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  • 2017
  • To view and listen to Ben Shaberman's presentation of "Top Retinal Research Advances for 2017," with full slides and audio, click here . (blindness.org)
  • This is Ben Shaberman, director of science communications, at the Foundation Fighting Blindness (FFB), and I'm pleased to present a quick overview of some of the exciting research advances for inherited retinal diseases made during 2017. (blindness.org)
  • therapies
  • Promising gene therapies for inherited retinal diseases (IRDs) - many of which have moved into clinical trials - use viral delivery systems (aka vectors) to get copies of the therapeutic gene to the retinal cells that need them. (blindness.org)
  • Their findings, which may lead to new therapies and improved diagnostics for retinal disease, will appear online in advance of publication in the journal Nature Genetics on January 17. (ucsd.edu)
  • Consequently, well-defined NHP models of heritable retinal diseases, particularly cone disorders that are predictive of human conditions, are necessary to more efficiently advance new therapies for patients. (jci.org)
  • But today, innovative diagnostic testing and breakthrough therapies allow optometrists to focus on retinal disease as a key aspect of our practices. (reviewofoptometry.com)
  • Horama , a French biotech developing gene therapies for rare eye diseases, was established in 2014 as a spin-off of INSERM, France's public scientific and technology institute. (blindness.org)
  • human retinal
  • Pre-clinical studies have demonstrated that retinal implantation of human retinal progenitor cells (hRPC) have the potential to preserve existing photoreceptors, potentially reducing or halting further deterioration of vision. (reneuron.com)
  • We are using proprietary human retinal progenitor cells as the basis of our programme. (reneuron.com)
  • Blindness
  • Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. (springer.com)
  • The Foundation Fighting Blindness and 4D Molecular Therapeutics (4DMT), an innovative leader in viral vector development, have formed a partnership to help companies and researchers quickly obtain and implement high-quality vectors for their retinal gene-therapy development efforts. (blindness.org)
  • The function of cilia has not been understood, but patients with ciliopathies can suffer from a spectrum of problems including retinal blindness, obesity, renal failure, liver fibrosis and mental impairment. (ucsd.edu)
  • The group then tested whether mutations in genes might contribute to retinal blindness in other related diseases. (ucsd.edu)
  • The scientists found that patients carrying a particular genetic alteration were between five and ten times more likely to have retinal blindness, and that some forms of this blindness may be particularly amenable to gene therapy. (ucsd.edu)
  • The Foundation Fighting Blindness is providing $600,000 to a consortium of Israeli scientists working toward the ambitious goal of recruiting and genetically screening every person in Israel with an inherited retinal degenerative disease. (blindness.org)
  • Israel has emerged as an outstanding player in genetic research for retinal diseases," says Stephen Rose, Ph.D., chief research officer, Foundation Fighting Blindness. (blindness.org)
  • optic nerve
  • In most common types of the disease, the optic nerve is damaged by an increase in intraocular pressure (IOP) which blocks fluid drainage through canals in the eye. (utah.edu)
  • genes
  • While researchers around the world have identified more than 200 genes linked to retinal diseases, there are perhaps dozens yet to be discovered. (blindness.org)
  • That's because only about 45 percent of the genes that cause these diseases are known, and the discovery of new genes is a research effort that can take many years. (blindness.org)
  • Finally, the Foundation is funding a number of outstanding researchers, who, thanks to advancing technology, are continually improving their ability to find disease-causing genes and make diagnoses. (blindness.org)
  • cone
  • A. Hayasaka, S. Machida, T. Ishibe, H. Miyamoto, and Y. Tazawa, "Change of the full-field cone and multifocal ERGs after retinal peripapillary cauterization in cats," The Journal of the Iwate Medical Association , vol. 57, pp. 367-382, 2005. (hindawi.com)
  • For example, cone-rod dystrophy affects the macula, the central region of the retina, much in the same way that Stargardt disease does. (blindness.org)
  • cure
  • There is currently no cure, however, the disease can be treated by lowering IOP. (utah.edu)
  • ocular
  • Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular investigators, ophthalmologists, and neuroscientists currently delving into this fascinating field of study. (springer.com)
  • The compounds currently used to treat these diseases are based on large antibodies that cannot penetrate from the ocular surface to the retina, so they must be administered by intravitreal injections. (news-medical.net)
  • In particular, 'efficacy studies have shown that the reduction of NRARP in the retina by means of siRNA leads to the regression of angiogenic retinal lesions and that the observed reductions are equivalent to those of anti-VEGF, which is the current treatment standard for these diseases with ocular injections', stresses the R&D manager. (news-medical.net)
  • Stephen Rose
  • We are pleased with Horama's growing presence and advancements in gene therapy development for inherited retinal diseases," says Stephen Rose, PhD, chief scientific officer at FFB. (blindness.org)
  • People
  • For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. (greenmedinfo.com)
  • As most people affected by retinal diseases know, firsthand, there are relatively few eye doctors who understand and can accurately diagnose those diseases. (blindness.org)
  • Because the retina is essential to vision, many people with retinal diseases usually realize they have a problem when the disease begins affecting the quality of their vision. (utah.edu)
  • This graph shows the total number of publications written about "Retinal Diseases" by people in Harvard Catalyst Profiles by year, and whether "Retinal Diseases" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Retinal Diseases" by people in Profiles. (harvard.edu)
  • There's the likelihood that a new retinal disease gene found in the Israeli population also affects people in other countries and with other ethnic backgrounds," explains Dr. Perlman. (blindness.org)
  • The investigators are now working with researchers worldwide to determine if other people have this particular disease. (rpbusa.org)
  • patient's
  • It can take referrals to several doctors before finding one - often at a Foundation-funded research center - with the knowledge and diagnostic tools necessary to determine which retinal disease is causing a patient's vision loss. (blindness.org)
  • research
  • Mayo Clinic has a long history of research on retinal diseases and cancers of the eye. (mayoclinic.org)
  • Mayo Clinic eye experts combine patient care with research to expand the understanding of retinal conditions. (mayoclinic.org)
  • We hope you'll tune in, share it with your friends, and learn more about the promising new advances in retinal research. (blindness.org)
  • No one in the retinal disease research community brought more passion and commitment to his or her work than Dr. Eliot Berson . (blindness.org)
  • The study was supported by funding from the National Eye Institute of the National Institutes of Health, the Howard Hughes Medicine Institute, and included collaborators from those institutions as well as the London Research Institute (Vascular Biology Laboratory) in the United Kingdom and the Center for Skeletal Disease Research, Grand Rapids, Mich. (cincinnatichildrens.org)
  • Academic research institutions are where most experts in inherited retinal diseases practice, and FFB funds many of them. (blindness.org)
  • Abstract
  • S. Viswanathan and L. J. Frishman, "Evidence that negative potentials in the photopic electroretinograms of cats and primates depend upon spiking activity of retinal ganglion cell axons (abstract)," Society for Neuroscience , vol. 23, p. 1024, 1997. (hindawi.com)
  • diagnoses
  • Another major reason diagnoses are tough is that some conditions can look the same to even a well-trained retinal specialist. (blindness.org)
  • mice
  • The study, to be published online May 29, demonstrates how retinal myeloid cells regulate blood vessel branching in the still-developing retinas of postnatal mice by using the Wnt protein signaling network. (cincinnatichildrens.org)
  • A UC Davis preclinical study in mice showed that when CD34+ cells were in injected into mice with retinal damage, they migrated to the affected tissue. (blindness.org)
  • Symptoms
  • Symptoms of retinal hemorrhage include blurred vision, the sudden loss of vision in one eye, and seeing rings, dark spots or flashing lights. (reference.com)
  • Researchers
  • While the primary goal of the study is to assess safety, the researchers are also observing the CD34+ BMSC's affect on vision and retinal structure. (blindness.org)
  • Get our email updates filled with the latest news from our researchers about preventing vision loss, treating eye disease and even restoring sight. (rpbusa.org)