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  • genes
  • The receptors bind to a retinoic acid response element (RARE), consisting of two 5′-AGGTCA-3′ direct repeats of the consensus half-site sequence 5′-AGGTCA-3′, in the promoter region of the target genes to initiate their transcription. (biomedcentral.com)
  • gene expression
  • LAMC1 gene expression is responsive to a multitude of extracellular signals , including glucose (14), IGF (14), IL-1β, TGF -β, phorbol esters (11) and retinoic acid (10). (dict.md)
  • 1990
  • Dmitrovsky E, Moy D, Miller WH Jr, Li A, Masui H (1990) Retinoic acid causes a decline in TGF-a expression, cloning efficiency, and tumorigenicity in a human embryonal cancer cell line. (springer.com)
  • roles
  • Currently, researchers have focused much attention on the roles of retinoic acid binding proteins and cellular retinol binding proteins (CRABPs and CRBPs) in carcinogenesis. (beds.ac.uk)
  • absence
  • Furthermore, β-catenin signaling is sufficient to induce neurogenesis in high-density cultures even in the absence of retinoic acid (RA), although RA potentiates the effects of β-catenin. (biologists.org)
  • transcription
  • Of major interest was that even under the influence of retinoic acid, a known caudalization factor, the NT2N population maintained a rostral phenotype subpopulation which expressed cortical regional transcription factors. (jove.com)
  • treatment
  • Its hallmark success has been the treatment of acute promyelocytic leukaemia (APL), a condition that is now highly curable by the combination of retinoic acid (RA) and arsenic. (nature.com)
  • least
  • 5. A method for treating at least one of erythema, irritation, reddening, swelling, edema, and/or desquamation attributable to UV radiation consisting essentially of applying an effective amount of a pharmaceutical composition consisting essentially of at least one inhibitor of retinoic acid. (google.com)