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  • infection
  • Only after about 80% of the body's own insulin production has ceased, will the condition become apparent in one third to one half of all patients - with the typical symptoms of fatigue, lack of energy, loss of weight, leg cramps, itching, increased thirst, frequent urination and susceptibility to infection. (getwellnow.co.za)
  • associated toxins from the tooth and root surfaces, is important to consider when evaluating the Prevention and control of oral infection and response of poorly controlled diabetic patients inflammation, i.e. , periodontal disease, is essential accumulation that is common on rough surfaces. (diseasepdf.com)
  • This increased susceptibility to infection may be related in part to impaired chemotactic, phagocytic, and antimicrobial activity associated with decreased neutrophil function. (behealthy2016.com)
  • macro
  • Using a combination of cellular, molecular and physiological approaches we characterized the mechanisms involved in the regulation of pterin metabolism and the consequences on endothelial NO and ROS signaling as it pertains to the pathogenesis of diabetic macro- and micro-angiopathies. (ufl.edu)
  • diseases
  • This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. (abnova.com)
  • patients
  • increasing levels of pro-inflammatory mediators Poor glycemic control in diabetic patients has several responsible for the degradation of connective tissues repercussions, including some on oral health. (diseasepdf.com)
  • affect
  • These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. (abnova.com)
  • support
  • In support, our results indicate that in the diabetic state, tetrahydrobiopterin salvage enzymes are impaired leading to the accumulation of pterin oxidation products and subsequent eNOS uncoupling. (ufl.edu)