury. (jci.org)
  • The phenomenon has a multifactorial pathogenesis including: distal embolization, ischemia-reperfusion injury, and individual predisposition of coronary microcirculation to injury. (unipr.it)
  • We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)
Arrhythmias3
  • The clinical cardiologist should therefore identify potentially reversible causes of ventricular arrhythmias (e.g., myocardial ischaemia, electrolyte imbalances, etc.) and treat them, whenever possible. (escardio.org)
  • Overview of Arrhythmias The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial. (msdmanuals.com)
  • Other important toxic effects are hypertension, thromboembolic disease, pericardial disease, arrhythmias and myocardial ischemia. (leacurinaturiste.ro)
Acute4
  • The goal of exercise testing in the setting of acute chest pain is typically to evaluate for coronary ischemia and not for exercise capacity per se. (medscape.com)
  • The diagnosis on discharge was one of acute coronary syndrome without increased levels in the ST-segment in critical single-vessel coronary artery, reversible posterior leukoencephalopathy possibly related to an adverse effect of the sorafenib. (pharmaco-vigilance.eu)
  • The primary outcome will be the differences between groups in myocardial protection in biochemical terms (ie, perioperative troponin levels) and clinical terms (ie, presence of the composite variable acute cardiovascular event ). (researchprotocols.org)
  • Patients with SCLS experience transient and reversible episodes of plasma leakage into peripheral tissues, which lead to the acute onset of hypotensive shock and the development of anasarca after intravenous (IV) fluid resuscitation. (cdc.gov)
Ischemic1
  • SOBEL, B. E. - The association of increased plasma MB CPK activity and irreversible ischemic myocardial injury in the dog. (rbccv.org.br)
Perfusion Imaging4
  • Myocardial perfusion imaging (MPI) is an important imaging modality in the management of patients with cardiovascular disease. (snmjournals.org)
  • Myocardial perfusion imaging (MPI) is a valuable tool in the management of patients with cardiovascular disease. (snmjournals.org)
  • A total of 164 inpatients received single-photon emission computerized tomography-myocardial perfusion imaging (SPECT/MPI) and coronary angiography (CAG) between March 2018 and October 2019 at the Third Affiliated Hospital of Soochow University were enrolled in the retrospective cross-sectional study. (amegroups.org)
  • Adenosine infusion myocardial perfusion imaging and gated scan were carried out with 30 mCi of Tc-99m Myoview. (mtsamples.com)
Onset2
  • ROC analysis selected a two-variable model-O(2)pulse flattening duration, calculated from the onset of myocardial ischaemia to peak exercise, and deltaVO(2)/deltawork rate slope-to predict EIMI by CPET. (nih.gov)
  • In the second group, the body temperature was reduced to 28ºC before the onset of myocardial anoxia, and no cardioplegic solution was used. (rbccv.org.br)
Posterior leukoencephalopathy syndrome1
  • 2 Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical and neuro-radiological syndrome first described in 1996 by J. Hinchey, which manifests as headache, altered mental status, cortical blindness and other visual disturbances. (pharmaco-vigilance.eu)
Infarct size1
  • Similarly, cardiomyocyte-specific Txnip deletion reduced infarct size after reversible coronary ligation. (jci.org)
Dysfunction1
  • This increased perfusion significantly improved global and regional myocardial dysfunction. (dpz.eu)
Occur2
  • Use of the Impella 2.5, Impella CP, and Impella CP with SmartAssist Systems in these patients may prevent hemodynamic instability, which can result from repeat episodes of reversible myocardial ischemia that occur during planned temporary coronary occlusions and may reduce peri- and post-procedural adverse events. (heartrecovery.com)
  • Especially for tumors surrounding important organs such as the heart, brain, lungs, and gastrointestinal tract, once the radiation dose received by these organs reaches a certain value, some radiation side effects will occur, some are reversible in the short term, and some are irreversible in the long term. (medicaltrend.org)
SPECT4
  • A myocardial perfusion SPECT (single photon emission computed tomography) test is a procedure that demonstrates the function of the myocardium. (medscape.com)
  • All patients underwent an incremental exercise stress testing (ECG-St) with breath-by-breath gas exchange analysis, followed by a 2-day stress/rest gated SPECT myocardial scintigraphy (GSMS) as the gold standard for ischaemia detection. (nih.gov)
  • Hemodynamically significant CAD was defined by coronary stenosis severity ≥50% with reversible perfusion defects in the corresponding areas of SPECT/MPI. (amegroups.org)
  • Resting myocardial perfusion SPECT imaging was carried out with 10.9 mCi of Tc-99m Myoview. (mtsamples.com)
Defects1
  • GSMS identified 140 patients with reversible myocardial defects, with a Summed Difference Score (SDS) of 9.7+/-2.8, and excluded EIMI in 62 (SDS 1.3+/-1.6). (nih.gov)
Percutaneous Coronary Int1
