JADE3 is identical to E9 protein identified in an earlier independent study which suggested role in apoptosis for PHF16/JADE3/E9 in breast cancer cells. (wikipedia.org)
High-throughput sequencing-RNA affinity profiling (HiTS-RAP) 22 is conceptually similar to RNA-MaP, but uses the E. coli replication terminator protein Tus to stall the RNA polymerase after transcribing the variable section of the DNA library. (nature.com)
They act to fasten the protein to an AT RICH SEQUENCE in the DNA. (lookformedical.com)
Interestingly, our previous studies revealed that the viral Np9 protein is an oncoprotein and potently activates a variety of pathways such as β-catenin, ERK, Akt and Notch1, and promotes the growth of human leukemia stem/progenitor cells [ 1 ]. (aging-us.com)
Given that we previously defined the viral np9 gene, which is aberrantly activated in human leukemia, as a potent oncogene [ 1 ], we next attempted to search for cellular homologs of the viral oncogene np9 in NCBI database by performing alignment using Np9 protein sequence. (aging-us.com)
And 4 from 207 independent Tol2 focusing on occasions occurred at the identical place positioned inside of the intron of signal regulatory protein delta. (plksignaling.com)
The reverse activity transcribes the ZAR2 mRNA with 966 nt coding sequence which codes for a 321 amino acid protein. (biomedcentral.com)
Proteins5
The UGT1 family constitutes a complex gene locus on human chromosome 2q37 and comprises 13 first exons that encode the unique N-terminal domains of the UGT1A proteins and exons 2 to 5 that encode the C-terminal domain, which is identical in all UGT1A family members ( Owens and Ritter, 1992 ). (aspetjournals.org)
On the other hand, although the transcription of TCL2 , like TCL1, is not controlled by the activator complex formed by GL1 and GL3, and TCL2 and TCL1 proteins are more than 80% identical at the amino acid level, the expression of TCL2 under the control of TCL1 promoter only partially recovered the mutant phenotype of tcl1 , implying that TCL2 and TCL1 are not fully functional equivalent. (biomedcentral.com)
Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations. (lookformedical.com)
Genetic analysis of early development in the Drosophila embryo has revealed that embryonic pattern formation depends on both maternal and zygotic genes. (silverchair.com)
Nucleotide4
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
Similarity1
The degree of similarity between sequences of amino acids. (lookformedical.com)
Transcription factor3
Orthologous to human PHTF1 (putative homeodomain transcription factor 1). (nih.gov)
Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells. (nih.gov)
Direct evidence for this model comes from the identification of heterozygous germline mutations in the homeodomain transcription factor PHOX2B , a regulator of sympathetic neuronal differentiation [3] - [8] . (prolekarniky.cz)
Genes2
The HOX genes encode a family of homeodomain-containing transcription factors that play important roles in the early embryo, including the establishment of cell and tissue identity, and the regulation of cell proliferation, differentiation, and survival [ 12 ]. (biomedcentral.com)
Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
Gene expression2
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
Motifs3
There are many superfamilies of Znf motifs, varying in both sequence and structure. (embl.de)
AMINO ACID MOTIFS are often composed of conserved sequences. (lookformedical.com)
Furthermore, in transcripts of both Brd and m4 there are three common regulatory sequence motifs within the 3' UTR. (sdbonline.org)
Organisms1
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. (lookformedical.com)
They consist of positively charged sequences of nine amino acids centered on the invariant tripeptide glycine-arginine-proline. (lookformedical.com)
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. (lookformedical.com)
Motif1
As in m4 , the sequence motif of the Brd box is found twice in the 3'-UTR of malpha mRNA at similar positions but without a GY box. (sdbonline.org)
Nucleic2
Based on sequence database analysis the study suggested that PHF17 may function in nucleic acid managing pathway. (wikipedia.org)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. (lookformedical.com)
Findings reveal2
These findings reveal that Np17 is a novel oncogene associated with refractory/relapsed leukemia. (aging-us.com)
Our findings reveal that both factors influence behavioral outcomes at the group level, underlining the importance of accounting for individual variations in naming latencies, especially for late processing stages closer to articulation, and recognizing the presence of nonspecific effects of TMS. (mpi.nl)
