• Assessment of retinal microvascular health along with BP monitoring can improve cardiovascular risk stratification in early childhood. (drugs.com)
  • Retinal vessel calibers have been associated with the presence of microvascular complications but their long-term predictive value has only been sparsely investigated. (diabetesjournals.org)
  • 2009). Retinal microvascular abnormalities and cognitive decline: the ARIC 14-year follow-up study. (core.ac.uk)
  • 2001). Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study. (core.ac.uk)
  • 2010). Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study. (core.ac.uk)
  • The researchers compared the retinal imaging results of 27 individuals who had developed schizophrenia with those of individuals who had not and found that the former had microvascular abnormalities reflective of insufficient brain oxygen supply. (psychnews.org)
  • This precise measurement could contribute to the diagnosis and evolution characterization of microvascular disorders which affect the retinal vessels. (umfcluj.ro)
  • Since Zingiber officinale (ginger) is known for its anti-inflammatory and antiangiogenic properties, we investigated the effects of its extract standardized to 5% 6-gingerol, the major active constituent of ginger, in attenuating retinal microvascular changes in rats with streptozotocin-induced diabetes. (molvis.org)
  • The current study showed that ginger extract containing 5% of 6-gingerol attenuates the retinal microvascular changes in rats with streptozotocin-induced diabetes through anti-inflammatory and antiangiogenic actions. (molvis.org)
  • We further demonstrated in 25 mM glucose-treated human retinal microvascular endothelial cells (HRMECs) that hyperoside (3-O-galactoside-quercetin), quercitrin (3-O-rhamnoside-quercetin), and 2″-O-acetylvitexin (8-C-(2″-O-acetyl-glucoside)-apigenin) were the active components of OSSCE that mediated its pharmacological action. (mdpi.com)
  • In this study the formation of such tubular structures was observed in post-confluent cultures of bovine retinal microvascular endothelial cells. (elsevier.com)
  • The segmented retinal images from the CHASE_DB1 database produced best case accuracy, sensitivity and specificity of 0.96, 0.74 and 0.98, respectively, and worst case measures of 0.94, 0.67 and 0.98, respectively. (springer.com)
  • The vessel tortuosity determined using optical coherence tomography angiography might be a useful parameter indicating the progression to PDR, circumventing the risk from invasive conventional angiography. (ovid.com)
  • We examined the impact of axial length on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurement using optical coherence tomography angiography. (surrey.ac.uk)
  • Purpose: To compare retinal vessel density in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) to age-matched healthy eyes by using projection-resolved optical coherence tomography angiography (PR-OCTA). (elsevier.com)
  • Therefore, automatic methods for extracting and measuring the vessels in retinal images are needed to save the workload of the ophthalmologists and to assist in characterizing the detected lesions and identifying the false positives [ 12 ]. (hindawi.com)
  • As a consequence, these global-based methods suffer in handling details, such as recognizing the small thin vessels, discriminating the optic disk, etc. (bioportfolio.com)
  • Methods: Retinal vessel morphology of 26 patients with acromegaly was examined at diagnosis and 1 year after treatment and compared to 13 healthy controls. (eur.nl)
  • An approach to localize the retinal blood vessels using bit planes and centerline detection," Computer Methods and Programs in Biomedicine, vol. (thefreedictionary.com)
  • In comparison to other published methods this method can estimate appropriate TI for vessels with constant curvature sign and vessels with equal arc to chord ratios, as well. (spie.org)
  • In this paper, we proposed approaches for improving the quality of blood vessel detection based on our initial blood vessel detection methods. (spie.org)
  • Although they were adapted to structures in retinal fundus imaging, neither eye specific knowledge nor supervised classification methods are used. (eurekaselect.com)
  • The approach results are better than the other state of the art methods used for vessel segmentation. (peerj.com)
  • Our performance evaluation shows that the proposed blood vessel segmentation approach is at least comparable with recent state-of-the-art methods. (theiet.org)
  • SUBJECTS AND METHODS: Twenty patients with multiple sclerosis (38.3 +/- 6.2 years) and twenty healthy subjects (37.4 +/- 15.2 years) were examined with the Retinal Vessel Analyzer. (unibas.ch)
  • Arteriovenous ratio (AVR) calculations showed a similar change for both methods when omitting one vessel each: AVR decreased when omitting one arteriole whereas it increased when omitting one venule. (aston.ac.uk)
  • Furthermore, in the same study researchers were able to reverse this pathway to accelerate the growth of branching vessels, which could be important to developing new methods for repairing damaged tissues. (cincinnatichildrens.org)
  • RESEARCH DESIGN AND METHODS- Wild-type mice, 5-lipoxygenase-deficient mice, and 12/15-lipoxygenase-deficient mice were assessed 1 ) after 9 months of diabetes for retinal histopathology and leukotriene receptor expression and 2 ) after 3 months of diabetes for leukostasis and retinal superoxide generation. (diabetesjournals.org)
  • Direct measurement of local retinal tissue oxygen saturation and metabolism is only possible using invasive methods, 1 and is therefore not suitable for screening and follow-up monitoring in routine practice. (arvojournals.org)
  • Methods and Results- Apelin-KO mice showed impaired retinal vascularization and ocular development, which were analyzed by histology, immunohistochemistry, real-time polymerase chain reaction, and the mouse corneal micropocket assay. (ahajournals.org)
