• Pocket proteins Rb, p107 and p130 play central roles in cell cycle progression and differentiation. (eu.org)
  • The LxDLFD motif ( LIG_RB_pABgroove_1 ) mediates binding to a highly conserved deep groove formed in the interface between the A and B subdomains of the Rb, p107 and p130 pocket domains. (eu.org)
  • Furthermore, using chromatin immunoprecipitation assays, we show that E2F1 and the pocket protein family members p107 and p130 bind to the AR promoter in vivo. (johnshopkins.edu)
  • Nuclear Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • Below are the most recent publications written about "Nuclear Proteins" by people in Profiles over the past ten years. (uams.edu)
  • Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. (wikipedia.org)
  • Pro-proliferative focus on genes cyclinD1 (CCND1) and E2F1 aswell as anti-proliferative goals CDKN1A (p21) PTEN RB1 RBL1 (p107) RBL2 (p130) had been proven as common goals for miR-17 -20 and -106b. (techblessing.com)
  • Ideas reveal that p53 transactivates the Retinoblastoma-like Two (Rbl2) gene to generate p130 throughout murine, although not individual, tissues. (vdacsignaling.com)
  • Furthermore, our work has shown that epigenetic mechanisms controlled by pRb2/p130, as well as epigenetic events affecting Rb2/130 gene expression itself, play an important role in retinoblastoma and lung cancer formation and progression, and can represent key events in the differentiation of cornea and conjunctiva normal cells. (shro.org)
  • pRb family proteins (in particular pRb2/p130) and regulation of estrogen receptors (alpha and beta) gene expression by chromatin remodeling in breast cancer. (shro.org)
  • The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes & Development. (wikipedia.org)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • Additionally, hpl-2 mutant animals also exhibited upregulation of autophagic genes, suggesting that SynMuv/DRM proteins participate in this process. (ehu.eus)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • The variety of keratin genes differentially expressed suggests that these proteins may however have additional functions. (exposed-skin-care.net)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
  • Activation of E2F transcription factors, through disruption of the retinoblastoma (Rb) tumor-suppressor gene, is a key event in the development of many human cancers. (johnshopkins.edu)
  • Many strikingly miR-17 -20 and -106b had been found to market cell proliferation by raising the intracellular activity of E2F transcription elements even though miR-17 -20 and -106b straight focus on the transcripts that encode because of this proteins family members. (techblessing.com)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
  • It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. (bvsalud.org)
  • Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. (ucdenver.edu)
  • Using different approaches we also found that the molecular system where these keratins modulate cell development appears to be associated with pRb as well as the molecular equipment controlling cell routine development during G1 which regarding K10 this function resides in the nonhelical termini from the protein. (exposed-skin-care.net)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • Funciona como andamio molecular para localizar y estabilizar estas proteínas en los sitios de recombinación homóloga. (bvsalud.org)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. (umassmed.edu)
  • Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. (ucdenver.edu)
  • The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
  • Several cell cycle-associated proteins, such as Ki-67, are also used as indicators of cell proliferation. (bdbiosciences.com)
  • The adenovirus E1A protein mimics the LxDLFD motif and competes with E2F for binding to Rb, promoting E2F activation and cell proliferation. (eu.org)
  • Our interest is to carry out the complex network of signals by which this family of proteins regulates cellular proliferation, survival and differentiation, and to disclose the mechanisms responsible for the regulatory disruption of these functions in the neoplastic process. (shro.org)
  • Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells. (umn.edu)
  • Levels of retinoblastoma protein (Rb), Ki67, and Bcl-2 were measured, reflecting cellular proliferation and death. (atsjournals.org)
  • p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. (nature.com)
  • The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
  • The retinoblastoma susceptibility gene RB1 was the first tumour suppressor gene to be identified and characterised. (eu.org)
  • 1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
  • Inside animals, your Rb pathway is a traditional example of species-specific gene rules, as being a germline mutation in a Rb allele encourages retinoblastoma in humans, however, not in mice. (vdacsignaling.com)
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
  • Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling. (ucdenver.edu)
