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  • cells
  • Two additional RB positive primary tumors have major foci in which all tumor cells showed no RB protein staining. (aacrjournals.org)
  • Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cy. (nih.gov)
  • We observed that the loss of Rb protein does not have a major impact on microspore division but causes limited hyperproliferation of the vegetative cell and, to a lesser degree, of the sperm cells. (le.ac.uk)
  • Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses , bind and inactivate pRb, this can lead to cancer. (ipfs.io)
  • This explains why sufferers of sporadic retinoblastoma are not at increased risk of cancers later in life, as both alleles are functional in all their other cells. (ipfs.io)
  • We show that its pocket C domain is both necessary and sufficient for nuclear anchorage by transiently expressing green fluorescent protein (GFP) chimeras of Rb fragments in tissue culture cells and by extracting the cells with hypotonic solutions. (dur.ac.uk)
  • We immunolocalized Rb protein in human cells during the cell cycle. (ox.ac.uk)
  • An ablation of retinoblastoma protein in mouse Sertoli cells resulted in their cell cycle re-entry in adult testes, dedifferentiation and a severe spermatogenic defect. (utupub.fi)
  • Assessment of RB1 protein loss in tumor cells. (nih.gov)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • loss of Rb protein
  • However, the primary developmental impact of the loss of Rb protein has remained unclear. (le.ac.uk)
  • Our results indicate that hyperproliferation caused by the loss of Rb protein prevents or delays cell determination during plant male gametogenesis, providing further evidence for a direct link between fate determination and cell proliferation. (le.ac.uk)
  • By IHC, 4 tumors (11.8%) had complete loss of RB protein expression, including 2 with homozygous deletion of RB1 by FISH and 1 with hemizygous deletion of RB1 by FISH combined with a novel nonsense mutation in RB1. (nih.gov)
  • Expression
  • Retinoblastoma (RB) protein expression was examined in paraffin and frozen tissue sections of 36 primary non-small cell lung carcinomas (NSCLC) using immunohistochemistry with confirmation by direct Western blotting. (aacrjournals.org)
  • Retinoblastoma protein function and p16(INK4a) expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16(INK4a) expression and infiltrative behavior. (lu.se)
  • Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer. (semanticscholar.org)
  • Retinoblastoma protein expression predicts response to bacillus Calmette-Guérin immunotherapy in patients with T1G3 bladder cancer. (semanticscholar.org)
  • Representative images of tumors analyzed for RB1 copy number by FISH (red) and for RB1 protein expression by IHC (brown). (nih.gov)
  • histone
  • The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin , reducing transcription of S phase promoting factors, further suppressing DNA synthesis . (ipfs.io)
  • cell
  • The transcription activating complexes of E2 promoter-binding-protein-dimerization partners (E2F-DP) can push a cell into S phase. (ipfs.io)
  • Sequence
  • Bioinformatic analysis was carried out to investigate the basis for differential targeting by these two proteins, and Rbf2-specific promoters were found to have distinct sequence motifs, suggesting unique targeting mechanisms. (sdbonline.org)
  • phase
  • These results suggest that hyperphosphorylated Rb protein is imported into nucleoli late in S or G2 phase with nucleophosmin/B23. (ox.ac.uk)