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Adenovirus Early ProteinsRetinoblastomaAdenoviruses, HumanRetinoblastoma ProteinRetinal NeoplasmsGenes, RetinoblastomaAdenoviridaeAdenovirus E1A ProteinsAdenovirus Infections, HumanEye NeoplasmsAdenoviridae InfectionsViral ProteinsAdenovirus E1B ProteinsImmediate-Early ProteinsAdenovirus E4 ProteinsAdenovirus E3 ProteinsDNA, ViralCell LineGenes, ViralAdenovirus E1 ProteinsAntigens, Polyomavirus TransformingOncogene Proteins, ViralGenetic VectorsVirus ReplicationE2F Transcription FactorsEye EnucleationRetinoblastoma-Like Protein p107Molecular Sequence DataTranscription, GeneticAntigens, Viral, TumorPolyomavirusHeLa CellsBase SequenceGene Expression Regulation, ViralAdenoviruses, CanineDNA-Binding ProteinsAdenovirus E2 ProteinsLambdapapillomavirusPromoter Regions, GeneticTranscription Factor DP1Retinoblastoma-Like Protein p130E2F1 Transcription FactorMutationRetinoblastoma-Binding Protein 1Transcription FactorsSimian virus 40Cell CycleTransfectionCytomegalovirusDNA ReplicationHerpesvirus 1, SuidCyclin-Dependent KinasesMastadenovirusGenetic TherapyTumor Cells, CulturedCells, CulturedRNA, MessengerPlasmidsAdenoviruses, PorcineHerpesvirus 1, EquidAmino Acid SequenceJC VirusGene Expression RegulationAviadenovirusNuclear ProteinsGene Transfer TechniquesCyclin-Dependent Kinase 4Cell NucleusRNA, ViralPhosphorylationFowl adenovirus AG1 PhaseCell Cycle ProteinsCyclinsCell Transformation, ViralAntigens, ViralProtein BindingCercopithecus aethiopsHerpesvirus 1, HumanCapsid ProteinsSimplexvirusTrans-ActivatorsPeptide BiosynthesisCyclin D1PhosphoproteinsChromosomes, Human, Pair 13Cell DivisionVaccinia virusOncolytic VirusesFibroblastsOncolytic VirotherapyProtein BiosynthesisRepressor ProteinsCyclin-Dependent Kinase Inhibitor p16Receptors, VirusFluorescent Antibody TechniqueTumor Suppressor Protein p53PapillomaviridaePapillomavirus E7 ProteinsCyclin-Dependent Kinase 2
Proto-OncogenePeptidesGenesPhosphorylationRECEPTORSInhibitionViralMutationsTumorTranscriptionalKinaseOncogenicMRNAPathwaysVIRUSESReplicationHumanDifferentiationBindsRegulatoryInducibleComplexBindNucleus1950sMediatesInteractionCellsSynthesisExpressionAssemblyCancerBacteriaVivoCellFamilyCyclinVaccinesSignalRoleDomainMediated by differentDisease
Proto-Oncogene4
  • Proto-Oncogene Proteins c-rel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-rel" by people in this website by year, and whether "Proto-Oncogene Proteins c-rel" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-rel" by people in Profiles. (childrensmercy.org)
  • A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. (bvsalud.org)
Peptides1
  • The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
Genes12
Phosphorylation3
  • Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
  • The mechanisms underlying this reduction of SMC proliferation by HDAC inhibition involve a growth arrest in the G(1) phase of the cell cycle that is due to BVD-523 cost an inhibition of retinoblastoma protein phosphorylation. (cret-signal.com)
  • This was associated with DIM‐enhanced phosphorylation of the signaling intermediates Akt, insulin receptor substrate‐1, and insulin receptor early in differentiation. (researchgate.net)
RECEPTORS1
  • Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
Inhibition1
  • Hamilton: B. C. Decker Inc.). A number of anti-angiogenic activities have been reported for this protein, such as inhibition of endothelial cell proliferation, migration, and tube formation. (justia.com)
Viral3
  • The mRNA vaccines contain only the code for the SARS-CoV-2 envelope spike protein, whereas the DNA-based vaccines both contain an adenovirus viral vector that has been augmented with DNA that codes for the SARS-CoV-2 spike protein. (theepochtimes.com)
  • The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have antioncogenic properties. (docksci.com)
  • These viral proteins-subsequently named tumor antigens (TA)-were recognized by the immune system and the different antibodies were found to target them specifically [ 5 ] . (encyclopedia.pub)
Mutations3
  • Physical mapping of temperature-sensitive mutations of adenoviruses. (cshlpress.com)
  • These preliminary results paved the way for a vast number of studies on the role of cellular protein p53 in the cancer biology field, leading to the discovery that p53 mutations are the most common genetic alteration in human cancers. (encyclopedia.pub)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
Tumor3
  • The Rb tumor suppressor protein (pRb) binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription machinery. (wikipedia.org)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Transcriptional5
  • Among E2F transcriptional targets are cyclins, CDKs, checkpoints regulators, DNA repair and replication proteins. (wikipedia.org)