  • The experimental results show that compared with the state-of-art methods, the proposed method has strong robustness, it not only avoids the adverse interference of the lesion background but also detects the tiny blood vessels at the intersection accurately. (biomedcentral.com)
  • Aiming at the above problems, many researchers proposed to adopt deep learning methods for retinal blood vessel segmentation. (biomedcentral.com)
  • The observed accuracy, speed, robustness and simplicity suggest that the algorithm may be a suitable tool for automated retinal image analysis in large population-based studies. (springer.com)
  • Dr. Lang said the Wnt-Flt1 response is a new pathway for regulating VEGF-stimulated angiogenesis (blood vessel formation). (cincinnatichildrens.org)
  • Here we describe a previously uncharacterized function for dll4 during sprouting angiogenesis, with dll4 suppressing endothelial tip cell formation and vessel branching by inhibiting the response of sprouting ECs to VEGF. (pnas.org)
  • Retinal vessel calibers were measured using a computer-based program as the central retinal artery and vein equivalent (CRAE and CRVE). (nih.gov)
  • Central retinal arteriole equivalent (CRAE) and central retinal venule equivalent (CRVE) were computed. (nih.gov)
  • Here, we set out to explore two such markers - CRAE and CRVE - obtained with two different techniques: one using a red-free filter and the other one using a dual wavelength filter used for taking retinal oximetry images and extracting only the information from the green channel. (biomedcentral.com)
  • Early retinal vessel development and iris vessel dilatation as factors in retinopathy of prematurity. (duke.edu)
  • OBJECTIVE: To determine whether the extent of retinal vessel development present on early screening examinations for retinopathy of prematurity has prognostic value? (duke.edu)
  • DESIGN: The prospectively collected data from the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity were used to compare the development of acute retinopathy of prematurity and long-term structural and visual outcomes for eyes with differing extents of retinal vessel development. (duke.edu)
  • RESULTS: The chance of developing threshold retinopathy of prematurity was inversely related to the early degree of vessel development: 54% for zone I eyes, 25% for transitional eyes, and 8% for zone II eyes. (duke.edu)
  • CONCLUSIONS: The degree of early retinal vessel development is a significant predictor of outcome from retinopathy of prematurity. (duke.edu)
  • The retinal vessels reportedly move onto the optic nerve head (ONH) in response to glaucoma damage, suggesting that RBVs are pulled toward the ONH in response to increased cupping. (ovid.com)
  • HIGHLIGHTS Retinal vessels as well as retinal nerve fibers are pulled down to the optic nerve head as cupping increases. (ovid.com)
  • The peripapillary retinal vessels were assessed in a concentric annulus around the optic nerve head. (arvojournals.org)
  • The interocular difference in retinal vessel rigidity was significantly correlated with the interocular difference in RNFL thickness in MS patients. (unibas.ch)
  • Compared with the RVA software method, SDRA demonstrated a marked difference in retinal vessel responses to flickering light (P 0.05). (aston.ac.uk)
  • The RVA software was unable to detect this difference or to find a difference in retinal vessel arteriovenous ratio between smokers and nonsmokers (P 0.243). (aston.ac.uk)
  • Systemic VEGF blockade does not alter retinal vessels ultrastructure or choriocapillaris fenestration. (nih.gov)
  • Although VEGF expression was not significantly altered in dll4 +/− retinas, dll4 +/− vessels showed increased expression of VEGF receptor 2 and decreased expression of VEGF receptor 1 compared with wild-type, suggesting they could be more responsive to VEGF stimulation. (pnas.org)
  • To test the role of astrocyte-derived VEGF, we used Cre-lox technology in mice to delete VEGF in retinal astrocytes during development. (city.ac.uk)
  • Their results suggest that SOCS3 prevents neurons and glial cells from releasing too much VEGF (a cytokine that promotes blood vessel formation) by inhibiting the transcription factor STAT3, which can trigger the production of VEGF. (sciencemag.org)
  • 15-18 FGFR1 dominant negative- and VEGF 164 -deficient mice show defective retinal vascularization. (ahajournals.org)
  • Muscarinic binding sites were less different (0.5 to 1.8 fmol/mg net weight) among the species studied, being the highest values in human retinal vessels. (elsevier.com)
  • The total retinal vessels in P17 OIR mice could be fully observed under a fluorescence microscope 3 s after RO injection of FITC-dextran. (nih.gov)
  • Our study showed that RO injection of FITC-dextran was suitable for observing the retinal vessels of all postnatal mice. (nih.gov)
  • Retro-orbital injection of FITC-dextran is an economical method for observing retinal vessels in mice, when compared with LV perfusion of FITC-dextran. (nih.gov)
  • The study, to be published online May 29, demonstrates how retinal myeloid cells regulate blood vessel branching in the still-developing retinas of postnatal mice by using the Wnt protein signaling network. (cincinnatichildrens.org)
  • To exclude the possibility that the defects observed in vessel branching were secondary to other defects in the embryo, e.g., disrupted blood flow, we cultured aortic explants from dll4 +/− and wild-type mice in collagen gels. (pnas.org)
  • Apelin-KO mice showed significantly impaired retinal vascularization in the early postnatal period. (ahajournals.org)
  • In addition, Wnt7b expression on retinal macrophages is essential for apoptotic regression of hyaloid vessels in mice . (ece-inhibitor.com)
  • In addition, the neovascular intra- and preretinal vessels of hyperoxia-treated P17 and P21 mice labeled strongly for 67LR mRNA. (ulster.ac.uk)
  • Xiaoyi J, Mojon D (2003) Adaptive local thresholding by verification-based multithreshold probing with application to vessel detection in retinal images. (springer.com)
  • in have presented an algorithm for vessel detection in retinal color images which works based on local Radon transform and morphological reconstruction. (scribd.com)