Loading...
  • endogenous retroelements
  • The present study demonstrates that KRAB/TRIM28-mediated regulation is responsible for controlling a very broad range of human-specific endogenous retroelements (EREs) in human embryonic stem (ES) cells and that it exerts, as a consequence, a marked effect on the transcriptional dynamics of these cells. (epfl.ch)
  • evolution
  • Although these retroelements are formidable motors of evolution, they can occasionally cause disease, and accordingly are inactivated during early embryogenesis through epigenetic mechanisms. (epfl.ch)
  • genetic
  • In particular, retroelements, transported by an intracellular copy-and-paste process involving an RNA intermediate, constitute a majority of these mobile genetic elements. (frontiersin.org)
  • As expected, cellular machineries of vertebrate's intrinsic immune system have evolved to support a balance between retroelement insertions that confer beneficial genetic diversity and those that cause deleterious gene disruptions. (frontiersin.org)
  • The finding indicated also that the jumping gene in the hybrid had probably been reconstructed (and reactivated) by the genetic combination of two incomplete, inactive segments of a retroelement present in one or both of the parents. (creation.com)
  • mechanism
  • We also show that nonhomologous end-joining (NHEJ), a mechanism of DNA repair found in all extant eukaryotes, but only some bacteria, significantly enhances the efficiency of retrotransposition and the effects of retroelements on the host. (pnas.org)
  • Evidence that this mechanism defines a new family of retroelements is presented. (pubmedcentralcanada.ca)
  • Based on the rapid jumping of retroelements in hybrid wallabies 6 and fruit flies, 2 on their ability to cause DNA rearrangements, and on their role in gene regulation, 1 it is plausible that these TEs were active in the past, and were an original mechanism for expressing God's programmed variation within kinds. (creation.com)
  • suggests
  • Phylogenetic evidence suggests that a factor in the emergence of the ancestral eukaryotic cell may have been selection pressure resulting from invasion and proliferation of retroelements. (pnas.org)
  • host
  • Here we experimentally determine the effects of a retroelement invasion on genetically simple host organisms, and we demonstrate theoretically that the observed effects are sufficient to explain their observed rarity in bacteria. (pnas.org)
  • found
  • Retroelements have been found in the chromosomes of eukaryotes (which unlike bacteria, have cells with a defined nucleus) such as yeast (the simplest eukaryote), fruit flies, and in vertebrates such as mice and man. (creation.com)
  • The researchers found that the retroelements in the DNA of the hybrid were indeed unmethylated. (creation.com)
  • ability
  • The researchers suggested that the ability of retroelements to produce genomic rearrangements in hybrid wallabies, due to deficient methylation (eventually resulting in the formation of new species) may be a widespread phenomenon in hybrid mammals. (creation.com)