Reveal cells use genetic. Medical search. Frequent questions

Durrett, R. Population genetics of neutral mutations in exponentially growing cancer cell populations. (nature.com)
The loss of such protective functions as a result of LRRK2 genetic mutations could explain the link between LRRK2 and Parkinson's disease, the researchers say. (medicalxpress.com)
When sequencing DNA, we are looking for the high priority variants, or genetic mutations that result in disease. (sciencedaily.com)
Scientists from The Scripps Research Institute have provided an answer to the 40-year-old mystery of how certain genetic mutations lead to Type 1 diabetes. (scripps.edu)
Thus, a number of mutations can result in increased druse crystal formation in mesophyll cells. (usda.gov)
As a graduate student, I discovered that human brain cells harbor genetic mutations that occur during brain development. (pewtrusts.org)
The flow cytometry-based Pig-a assay detects cells deficient in Glycosylphosphatidylinositol (or GPI)-anchored surface markers and provides a rapid and cost-effective enumeration of cells that are presumed to contain mutations in the endogenous X-linked Pig-a gene. (fda.gov)
Somatic mutations are genetic alterations in cells that increase cancer risk. (fda.gov)
Dr. Revollo is developing NGS methods capable of directly and efficiently identifying somatic mutations in the whole genome - in any tissue, and in any species, or any established cell culture - without the need for selecting and expanding cells that have mutations in only a few specific reporter genes. (fda.gov)
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. (thebiogrid.org)
Researchers irradiated stem cells from mouse embryos to cause genetic mutations, then stained the cells to reveal the tumour suppressing protein p53. (newscientist.com)
Tumors were genetically variable, and a similar genetic landscape as previous studies using non-formalin fixed samples was identified, with recurrent mutations including ATM, KMT2D, and TP53. (lu.se)
Sometimes, people with family histories and genetic mutations related to medullary thyroid cancer will have their thyroid gland removed to prevent cancer. (medlineplus.gov)
Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A. (lu.se)
Genetic analysis of patients with leukocyte adhesion deficiency: genomic sequencing reveals otherwise undetectable mutations. (lu.se)

Cases exhibited elevated expression of type 1 interferon-stimulated genes (ISGs) in monocytes, reduction of naïve CD4 + T cells that correlated with monocyte ISG expression, and expansion of repertoire-restricted cytotoxic GZMH + CD8 + T cells. (nih.gov)
Candidate genes and pathways identified here could reveal therapeutic opportunities in platinum60 resistant HGSC. (mysciencework.com)
LRRK2 genes can also reduce activity of macrophages and microglia, specialized cells that act as the body's scavengers, clearing away misfolded proteins, cell debris, dead cells, and pathogens, the researchers found. (medicalxpress.com)
The genes for the formation of these active substances are expressed in different cell types. (analytica-world.com)
By using single-cell analyses, the scientists were able to discover new genes important for biosynthesis and show that the intermediates of the metabolic pathway accumulate in specific cell types. (analytica-world.com)
Here, we used quantitative real-time PCR, profiling the expression of 93 genes in single-cells from three different cell lines. (frontiersin.org)
We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
Detailed analysis of cell cycle predictive genes allowed us to define subpopulations with distinct gene expression profiles and to calculate a cell cycle index that illustrates the transition of cells between cell cycle phases. (frontiersin.org)
In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
Here, we employed single-cell gene expression profiling to describe the dynamic transition between cell proliferative states in three different cell lines using a panel consisting of 93 marker genes. (frontiersin.org)
While genes predispose people to many different types of diseases in many different ways, specific genetic variations are an especially strong predictor of the development of type 1 diabetes. (scripps.edu)
These three genes encode molecules that present peptides (protein fragments) to the body's T cells. (scripps.edu)
Our analysis reveals extensive functional overlap between even the most distantly related TIR1/AFB genes except for AFB1 . (elifesciences.org)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
We performed transcriptomic analyses to reveal genes, cell types and mechanisms perturbed in CD, leveraging the power of the two cohorts to confirm our findings and assess replicability. (medrxiv.org)
We observed an enrichment of CD heritability among marker genes for various activated T cell types and myeloid cells, supporting a causal role for these cell types in CD aetiology. (medrxiv.org)
Overall, our results provide a rich resource for identifying cell type specific biomarkers of Crohn's disease and identifying genes, cell types and pathways that are causally and replicably associated with disease. (medrxiv.org)
Now researchers at La Jolla Institute for Immunology (LJI) have created 3D maps of how enhancer sequences and genes interact in several types of immune cells. (ddw-online.com)
Many of us are taught that a cell has machinery that hums along the genetic code, "reading" genes and making proteins. (ddw-online.com)
These are the DNA sequences that sit in the genetic code in front of genes. (ddw-online.com)
One key difference involved genes that cause a cell to respond to the chemical messenger serotonin, says Ed Lein , a study author and investigator at the institute. (kalw.org)
The technology does this by detecting which genes are switched on in each cell. (kalw.org)
We develop a computational model for the hematopoietic erythroid/myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)

