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  • ubiquitin-protei
  • E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene. (wikipedia.org)
  • Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. (wikipedia.org)
  • JARID1A
  • The JARID 1 proteins (JARID1A, JARID1B, JARID1C and JARID1D) catalyze the demethylation of histones on lysine, and JARID1B specifically demethylates lysine 4 on Histone H3. (novusbio.com)
  • The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. (novusbio.com)
  • RBP1
  • AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene. (wikipedia.org)
  • kinase
  • The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. (wikipedia.org)
  • LMO2
  • LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene. (wikipedia.org)
  • The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. (wikipedia.org)
  • Breast Cancer Metastasis Suppressor
  • Breast cancer metastasis suppressor 1 (BRMS1) affects multiple steps in the metastatic cascade leading to ∼90% metastasis suppression in xenograft models of breast carcinoma, melanoma, and ovarian carcinoma ( 2 , 3 ). (aacrjournals.org)
  • Recent evidence showed the importance of breast cancer metastasis suppressor 1 (BRMS1) in control of OS invasiveness, but the regulation of BRMS1 in OS remains largely unknown. (molcells.org)
  • Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene. (wikipedia.org)
  • human cancers
  • In view of the pro-tumourigenic effects of YB-1 in many human cancers, these results lay the foundation for an understanding of the regulatory effect of RBBP6 on YB-1 and its potential role in anti-tumour therapy. (uwc.ac.za)
  • nucleotide
  • Our data suggest that the growth arrest observed upon E2Fa-DPa overexpression results at least partly from a nitrogen drain to the nucleotide synthesis pathway, causing decreased synthesis of other nitrogen compounds, such as amino acids and storage proteins. (biologists.org)
  • estrogen receptor
  • Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. (wikipedia.org)
  • In humans, ERα is encoded by the gene ESR1 (EStrogen Receptor 1). (wikipedia.org)
  • PARP1
  • The PARP1 protein, attached to both DDB1 and DDB2, then PARylates (creates a poly-ADP ribose chain) on DDB2 that attracts the DNA remodeling protein ALC1. (wikipedia.org)
  • subunit
  • The DDB2 component of the heterodimer contains the specificity for binding to damaged DNA, since a heterodimer DDB complex containing amino acid substitutions in the DDB2 subunit, as found in XP-E patients, is very deficient in binding to damaged DNA. (wikipedia.org)
  • Within each subunit, there are a variety of protein binding sites, as well as a total of 15 possible phosphorylation sites. (wikipedia.org)
  • functional
  • Here, we used bioinformatics analyses to predict BRMS1-targeting microRNAs (miRNAs), and the functional binding of miRNAs to BRMS1 mRNA was evaluated using a dual luciferase reporter assay. (molcells.org)
  • Rb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. (wikipedia.org)
  • This explains why sufferers of sporadic retinoblastoma are not at increased risk of cancers later in life, as both alleles are functional in all their other cells. (wikipedia.org)
  • JARID1B
  • As result, the JARID1B protein is up regulated in breast cancer and down regulated in melanoma and glioblastomas. (novusbio.com)
  • JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. (novusbio.com)
  • There are three splicing isoforms of JARID1B, however the links between the protein structure and function are not clear. (biomedcentral.com)
  • Up to now the expression of JARID1B in cancer cells was studied for specific variants or for a total pool of the protein without analysis of its isoform composition. (biomedcentral.com)
  • substrates
  • There are many variations, but the basic ABPP premise is to develop probes that attach to proteins even when their targets, or substrates, are not known, for instance by exploiting structural or mechanistic elements used by a wide range of proteins in a given class. (bio-medicine.org)
  • To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. (wikipedia.org)
  • In kinetic partitioning, Hsp70s repetitively bind and release substrates in cycles that maintain low concentrations of free substrate. (wikipedia.org)
  • Substrates of Cdk1 bind near the mouth of the cleft, and Cdk1 residues catalyze the covalent bonding of the γ-phosphate to the oxygen of the hydroxyl serine/threonine of the substrate. (wikipedia.org)
  • several proteins involved
  • No evidence was obtained in yeast 2-hybrid assays for a direct interaction between either UVR8 or HY5 and several proteins involved in light-regulated histone modification, nor for the involvement of these proteins in UVR8-mediated responses in plants, although functional redundancy between proteins could influence the results. (deepdyve.com)
  • Regulation of p16 is complex and involves the interaction of several transcription factors, as well as several proteins involved in epigenetic modification through methylation and repression of the promoter region. (wikipedia.org)
  • cyclins
  • Taxi has not restriction point and transition at G1/S. Three been shown to bind directly to Taxi-responsive novel types of putative mammalian G1 cyclins were isolated by using human cDNA libraries to transactivation occurs through indirect effects of complement CLN-deficient yeast and designated Taxi on transcription factors which bind to the as cyclins C, D, and E . (internetpdfarticles.com)
  • Targets
  • The E2F transcription factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. (mit.edu)
  • The Proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. (wikipedia.org)
  • Numerous research works have focused interest on defining the direct protein targets of action of ceramide. (wikipedia.org)
  • Phosphorylation of the pocket proteins causes the release of their bound targets, thereby relieving the repression of the E2F1-3 activators and translocating repressors E2F4 and E2F5 from the nucleus to the cytoplasm. (wikipedia.org)
  • murine
  • Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9. (wikipedia.org)
  • viral
  • coding capacity of the viral genome, viral Interestingly, when the pX coding sequences were cloned into a transformation-defective herpes virus or transgenic mice containing only regulatory protein function. (internetpdfarticles.com)
