Results suggest that luteolin. Medical search. Frequent questions

In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators. (alstuttu.org)
CONCLUSION: Our findings provide further support for apigenin and luteolin's anti-inflammatory effects and suggest that these flavonoids may have neuroprotective/disease-modifying properties in various neurodegenerative disorders, including Alzheimer's disease (AD). (alstuttu.org)
Although previous research suggests that flavonoids like Luteolin have poor bioavailability, current research has found that, indeed, Luteolin can bind with proteins and carbohydrates increasing uptake, therefore, increasing antioxidative activity in our bodies. (nstchemicals.com)
For example, natural flavonoids regulate the immune response, while luteolin inhibits both microglia and the unique tissue immune cells, or mast cells. (meresearch.org.uk)
Epidemiological studies suggest that a high dietary intake of flavanols, a subclass of flavonoids, is associated with reduced risk of vascular disease. (raysahelian.com)
Flavonoids are polyphenolic plant compounds that can inhibit mast cell activity and resulting histamine release. (professionalsupplementcenter.com)
Two of the most beneficial flavonoids are quercetin and luteolin. (professionalsupplementcenter.com)
It's simply a concentrated amount of the flavonoids Luteolin, Quercetin and Rutin. (blogspot.com)
In the project 2, the mechanism of the protective effects of two flavonoids, namely luteolin and quercetin, on APAP induced hepatotoxicity was investigated in the in vitro settings using HLMs. (tufts.edu)
Luteolin was discovered to be one of the flavonoids that can inhibit xanthine oxidase in an in vitro investigation. (vitanergy.ca)

Dr. Pamela J. Mink of Exponent, Inc., used three newly available databases from the U.S. Department of Agriculture to determine the flavonoid contain of foods, the researchers analyzed results of food questionnaires on diet from 34,489 postmenopausal women participating in the Iowa Women's Health Study. (raysahelian.com)
And the barley sprout extract of the nutrient solution treatment group had higher total flavonoid content and luteolin content. (kspbtjpb.org)
Celery contains a flavonoid called luteolin. (medicalnewstoday.com)
The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. (heightquest.com)
Furthermore, luteolin is a flavonoid that may lower uric acid synthesis directly. (vitanergy.ca)
Both flavonoid subunits of this compound, naringenin and luteolin, equally competed with HMGCoA with K i of 83.58 ± 4.37 mM and 83.59 ± 0.94 μM, respectively, and were also non-competitive with NADPH (K i of 182 ± 0.67 μM and 188 ± 0.14 μM, respectively). (houstonmethodist.org)

Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. (omicsdi.org)

Moreover, chamomile extract showed potent inhibition against aldose reductase (ALR2), with an IC50 value of 16.9 microg/mL, and its components, umbelliferone (1), esculetin (3), luteolin (6), and quercetin (7), could significantly inhibit the accumulation of sorbitol in human erythrocytes. (nih.gov)
In conclusion, these results demonstrate that artichoke extracts may inhibit hepatic cholesterol biosynthesis in an indirect but efficient manner and, thus, may contribute via this action to the recently confirmed hypolipidemic influence of this phytopharmacon in man. (aspetjournals.org)
It has been proved that luteolin can lower oxidative stress, reduce inflammation and inhibit several enzymes in the brain that could lead to seizures. (nstchemicals.com)
In addition, although both luteolin and quercetin inhibited individually several UGT isoforms in vitro, they didn't inhibit the overall APAP glucuronidation. (tufts.edu)
Luteolin may lower uric acid levels and inhibit the formation of inflammatory nitric oxide. (vitanergy.ca)
The transcriptomic findings exhibited that the differentially expressed genes of fungus after rosmarinic acid intervention were mainly enriched in the carbon metabolism pathway, while the proteomic findings suggested that rosmarinic acid could inhibit the average growth of Trichophyton mentagrophytes by interfering with the expression of enolase in the glycolysis pathway. (biomedcentral.com)

