• The third layer (Layer III) forms a ribbon of astrocyte cell bodies that are believed to maintain a subpopulation of astrocytes able to proliferate in vivo and form multipotent neurospheres with self-renewal abilities in vitro. (wikipedia.org)
  • Genetic deletion of both miR-92a and miR-92b demonstrates an essential cell-autonomous role for these miRNAs in maintaining neuroblast self-renewal through inhibiting premature differentiation. (umassmed.edu)
  • Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
  • The term stem cell is also used in reference to any adult cells that are capable of assisting in the restoration of adult tissue via self-renewal. (citizendium.org)
  • DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. (ca.gov)
  • In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)
  • TBC1D15-NuMA1 association impaired asymmetric division machinery by hijacking NuMA from LGN binding, thereby favoring TIC self-renewal. (nature.com)
  • TBC1D15 activated three novel oncogenic pathways to promote self-renewal, p53 loss, and Nanog transcription in TICs. (nature.com)
  • Such CD133+ TICs have also been isolated from three other HCC animal models and patient HCC tissues and were characterized by their NANOG-dependent self-renewal and tumor-initiating activities 6 , 7 , 8 . (nature.com)
  • Thus, the data described here use a novel genetic approach to birthdate centrosomes in human cells and identify asymmetric inheritance of centrosomes as a mechanism to maintain self-renewal properties and to ensure proper neurogenesis in human NPCs. (elifesciences.org)
  • A distinctive feature of neural progenitor cells is that they have limited proliferation capacity, do not produce non-nerve cells, and will not exhibit self-renewal. (creative-biolabs.com)
  • Each lot of NeuCELL™ cells has been validated for high level of expression of Nestin and Sox 2 and for their self-renewal and multi-lineage differentiation capacities. (creative-biolabs.com)
  • These results reveal a novel function of the miR-92 family in Drosophila neuroblasts and provide another example that local negative feedback regulation of host genes by intragenic miRNAs is essential for animal development. (umassmed.edu)
  • Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. (ca.gov)
  • In Drosophila , neuroblasts and cortex glia use a receptor tyrosine kinase-dependent feed-forward mechanism to actively maintain each other during neurogenesis, which contributes to glial tumorigenesis. (silverchair.com)
  • Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS. (jneurosci.org)
  • Studies on early neurogenesis have had considerable impact on the discussion of the phylogenetic relationships of arthropods, having revealed striking similarities and differences between the major lineages. (biomedcentral.com)
  • In Hexapoda and crustaceans, neurogenesis involves the neuroblast, a type of neural stem cell. (biomedcentral.com)
  • In Hexapoda and at least some crustaceans (malacostracans and branchiopods), neurogenesis is coupled to a type of neural stem cell (NSC), the neuroblast (NB) [ 24 - 37 ]. (biomedcentral.com)
  • In the mouse brain, we found that the plasticity inhibitors Nogo-A and Nogo receptor 1 (NgR1) are differentially expressed in the SVZ-OB system, in which Nogo-A identifies immature neuroblasts and NgR1 germinal astrocytes. (jneurosci.org)
  • Slow Proliferating Cells (Type B): express Nestin and GFAP, and function to ensheathe migrating Type A Neuroblasts 4. (wikipedia.org)
  • Such tissue renewal may be accomplished via the use of adult stem cells, or embryonic stem cells, which may be derived from a human embryo in the blastocyst stage. (citizendium.org)
  • In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
  • We revealed that WDR45 and WDR45B are critical for autophagosome-lysosome fusion in neural cells. (biomed.news)
  • After pharmacologically-induced elimination of proliferative cells in the subventricular zone (SVZ), there was enhanced re-activation of quiescent NSCs in old Becn1 KI mice as compared to those in WT mice, with more efficient exit from quiescent status to generate proliferative cells and neuroblasts. (biomed.news)
  • In each hemi-segment, a set of neuroblasts produces neural cells by repeated asymmetrical and interiorly directed divisions. (biomedcentral.com)
  • With the currently available data, a common origin of pycnogonid neural stem cells and tetraconate neuroblasts remains unresolved. (biomedcentral.com)
