• P53 is one of the most important tumour suppressor proteins in the body which protects the cell against the tumourigenic effects of DNA damage by initiating processes such as apoptosis, senescence and cell cycle arrest. (uwc.ac.za)
  • Retinoblastoma protein (Rb) is a tumour suppressor nuclear phosphoprotein capable of binding to DNA. (ximbio.com)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF. (cshlpress.com)
  • Structural and biochemical data revealed that binding of phosphorylated p27 (phosp27) to CDK4 altered the kinase adenosine triphosphate site to promote phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and other substrates. (rcsb.org)
  • SnRK1: a versatile plant protein kinase that limits geminivirus infection. (ncsu.edu)
  • The plant protein kinase, SnRK1, has been implicated in host defenses against geminiviruses. (ncsu.edu)
  • GRIK, the SnRK1 activating kinase, is upregulated by geminivirus infection, while the viral C2 protein inhibits the SnRK1 activity. (ncsu.edu)
  • Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection. (ncsu.edu)
  • Sucrose nonfermenting 1-related protein kinase 1 targets the geminivirus Rep protein to interfere with viral infection. (ncsu.edu)
  • In this study, we found that the Tomato golden mosaic virus (TGMV) Rep is phosphorylated at serine-97 by sucrose nonfermenting 1-related protein kinase 1 (SnRK1), a master regulator of plant energy homeostasis and metabolism. (ncsu.edu)
  • Together, we demonstrate that Ocln is a downstream target of Src kinase and promotes LD secretion by binding to BTN1a1 and XOR. (bvsalud.org)
  • The NEMO protein is required for the activation of the kinase complex. (medscape.com)
  • The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
  • Phosphorylation of Rep or the phosphomimic S97D mutation impaired Rep binding to viral DNA. (ncsu.edu)
  • Overexpression of a directed mutant of 14-3-3 omega in Arabidopsis leaves affects phosphorylation and protein content of nitrate reductase. (ncsu.edu)
  • In most cases, the binding was dependent on phosphorylation of the target protein, whereas that was not necessarily the case for binding to target proteins that were unaffected by polycations. (ncsu.edu)
  • High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells. (ximbio.com)
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
  • MicroRNAs (miRNAs/miRs), composed of 19-25 nucleotides, are a group of short non-coding endogenous RNA molecules that function as negative regulators on gene expression via binding to the 3′ untranslated regions (3′UTRs) of target mRNAs ( 9 , 10 ). (spandidos-publications.com)
  • Phospho-Retinoblastoma (Ser780) Antibody detects endogenous levels of Retinoblastoma only when phosphorylated at Serine 780. (affbiotech.cn)
  • The first mutation of RB1 in cases of retinoblastoma can be either constitutional or somatic, whereas the second mutation is always somatic. (medscape.com)
  • The 14-3-3 family of proteins are highly conserved signaling proteins in eukaryotes that bind to their client proteins, usually through specific phosphorylated target sequences. (ncsu.edu)
  • Here, we focused on retinoblastoma-binding protein 7 (RBBP7), which is a highly conserved in WD-repeat subfamily that are primarily expressed in the nucleus [ 10 ]. (biomedcentral.com)
  • Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. (wikipedia.org)
  • Nearly all geminivirus Rep proteins have a serine residue at the position equivalent to TGMV Rep serine-97. (ncsu.edu)
  • While the 14-3-3 proteins are thought to interact with a wide array of cellular proteins, there have been few studies addressing the in-vivo role of 14-3-3. (ncsu.edu)
  • Two-dimensional difference gel electrophoresis analysis of proteins extracted from leaves of plants expressing the mutant 14-3-3 identified numerous cellular proteins that were altered in abundance. (ncsu.edu)
  • In order to determine whether binding to other cellular proteins is affected similarly, far-Western overlays of extracts prepared from light- or dark-treated spinach (Spinacia oleracea) leaves were performed using digoxigenin (DIG)-labeled Arabidopsis 14-3-3omega. (ncsu.edu)
  • This demonstrates the utility of bioinformatics to identify subtle variations within large datasets of protein domain sequences which can be used to predict differences in domain function and / or specificity that are not obvious in existing domain databases. (iscb.org)
  • Mg(2+) vs. spermine(4+)) altered the specificity for target proteins. (ncsu.edu)
  • The regulatory effect of transcription factors of specificity protein 1 (SP1) on RBBP7 mRNA expression was confirmed in dual-luciferase reporter assays and chromatin immunoprecipitation experiments. (biomedcentral.com)