Genetic drift, selection and the evolution of the mutation rate. (nature.com)
In the first study, Lyons and her team used the 99 Lives consortium to identify a genetic mutation that causes blindness in the African black-footed cat, an endangered species often found in U.S. zoos. (sciencedaily.com)
The genetic mutation identified was located the IQCB1 gene and is associated with progressive retinal atrophy, an inherited degenerative retinal disorder that leads to blindness. (sciencedaily.com)
The affected cat had two copies of the genetic mutation, indicating that it was an inherited disorder. (sciencedaily.com)
We evaluated each gene of the African black-footed cat, one at a time, to look for the genetic mutation that is associated with vision loss. (sciencedaily.com)
Genetic analysis revealed that each mutation was recessive and resided in different loci. (usda.gov)
Using those mutation patterns as genetic fingerprints, we can reveal the developmental relationships between different cells. (pewtrusts.org)
Current genetic toxicology assays can only estimate somatic-mutation rates by assaying the function of certain gene markers (e.g. (fda.gov)
Then one of those cells mutates through a DNA insertion, deletion, or point mutation, and suddenly a new pattern appears. (cdc.gov)

Here we report the genetic characterization of CPOAA biosynthesis with revealing a "pathway redundancy" in metabolic networks. (biomedcentral.com)
To determine the role of these proteins in plant development we performed an extensive genetic analysis involving the generation and characterization of all possible multiply-mutant lines. (elifesciences.org)
Population Genomics Approaches for Genetic Characterization of SARS-CoV-2 Lineages. (cdc.gov)
Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. (lu.se)

New Rochelle, NY, April 4, 2016--A new study shows that Frizzled7 (FZD7), a protein present on human breast epithelial cells and a component of the Wnt signaling pathway is uniquely controlled by the Notch signaling pathway, both of which play key roles in mammary gland formation and breast cancer development. (eurekalert.org)
Vasudeva Bhat, Yu Jia Sun, Steve Weger, and Afshin Raouf, University Manitoba and CancerCare Manitoba, Winnipeg, Canada, determined how the Notch signaling pathway uniquely regulates a specific component of the Wnt signaling pathway--the FZD7receptor--in human breast epithelial cells. (eurekalert.org)
On day nine, they seeded retinal pigment epithelial cells on the reverse side of the scaffold. (scienceboard.net)

As the analyses showed, the entire biosynthetic pathway for the alkaloid vinblastine is organized in three stages and three discrete cell types. (analytica-world.com)
Tissue analyses and genetic and functional testing showed that the printed tissue looked and behaved like normal outer blood-retina barrier tissue. (scienceboard.net)

October 31, 2022 -- A genetic timestamping mouse model has shown the rate at which antibody-producing cells accumulate and disappear after vaccination, which could ultimately allow researchers to be able to increase the longevity of immunity from vaccines. (scienceboard.net)
The fluorescence enabled the researchers to see individual cells as they were made and moved to storage sites in the bone marrow. (scienceboard.net)
In the article "Notch-induced Expression of FZD7 Required Noncanonical NOTCH3 Signaling in Human Breast E0pithelial Cells" , the researchers provide evidence that Notch-induced expression of FZD7 is controlled only by the NOTCH3 receptor and in a unique way that differs from other demonstrated mechanisms of Notch-mediated modulation of the Wnt signaling pathway. (eurekalert.org)
In a new study, Yale researchers reveal new insights into this question, finding that the LRRK2 gene can suppress activity in lysosomes, microscopic organelles that play a key role in breaking down and disposing of cellular waste. (medicalxpress.com)
With single-cell omics, we have a method that allows researchers to assign genetic and metabolic information to individual cells. (analytica-world.com)
A team of researchers at the University of Bayreuth led by biochemist Dr. Claus Kuhn now reveals insights into the mode of action of these proteins in more detail. (bionity.com)
When researchers uncover a genetic variant linked to a disease, they usually go looking for the nearby gene. (ddw-online.com)
These snapshots were then strung together into time-lapse movies, which the researchers analyzed for the timing of various cell-division phases. (livescience.com)
The abnormal cells showed more variations in their cell-division cycles than normal cells, the researchers found. (livescience.com)
Combining data about the abnormal timing with other signs that something has gone wrong (such as fragmented DNA and asymmetrical cell sizes within a developing embryo) could reliably show which cells have the right number of chromosomes and which don't, the researchers report. (livescience.com)
Researchers reveal a fresh three-dimensional look at the spike proteins on HIV's coating that allow it to bind and fuse with human cells. (hum-molgen.org)
The researchers then printed a combination of cells to form the outer blood-retina barrier. (scienceboard.net)
The researchers are currently experimenting with adding additional cell types, such as immune cells, to the printing process to better recapitulate native tissue. (scienceboard.net)
The list of cell types also should help researchers see what goes wrong in human brain disorders, Koch says. (kalw.org)
Now, researchers have a way to make sure the types of cells involved in a particular disease work the same way in people as in an animal model, Koch says. (kalw.org)
To compare mouse and human brain cells, researchers first analyzed sixteen thousand human brain cells taken from the middle temporal gyrus, a part of the cortex, the brain's outermost layer. (kalw.org)
ONE of the mechanisms that make damaged cells commit suicide is switched off in the embryo, say researchers. (newscientist.com)