Apigenin and luteolin concentration-dependently suppressed IFN-γ-induced CD40 expression. (alstuttu.org)
Apigenin and luteolin also suppressed microglial TNF-α and IL-6 production stimulated by IFN-gamma challenge in the presence of CD40 ligation. (alstuttu.org)
In addition, apigenin and luteolin markedly inhibited IFN-γ-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. (alstuttu.org)
RESULTS: Apigenin and luteolin concentration-dependently suppressed IFN-gamma-induced CD40 expression. (alstuttu.org)
In addition, apigenin and luteolin markedly inhibited IFN-gamma-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
Beyond apigenin and luteolin, celery contains other plant compounds that have powerful antioxidant properties. (medicalnewstoday.com)

Screening of several known constituents of artichoke extracts revealed that cynaroside and particularly its aglycone luteolin were mainly responsible for inhibition, whereas chlorogenic acid was much less effective and caffeic acid, cynarin and other dicaffeoylquinic acids were without significant influence. (aspetjournals.org)
In addition, the 6 selected anti-TB drugs produced minimal inhibition of acetaminophen glucuronidation suggesting that DDI between APAP and the selected drugs is unlikely. (tufts.edu)

Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner. (alstuttu.org)
As concerns Ca2+ signalling, luteolin and quercetin inhibited Ca2+ influx strongly, although baicalein did slightly. (alstuttu.org)
With regard to PKC signalling, luteolin and quercetin inhibited PKC translocation and PKC activity strongly, although baicalein did slightly. (alstuttu.org)

Clinical studies have also shown that the consumption of certain flavanol-rich foods (e.g., cocoa, tea, red wine), as well as intake of the individual flavanol epicatechin, can result in improvement in a number of parameters associated with vascular disease, including improved endothelial function, reduced platelet reactivity, and reduced oxidative stress. (raysahelian.com)

Biochemical and pharmacological studies revealed that the anti-inflammatory effect of luteolin was accompanied by down-regulation of extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK), Akt and Src. (alstuttu.org)
Some common skin diseases, such as psoriasis, are characterized by hyperproliferation accompanied by inflammatory reactions, suggesting that molecules with topical anti-inflammatory and ROS scavenging abilities may be useful for their treatment. (omicsdi.org)

Luteolin being a prime example of this compound class has shown an ability to act as an antioxidant. (nstchemicals.com)
In order to be a successful antioxidant, Luteolin has to be able to counteract several reactive molecules like reactive oxygen and nitrogen species. (nstchemicals.com)
Super Carnosine protects DNA with powerful antioxidant properties plus luteolin, thiamine (vitamin B1) and benfotiamine. (vitacart.com)

These results suggest an indirect modulation of hydroxymethylglutaryl-CoA-reductase activity as the most likely inhibitory mechanism of the artichoke extracts. (aspetjournals.org)
These results suggest the mediation of mPFC‐LHb circuit in the inhibitory effects of acupuncture on cocaine psychomotor activity in rats. (researchgate.net)
Luteolin exerted an inhibitory effect on transcription factor activity including nuclear factor κB (NF-κB), signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF-1) in LPS/IFN-γ-activated BV-2 microglial cells. (alstuttu.org)
An increasing number of foods have been reported to have platelet-inhibitory actions, and research with a number of flavanol -rich foods, including, grape juice, cocoa and chocolate , suggests that these foods provide some protection against thrombosis. (raysahelian.com)
Following a preliminary screening using carboxymethylated transferrin as substrate, we focused our interest on luteolin due to its inhibitory effect on ADAMTS-4 and ADAMTS-5 activities using aggrecan and fluorogenic peptides as substrates . (heightquest.com)

The authors of an article published in 2009 suggested that luteolin may have anticancer properties - it may help prevent the spread of cancer cells and induce cell death. (medicalnewstoday.com)

Given the potential involvement of immune activation genes, the researchers conclude by suggesting some pharmacological agents that might be considered in the management of ME/CFS and/or long COVID. (meresearch.org.uk)
Next, we established effects of luteolin in the presence of pharmacological inhibitors of PI3K/AKT, ERK1/2 MAPK, and mTOR on proliferation of JAR and JEG-3 cells. (ewha.ac.kr)

The top five potential antifungal compounds in P. frutescens screened by network pharmacology are: progesterone, luteolin, apigenin, ursolic acid and rosmarinic acid. (biomedcentral.com)

The KEGG suggested that PI3K-AKT, Estrogen, FoxO, MAPK, HIF-1 signaling pathway may play a significant role in treating asthma. (researchsquare.com)