  • A hidden Markov model (HMM) consensus sequence was created for each cluster and used to identify CD-containing proteins in several model eukaryotes. (iscb.org)
  • Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. (cshlpress.com)
  • The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
  • The CD is 60-90 amino acids long and has been proposed to be a protein-protein interaction module, an RNA and/or DNA-binding domain, and a recognition module for histone tail modification. (iscb.org)
  • The chromatin modifier domain or chromodomain (CD) is a conserved domain that is contained within a number of eukaryotic proteins involved in chromosome maintenance and remodelling. (iscb.org)
  • A subset of these proteins is conserved across eukaryotic kingdoms. (embl.de)
  • Purification: This antibody is purified through a protein A column, followed by peptide affinity purification. (hatinhibitor.com)
  • The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). (rcsb.org)
  • Arabidopsis Protein Kinases GRIK1 and GRIK2 Specifically Activate SnRK1 by Phosphorylating Its Activation Loop. (ncsu.edu)
  • Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1-and mammalian AMPK-activating kinases. (ncsu.edu)
  • Treating healthy seedlings and infected leaves with the proteasome inhibitor MG132 resulted in higher GRIK1 and GRIK2 protein levels, whereas treatment with the translation inhibitor cycloheximide reduced both kinases, demonstrating that their accumulation is modulated by posttranscriptional processes. (ncsu.edu)
  • [ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
  • In contrast, both mutations in nonhereditary retinoblastoma are somatic. (medscape.com)
  • NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
  • Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)
  • We identified histone demethylase RBP2 as directly downregulated by miR-181d and found that RBP2 inhibited p65 expression in leukemia cells by its binding to the p65 promoter and demethylating the tri/dimethylated H3K4 region in the p65 promoter locus. (researchsquare.com)
  • Here, genome-wide chromatin occupancy analysis of UTX and associated histone modifications reveals distinct classes of UTX target genes, including genes encoding Retinoblastoma (RB)-binding proteins. (ca.gov)
  • These CD-containing proteins can be classified into protein families based on other domains contained in the protein, for example the histone acetyltransferase family, the histone methyltransferase family and the Retinoblastoma-binding protein family (which contains TUDOR and BRIGHT domains), in addition to the CD. (iscb.org)
  • Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (bvsalud.org)
  • Dishevelled Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Moreover, the expression of miR-328 was lost in blast crisis of CML and its overexpression could promote cell differentiation and inhibit cell proliferation, by inducing the survival factor PIM1 and suppressing the binding between the translational regulator poly(rC)-binding protein hnRNP E2 and CEBPA [9]. (researchsquare.com)
  • The retinoblastoma-related protein (RBR) is required for cell cycle control and differentiation and is expressed throughout the life of plants and animals. (ncsu.edu)
  • Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY. (umassmed.edu)
  • Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
  • Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
  • Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). (embl.de)
  • The geminivirus replication initiator protein (Rep) binds to the viral replication origin and catalyzes DNA cleavage and ligation to initiate rolling circle replication. (ncsu.edu)
  • Overall, the results suggest that the binding of 14-3-3s to targets in addition to pNR may also be regulated by polycations and 5'-AMP. (ncsu.edu)
  • 11. Amsel, A. & Roussel, J. Motivational properties of ences in post-transcriptional processes spark interest in the development of frustration: I. Effect on a running response of the (protein redistribution, degradation), pharmacotherapies that selectively reg- addition of frustration to the motivational com- plex. (lu.se)
  • MicroRNAs (miRNAs) are a class of small non-coding RNAs, which negatively or positively regulate genes expression, by directly binding to the 3'untranslated regions (3'UTR) of the target genes mRNAs [7]. (researchsquare.com)
  • It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
  • Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa RING finger-containing protein whose function is known to be mediated through interaction with other proteins. (uwc.ac.za)
  • Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot. (cdc.gov)
  • Retinoblastoma genetics screening and clinical management. (cdc.gov)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • For instance, Huang et al ( 14 ) reported that overexpression of miR-133a-3p inhibits the proliferation, migration and invasion abilities of gallbladder carcinoma cells through directly targeting recombination signal-binding protein Jκ. (spandidos-publications.com)
  • The similar suppressive effects of miR-133a-3p on cell proliferation and migration were also demonstrated in retinoblastoma ( 16 ), gastric cancer ( 17 ) and prostate cancer ( 18 ). (spandidos-publications.com)
  • TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture. (rbprotein.com)
  • Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. (ximbio.com)
  • Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
  • The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes & Development. (wikipedia.org)
  • We also found that the CD contained within the proteins in the same family is almost invariably of the same subclass, and that different families, in most cases, contain a specific subclass of CD, which indicates there is a strong correlation between the CD subclass and the specific function of the proteins within the family. (iscb.org)
  • A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. (umassmed.edu)
  • Altered responsiveness to co- oup the nucleus accumbens reflect the behavioral approaches that incorporate caine and increased immobility in the forced swim test associated with elevated cAMP response ele- memory of associations between the extinction-like processes may have effi- ment binding protein in nucleus accumbens. (lu.se)
  • Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. (affbiotech.cn)
  • The resulting absence of MICB protein protects HCMV-infected cells against lysis by natural killer cells. (biomedcentral.com)
  • Retinoblastoma Binding Protein 6 (RBBP6) is a RING finger-containing protein which plays a critical role in the 3'-end processing of mRNA transcripts. (uwc.ac.za)
  • Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. (embl.de)
  • Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)
  • UTX removes H3K27me3 and maintains expression of several RB-binding proteins, enabling cell cycle arrest. (ca.gov)
  • [ 4 ] The E6 protein product of these high-risk HPVs binds to the tumor suppressor protein p53, which is thought to disrupt the p53-dependent control of the cell cycle. (medscape.com)
  • Polycations globally enhance binding of 14-3-3 omega to target proteins in spinach leaves. (ncsu.edu)
  • The presence of 5 mM Mg(2+) or 0.5 mM spermine enhanced binding to most of the target proteins to a maximum of about a doubling of the observed binding. (ncsu.edu)
  • The extent of stimulation varied among the target proteins, but there was no indication that the nature of the cation activator (e.g. (ncsu.edu)
  • In addition, binding of DIG-labeled 14-3-3omega to some, but not all, target proteins was reduced by 5 mM 5'-AMP. (ncsu.edu)
  • Interestingly, light/dark treatment of spinach leaves affected the subsequent binding of DIG-labeled 14-3-3omega in the overlay assay to only a few of the target proteins, one of which was identified as NADH:nitrate reductase. (ncsu.edu)
  • In this work we integrate multiple information sources, including miRNA-target binding information, miRNA expression profiles, and GO annotations. (biomedcentral.com)
  • Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma. (cdc.gov)
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
  • He hypothesized that loss of function of both copies of RB1 are required for the development of retinoblastoma. (medscape.com)
  • Taxonomic distribution of proteins containing ARM domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with ARM domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing ARM domain in the selected taxonomic class. (embl.de)
  • and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. (umassmed.edu)
  • SnRK1 also directly phosphorylates geminivirus proteins to reduce infection. (ncsu.edu)
  • Y. Incubation of cocaine craving during with- caused by the binding of a powerful directly to aversive states2,9. (lu.se)
  • Unlike the protein patterns, GRIK1 and GRIK2 transcript levels only show a small increase during infection and do not change significantly during development. (ncsu.edu)
  • SnRK1 phosphorylated the equivalent serines in the Rep proteins of Tomato mottle virus and Tomato yellow leaf curl virus and reduced DNA binding, suggesting that SnRK1 plays a key role in combating geminivirus infection. (ncsu.edu)