Genomic instability in silica- and cadmium chloride-transformed BALB/c-3T3 and tumor cell lines by random amplified polymorphic DNA analysis. (cdc.gov)
Non-transformed, transformed BALB/c-3T3 cells, and tumor cell lines (obtained by injecting nude mice with transformed cell lines) were analyzed for genomic changes. (cdc.gov)
Five of the 10 primers tested revealed genomic changes in silica-transformed cell lines when compared to non-transformed BALB/c-3T3 cells. (cdc.gov)
Comparison of all 10 transformed and tumor cell lines showed varied degrees of genomic changes using all 10 primers. (cdc.gov)
CdCl2-transformed cell lines displayed fewer genomic changes, only three of 10 primers showed a positive result. (cdc.gov)

We integrated dense genotyping data to map cell type-specific cis-expression quantitative trait loci and to link SLE-associated variants to cell type-specific expression. (nih.gov)
By applying a quantitative framework to estimate the degree of undersampling we revealed the existence of tripotent mesodermal progenitors derived from pluripotent stem cells, and the subsequent bifurcation of their differentiation into bipotent endothelial/hematopoietic or endothelial/mesenchymal progenitors. (ca.gov)
Such data are only indirectly related to quantitative changes in cells at different states of division and growth. (frontiersin.org)
To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases as well as key cellular regulators. (thebiogrid.org)

In this study, single-cell microfluidic genetic profiling of primary human glioblastoma was performed to characterize intra-tumoral BTIC heterogeneity, identify unique surface markers of BTIC subsets, and associate BTIC subsets with clinically-relevant bulk tissue molecular subtypes. (cns.org)
Microfluidic genetic profiling of BTICs at the single-cell level was performed to characterize intra-tumoral BTIC heterogeneity. (cns.org)
This is the first demonstration of cancer stem cell heterogeneity in glioblastoma at the single-cell level, and particularly as it relates to prospective isolation and bulk tumor subtypes. (cns.org)
SummaryThe inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). (ox.ac.uk)
NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. (ox.ac.uk)
Most studies have been performed on large cell populations, but detailed understanding of cell dynamics and heterogeneity requires single-cell analysis. (frontiersin.org)

Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
B, T and myeloid cells showed particularly poor replicability, suggesting caution should be exercised when interpreting unreplicated differential gene-expression results in these cell types. (medrxiv.org)

However, limited data are available about sequence variability in CD8 + T cell epitope regions of mumps virus (MuV) proteins. (mdpi.com)
Its stem cells contain the proteins SMEDWI-2 and SMEDWI-3. (bionity.com)
They work by recognizing and finding specific proteins or targets on cancer cells. (lu.se)

Polyoxin, a peptidyl nucleoside antibiotic, consists of three building blocks including a nucleoside skeleton, polyoximic acid (POIA), and carbamoylpolyoxamic acid (CPOAA), however, little is known about the "pathway redundancy" of the metabolic networks directing the CPOAA biosynthesis in the cell factories of the polyoxin producer. (biomedcentral.com)
The proposed CPOAA biosynthetic pathway (A) and Genetic organization of the polyoxin biosynthetic gene cluster (B). The initial two steps involved in CPOAA biosynthesis are overlapped with those of L-Arginine pathway. (biomedcentral.com)
The second stage of the biosynthetic pathway is expressed only in cells of the epidermis, the layer of cells that cover the leaves, and the last known steps of the biosynthetic pathway are expressed exclusively in idioblasts, a rare cell type of the leaf," Chenxin Li summarizes the results. (analytica-world.com)
Therefore, we identified Lnk as a physiological negative regulator of JAK2 in stem cells and TPO/Mpl/JAK2/Lnk as a major regulatory pathway in controlling stem cell self-renewal and quiescence. (jci.org)