Results of the present study revealed that luteolin decreased viability of JAR and JEG-3 cells, which are valuable placental models, in a dose-dependent manner, and it induced apoptosis and loss of mitochondrial membrane potential in JAR and JEG-3 cells. (ewha.ac.kr)

From our results we conclude that activated glutathione (GSH) metabolism may participate in these protective effects. (thieme-connect.com)
Research yet to be confirmed also suggests that taking resveratrol, curcumin, glutathione, luteolin, hesperidin and the herbs baicalin and echinacea, might augment our immune response and minimise any damage that might result from vaccination. (eternalhealth.org)
Comparison of real-time PCR and transcriptomics results showed that the trends of gene expression in glycolytic, carbon metabolism and glutathione metabolic pathways were identical. (biomedcentral.com)

Luteolin concentration-dependently abolished LPS/IFN-γ-induced NO, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production as well as inducible nitric oxide synthase (iNOS) protein and mRNA expression. (alstuttu.org)
Other studies suggest more positive effects of luteolin like improving cardiomyocyte function, regulates nitric oxide production and prevents damage from its free radicals, improves cardiac functions in case of heart failure and more. (nstchemicals.com)
In one animal study, researchers looked at how luteolin affected the production of nitric oxide from uric acid. (vitanergy.ca)
The researchers discovered that celery seed luteolin inhibited the generation of nitric oxide from uric acid. (vitanergy.ca)

Collectively, our results demonstrate the great potential of plant-derived compounds as antibacterial agents against R. solanacearum, providing alternative ways for the efficient control of bacterial wilt. (bvsalud.org)
These results suggest that luteolin could be employed as a prototypic modifying disease-agent to create new chondroprotective compounds aimed to specifically block the unwanted aggrecanase activities in arthritic diseases. (heightquest.com)

Collectively, these results showed that luteolin plays an important role in the treatment of human choriocarcinoma cells by inhibiting the PI3K/AKT/mTOR/SREBP cascade and expression of lipogenic genes. (ewha.ac.kr)
Collectively, these findings suggest that S1P lyase is a modulating factor for proliferation and differentiation, and support its potential as a therapeutic target for psoriasis in human keratinocytes. (omicsdi.org)

Luteolin is a commonly found natural chemical that can be found in several plant species like carrots, peppers, celery, cucumbers and many more. (nstchemicals.com)
Celery is also a good source of fiber, and results of a 2016 Cochrane review suggested that people with a high fiber intake may have lower blood pressure than those on a low fiber diet. (medicalnewstoday.com)
These findings suggest that celery seed may aid in the reduction of gout-related inflammation. (vitanergy.ca)
On the other hand, celery stems contain fiber, and some studies suggest that increasing dietary fiber can help prevent gout attacks. (vitanergy.ca)

The balance between keratinocyte proliferation, differentiation, and death is essential, and its perturbation can result in pathological changes. (omicsdi.org)

RESULTS@#The target prediction results showed that there were 19 common targets between the 268 potential targets of methylene blue and 1 865 Pg proteins. (bvsalud.org)
Results showed that OPD' (1 μmol·L-1) significantly induced the expression of ferroptosis-related proteins, the contents of Fe2+, ROS, and GSH-Px were increased, and the content of GSH were decreased. (bvsalud.org)
16 Furthermore, its oxidation products can act as electrophiles to bind specific proteins , resulting in the modification of their cellular functions. (rsc.org)

The results also suggested that the PI3K/AKT pathway was inhibited by luteolin treatment of JAR and JEG-3 cells in a dose- and time-dependent manner. (ewha.ac.kr)

As a result, it gives a boost to your testosterone levels, strengthens your muscles, and helps you lose weight. (gentleman-sa.com)
The data from the Iranians suggests that the optimal dose of Alpinia galanga to raise testosterone levels may be less than the tested 100 milligrams per kilo of body weight. (ergo-log.com)

Thus, the beneficial effects of luteolin and quercetin against APAP induced hepatotoxicity possibly result from their properties of being able to partially block the CYP-mediated oxidation and to drive the reaction via APAP glucuronidation. (tufts.edu)

Preliminary results suggest that treatment with kinase inhibitors may improve symptoms of depression and cognitive impairment (1). (aad.org)

