Loading...
  • kinases
  • However, due to the high degree of structural homology within the CDK protein family, putative small-molecule CDK inhibitors may exert their effects through combinatorial inhibition of multiple CDKs and other closely related serine/threonine kinases. (aacrjournals.org)
  • Zhang, Xian 2007-04-19 00:00:00 Cyclins, cyclin-dependent kinases, and a number of other proteins control the progression of plant cell cycle. (deepdyve.com)
  • PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC 50 , 0.011 μmol/L) and Cdk6 (IC 50 , 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases. (aacrjournals.org)
  • adenovirus E1A pro
  • In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. (abcam.com)
  • CDK4
  • p16 INK4A , originally identified as a protein associating with CDK4 in transformed cells ( 57 ), was cloned in a two-hybrid screen for proteins interacting with CDK4 ( 48 ). (asm.org)
  • transactivation
  • To explore repressive mechanisms of E2F-responsive genes in quiescent cells, we investigated E2F-6, which differs from other E2F family members (E2F-1 to E2F-5) in that it lacks domains for binding to RB family proteins and for transactivation ( 7-9 ). (sciencemag.org)
  • Interaction
  • Targeting the retinoblastoma protein by MC007L, gene product of the molluscum contagiosum virus: detection of a novel virus-cell interaction by a member of the poxviruses. (semanticscholar.org)
  • The ability of SWI-SNF complexes to regulate cell growth is believed to be mediated through the interaction of the human homologs of the SWI2-SNF2 protein (BRG1 and hBRM) with pRb ( 11 , 49 , 51 ). (asm.org)
  • regulation
  • The presence of unique Rbf2 targets suggest that evolutionary appearance of this corepressor represents the acquisition of potentially novel roles in gene regulation for the RB family. (sdbonline.org)
  • Insulin signaling plays key roles in development, growth and metabolism through dynamic control of glucose uptake, global protein translation and transcriptional regulation. (biologists.org)
  • In normal cells, the transition from G 1 to S phase and the start of DNA synthesis is tightly controlled by mechanisms that include transcriptional regulation of genes encoding proteins required in the S phase. (asm.org)
  • These same regions of E1A have also been implicated in interactions with other cellular transcription factors, such as TATA-binding protein (TBP), raising the possibility that transcriptional regulation and cellular transformation by E1A may involve additional mechanisms ( 22 , 61 ). (asm.org)
  • Activation
  • Src Family Kinase Activity Is Required for Kit-mediated Mitogen-activated Protein (MAP) Kinase Activation, However Loss of Functional Retinoblastoma Protein Makes MAP Kinase Activation Unnecessary for Growth of Small Cell Lung Cancer Cells -- Bondzi et al. (aacrjournals.org)
  • We demonstrate that uncontrolled DNA unwinding by minichromosome maintenance proteins upon Cdt1 overexpression is an important mechanism that leads to ssDNA accumulation and checkpoint activation. (rupress.org)
  • Here we report the identification and characterization of a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. (asm.org)
  • The activation of cyclin-cdk complexes is strictly regulated both at the level of protein synthesis and destruction and by posttranslational modifications to dictate precisely when in the cell cycle each complex becomes active ( 28 , 36 ). (asm.org)
  • Bouvard V, Storey A, Pim D et al (1994) Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. (springer.com)
  • interactions
  • Interestingly, many ribosomal protein genes are similarly targeted in human cells, indicating that these interactions may be relevant for control of ribosome biosynthesis and growth. (sdbonline.org)
  • novel
  • To further elucidate the role of cyclin E-cdk2 in growth control and in cell cycle transitions, we looked for novel proteins that associate with cyclin E within the cell. (asm.org)
  • sequence
  • The field of epigenetic is the study of modifications of DNA and DNA-binding proteins that alter the structure of chromatin without change in DNA sequence ( 1 , 2 ). (aacrjournals.org)
  • cell cycle
  • An ablation of retinoblastoma protein in mouse Sertoli cells resulted in their cell cycle re-entry in adult testes, dedifferentiation and a severe spermatogenic defect. (utupub.fi)
  • Oncoviruses have been important not only in epidemiology, but also in investigations of cell cycle control mechanisms such as the Retinoblastoma protein. (wikipedia.org)
  • Reexpression of hSNF5 induces G 1 cell cycle arrest in MRT cell lines, accompanied by upregulation of p16 INK4A and downregulation of cyclin D 1 , cyclin A, and phosphorylated retinoblastoma protein (pRb), suggesting a key role for these genes in MRT cell cycle control ( 17 - 20 ). (aacrjournals.org)
  • cells
  • Consistent with this, we show that AtE2F1 and AtE2F3 activate transcription in yeast cells and bind a plant Rb protein, but AtE2F2 cannot activate transcription or bind Rb. (deepdyve.com)