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  • repression
  • As p107-deficient mice exhibit enhanced levels of Hes1, we questioned whether p107 regulates neural precursor self-renewal through the repression of Hes1. (rupress.org)
  • Whether the DNA-binding domain is always needed for direct DNA binding to target gene promoters or interaction of p53 with other proteins through this domain can evoke p53-dependent repression, remains to be elucidated. (hindawi.com)
  • cancers
  • Several diseases, including certain types of cancers and neurological disorders, can result from aberrant protein degradation. (pnas.org)
  • gene name abbreviated RB or RB1 ) is a tumor suppressor protein that is dysfunctional in several major cancers . (wikipedia.org)
  • This explains why sufferers of sporadic retinoblastoma are not at increased risk of cancers later in life, as both alleles are functional in all their other cells. (wikipedia.org)
  • Although Rb has diverse tumour-suppressor functions and is inactivated in many cancers, germline RB1 mutations predispose to retinoblastoma far more strongly than to other malignancies. (nih.gov)
  • Multivariate analysis showed that pRb2/p130 and p107 may be involved in the pathogenesis and progression of prostate cancers, and that the expression of the retinoblastoma-related protein pRb2/p130 along with Ki-67 (MIB-1), expressed as differences between cytoplasmic and nuclear concentrations, could be considered new parameters to be evaluated in discriminating patients at a higher risk for prostate cancer. (aacrjournals.org)
  • mutations
  • FGF signaling inhibits chondrocyte proliferation, a cell type-specific response that is the basis for several genetic skeletal disorders caused by activating FGFR mutations.To determine whether p107 dephoshorylation played a critical role in the chondrocyte response to FGF, we sought to counteract this process by overexpressing in RCS chondrocytes the cyclin D1/cdk4 kinase complex.Furthermore, an association between p107 and PP2A was induced by FGF treatment. (nih.gov)
  • target proteins
  • The role of polyubiquitination in degradation mediated by the proteasome seems to be 2-fold: target proteins to proteasomes and assist in their unfolding. (pnas.org)
  • degradation
  • These proteins are involved in the ubiquitin-mediated protein degradation pathway. (searlescholars.net)
  • The retinoblastoma protein (p105), p107, and p130 are each targeted for degradation by the pp71 protein, which is encoded by the UL82 gene of human cytomegalovirus. (pnas.org)
  • It functions to direct their degradation in the absence of other viral proteins. (pnas.org)
  • Most intracellular protein degradation is handled by the ubiquitin-proteasome pathway ( 3 , 4 ). (pnas.org)
  • The majority of proteins degraded by the proteasome are tagged with polyubiquitin, which serves as a signal for their degradation ( 3 ). (pnas.org)
  • The actual degradation step requires that ubiquitinated proteins first be denatured and deubiquitinated, to allow them to fit into the narrow channel of the core particle. (pnas.org)
  • Therefore, if a protein can be delivered to the proteasome in a denatured or partially unfolded state, ubiquitination should not be required for its degradation. (pnas.org)
  • Recently, there have been several reports of proteasome-dependent, ubiquitin-independent degradation of proteins in vivo ( 15 - 19 ). (pnas.org)
  • This type of degradation seems to be much less common than the proteasomal degradation of ubiquitinated proteins ( 20 ). (pnas.org)
  • Prognostic
  • Ruoslahti E. Prognostic factors in cases of retinoblastoma Analysis of 974 patients from Germany and the United States treated by enucleation. (msiw.ru)
  • progenitor
  • However, several lines of evidence also indicate that neural progenitor proliferation is intrinsically controlled by a molecular network of kinases and accessory proteins. (rupress.org)
  • Together, we identify a novel function for p107 in promoting neural progenitor commitment to a neuronal fate. (rupress.org)
  • Despite the expanded progenitor population, p107- deficient brains exhibit a reduction in the number of cortical neurons that cannot be accounted for by apoptosis. (rupress.org)
  • cdks
  • Different cyclins are present in different phases of the cell cycle and they will periodically activate CDKs which will induce downstream processing by phosphorylating other proteins. (biotecharticles.com)
  • precursor
  • The Retinoblastoma protein p107 regulates the neural precursor pool in both the developing and adult brain. (rupress.org)
  • Despite an expanded neural precursor population, p107-null mice exhibit a striking reduction in the number of cortical neurons. (rupress.org)
  • To determine the temporal requirement for p107 in regulating the neural precursor population, we counted the number of proliferating precursors in the brains of mice at three different ages: in adults and in embryos at embryonic days (E) 10.5 and 13.5. (rupress.org)
  • Rb suppresses human cone-precursor-derived retinoblastoma tumours. (nih.gov)
  • These findings provide a compelling molecular rationale for a cone precursor origin of retinoblastoma. (nih.gov)
  • antibody
  • Rbl1 monoclonal antibody, clone KAB6 ( Cat # MAB2025 ) recognizes both the phosphorylated and unphosphorylated forms of p107 at 107kDa. (acris-antibodies.com)
  • metabolism
  • Lastly, isolated p107-deficient muscle tissue display a threefold increase in lipid metabolism. (rupress.org)
  • Therefore, p107 determines the oxidative state of multiple tissues involved in whole body fat metabolism, including skeletal muscle. (rupress.org)
  • SV40
  • Most strikingly, they contain homologous protein domains that mediate interaction with the oncoproteins of several small DNA tumour viruses, including adenovirus E1A and SV40 large-T antigen. (nih.gov)
  • deficiency
  • Hes1 deficiency rescues neurosphere numbers in p107-null embryos. (rupress.org)
  • Mice lacking p107 exhibit a white adipose deficiency yet do not manifest the metabolic changes typical for lipodystrophy, and instead exhibit low levels of serum triglycerides and a normal liver phenotype. (rupress.org)
  • ubiquitin
  • The single E1 ubiquitin-activating enzyme primes ubiquitin monomers, allowing their covalent attachment to substrate proteins. (pnas.org)
  • downstream
  • Intracellular and extracellular stress signals can lead to induction of central signalling proteins which generate different downstream effects. (hindawi.com)
  • viral
  • The geminiviral replication initiator protein Rep is the only essential viral factor required for replication. (deepdyve.com)
  • This review provides a holistic view of the research related to the viral Rep protein and various host factors involved in geminiviral DNA replication. (deepdyve.com)