Retroviral sarcoma viruses murine. Medical search. Frequent questions

Example species are the murine leukemia virus and the feline leukemia virus. (wikipedia.org)
A few examples of the virus are Moloney murine leukemia virus, xenotropic MuLB-related virus, feline leukemia virus, and feline sarcoma virus. (wikipedia.org)
One specific gammaretrovirus that is commonly used as a retroviral vector is the Moloney murine leukemia virus. (wikipedia.org)
A specific gammaretrovirus called xenotropic murine leukemia virus-related virus (XMRV) has been found to infect prostate cancer tissue in laboratories. (wikipedia.org)
There were over 50 human cancer cell lines that were claimed to be linked to murine leukemia virus-related virus or murine leukemia virus. (wikipedia.org)
[19] Benchaibi M, Mallet F, Thoraval P, Savatier P, Xiao JH, Verdier G, Samarut J, Nigon V. Avian retroviral vectors derived from avian defective leukemia virus: role of the translational context of the inserted gene on efficiency of the vectors. (org.ua)
HTBS recruits HIV reverse transcriptase, which nucleates DNA synthesis and is aided in elongation by murine leukemia reverse transcriptase. (nature.com)
Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. (biomedcentral.com)
Among the ETS family members, Friend leukemia virus integration 1 ( FLI1 ) was first identified as a proto-oncogene activated by proviral integration in F-MuLV-induced erythroleukemias [ 4 ]. (biomedcentral.com)
HTLV-linked leukemia, Kaposi's sarcoma) and neurodegenerative diseases as well as traumatic brain injury and ophthalmologic injury. (usc.edu)
It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS. (childrensmercy.org)
The Abelson non receptor tyrosine kinase gene was initial recognized as the mammalian homolog from the oncogenic gene products from the Abelson murine leukemia virus. (pkc-inhibitors.com)
When bovine leukemia virus (BLV), a causative agent of B-cellleukemia and lymphoma of cows, is injected into sheep, lymphoid leukemia and lymphoma, including a cutaneous form, occur which to our knowledge have not been subclassified (Olson 1979). (science-connections.com)

Gammaretroviruses are very popular retroviral vectors in laboratory studies. (wikipedia.org)
[11] Prasolov VS. [Retroviral vectors--an effective system for transfer and expression of foreign genes in mammalian cells]. (org.ua)
Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected]. (org.ua)
Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo. (org.ua)
Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: potential as stable genetic markers. (org.ua)
[18] Cosset FL, Legras C, Thomas JL, Molina RM, Chebloune Y, Faure C, Nigon VM, Verdier G. Improvement of avian leukosis virus (ALV)-based retrovirus vectors by using different cis-acting sequences from ALVs. (org.ua)
Elucidating these mechanisms and identifying which cellular factors are exploited by the retroviruses and which hinder their life cycle, will certainly lead to the discovery of new ways to inhibit viral replication and to improve retroviral vectors for gene transfer. (biomedcentral.com)
Fully elucidating the early steps of retrovirus replication is therefore crucial not only for identifying new antiretroviral drugs, but also for improving the design of retroviral vectors for gene therapy. (biomedcentral.com)
Adenoviral vectors were constructed encoding one or both subunits of murine IL-12 (Ad.p35, Ad.p40 and Ad.IL-12) or cytosine deaminase (Ad.CD). (biomedcentral.com)
Although virus-based gene therapy is a promising strategy to combat advanced prostate cancer, its current effectiveness is limited partially due to inefficient cellular transduction by therapeutic viral vectors in vivo . (hindawi.com)

Structure of the retroviral genome. (org.ua)
Retroviral particles must bind specifically to their target cells, cross the plasma membrane, reverse-transcribe their RNA genome, while uncoating the cores, find their way to the nuclear membrane and penetrate into the nucleus to finally dock and integrate into the cellular genome. (biomedcentral.com)
The life cycle of retroviruses is arbitrarily divided into two distinct phases: the early phase refers to the steps of infection from cell binding to the integration of the viral cDNA into the cell genome, whereas the late phase begins with the expression of viral genes and continues through to the release and maturation of progeny virions (see Figure 1 for a schematic view of the retroviral life cycle). (biomedcentral.com)

Zhang P, Samuel G, Crow J, Godwin AK, Zeng Y. Molecular assessment of circulating exosomes toward liquid biopsy diagnosis of Ewing sarcoma family of tumors. (childrensmercy.org)
Dr. Beutler has identified several natural products which have potential for development as cancer drugs, among them, englerins, which are in preclinical development for kidney cancer and Ewing's sarcoma, schweinfurthins, which are preclinical candidates in glioblastoma and malignant peripheral nerve sheath tumors, and salicylihalamides, of interest in sarcomas. (cancer.gov)