Genome2
By conducting a Blat search against the UCSC genome browser database, we recognized 16 piggyBac and twelve Tol2 targeting sequences which have a minimum of the very first 100 bp nucleotides 3 to the target website share greater than 97% sequence identity with other sequences from the gen ome. (plksignaling.com)
A different example, B87 4, was identified to share at the least 97% sequence identity with 510 sequences elsewhere while in the human genome, yet none of these remarkably similar sequences had been targeted by piggyBac. (plksignaling.com)
Promoter1
Quantitative analysis of RNA on a massively parallel array (RNA-MaP) 21 , 23 starts with ssDNA sequencing libraries including an RNA polymerase promoter region, a stall sequence, and a variable region complementary to the desired RNA. (nature.com)
Highly2
Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. (nih.gov)
The truth that piggyBac targeted repeatedly on the very same TTAA but not the adjacent TTAA tetranucleotides or for the TTAA website on yet another highly identical sequence close by raise the likelihood the real TTAA pig gyBac targets could possibly be determined by some intrinsic sequence constraints flanking the target internet site. (plksignaling.com)
Search2
A Blat search has identified yet another sequence which can be found three. (plksignaling.com)
By a Blat search, we recognized 4 sequences on chromo some 16 that share 100% sequence identity with among the list of piggyBac hotspot as in B89 four and B77 4. (plksignaling.com)
Interactions1
In the absence of quantitative predictive capacity for such bioaffinity interactions, high throughput experimental approaches are needed to sufficiently sample RNA sequence space. (nature.com)
Family1
The database analysis revealed two additional JADE1 paralogues and members of JADE family, JADE2, and JADE3. (wikipedia.org)
Identity1
5% sequence identity with all the target website of B92 one and B75 4. (plksignaling.com)
Studies2
Recent studies have revealed an extensive superfamily of UDP-glucuronosyltransferases (UGTs), 2 previously termed glucuronyl transferases, which catalyze the conjugation of UDP-glucuronic acid with lipid-soluble substrates to form polar conjugates that are excreted in the urine and feces. (aspetjournals.org)
Lineage tracing studies have revealed that both endocrine and exocrine cells are derived from Pdx1 -expressing progenitors [ 1 - 3 ]. (biomedcentral.com)
Nature3
To additional explore the nature of target web-site variety by piggyBac and Tol2, we performed a series of in depth analyses on their target sequences. (plksignaling.com)
Additional analyses are essential to reveal the nature of this discrepancy. (plksignaling.com)
To examine the nature of piggyBac target specificity, we subsequent examined the neighboring sequences close to five piggyBac hotspots. (plksignaling.com)
Additional1
Similarly, the sequence of an additional piggyBac hotspot, is made up of 3 TTAA tetranucleotides inside of the one hundred bp interval downstream of your real TTAA piggyBac target web page. (plksignaling.com)
Properties1
Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl.de)
Target6
By applying this sequence constrain, the frequency of targeting repeats lessen way more dramatically in piggyBac than in Tol2 to the bulk of repeat styles suggesting that piggyBac might display a greater degree of sequence constrains than Tol2 in selecting their target internet sites. (plksignaling.com)
Sequence analyses of Tol2 and piggyBac target web pages To analyze the sequence preference for piggyBac and Tol2 focusing on, we produced sequence logos for both transposon systems. (plksignaling.com)
Yet again this observation could reflect a higher degree of sequence constrains in target internet site choice for piggyBac than for Tol2. (plksignaling.com)
The target sequences in B102 two and B38 four are identical and have three TTAA tetranu cleotides within a one hundred bp interval upstream in the actual piggyBac TTAA target. (plksignaling.com)
As in depth from the lower sequence of Figure 5B, a G to A substitution is identified at 88 on the other sequence the place the piggyBac target internet site is designated as 0. (plksignaling.com)
To further handle this probability, we targeted on two other piggy Bac target sequences, the B89 four and B87 four. (plksignaling.com)
Degree1
The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. (lookformedical.com)
Cell1
After the DNA library is sequenced on the Illumina flow cell, it is enzymatically double stranded by extension of a 5′ biotinylated primer. (nature.com)