  • Notchless regulates crucial steps in ribosome biogenesis, yet its inactivation reveals that it is required for proliferating myogenic cells, but not quiescent and differentiated myogenic cells. (silverchair.com)
  • the neuroblast stage has the highest temporal variance within the cell types of the neurogenic cascade, while the apoptotic stage is short. (biomedcentral.com)
  • Temporal and spatial analysis of Plasmodium falciparum genomics reveals patterns of parasite connectivity in a low-transmission district in Southern Province, Zambia. (umassmed.edu)
  • Histological and molecular approaches reveal that Kmt2b epigenetically primes mouse SSCs to upregulate genes during late spermatogenesis and embryogenesis, and that Kmt2b is required for SSC differentiation. (silverchair.com)
  • KNAT1-overexpressing Arabidopsis mutants reveal that gibberellin signaling promotes xylem fiber development by preventing DELLA-dependent inhibition of KNAT1 activity. (silverchair.com)
  • Subsequent research revealed that microRNAs are more dynamic than previously thought, with each precursor being able to generate multiple mature microRNA species known as isomiRs. (pharmaceuticalintelligence.com)
  • Notch signaling also promoted midline glial and median neuroblast cell fate. (biologists.com)
  • This latter result suggests that the median neuroblast resembles brain neuroblasts that require Notch signaling, rather than nerve cord neuroblasts, the formation of which is inhibited by Notch signaling. (biologists.com)
  • The tongue pathology in mice that lack β-catenin in the Myog-Cre -expressing myoblast population reveals that WNT/β-catenin signaling controls the myoblast fusion process through regulation of the nephrin gene. (silverchair.com)
  • ChIP-QPCR analysis revealed that ATF4, an ER-stress inducible transcription factor, directly activated Zbtb38 transcription by binding to the Zbtb38 promoter. (oncotarget.com)
  • Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. (ca.gov)
  • Visualisation of lignifed cell walls reveals two types of xylem elements: smaller xylary fibres and larger, hollow vessels. (silverchair.com)
  • miR-92a and miR-92b are highly expressed in neuroblasts of larval brain where Jigr1 expression is low. (umassmed.edu)
  • We also provide evidence that neuroblast migration to the OB is supported by the activity of the Nogo-A-Δ20 domain, independently of NgR1. (jneurosci.org)
  • Recent studies have revealed that CD109, a glycosylphosphatidylinositol-anchored glycoprotein, is involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis and psoriasis. (nagoya-u.ac.jp)
  • Neuroblast numbers decrease with age, as do transitory amplifying progenitor cells, while both SVZ astrocytes and adjacent ependymal cells remain relatively constant. (nih.gov)
  • In vivo, p27 is also required for the regulation of the proper level of SOX2 necessary for neuroblasts and oligodendroglial progenitor cells to timely exit cell cycle in a lineage-dependent manner. (farinaslab.com)
  • In fact, their composition is highly heterogeneous being the growing cell population characterized by progenitor cells, astroblasts, neuroblasts and differentiated progeny [ 9 ]. (biomedcentral.com)
  • During embryonic stages neural precursor cells termed neuroblasts (NBs) divide asymmetrically in a stem cell-like fashion thereby self-renewing and producing smaller ganglion mother cells (GMCs). (biomedcentral.com)
  • 2. Proliferating Neuroblasts (Type A): express PSA-NCAM (NCAM1), Tuj1 (TUBB3), and Hu, and migrate in line order to the olfactory bulb 3. (wikipedia.org)
  • This was the first study to reveal the presence of a human RMS by which neuroblasts migrate long distances from the subventricular zone to the olfactory bulb where they differentiate into mature neurons. (5dok.org)
  • Functional analysis of this dysregulated transcriptome reveals the significant downregulation of cAMP signalling components immediately after SCI, involving genes such as EPAC2 (exchange protein directly activated by cAMP), PKA, BDNF, and CAMKK2. (bvsalud.org)
  • We revealed that let 7b-P21 axis was involved in regulating the inhibition of NSC proliferation which was activated by NEAT1 in NSCs. (researchsquare.com)
  • The enzyme telomerase, which elongates chromosome termini, is a critical factor in determining long-term cellular proliferation and tissue renewal. (shengsci.com)
  • Our data reveal both a direct association of p27 with regulatory sequences in the three genes and an additional hierarchical relationship where p27 repression of Sox2 leads to reduced levels of its downstream targets Olig2 and Ascl1. (farinaslab.com)