Tanaka K, Iwakuma T, Harimaya K, Sato H, Iwamoto Y. EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells. (childrensmercy.org)

DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. (lookformedical.com)

An amphipathic alpha-helical synthetic peptide analogue of melittin inhibits herpes simplex virus-1 (HSV-1)-induced cell fusion and virus spread. (microbiologyresearch.org)

Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). (lookformedical.com)

During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. (biomedcentral.com)
However, while the late stages of the retrovirus life cycle, consisting of virus replication and egress, have been partly unraveled, the early steps remain largely enigmatic. (biomedcentral.com)
A schematic view of early and late stages of the retroviral replication cycle is represented. (biomedcentral.com)
In this report, the effects are assessed of two well-characterized antimicrobial amphipathic peptides (melittin and cecropin) on human immunodeficiency virus 1 (HIV-1) replication and gene expression in acutely infected cells at subtoxic concentrations. (microbiologyresearch.org)
Because the APOBEC and IFITM proteins restrict the replication of a number of viruses in addition to HIV, this work has broad implications for the understanding of host-pathogen interactions. (cancer.gov)
In 2017, Dr. Compton joined the HIV Dynamics and Replication Program as Head of the Antiviral Immunity and Resistance Section to develop a research program focused on mechanisms of protection mediated by the cell-intrinsic innate immune response, as well as the strategies employed by HIV and emerging viruses to evade or overcome these immune barriers. (cancer.gov)
To overcome this obstacle, conditional oncolytic viruses (such as conditional replication adenovirus (CRAD)) are developed to specifically target prostate without (or with minimal) systemic toxicity due to viral self-replication. (hindawi.com)
Replication-competent viruses, also known as oncolytic viruses, replicate within transduced cells and force these cells into a lytic cycle. (hindawi.com)
Therefore, strategies to use conditional oncolytic virus, or the so-called attenuated replication-competent viruses, to specifically target prostate tissue have been developed [ 2 - 4 ]. (hindawi.com)

[3] Aronoff R, Linial M. Specificity of retroviral RNA packaging. (org.ua)

Since several animal RNA tumor viruses (Klein 1980) and cells of the putative human retroviruses isolated to date (Bronson et al. (science-connections.com)

They cause various sarcomas, leukemias and immune deficiencies in mammals, reptiles and birds. (wikipedia.org)

1975). Although the Epstein-Barr virus (EBV), a DNA virus of the herpes group, is implicated in some aspect of Burkitt's lymphoma, a B-cell disease (De- The 1980), the etiology of all the T -cell neoplasias is, as of yet, obscure. (science-connections.com)

Close transposon relatives and other recombination enzymes, including retroviral integrases, have served as useful models to infer functional information relevant to SB. (encyclopedia.pub)

In 2016, 2018, and 2020, we organized international virology conferences, held in Basel, Switzerland (2016) and Barcelona, Spain (2018 and 2020), and we are currently planning the Viruses 2022 conference, to be held virtually. (mdpi.com)

[6] Katz RA, Terry RW, Skalka AM. A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging. (org.ua)
Identification of a sequence likely to be required for avian retroviral packaging. (org.ua)

[4] Aronoff R, Hajjar AM, Linial ML. Avian retroviral RNA encapsidation: reexamination of functional 5' RNA sequences and the role of nucleocapsid Cys-His motifs. (org.ua)

HIV LTR activity was also reduced in human cells stably transfected with retroviral expression plasmids for the melittin or cecropin gene. (microbiologyresearch.org)
Thus, E1 protein expression will be confined strictly to the prostate tissues and render this a conditional oncolytic virus (CRAD) within the prostate. (hindawi.com)

The molecular biology of RNA tumor virus. (org.ua)

The nucleocapsid is a nucleic acid protein assembly within the virus particle, it is a substructure of the virion. (wikipedia.org)
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. (lookformedical.com)
Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
A number of PSPs have been defined over the years that include, but not limited to, promoters of prostate-specific antigen (PSA), probasin (PB), mouse mammary tumor virus (MMTV LTR), prostate-specific membrane antigen (PSMA), human glandular kallikrein 2 (hK2), and prostatic steroid-binding protein C3. (hindawi.com)

Bats can have a prolonged exposure to a variety of pathogens without showing any warning signs, which leads to the debated belief that bats have the ability to develop immunity to viruses that may harm other species. (wikipedia.org)
When a virus meets a new species for the first time it will burn through the immunologically- naive animals mercilessly, until a period of coevolution takes place in which resistance alleles spread in the host populations and the fiercest strains of virus lose out to strains which keep the host alive long enough to spread more widely. (balloon-juice.com)

