Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. (sens.org)
Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. (wikipedia.org)
Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). (nature.com)
instead, they secrete a range of harmful inflammatory chemical signals, which are collectively known as the senescence-associated secretory phenotype (SASP). (transhumanist-party.org)
On the other hand, senescent cells secrete many proinflammatory cytokines, chemokines, growth factors, and proteases, collectively termed as the senescence-associated secretory phenotype (SASP), which causes chronic inflammation and tissue dysfunction. (molcells.org)
this senescence-associated secretory phenotype (SASP) leads to cancer progression and chemoresistance. (kumamoto-u.ac.jp)
Single-cell mass cytometry revealed that fibroblasts exist in the ascites of GC patients with peritoneal dissemination, and the fibroblast population shows p16 expression and SASP factors at high levels. (kumamoto-u.ac.jp)
Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. (houstonmethodist.org)
However, transcriptome-wide analysis revealed activation of the senescence-associated secretory phenotype and dampened cytotoxicity in iNKT cells, weakening their immune surveillance capacity. (bvsalud.org)
Another characteristic is that senescent cells that accumulate in body tissues over time cause chronic inflammation through the secretion of proinflammatory cytokines, termed senescence-associated secretory phenotype. (biomedcentral.com)
Publication: Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype Cell Metabolism, February 9, 2016. (h2020awe.eu)
Subsequent studies have revealed that cellular senescence is caused not only by telomere length reduction, but also by external factors such as oncogene activation, oxidative stress, and DNA damage. (dojindo.com)
Secretion2
Biochemical and molecular dynamic simulation experiments revealed that the two substitutions do not regulate secretion by affecting the property of SNARE complex itself, but rather make the SNAP-25b-containing SNARE complex more available for the interaction with accessory factor(s). (nih.gov)
Nevertheless, recent work has revealed defects in glucagon secretion in islets isolated from donors positive for a single GAD autoantibody (GADA) [ 13 ]. (springer.com)
Pathway6
Our study reveals a sex-dependent effect of EO diet in both tissues, and an influence on the expression of genes mainly involved in immune, inflammatory and stress pathway. (biomedcentral.com)
We show here that the biogenesis of CLEL6 and CLEL9 peptides in Arabidopsis thaliana requires a series of processing events in consecutive compartments of the secretory pathway. (elifesciences.org)
SBT6.1-mediated cleavage within the variable domain allows for continued passage of the partially processed precursors through the secretory pathway, and for subsequent post-translational modifications including tyrosine sulfation and proline hydroxylation within, and proteolytic maturation after exit from the Golgi. (elifesciences.org)
Early to late endosome transport may be mediated by small vesicular intermediates, or may be a maturation process whereby early endosomes lose components through recycling pathways and gain components through fusion with vesicles derived from the secretory pathway. (wormbook.org)
This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
Recent study at IMBB, published in Cell Death and Disease revealed that CISD-1, an iron sulfur cluster binding protein implicated in the pathogenesis of the neurodegenerative disorder Wolfram Syndrome type 2, modulates longevity and proteostasis by engaging autophagy and the mitochondrial intrinsic apoptosis pathway. (forth.gr)
Autophagy1
According to recent data, Ras-transformed cells require autophagy to survive and maintain malignant phenotype [ 5 - 10 ]. (aging-us.com)
Clinical4
This study aimed to investigate the epidemiological characteristics, the spectrum of variation, clinical phenotype, and prognosis of MCADD in Chinese newborns. (bvsalud.org)
the phenotype is complex and all the clinical features are progressive, suggesting a degenerative process. (medscape.com)
In PFIC3, patients have a similar clinical presentation, but laboratory results reveal an elevated serum GGT. (medscape.com)
Patients with multiple sclerosis are classified according to their clinical phenotype, with ~85% following a relapsing-remitting course (relapsing-remitting multiple sclerosis) characterized by recurrent, acute neurological deficits punctuating periods of latency or remission (Lublin and Reingold, 1996). (medscape.com)
Neuronal5
Unbiased proteomic analysis of Magel2pΔ/m+ mice revealed a reduction in components of SG in the hypothalamus that was confirmed in 2 PWS patient-derived neuronal cell models. (jci.org)
Further analysis of damaged brain samples revealed that astrocytes, which are brain cells that sustain neuronal metabolism, were particularly likely to be infected with SARS-CoV-2 and that the virus enters these cells through the NRP1 receptor. (hindustantimes.com)