  • In vivo footprinting experiments obtained on Cdc2 and B-myb promoters demonstrated E2F DNA binding site occupation during G0 and early G1, when E2F is in transcriptional repressive complexes with the pocket proteins. (wikipedia.org)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • FMIP(Fms interacting protein) is a member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export complex. (biomedcentral.com)
  • A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
Kinase2
  • cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF. (cshlpress.com)
  • Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
Oncogenic4
  • pRb is one of the targets of the oncogenic human papilloma virus protein E7, and human adenovirus protein E1A. (wikipedia.org)
  • HPV is present in cervical cancer, where it expresses the oncogenic proteins E6 and E7 that inactivate the host regulatory proteins p53 and RB, respectively. (sv40.org)
  • SV40 also expresses the oncogenic protein T Ag in human mesotheliomas, which inactivates p53 and RB. (sv40.org)
  • This work pinpoints E2 as a key protein in the initiation of HPV-induced cervical cancer and identifies the SAC as a target for oncogenic pathogens. (docksci.com)
MRNA7
  • Schematic diagram of the amino acid sequences of E2F family members (N-terminus to the left, C-terminus to the right) highlighting the relative locations of functional domains within each member: Homo sapiens E2F1 mRNA or E2F1 protein sequences from NCBI protein and nucleotide database. (wikipedia.org)
  • The mRNA in these vaccines codes for the spike protein normally synthesized by the SARS-CoV-2 virus. (theepochtimes.com)
  • However, both the mRNA and the protein it produces have been changed from the original version in the virus with the intent to increase rate of production of the protein in an infected cell and the durability of both the mRNA and the spike protein it codes for. (theepochtimes.com)
  • Based upon the known function of the normal SMN protein, it is speculated that gems are involved in trafficking mRNA spliceosome subunits through the nucleus and may indirectly help remove mRNA introns. (jrank.org)
  • Small nuclear ribonucleoproteins are RNA-protein complexes that are subunits of the spliceosome involved in mRNA intron removal. (jrank.org)
  • These data suggest that various nuclear mRNA export pathways, which may be indicated by different adaptor RNA binding proteins, exist in higher eukaryotes. (biomedcentral.com)
  • Recent data show that Aly and THOC5 function in the tip associating protein (TAP)-p15 mediated nuclear export of Hsp70 mRNA [ 11 ]. (biomedcentral.com)
Pathways2
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
VIRUSES2
  • Approximately 70 years ago, several DNA viruses such as adenovirus, human Epstein-Barr virus, polyoma and SV40 were found to be able to cause tumors in humans and rodents [ 1 ] . (encyclopedia.pub)
  • It was not until early 1950s that the potential of viruses as anti-cancer agents had been recognized and applied [ 7 , 9 ]. (biomedcentral.com)
Replication1
Human5
  • Roseola infantum (caused by human herpes virus 6), cytomegalovirus (CMV), varicella, and adenovirus all cause generalized lymphadenopathy. (medscape.com)
  • They are known to contain a protein called SMN (which stands for "survival of motor neurons") that, when mutated, is responsible for a severe inherited form of a human muscular wasting disease called spinal muscular atrophy. (jrank.org)
  • When cells are infected with herpes simplex virus type 1, adenovirus, or human cytomegalovirus, PML bodies are disrupted. (jrank.org)
  • Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
  • The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
Differentiation2
  • Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. (cshlpress.com)
  • Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
Binds2
  • Just as in the case of antibiotic resistance, new strains evolve within an infected immune-compromised person's body that produce a version of the spike protein that no longer binds with the acquired antibodies. (theepochtimes.com)
  • Synchronous neurotransmission is triggered when Ca(2+) binds to synaptotagmin 1 (Syt1), a synaptic-vesicle protein that interacts with SNAREs and membranes. (cret-signal.com)
Regulatory2
  • Below are the most recent publications written about "Leucine-Responsive Regulatory Protein" by people in Profiles. (rush.edu)
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
Inducible1
  • Since these mice are embryonic lethal, we then generated interferon inducible conditional THOC5/Fms interacting protein knockout mice. (biomedcentral.com)
Complex3
  • This phenotype is associated with interaction of E2 with the Mitotic Checkpoint Complex (MCC) proteins Cdc20, MAD2 and BUBR1. (docksci.com)