Cell type-specific expression features predicted case-control status and stratified patients into two molecular subtypes. (nih.gov)
Each BTIC subtype was characterized by distinct surface markers, and single-cell molecular profiles relating to distinct bulk tissue molecular subtypes. (cns.org)
MAAT uses molecular markers to assign collections to genetic groups. (phys.org)
Katharine R. Hind, Paul W. Gabrielson, and Gary W. Saunders (2014) "Molecular-assisted alpha taxonomy reveals pseudocryptic diversity among species of Bossiella (Corallinales, Rhodophyta) in the eastern Pacific Ocean. (phys.org)
Here we show that NGH can be accurately measured when informed by the molecular signatures of the normal cells of origin. (ox.ac.uk)
The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)
The result of this molecular change was that the mutated MHC molecules selected a unique subset of T cells that bound to it strongly, with "higher affinity. (scripps.edu)
It is the prototype of the primary immunodeficiency diseases and is caused by numerous molecular defects that lead to severe compromise in the number and function of T cells, B cells, and occasionally natural killer (NK) cells. (medscape.com)
Over the past few decades, the diverse molecular genetic causes of SCID have been identified with progress from studies of the immune system. (medscape.com)
These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)

Next-generation sequencing has provided a snapshot of the genetic landscape of most cancer types, and cancer genomics approaches are driving new insights into cancer evolutionary patterns in time and space. (nature.com)

Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. (frontiersin.org)
However, most of our knowledge about cell proliferation comes from studies that average data from large and mixed cell populations. (frontiersin.org)
Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. (mpg.de)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)
Burkitt lymphoma is the most rapidly growing human tumor, and pathology reveals a high mitotic rate, a monoclonal proliferation of B cells, and a "starry-sky" pattern of benign macrophages that have engulfed apoptotic malignant lymphocytes. (msdmanuals.com)

these include relatively rare heritable diseases like cystic fibrosis and sickle cell disease, along with many others. (cdc.gov)

These results demonstrate mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with SLE. (nih.gov)
But caution is warranted, he said, since there may be risks with weakening the ability of LRRK2 to serve as a brake, which might unleash an excessive cellular cleanup that could harm healthy cells . (medicalxpress.com)
Polarization is a fundamental cellular property that plays a vital role in various biological processes in multi-cellular as well as single-cell organisms. (elifesciences.org)
Using non-negative matrix factorization we revealed intra- and inter-cellular upregulation of expression programmes such as G-protein coupled receptor signalling and interferon signalling, respectively, in CD. (medrxiv.org)

Methods: We created five in vitro and two in vivo platinum-resistant HGSC models and characterised the entire cell panel via whole genome sequencing, RNASeq and creation of intraperitoneal models. (mysciencework.com)
Now, in a series of recent studies, scientists at the University of Missouri are using whole genome sequencing through the 99 Lives Cat Genome Sequencing Consortium to identify genetic variants that cause rare diseases, such as progressive retinal atrophy and Niemann-Pick type 1, a fatal disorder in domestic cats. (sciencedaily.com)

The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease. (ddw-online.com)
What we've shown is that by watching, you can detect some differences in the movements in the cell cycle of those [embryos] that are carrying errors from those that are more likely to survive," said study researcher Renee Reijo Pera, who studies stem cells and early embryo development at Stanford University. (livescience.com)
A detailed comparison of the cell types in mouse and human brain tissue found subtle but important differences that could affect the response to many drugs, a team reports Wednesday in the journal Nature . (kalw.org)
But a close comparison of 75 of these brain cell types revealed small differences. (kalw.org)
CdCl2-transformed cells and their corresponding tumor cell lines showed specific banding pattern differences in six of the 10 samples tested with six of the 10 primers. (cdc.gov)
The Agency's first comprehensive, population-based study, 6XUYLYDO RI FDQFHU SDWLHQWV LQ (XURSH (852&$5( , evoked a strong reaction in the public health community since it revealed surprisingly large differences, even among highly developed countries. (who.int)
Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)
Some DNA differences result from the blunders during the DNA replication necessary for cell division. (cdc.gov)