  • Functional hepatic stellate cells coexpressing both LRAT (zeige LRAT ELISA Kits ) and CRBP-1 , that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis. (antikoerper-online.de)
  • The protein consists of four conserved domains (RNA-Binding Domain (TRBD), fingers, palm and thumb), organized into a ring configuration that shares common features with retroviral reverse transcriptases, viral RNA polymerases and bacteriophage B-family DNA polymerases. (wikipedia.org)
  • PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. (wikipedia.org)
  • Regulation
  • Such lesions have the capacity to interfere with normal gene regulation through direct interactions with promoter elements, or indirectly by establishing new transcription factor (TF) binding sites. (springer.com)
  • The two terminal domains are linked together by a conserved region referred to as loop LL,1, which is critical for allosteric regulation. (wikipedia.org)
  • phosphorylation
  • The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. (wikipedia.org)
  • Its function in these cells may be regulated by phosphorylation of serine196, in its N-terminal DNA binding domain. (wikipedia.org)
  • phosphorylation of these proteins leads to cell cycle progression. (wikipedia.org)
  • molecular
  • Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor). (springer.com)
  • The bulk of these so far enigmatic proteins may now be open to study, thanks to research by a team at The Scripps Research Institute and its Molecular Screening Center. (bio-medicine.org)
  • CSHL is ranked among the leading basic research institutions in molecular biology and genetics with Thomson Reuters ranking it #1 in the world. (wikipedia.org)
  • Functional
  • This allows scientists to build broad-spectrum probes that will work with a whole host of uncharacterized proteins, propelling their functional analysis. (bio-medicine.org)
  • promoters
  • These studies reveal diverse responses of TF to oxidative damage in promoters that can have either no effect, induce a full or partial inhibition or, in some cases, actually enhance binding depending on the particular TF-promoter system under investigation and the location of the damage within the promoter element. (springer.com)
  • Current data support the concept of dual roles of Stat5a/b proteins as promoters of mammary tumorigenesis, and as suppressors of the progression of established breast cancer [ 11 , 12 ], although our knowledge of individual roles of Stat5a and Stat5b in breast cancer remains rudimentary. (biomedcentral.com)
  • replication
  • Bidirectional transcription from a long intergenic region (LIR) results in the virion-sense expression of a movement protein (MP) and a coat protein (CP), and the complementary-sense expression of the replication-associated proteins, Rep and RepA. (wikipedia.org)
  • Due to genome size restrictions, MSV usurps host DNA replication and double-stranded DNA break repair proteins to replicate its genome via, respectively, rolling-circle and recombination-dependent mechanisms. (wikipedia.org)
  • proteome
  • Understanding the tens of thousands of proteins that compose the human proteome has emerged as a key challenge of this century, and research efforts to date have already enabled major advances in drug discovery and understanding basic biology. (bio-medicine.org)
  • eukaryotes
  • TERT proteins from many eukaryotes have been sequenced. (wikipedia.org)
  • As the eukaryotic cell cycle is a complex process, eukaryotes have evolved a network of regulatory proteins, known as the cell cycle control system, which monitors and dictates the progression of the cell through the cell cycle. (wikipedia.org)
  • lipid
  • It lacks the DNA binding region of CUTL1, but instead contains a trans-membrane domain that allows it to insert into lipid bilayers. (wikipedia.org)
  • As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum. (wikipedia.org)
  • nucleotides
  • Telomerase can bind the first few nucleotides of the template to the last telomere sequence on the chromosome, add a new telomere repeat (5'-GGTTAG-3') sequence, let go, realign the new 3'-end of telomere to the template, and repeat the process. (wikipedia.org)
  • pathway
  • Hsc70 is a key component of chaperone-mediated autophagy wherein it imparts selectivity to the proteins being degraded by this lysosomal pathway. (wikipedia.org)
  • promoter
  • Evidence is accumulating that base damage, particularly that produced by oxidation reactions, can modulate DNA protein interactions and affect promoter function. (springer.com)
  • Other, more hypothetical pathways are presented including the de novo production of new consensus binding motifs by oxidative damage/mutations and changes in promoter structure or sequence such that they acquire higher affinity for inappropriate transcription factors. (springer.com)
  • Chromatin immunoprecipitation was used to determine binding of mdm2 to the hTR promoter. (biomedcentral.com)
  • Here we show using chromatin immunoprecipitation that mdm2 specifically binds the hTR promoter in vivo. (biomedcentral.com)
  • homeostasis
  • Ultimately, its role in protein folding contributes to its function in signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. (wikipedia.org)
  • As part of the Ubiquitin-Proteasome System (UPS), the proteasome maintains cardiac protein homeostasis and thus plays a significant role in cardiac Ischemic injury, ventricular hypertrophy and Heart failure. (wikipedia.org)
  • distinct
  • The mechanism of associated myelopathy/tropical spastic para- HTLV-I transformation appears to be distinct paresis (HAM/ TSP) [ 1, (internetpdfarticles.com)
  • telomerase
  • Telomerase is a ribonucleoprotein complex that consists of an essential RNA molecule, hTR, with a template domain for telomeric DNA synthesis and of a catalytic protein, hTERT, with reverse transcriptase activity. (biomedcentral.com)
  • Oncogene
  • Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. (wikipedia.org)
  • proteasome
  • Subsequently, a compromised proteasome complex assembly and function lead to reduced proteolytic activities and the accumulation of damaged or misfolded protein species. (wikipedia.org)