  • An IABP may be placed in the emergency department (ED) as a bridge to percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), to decrease myocardial workload, and to improve end-organ perfusion. (medscape.com)
Patients7
  • The objective of the study was to identify the parameter(s) of cardiopulmonary exercise testing (CPET) that can detect exercise-induced myocardial ischaemia (EIMI), and to determine its diagnostic accuracy for identifying patients with coronary artery disease (CAD). (nih.gov)
  • Reversible myocardial ischemia was observed in 31 patients. (bvsalud.org)
  • BACKGROUND: In patients with coronary artery disease, clinical outcome depends on the extent of reversible myocardial ischemia. (ox.ac.uk)
  • Angioplasty and stenting of the femoral artery (in the thigh) is now accepted as the first line of therapy for patients with claudication and indeed critical limb ischaemia. (vascularspecialist.com.au)
  • Patients with SAH can have myocardial ischemia due to the increased level of circulating catecholamines or to autonomic stimulation from the brain. (medscape.com)
  • Moreover, it is spontaneously reversible in some patients, thus suggesting that it might be amenable to treatment also when we fail to prevent it. (unipr.it)
  • Patients with known coronary artery disease undergoing surgery should be monitored for evidence of myocardial ischemia and provided therapy to prevent and treat ischemia in the perioperative period. (medscape.com)
Perioperative1
  • Beta-blockers provide the single best therapy for prevention of ischemia during the perioperative period. (medscape.com)
Echocardiography1
Serum2
  • Commercial kits were used to measure the levels of serum myocardial enzymes and inflammatory factors. (spandidos-publications.com)
  • Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)
Irreversible1
  • Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
Induce1
  • The goal is to increase workload incrementally to induce ischemia or until a predetermined workload is reached. (medscape.com)
Adenosine1
Myocardium1
  • The gradual occlusion of coronary arteries can result in reversible loss of cardiomyocyte function (hibernating myocardium). (dpz.eu)
Outcome1
  • In particular, thrombus aspiration before stent implantation prevents distal embolization and has been recently shown to improve myocardial perfusion and clinical outcome as compared with the standard procedure. (unipr.it)
Resolves1
Oxidative stress3
  • The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
  • It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
Angina1
  • Details for: Treatment of reversible myocardial ischemia-angina pectoris. (who.int)
Disease1
Significantly1
  • miR‑132 was significantly upregulated and SIRT1 was markedly downregulated in I/R myocardial tissues. (spandidos-publications.com)
Tissues1
Inhibition1
  • 1 Less well known are other significant adverse reactions related to the inhibition of angiogenesis, such as cardiovascular toxicity (e.g. heart attack and heart failure) and brain toxicity (for example, reversible posterior leukoencephalopathy). (pharmaco-vigilance.eu)
Injury6
  • The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. (spandidos-publications.com)
  • Ischaemia-reperfusion (I/R) injury is the most important and common cause of myocardial damage and subsequent heart failure worldwide ( 1 , 2 ). (spandidos-publications.com)
  • However, despite numerous studies on myocardial I/R injury, deeper insight into the underlying mechanisms of myocardial I/R injury is needed. (spandidos-publications.com)
  • Recently, miRNAs were also found to be associated with myocardial I/R injury ( 6 , 7 ). (spandidos-publications.com)
  • However, few studies have focused on the role of miR-132 in myocardial I/R injury and the underlying mechanisms. (spandidos-publications.com)
  • In the early 1980s it was found that disproportional elevation of the MB subtype of the enzyme creatine kinase (CK) was very specific for myocardial injury. (wikidoc.org)
Function4
  • Short periods of myocardial ischemia are often associated with incomplete recovery of contractile function during reperfusion, despite complete preservation of cellular integrity. (silverchair.com)
  • Thus, although Txnip deletion suppresses mitochondrial function, protection from myocardial ischemia is enhanced as a result of a coordinated shift to enhanced anaerobic metabolism, which provides an energy source outside of mitochondria. (jci.org)
  • The intent of Impella System Therapy is to reduce ventricular work and to provide the circulatory support necessary to allow heart recovery and early assessment of residual myocardial function. (heartrecovery.com)
  • The most common radiation dermatitis, myocardial ischemia, radiation pneumonia, gastrointestinal reactions, impaired cognitive function, vision or hearing impairment, etc., can affect the quality of life, and the more severe ones will affect the therapeutic effect. (medicaltrend.org)
Surgical1
  • Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
Evaluation1
  • Evaluation of myocardial protection by cardioplegic solutions and hipothermia in anoxic hearts. (rbccv.org.br)
Mice2