We manipulated the genome of zebrafish embryos and made bone-forming cells fluorescently visible in green. (scitechdaily.com)
Three genetic variations in particular (HLA-DQ2, HLA-DQ8, and HLA-DR0405)-all located in the region of the genome called HLA for "human leukocyte antigen"-are known to dramatically increase risk of coming down with the condition. (scripps.edu)
Here, we review the arrival of genetic screens in malaria parasites to analyse parasite gene function at a genome-scale and their impact on understanding parasite biology. (portlandpress.com)
We therefore introduce the reader to CRISPR-based screens in the related apicomplexan Toxoplasma gondii and discuss how these approaches could be adapted to develop CRISPR/Cas9 based genome-scale genetic screens in malaria parasites. (portlandpress.com)

However, cisplatin-resistant and carboplatin-resistant cells evolved recurrent changes in gene expression that significantly overlapped with independent samples obtained from multiple patients with relapsed HGSC. (mysciencework.com)
Gene Ontology Biological Pathways (GOBP) related to the tumour microenvironment, particularly the extracellular matrix, were repeatedly enriched in cisplatin50 resistant cells, carboplatin-resistant cells and also in human resistant/refractory samples. (mysciencework.com)
This suggests that recurrent gene expression changes provide a fitness advantage during platinum therapy and also that cancer cell intrinsic mechanisms influence the tumour microenvironment during the evolution of drug resistance. (mysciencework.com)
The scientists know that gene activity is not the same in all cells of a plant and that the chemistry can differ drastically from cell to cell. (analytica-world.com)
By applying the random forests algorithm, a supervised machine learning approach, we show how a multi-gene signature that classifies individual cells into their correct cell cycle phase and cell size can be generated. (frontiersin.org)
Comparisons between our discovery and replication cohort revealed significant variation in differential gene-expression replicability across cell types. (medrxiv.org)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)
An enhancer serves as a specific switch to turn a gene on in a cell-specific manner. (ddw-online.com)
The new study shows that variations in the enhancer sequences can actually disable the "switch"-or impair the "wiring"-leading to problems in turning on the right gene in the right cell type. (ddw-online.com)
National Eye Institute scientists have mapped the genetic architecture that determines gene expression and disease phenotype in human age-related eye. (scienceboard.net)
There is a distinctive genetic translocation involving the C-myc gene on chromosome 8 and the immunoglobulin heavy chain of chromosome 14. (msdmanuals.com)

Planarians, in contrast, have large numbers of piRNAs in adult pluripotent stem cells, which go on to differentiate and develop into various tissue types. (bionity.com)

Identification of cell surface markers of distinct BTIC subpopulations will support future study of glioblastoma cancer stem cells, and the potential development of BTIC subpopulation-specific therapeutic strategies. (cns.org)
Improved understanding of the underlying cancer biology of this subpopulation of cancer stem cells, thought to drive tumor formation and therapeutic resistance, could potentially lead to improved targeted therapies that prolong patient survival. (cns.org)
Biological pathways relevant to the extracellular matrix were repeatedly expressed by resistant cancer cells in multiple settings. (mysciencework.com)
We surveyed the transcriptomes of ∼ 4000 normal fallopian tube epithelial (FTE) cells, the cells of origin of serous ovarian cancer (SOC), and identified six FTE subtypes. (ox.ac.uk)
In contrast to species evolution, cancer is a particular case owing to the vast size of tumour cell populations, chromosomal instability and its potential for phenotypic plasticity. (nature.com)
Cancer Cell 27 , 15-26 (2015). (nature.com)
NEW YORK - New research suggests circularized DNA falling outside of linear chromosomes may serve as a recurrent source of somatic rearrangements in neuroblastoma, a pediatric cancer affecting immature cells in the sympathetic nervous system. (genomeweb.com)
What can Frizzled7 reveal about breast cancer development? (eurekalert.org)
How And When Should Genetic Tests For Cancer Be Used? (hum-molgen.org)
Our earlier studies using random amplified polymorphic DNA (RAPD) analysis have shown genetic instability in human lung cancer tissues. (cdc.gov)
Anaplastic carcinoma (also called giant and spindle cell cancer) is the most dangerous form of thyroid cancer. (medlineplus.gov)
Medullary carcinoma is a cancer of non-thyroid hormone-producing cells that are normally present in the thyroid gland. (medlineplus.gov)
A major epidemiological study on environmental tobacco smoke has been completed and revealed a significant dose-response relationship between passive smoking (at home or at the workplace) and lung cancer. (who.int)
For example, you have a cancer cell, and you want antibodies that can kill the cancer cell or activate a certain immune cell or so on, and then you develop the antibodies based on this. (lu.se)
CLL is considered the most common form of leukemia in adults and is a type of cancer that starts in white blood cells, known as lymphocytes. (lu.se)

The journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. (eurekalert.org)
LRRK2 acts like a brake on a garbage truck and if the brake is too strong it limits the ability of these scavenger cells to eliminate damaging material," said Shawn Ferguson, associate professor of cell biology and of neuroscience at Yale School of Medicine and senior author of the study. (medicalxpress.com)
Going forward, we can apply this framework to understand cell types involved in many different diseases," says study co-senior author Ferhat Ay, the Institute Leadership assistant professor of computational biology at LJI and an assistant adjunct professor at the UC San Diego School of Medicine. (ddw-online.com)

Using the largest multi-locus data set known to date, we investigated genetic differentiation of early modern humans, human admixture and migration events, and relationships among ancestries and language groups. (nature.com)
Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. (ca.gov)
In contrast to studies that have used VISA to track differentiation of self-renewing stem cell clones that amplify significantly over time, we focused on a population of progenitor clones with limited self-renewal capability. (ca.gov)

Here, we report clinical features and genetic alterations in patients with MNKPL. (confex.com)
DNA from non-transformed BALB/c-3T3 cells was used as a control to compare genetic alterations, if any, between non-transformed, transformed and tumor cell populations. (cdc.gov)

In 2018, the Vijayanand Laboratory published a seminal Cell study that revealed the impact of genetic variants in a set of human immune cells. (ddw-online.com)
This work gave Vijayanand's team a window into which genetic variants are important in which immune cells. (ddw-online.com)
Studies that incorporate sequencing are also revealing the role of rare variants with substantial effects in carriers (e.g. (cdc.gov)
Risk scores that integrate information on common and rare variants will produce more precise individual estimates of genetic risk than those based on either alone. (cdc.gov)

We then treated them with chemicals that are known to cause facial defects in human newborns, and tracked the trajectories of the bone-forming cells throughout embryonic stages," explained Kawanishi. (scitechdaily.com)
Sequencing and other techniques may reveal the actual genetic defects in these patients. (medscape.com)
An Epistatic MiniArray Profile (E-MAP) analysis was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. (thebiogrid.org)
A lot of neurological diseases, a lot of psychiatric diseases that we're suffering from are due to specific defects in particular types of cells," Koch says. (kalw.org)

These fluorescent images of live zebrafish embryos show the movement, assembly, and growth of cartilage-forming cells at 48, 72, and 96 hours post-fertilization. (scitechdaily.com)
Zebrafish embryos are transparent and grow outside the mother, so we can monitor the behavior of live cells as they develop," said Toru Kawanishi, project assistant professor at the University of Tokyo's Department of Biological Sciences at the time of the study. (scitechdaily.com)
In embryos, however, these cells seem to break apart instead. (livescience.com)
They took 75 human embryos that had been frozen at the single-cell phase and cultured them in Petri dishes for two days, taking a microscopic snapshot of each embryo every five minutes. (livescience.com)

Conclusions: Our clinically relevant and usable models reveal a key role for non-genetic factors in the evolution of chemotherapy resistance. (mysciencework.com)

This way, scientists are now closer to understand how the stem cells of planarians maintain the flexibility necessary to regenerate body parts without destroying themselves at the same time. (bionity.com)
December 27, 2022 -- National Eye Institute (NEI) scientists have produced viable eye tissue using patient stem cells and 3D bioprinting. (scienceboard.net)
The comparison was possible because of new technology that allows scientists to quickly identify which of the hundreds of types of brain cells are present in a particular bit of brain tissue. (kalw.org)

Although clonal studies of lineage potential have been extensively applied to organ specific stem and progenitor cells, much less is known about the clonal origins of lineages formed from the germ layers in early embryogenesis. (ca.gov)
The human brain contains a variety of progenitor cells that give rise to hundreds of cell types, which in turn form the myriad structures of the brain. (pewtrusts.org)

The best evidence supports 21 ancestries that delineate genetic structure of present-day human populations. (nature.com)
In a recent commentary , McCarthy and Birney argue that these studies can provide an evidentiary path to personalized medicine - but only if they are done in diverse populations, and integrate rare and common genetic risk factors with measurements of changing environments and health indices over time. (cdc.gov)
Just as with genetic risk, epidemiologic models based on narrowly selected populations (such as well-off, well-educated volunteers) may not translate accurately to other communities. (cdc.gov)