[7] Knight JB, Si ZH, Stoltzfus CM. A base-paired structure in the avian sarcoma virus 5' leader is required for efficient encapsidation of RNA. (org.ua)

The avian reticuloendotheliosis viruses are not strictly avian viruses-it appears that reticuloendotheliosis viruses are mammalian viruses that were accidentally introduced into birds in the 1930s during research on malaria. (wikipedia.org)

Transgenic mice bearing PB promoter fused to simian virus 40 large tumor antigen gene all consistently develop prostate adenocarcinoma [ 13 ]. (hindawi.com)

Human Immunodeficiency Virus Type-1 (HIV-1) belongs to the retroviridae family and to the Lentivirus genus. (openaccesspub.org)

A novel retrovirus, human T -celllymphomaleukemia virus (HTLV), has been isolated from the fresh and cultured cells of two of these patients. (science-connections.com)
Subsequent characterization of this virus has shown that it is not significantly related to any known animal retrovirus, is not an endogenous (genetically transmitted) virus of man, and so far has been associated only with fresh or cultured T -cells from patients with T -cell neoplasia. (science-connections.com)

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
Less well appreciated is the fact that the PD-1/PD-L1 axis also regulates antiviral immune responses and is therefore modulated by a number of viruses. (frontiersin.org)

While it was unclear what role these viruses have in the cancer development, it was believed that they are most prevalent during the tumor developing stage of the cancer by inhibiting tumor suppressing genes. (wikipedia.org)

The simple reason for this is that the virus has burned its way through chimpanzee populations for thousands of years, a long enough time for the virions which do not kill their host, at least not quickly, to outcompete the most lethal strains. (balloon-juice.com)

Nude mice were subcutaneously or intramuscularly implanted with luciferase-expressing murine 1029H or human KRIB osteosarcoma cells. (biomedcentral.com)

As well as solving the mystery of the origin of the virus, the findings prepare the way for future work exploring the history and behaviour of the simian form of HIV in its natural host. (balloon-juice.com)

Retroviral proteins, often glycosylated, coded by the envelope (env) gene. (lookformedical.com)
The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. (lookformedical.com)
Proteins coded by the retroviral gag gene. (lookformedical.com)
Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)

Finally, the molecular mechanisms of integration, the last event of the early phase of retroviral life cycle, are now well understood, but the choice of target site remains mysterious. (biomedcentral.com)

The surge in Human Immunodeficiency Virus (HIV) research in order to identify new therapeutic targets has led to a better understanding of the retroviral life cycle. (biomedcentral.com)
In this study, we sought to improve bioavailability of Rapa with subcutaneous (SC) administration and to test its therapeutic feasibility and practicality in a murine model of Sjögren's syndrome (SS), a systemic autoimmune disease with no approved therapies. (usc.edu)

Upregulation of PD-1 and its ligands PD-L1 and PD-L2 is observed during acute virus infection and after infection with persistent viruses including important human pathogens such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV). (frontiersin.org)

Released virus is then able to infect neighboring cells until all susceptible cells are eliminated. (hindawi.com)

This immunopeptidomics-based pipeline was carefully validated in a murine colon tumor model CT26. (elifesciences.org)

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)
Analysis of the effect of melittin on cell-associated virus production revealed decreased levels of Gag antigen and HIV-1 mRNAs. (microbiologyresearch.org)

Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. (microbiologyresearch.org)
Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor. (dukecancerinstitute.org)
Previous work revealed that cells from murine osteosarcomas were efficiently sensitized by physiologically achievable concentrations of some Smac mimetics (including GDC-0152 and LCL161) to killing by the inflammatory cytokine TNFα in vitro, but survived exposure to Smac mimetics as sole agents. (biomedcentral.com)

SIVcpz does not cause an Aids-like illness among chimpanzees, despite its similarity to the human virus and the very close genetic relationship between chimps and humans. (balloon-juice.com)

There have also been claimed discoveries of murine gammaretroviruses in lung cancer cell lines. (wikipedia.org)
Production of infectious, cell-free virus was inhibited in a dose-dependent manner, with ID 50 values in the range 0·9-1·5 μM for melittin and 2-3 μM for cecropin. (microbiologyresearch.org)

Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis. (childrensmercy.org)

XMRV is a recombinant virus created in a laboratory accident in the mid-1990s. (wikipedia.org)
Some conspiracy theorists have suggested that the virus was created in a bioweapons laboratory. (balloon-juice.com)

Anatomy20

Organisms86

Diseases29

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes58

Information Science4

Health Care1

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Vectors10

Genome3

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Inhibits1

Acquired Immunode1

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Retroviruses1

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Virology1

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