aaaaxxxRetinoblastoma like protein p130. Medical search. FAQ
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  • substrate
  • The 19S regulator contains ATPases and other proteins and serves numerous functions, including the recognition of the substrate and its translocation to the catalytic core ( 5 ). (pnas.org)
  • The single E1 ubiquitin-activating enzyme primes ubiquitin monomers, allowing their covalent attachment to substrate proteins. (pnas.org)
  • These are the scaffold protein Cul1, the RING-domain protein Rbx1/Roc1, the adaptor protein Skp1, and an F box protein that specifically recognises the substrate. (eu.org)
  • This protein has a substrate domain with up to 15 tyrosines that are potential kinase substrates, able to serve as docking sites for proteins with SH2 or PTB domains. (nih.gov)
  • intracellular
  • Intracellular and extracellular stress signals can lead to induction of central signalling proteins which generate different downstream effects. (hindawi.com)
  • Most intracellular protein degradation is handled by the ubiquitin-proteasome pathway ( 3 , 4 ). (pnas.org)
  • A number of effector molecules have been shown to interact with Cas and play a role in its function, including c-crk and v-crk, two adaptor proteins involved in intracellular signaling. (nih.gov)
  • inhibitors
  • Interestingly, in quiescent cells the restriction point is identical to the G 1 arrest point induced by other conditions, including protein synthesis inhibitors and amino acid deprivation ( 29 ). (asm.org)
  • Receptors
  • Upon binding to their receptors, peptide growth factors initiate a cascade of signaling events which leads to the activation of cellular Ras, which in turn functions as a molecular switch to transmit mitogenic signals to a cascade of cytoplasmic kinases ( 35 ), ultimately resulting in the activation of mitogen-activated protein kinases (MAPKs) ( 20 ). (asm.org)
  • mutations
  • Although Rb has diverse tumour-suppressor functions and is inactivated in many cancers, germline RB1 mutations predispose to retinoblastoma far more strongly than to other malignancies. (nih.gov)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • target proteins
  • The role of polyubiquitination in degradation mediated by the proteasome seems to be 2-fold: target proteins to proteasomes and assist in their unfolding. (pnas.org)
  • Two YopH target proteins were p130Cas and ADAP, of which the latter interestingly is an adapter protein specifically expressed in hematopoietic cells. (diva-portal.org)
  • Peptides
  • The openings to this cavity permit only denatured proteins to enter, where they are processively cleaved to small peptides. (pnas.org)
  • cdks
  • Different cyclins are present in different phases of the cell cycle and they will periodically activate CDKs which will induce downstream processing by phosphorylating other proteins. (biotecharticles.com)
  • degradation
  • It functions to direct their degradation in the absence of other viral proteins. (pnas.org)
  • Several diseases, including certain types of cancers and neurological disorders, can result from aberrant protein degradation. (pnas.org)
  • The majority of proteins degraded by the proteasome are tagged with polyubiquitin, which serves as a signal for their degradation ( 3 ). (pnas.org)
  • The actual degradation step requires that ubiquitinated proteins first be denatured and deubiquitinated, to allow them to fit into the narrow channel of the core particle. (pnas.org)
  • Therefore, if a protein can be delivered to the proteasome in a denatured or partially unfolded state, ubiquitination should not be required for its degradation. (pnas.org)
  • This type of degradation seems to be much less common than the proteasomal degradation of ubiquitinated proteins ( 20 ). (pnas.org)
  • transcription
  • Transactivation is achieved by interactions with components of the general transcription factor TFIID like the TATA box binding protein (TBP) [ 9 , 10 ] and TAFII31 [ 11 ]. (hindawi.com)
  • viral
  • The geminiviral replication initiator protein Rep is the only essential viral factor required for replication. (deepdyve.com)
  • This review provides a holistic view of the research related to the viral Rep protein and various host factors involved in geminiviral DNA replication. (deepdyve.com)
  • adaptor
  • The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation. (nih.gov)
  • proteasomal
  • The role of ubiquitylation in regulating cell state by targeting proteins for proteasomal destruction is a major field of research. (eu.org)
  • downstream
  • Here we show that SFN enhances the RB-E2F-1 interaction in MDAH-2774 ovarian cancer cell line linking for the first time the upstream AKT inhibition to the downstream blocking of cell cycle by activating RB protein. (biomedcentral.com)
  • human
  • Rb suppresses human cone-precursor-derived retinoblastoma tumours. (nih.gov)
  • Moreover, Rb-depleted cone precursors formed tumours in orthotopic xenografts with histological features and protein expression typical of human retinoblastoma. (nih.gov)
  • Several F box proteins (FBPs), including Cdc4 and Grr1 in yeast, COI1 in plants and betaTrCP, Skp2 and Fbw7 (Fbxw7, hCdc4) in human, recognise phosphorylated degrons in their substrates. (eu.org)
  • substrates
  • The Skp2 F box protein recognises substrates via its leucine-rich repeats (LRRs). (eu.org)
  • F box proteins often contain WD40 beta propeller or leucine-rich repeat (LRR) modules, which interact with one or more short sequences, termed degrons, in their target substrates. (eu.org)
  • activation
  • Here we report the identification and characterization of a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. (asm.org)
  • vivo
  • The overarching goal of our research is to better define the mechanisms by which the p53 protein promotes different responses in different settings, ranging from tumor suppression to responses to chemotherapeutics, using the mouse as an in vivo model system, with the ultimate goal of gaining insight that may facilitate clinical advances in diagnosis, prognostication and therapy. (stanford.edu)
  • tyrosine
  • This region of the almost ubiquitously expressed β1-integrin, β1A, contains two protein tyrosine motifs (NPXYs) interspaced with a threonine-rich region, while this region of the β1B splice variant is completely different and lacks known motifs. (diva-portal.org)