Persistent plasma cells accrue in bone marrow "at an approximately constant rate" of one cell per hour for several weeks after a single immunization with a model antigen. (scienceboard.net)
In the mouse model, the administration of a single vaccine dose triggered the production of around 40,000 persisting plasma cells in the bone marrow. (scienceboard.net)
SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)

Fresh human glioblastoma tumors obtained directly from neurosurgical resections were immediately dissociated and passaged in neural stem cell media to enrich the subpopulation of tumor cells with stem-like properties. (cns.org)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)

Cell Rep Med, Mar 15, 2022. (cdc.gov)

Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)

The mouse model expressed a fluorescent protein, TdTomato, in cells that produced antibodies against a specific vaccine. (scienceboard.net)
Disrupting this protein wouldn't require any hormonal interference, a key hurdle in male contraception since testosterone plays other roles beyond sperm production in men including building bone mass and muscle strength as well as red blood cell production. (sciencedaily.com)
Heat shock protein 60 enhances CD4CD25 regulatory T cell function via innate TLR2 signaling. (hum-molgen.org)

The majority of significantly over-represented GOBP however, evolved uniquely in either cisplatin- or carboplatin52 resistant cell lines resulting in diverse intraperitoneal behaviours that reflect different clinical manifestations of relapsed human HGSC. (mysciencework.com)
A) Airyscan live cell confocal micrographs showing lysosome labeling in human iPSC-derived macrophages following labeling with DQ-BSA and Alexa488-BSA. (medicalxpress.com)
The Evrony lab is developing single-cell technologies for constructing a "family tree" of human brain cells. (pewtrusts.org)
My lab will create and implement new single-cell genomics technologies spanning bioengineering, neuroscience, and human genetics to generate comprehensive maps of the human brain's cell lineages. (pewtrusts.org)
Astrocyte cells like these from the brain of a mouse may differ subtly from those in a human brain. (kalw.org)
They're expressed in both mouse and human, but they're not in the same types of cells," Lein says. (kalw.org)
In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
The phrase lives of a cell refers to the independent yet interrelated parts of a human cell including mitochondria, centrioles, and basal bodies that once led independent lives. (cdc.gov)
Our human lives do not depend just on the lives in our individual cells. (cdc.gov)

Genetic variations are important, but there's more to the puzzle. (ddw-online.com)

Of those, 45 were usable for genetic analysis . (livescience.com)

We profiled more than 1.2 million peripheral blood mononuclear cells (162 cases, 99 controls) with multiplexed single-cell RNA sequencing (mux-seq). (nih.gov)
Therefore, the goal of the current study was to use a new set of methods collectively termed single-cell omics to investigate specialized and rare cell types that play a central role in the biosynthesis of plant natural products, and whose signals are often obscured by more abundant cell types in plant organs. (analytica-world.com)
Analysis at the single-cell level can overcome most of these limitations. (frontiersin.org)
We generated a large single-cell RNA sequencing dataset from the terminal ileal biopsies of two independent cohorts comprising a total of 50 CD patients and 71 healthy controls. (medrxiv.org)
High-throughput single-cell transcriptomics on organoids. (mpg.de)
All 3 interpretations of lives of a cell the once independent lives of a single cell, the many lives of the earth, and the lives of a bacterial cell that travels throughout the earth strongly suggest a need for multidisciplinary and interdisciplinary collaborations, such as, One Health. (cdc.gov)

Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. (mpg.de)

Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. (eurekalert.org)

Cell polarization involving the Par-complex in situ is linked to various other processes. (elifesciences.org)
Because of such association between Par-dependent polarization and other processes, the Par-complex exhibits different behavioral characteristics in an individual context, making it difficult to determine general features of the dynamic process taking place during cell polarization by the Par-complex. (elifesciences.org)

Surface markers of distinct BTIC subpopulations were validated in fluorescence-activated cell sorting (FACS) and colony forming assays. (cns.org)

Knowledge of circulating immune cell types and states associated with SLE remains incomplete. (nih.gov)

This study received support from the National Institutes of Health and WSU's Functional Genomics Initiative, a multi-year university investment to support development of genetic technology research. (sciencedaily.com)
This is due to a paucity of functional annotation from sequence homology, which is compounded by low genetic tractability compared with many model organisms. (portlandpress.com)

The team focused on a specific genetic marker for a group of cells involved in craniofacial development in both mammals and fish. (scitechdaily.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)

