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  • inhibition
  • We conclude that receptor expression is necessary for inhibition of thyroid carcinoma growth with ligand treatment but may not be sufficient for response. (aacrjournals.org)
  • We provide evidence that RARE-dependent transcription and local homeostatic control of retinoids is required for the maintenance of a population of functional neurons with established projections and that inhibition of retinoid signaling results in postnatal and adult neurodegeneration. (jneurosci.org)
  • known as retinoic
  • When seen in association with the use of tretinoin, this syndrome is also known as retinoic acid-acute promyelocytic leukemia (RA-APL) syndrome (see Adverse Reactions for more detailed description of RA-APL syndrome). (pdr.net)
  • amino
  • Ryan, M.D., King, A.M. and Thomas, G.P. (1991) Cleavage of Foot-and-Mouth Disease Virus Polyprotein Is Mediated by Residues Located within a 19 Amino Acid Sequence. (scirp.org)
  • The PELP1 protein encodes a protein of 1130 amino acids, and exhibits both cytoplasmic and nuclear localization depending on the tissue. (wikipedia.org)
  • In humans, NEDD9 is 834 amino acids long. (wikipedia.org)
  • The predicted 824-amino acid human NPAS2 protein shares 87% sequence identity with mouse Npas2. (wikipedia.org)
  • CERK is a 537 amino acid enzyme in humans (531 in mice). (wikipedia.org)
  • Binding of calmodulin occurs between amino acids 420 and 437 in CERK at a putative 1-8-14B calmodulin binding motif. (wikipedia.org)
  • molecule
  • We employed CABS-a reduced model of protein dynamics to model folding pathways of binding 9-cis retinoic acid to apo-RXR molecule and TRAP220 peptide fragment to the holo form. (edu.pl)
  • During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. (wikipedia.org)
  • Retinoic acid is a morphogen signaling molecule, which means it is concentration dependent. (wikipedia.org)
  • metabolism
  • Livers from aryl hydrocarbon receptor-null mice showed a 3-fold increase in retinoids and a 65% decrease in retinoic acid metabolism. (ucl.ac.uk)
  • Collectively, the results provide evidence for a role of locally regulated retinoid metabolism in neuroprotection and in determining population size of neurons at a late stage of neural circuit formation. (jneurosci.org)
  • Retinoic acid is responsible for most of the activity of vitamin A, save visual pigment effects that require retinal (retinaldehyde), and cell metabolism effects that may require retinol itself. (wikipedia.org)
  • Vitamin A is fat-soluble and high levels have been reported affect metabolism of the other fat-soluble vitamins D, E, and K. The toxic effects of vitamin A might be related to altered vitamin D metabolism, concurrent ingestion of substantial amounts of vitamin D, or binding of vitamin A to receptor heterodimers. (wikipedia.org)