The altered secretory phenotype of infected astrocytes then impairs neuronal viability. (hindustantimes.com)
Moreover, human astrocyte infection elicits a secretory phenotype that reduces neuronal viability. (hindustantimes.com)
Evidence of neuronal degeneration associated with depletion of secretory granules in the acinar cells was observed. (medscape.com)
Metabolism2
Lipidomic profiling revealed the accumulation of long-chain acylcarnitines (LCAC) and aberrant lipid metabolism in HCC tissue. (bvsalud.org)
In a paper published in Metabolism, Kardassis lab reveals a novel role of the nuclear receptor HNF4A in glucose homeostasis and in the liver-α-cell axis in mice. (forth.gr)
Protein2
This research confirmed that deletion of some regions of the secretory signal sequence significantly improved the efficiency of HIP protein expression in P. pastoris . (springeropen.com)
Aliases include fallotein, SCDGF, spinal cord-derived growth factor, and secretory growth factor-like protein. (mmrrc.org)
Prognosis2
Survival analysis revealed that IL8, IL2Ra (CD25) and PF4 were independent determinants of a more negative prognosis in mesothelioma patients, independent of other known prognostic factors. (iospress.com)
These patients have a poor prognosis, with unselected large series revealing median survivals between 7 and 11 months [ 3 , 4 ]. (iospress.com)
Mice3
Here, we report deficits in secretory granule (SG) abundance and bioactive neuropeptide production upon loss of MAGEL2 in humans and mice. (jci.org)
These data identify distinct electrophysiologic abnormalities in FHC mice with a specific alpha-myosin mutation, and also validate a novel method to explore in vivo the relationship between specific genotypes and their electrophysiologic phenotypes. (jci.org)
RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (mmrrc.org)
Mechanisms2
Overall, this study reveals the impact of cln5 -deficiency on gene expression in D. discoideum , provides insight on the genes and proteins that play a role in regulating Cln5-dependent processes, and sheds light on the molecular mechanisms underlying CLN5 disease. (frontiersin.org)
have begun to reveal new components and new mechanisms associated with intracellular membrane traffic in a variety of cell types. (wormbook.org)
Epidemiological1
Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa. (cancerindex.org)
Signals1
This study aimed to compare the HIP expression from full-length and truncated α-factor secretory signals clones that grown in two types of media, buffered methanol complex medium (BMMY) and methanol basal salt medium (BSMM). (springeropen.com)
Regulate1
Furthermore, loss of Rab11 can act synergistically with the oncoprotein Ras(V12) to regulate these cancer related phenotypes. (sdbonline.org)
Diabetes1
To determine the correlates of the "metabolically healthy obese" (MHO) phenotype and the longitudinal risks of diabetes and cardiovascular disease (CVD)/stroke associated with this phenotype. (diabetesjournals.org)
Aging1
Research at IMBB, published in Nature Aging, reveals a fundamental quality control mechanism that operates in cells to safeguard the integrity and function of the nucleus. (forth.gr)
Elegans1
Publication: A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. (h2020awe.eu)
Cells2
Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells. (unicyte.ch)
The cytokine secretory phenotype of MDA-MB-231LN breast cancer cells with altered AF1q expression revealed changes in expression of platelet-derived growth factor subunit B (PDGF-B). AF1q-induced PDGF-B stimulated motility, migration, and invasion of MDA-MB-231LN cells, and AF1q up-regulated platelet-derived growth factor receptor (PDGFR) signaling. (mainehealth.org)
Study2
In this study, we used comparative transcriptomics to identify differentially expressed genes underlying cln5 -deficiency phenotypes during growth and the early stages of multicellular development. (frontiersin.org)
However, a serologic study revealed the presence of antibodies to an HPAI H5N8 clade 2.3.4.4 virus in 61 of 760 serum samples from persons who had had contact with infected or deceased birds during the 2016-17 HPAI outbreaks in Russia ( 10 ), providing evidence of overlooked human infection. (cdc.gov)
Human1
This phenotype is rescued by transgenic expression of the human ABCB4 gene, confirming that phospholipid excretion is dependent on ABCB4. (medscape.com)
Full-length2
CL4 clone, which utilized a truncated α-factor in the P. pastoris HIP expression cassette, significantly expressed HIP 8.97 times (in BMMY) and 1.17 times (in BSMM) higher than HF7 clone, which used a full-length α-factor secretory signal. (springeropen.com)
2015 . The crystal structure of full-length E. coli YidC revealed that a hydrophilic groove, formed by five transmembrane helices, is a conserved structural feature of YidC, as compared to the previous YidC structure from Bacillus halodurans , which lacks a periplasmic domain. (tcdb.org)
Analysis1
CT scanning reveals atrophic adrenal glands, but no reports of histologic analysis are available. (medscape.com)