  • Keratins are a large family of proteins which form the intermediate filament (IF) cytoskeleton of epithelial cells and their appendages hairs and nails (reviewed in references 8 and 15). (exposed-skin-care.net)
  • We show that exogenous expression of E2F1 significantly inhibited AR mRNA and AR protein levels in prostate epithelial cells. (johnshopkins.edu)
  • Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235. (umn.edu)
  • A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (jefferson.edu)
  • The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
  • A group of cell cycle proteins that negatively regulate the activity of CYCLIN / CYCLIN-DEPENDENT KINASE complexes. (nih.gov)
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
  • Below are the most recent publications written about "BRCA1 Protein" by people in Profiles. (jefferson.edu)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype. (uams.edu)
  • Pocket proteins play essential roles in cell cycle progression, quiescence and differentiation, and their functional disruption is associated with human cancer. (eu.org)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
  • Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (bvsalud.org)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
  • An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. (umassmed.edu)
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
  • Furthermore, 5hmC is widely lost in human tumors, including retinoblastoma, although the mechanism behind its loss is unclear, as is the anti-tumor effectiveness of restoring 5hmC. (umn.edu)
  • These include changes in the plasma membrane (such as loss of membrane symmetry and loss of membrane attachment), a condensation of the cytoplasm and nucleus, protein cleavage, and internucleosomal cleavage of DNA. (bdbiosciences.com)
  • Proteins found in the nucleus of a cell. (uams.edu)
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (uams.edu)
  • Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection. (umassmed.edu)
  • GRP78 is a resident protein of the endoplasmic reticulum (ER) and mayassociate transiently with a variety of newly synthesized secretory and membrane proteins orpermanently with mutant or defective proteins that are incorrectly folded, thus preventing theirexport from the ER lumen. (exposed-skin-care.net)
  • The most studied function of the Rb protein is in the regulation of cell cycle progression at the G1/S boundary ( Giacinti,2006 ). (eu.org)
  • It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
  • Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
  • The pocket protein family controls several cellular functions such as cell cycle, differentiation, and apoptosis, among others. (ehu.eus)
  • The members from the large keratin family of cytoskeletal proteins are expressed in a carefully regulated tissue- and differentiation-specific manner. (exposed-skin-care.net)
  • The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shockproteins (HSP 70). (exposed-skin-care.net)
  • A family of cell cycle proteins containing ANKYRIN REPEATS that are specific inhibitors of cyclin D-dependent kinases. (nih.gov)
  • Our specific research has concentrated on the mechanisms regulated by pRb-family proteins and governing the neoplastic processes. (shro.org)
  • Role of pRb family proteins in lung cancer formation and progression. (shro.org)
  • Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)
  • Inactivation of Rb may contribute to many human malignancies including familial retinoblastoma, small-cell lung carcinomas, cervical carcinomas, prostate carcinomas, breast carcinomas, and some forms of leukaemias ( Burkhart,2008 ). (eu.org)
  • GRP78 is a highly conserved protein that is essential for cell viability.The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78and other resident ER proteins including glucose regulated protein 94 (GRP 94) and proteindisulfide isomerase (PDI). (exposed-skin-care.net)
  • The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology. (jefferson.edu)
  • These mechanisms can malfunction in pediatric retinoblastoma, and may be harnessed during retinal regeneration to produce new retinal cell types after they've been lost. (umn.edu)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • The LxSxE motif is specific for p107/p130 and is present in LIN52, a component of the DREAM complex. (eu.org)
  • The protein interaction landscape of the human CMGC kinase group. (nature.com)
  • The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
  • Additionally utilizing a cocktail of development and differentiation elements (XXL-medium) differentiation of USSC into cells of neuronal lineage (XXL-USSC) expressing neurofilament and Vandetanib trifluoroacetate sodium route proteins was acquired [3]. (techblessing.com)
  • During the first stage called G1, cells monitor their environment and, when the requisite signals are received, the cells synthesize RNA and proteins to induce growth. (bdbiosciences.com)
  • Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. (umn.edu)