The signalling molecules are delivered directly to the receiving cells by a direct-contact model and parameters such as cytoneme length or speed of filopodia formation dictate local Wnt concentration. (exeter.ac.uk)
However, mammalian cells in soft tissues function in 3D microenvironments, which are soft and viscoelastic, and in which cells are surrounded by neighboring cells and an extracellular matrix. (stanford.edu)
Complex1
As it is very difficult to determine the specific impact of individual parameters in a complex biological system by a purely experimental approach, we interact with mathematicians using computational modelling. (exeter.ac.uk)