The cells, which can persist for decades, produce high-affinity antibodies that provide durable protective immunity against pathogens. (scienceboard.net)
Timestamping showed when the cells were made, thereby revealing which were the persistent LLPCs that are central to long-lasting immunity after vaccination. (scienceboard.net)
CD8 + T cells play a critical role in immunity to viruses. (mdpi.com)
Is the Subject Area "Cell-mediated immunity" applicable to this article? (plos.org)
NK cells, a component of innate immunity, are variably affected. (medscape.com)

This zebrafish larva has been genetically modified so that the bone-forming cells in the face emit a green fluorescence. (scitechdaily.com)
The database has genetically sequenced more than 50 felines and includes DNA from cats with and without known genetic health problems. (sciencedaily.com)
By watching the timing of the cells' development, doctors could determine which cells are genetically healthy, and which have abnormal numbers of chromosomes, finds the study published today (Dec. 4) in the journal Nature Communications. (livescience.com)
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. (lu.se)

We used Drosophila Schneider cells (S2 cells) of mesodermal origin, as host cells for cell-autonomous reconstruction of cell polarity ( Schneider, 1972 ). (elifesciences.org)

Here we have investigated the potential for genetic instability in silica- and cadmium chloride (CdCl2)-transformed BALB/c-3T3 cell lines. (cdc.gov)

PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

Brain tumor-initiating cells (BTICs), self-renewing multi-potent cells critical for tumor maintenance and growth, are attractive targets of glioblastoma therapy. (cns.org)
Recent findings have revealed new targets for treatment that could lead to more efficient therapies. (medscape.com)

CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages. (mpg.de)
Defective migration of monocyte-derived dendritic cells in LAD-1 immunodeficiency. (lu.se)

Nowakowsky is especially intrigued by the finding that cells called microglia have a slightly different genetic signature in mice and people. (kalw.org)

Continued collaboration with geneticists and veterinarians could lead to the rapid discovery of undiagnosed genetic conditions in cats. (sciencedaily.com)
Two experts in the use of genetic testing call for primary-care physicians and oncologists to work with medical geneticists and genetic counsellors, to identify the best clinical course of action. (hum-molgen.org)
Participants included geneticists, obstetricians, pediatricians, epidemiologists, teratologists, dysmorphologists, and genetic counselors who had a particular interest in CVS studies or who represented professional organizations and government agencies. (cdc.gov)

For example, CVS is generally done earlier in pregnancy than amniocentesis and is particularly advantageous for detecting certain genetic conditions. (cdc.gov)

In the present study, sequences of 40 CD8 + T cell epitope candidates, including previously and newly identified, obtained from Jeryl-Lynn mumps vaccine strains were compared with genomes from 462 circulating MuV strains. (mdpi.com)
Whereas a morphological study showed four Bossiella species in the eastern Pacific Ocean, this genetic screening revealed 17 species groups. (phys.org)
With genetic data and further morphological study, these groups could be identified, described, and named, or assigned to existing species. (phys.org)
Because these algae have made adjustments to their environments and followed individual but similar lines of development, genetic study is particularly useful in uncovering pseudocryptic species . (phys.org)
Given the large number of species revealed, this study narrowed its focus to species with predominantly dichotomous branching, which encompasses the known morphospecies B. californica and B. orbigniana. (phys.org)
Evidence supporting the potential ability to regulate Notch-mediated Wnt signaling by targeting the NOTCH3-FZD7signaling network is presented in the study published in Stem Cells and Development , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers . (eurekalert.org)
Thus, this reconstruction system provides an experimental paradigm to study features of the assembly process and structure of Par-dependent cell-autonomous polarity. (elifesciences.org)
Nobody has done this mapping, either technically or analytically, to this precision in immune cells," says LJI Associate Professor Pandurangan Vijayanand, co-senior author of the new study. (ddw-online.com)
The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL. (lu.se)

Although the cells produced abundant p53, it didn't get transported to the nucleus where it does its work. (newscientist.com)
Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)

This may reveal a lump in the thyroid or swollen lymph nodes in the neck. (medlineplus.gov)

Anatomy22

Organisms17

Diseases1

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes112

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

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Mutations15

Genes23

Mutation9

Characterization4

Epithelial cells3

Analyses2

Researchers17

Genomic5

Quantitative4

Heterogeneity6

Myeloid3

Proteins3

Pathway4

Molecular10

Insights1

Proliferation5

Sickle Cell Di1

Cellular4

Whole genome2

Differences8

Genome4

Gene11

Pluripotent stem1

Cancer15

Biology3

Differentiation3

Alterations2

Variants4

Defects4

Embryos4

Clinically1

Scientists3

Progenitor cells2

Populations3

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20221

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Human9

Variations1

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Study9

Abundant2

Lymph nodes1