  • Furthermore, mechanistically depletion of THOC5/Fms interacting protein causes the down-regulation of its direct interacting partner, THOC1 which may contribute to altered THO complex function and cell death. (biomedcentral.com)
  • Furthermore, the embryonic development of the conventional THOC1 knockout mice is arrested around the time of implantation [ 13 ], suggesting that the THO complex may play an essential role in early development. (biomedcentral.com)
Bind3
  • E2F1-6 have DP1,2 heterodimerization domain which allows them to bind to DP1 or DP2, proteins distantly related to E2F. (wikipedia.org)
  • Pocket proteins such as pRB and related proteins p107 and p130, can bind to E2F when hypophosphorylated. (wikipedia.org)
  • In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)
Nucleus1
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
1950s1
  • The discovery of the structure of DNA by Francis Crick and James Watson in the early 1950s ushered in a new era in molecular biologic science. (medscape.com)
Mediates1
  • A DNA-binding protein that mediates DNA REPAIR of double strand breaks, and HOMOLOGOUS RECOMBINATION . (nih.gov)
Interaction1
  • The "don't eat me signal" CD47 is a pleitropic surface marker expressed on numerous cell types that inhibits myeloid cell phagocytic activity through binding SIRPalpha as well as an antagonizes T cell function mediated by interaction with matricellular protein Thrombospondin-1. (sitcancer.org)
Cells4
  • Among these four studies, the same 53kD protein (called p53) was detected-and confirmed with peptide maps-in SV40-transformed cells and malignant cells that are not transformed by a virus, whereas decreased p53 levels were observed in uninfected normal cells. (encyclopedia.pub)
  • Furthermore, infusion of normal bone marrow cells rescued mice from death induced by loss of THOC5/Fms interacting protein. (biomedcentral.com)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • Immortalized cells were clonally expanded and characterized based on collagen type I, collagen type II, α1 (COL2A1), and SRY-box 9 (SOX9) protein expression profiles, as well as on expression of a subset of established in vivo NP cell lineage markers. (biomedcentral.com)
Synthesis1
  • But a disadvantage is that those who have been exposed to natural forms of the adenovirus have antibodies to the virus that will likely block the synthesis of the spike protein, and therefore not afford protection against SARS-CoV-2. (theepochtimes.com)
Expression2
  • The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
  • A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. (childrensmercy.org)
Assembly1
  • 574Structural Proteins: Translation, Processing, and Assembly. (vdocuments.net)
Cancer3
  • Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)
  • Nonsurgical Options for Risk Reduction of Contralateral Breast Cancer in BRCA Mutation Carriers With Early-Stage Breast Cancer. (jefferson.edu)
  • Interestingly, this belief continued to be accepted right up to Hippocrates (460-370 BC), who postulated the earliest scientific theory about cancer. (jcancer.org)
Bacteria1
  • A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. (rush.edu)
Vivo1
  • To study the role of THOC5/Fms interacting protein in vivo , we generated THOC5/Fms interacting protein knockout mice. (biomedcentral.com)
Cell3
  • DNA microarray analysis reveals unique sets of target promoters among E2F family members suggesting that each protein has a unique role in the cell cycle. (wikipedia.org)
  • [ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
  • Early passage NP monolayer cell cultures were initially characterized using a recently established NP marker set. (biomedcentral.com)
Family1
Cyclin1
  • Cdk4(6)/cyclin D and cdk2/cyclin E phosphorylate pRB and related pocket proteins allowing them to disassociate from E2F. (wikipedia.org)
Vaccines1
  • People don't realize that these vaccines are vastly different from the many childhood vaccines we are now used to getting early in life. (theepochtimes.com)
Signal3
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)
Role1
  • The protein plays a role in regulating DNA topology and activation of RIBOSOMAL RNA transcription. (childrensmercy.org)
Domain1
Mediated by different1
  • It is likely that endostatin has a number of biological functions mediated by different regions of the protein. (justia.com)
Disease2
  • The combination of encephalopathy and cirrhosis, myxedema, salt-wasting states eg, activated protein c xigris for severe chronic lung disease. (elastizell.com)
  • The earliest descriptionof rubella appears to date back to the 1700s, when the clinicalmanifestations of the disease were described by two Germanphysicians, de Bergan in 1752 and Orlow in 1758 (155). (vdocuments.net)