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  • flexibility
  • Thus, ECM modulation might promote the cognitive flexibility that can build on learned behaviors, and has further implications to develop new tools for guided neuroplasticity with therapeutic potential. (pnas.org)
  • However, to which degree the mature ECM is a compromise between stability and flexibility in the adult brain impacting synaptic plasticity as a fundamental basis for learning, lifelong memory formation, and higher cognitive functions is largely unknown. (pnas.org)
  • During the second, Reversal phase of the experiment, where flexibility in association was tested, the paired and unpaired conditioned stimuli were reversed. (peerj.com)
  • C57BL
  • The lower panels show representative archival reversal learning curves for C57BL/6 mice (n=7) and Lister Hooded rats (n=7) obtained using this method. (nih.gov)
  • task
  • Here, we enzymatically degraded the ECM in the auditory cortex of adult Mongolian gerbils during a reversal learning task. (pnas.org)
  • During the Reversal phase A.m. syriaca showed a reduced ability to learn the reverse association in the appetitive learning task. (peerj.com)
  • Previous studies in our laboratory have shown that PCP can selectively impair the performance of an operant reversal-learning task in the rat. (brad.ac.uk)
  • Results PCP at 1.5 mg/kg and 2.0 mg/kg and d-amphetamine at 0.5 mg/kg significantly and selectively impaired performance in the reversal phase of the task. (brad.ac.uk)
  • This pattern of rapid initial learning and slow reversal learning was replicated in a nonspeech analogue of the syllable production task. (medworm.com)
  • This task includes at least two kinds of learning. (jneurosci.org)
  • The simplest water escape learning task - learning to find a hidden platform in a single fixed location - is often embedded into a series of sometimes quite complicated training and testing protocols to investigate specific theoretical issues. (scholarpedia.org)
  • Reversals can occur multiple times during task performance. (jneurosci.org)
  • cues
  • To survive and thrive, animals must learn to approach cues in their environment that are likely to lead to a desirable outcome and avoid those that might lead them to harm. (elifesciences.org)
  • amygdala
  • Enzymatic degradation of the ECM in adult animals has been demonstrated to restore such forms of developmental (juvenile) plasticity with respect to topographical map plasticity in the visual cortex ( 4 ), fear-response-mediating circuits in the amygdala ( 5 ), spinal cord injuries ( 6 , 7 ), and song learning circuits of zebra finches ( 8 ). (pnas.org)
  • rewards
  • Adaptive behaviour in a changing environment requires that we have to learn and update associations between unconditioned rewards and punishments, and the sensory stimuli that predict them. (elifesciences.org)
  • neurons
  • Normal flies quickly learned both the initial and the reversed association, but reversal learning was blocked by knocking down either GABA A receptors in the mushroom bodies or GABA synthesis in a single pair of giant GABAergic neurons that innervate the mushroom bodies. (jneurosci.org)
  • novel
  • Publication date: June 2019Source: Journal of Memory and Language, Volume 106Author(s): Nathaniel D. Anderson, Eric W. Holmes, Gary S. Dell, Erica L. MiddletonAbstractSpeakers implicitly learn novel phonotactic patterns while producing strings of syllables. (medworm.com)
  • inhibit
  • This choice of water temperature at around 13°C below body temperature is sufficiently stressful to motivate the animals to escape, but not so stressful as to inhibit learning. (scholarpedia.org)
  • Pregnancy
  • Pregnancy rate after vasectomy reversal in a contemporary series: influence of smoking, semen quality and post-surgical use of assisted reproductive techniques. (vasectomy.com)