Luteolin is a natural compound known for its anticancer effects on various human cancers by regulating signal transduction cascades. (ewha.ac.kr)
However, the effects of luteolin on human placental choriocarcinoma are not known. (ewha.ac.kr)
We compared viability of JAR and JEG-3 cells in response to luteolin alone or in combination with other chemotherapeutic drugs (etoposide, cisplatin, and paclitaxel) and found that luteolin has synergistic effects with the conventional chemotherapeutic drugs as an anticancer agent. (ewha.ac.kr)
Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
Since ADAMTS4 is upregulated by LSJL and ADAMTS4 has anti-chondrogenic effects luteolin may be able to nullify some of the side effects. (heightquest.com)

But not only that, several research have suggested that Luteolin's structure is indeed favorable to induce several cellular pathways. (nstchemicals.com)

Obesity is a known risk factor in the development of severe asthma, and work has suggested that IL-6 plays a role in regulating disease severity in obesity-related asthma. (wikipedia.org)

Expression levels of both SREBP1 and SREBP2 mRNAs were significantly reduced, but only SREBP1 protein was influenced by luteolin. (ewha.ac.kr)
Actual results may vary significantly and are dependent on individuals. (vitacart.com)
The result is that the per capita household health expenditure forecasts can be significantly improved at the 0.05 threshold by the per capita public health expenditure and by the per capita health expenditure forecasts of the Government external technical and financial partners. (csnrdc.net)

both luteolin and quercetin strongly inhibited APAP sulfation. (tufts.edu)

Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)

Indeed, luteolin also efficiently blocked the insulin effect on cholesterol biosynthesis. (aspetjournals.org)

Luteolin has been quite extensively studied for its neuroprotective properties. (nstchemicals.com)
12,13 However, its catechol structure ( o -dihydroxyl structure in the B-ring) leads to pro-oxidant properties by generating ROS during its oxidation process, which may result in quinone toxicity. (rsc.org)

Study showed the seagrass to be high in kilocalorie content, with high content of phenols in the leaves and rhizomes, suggesting a potential for feed/food. (stuartxchange.org)
As we discussed, the antioxidative potential of Luteolin could be a great factor for it to be a tool as an anticancer prevention tool and therapeutic agent. (nstchemicals.com)
Here we investigate the potential of the flavone Luteolin-7-glucoside (LUT-7G) as a treatment for psoriasis. (omicsdi.org)
These results demonstrate the potential for such treatments to enhance their quality of life and employment chances. (epiphanyasd.com)

The review included 26 studies in people with ME/CFS and 71 studies in people with COVID-19, and significant results were found for 429 genes in ME/CFS and for 97 genes in COVID-19. (meresearch.org.uk)

In addition, these inhibitors were used to verify phosphorylation of AKT, GSK3beta, and ERK1/2 and to confirm mechanisms regulated by luteolin in JAR and JEG-3 cells. (ewha.ac.kr)

3-n-butylphthalide of luteolin (3nB) beta-selinene involvement in inflammation and uric acid generation, which is a driving force behind the severity of gout attacks, has been studied. (vitanergy.ca)
This research reveals that luteolin may offer some protection against uric acid-induced gout inflammation. (vitanergy.ca)

A lab-created cocoa drink with a high flavonol content, created by Mars, Inc., appears to improve normal age-related memory loss, a small study suggests, Oct. 26, 2014 Nature Neuroscience. (raysahelian.com)
Therefore, this study suggests that nutrient input is effective for increasing polyphenol content and increasing production in barley sprout hydroponics. (kspbtjpb.org)

Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis vulgaris. (omicsdi.org)
This fundamental biological difference suggests that "therapeutic avenues may be drastically different for these subtypes," says lead investigator Flora Vaccarino , professor of neuroscience at Yale University. (epiphanyasd.com)

Luteolin reduces IL-6 production in some neurons. (wikipedia.org)

Luteolin is an interesting naturally occurring bioflavinoid. (alstuttu.org)
In summary, luteolin is an interesting naturally occurring bioflavinoid that has been shown to have a myriad of functions in various models that could potentially be useful in slowing progression in patients with ALS. (alstuttu.org)

We also determined levels of SREBP1 and SREBP2 expression to investigate regulatory functions of luteolin in lipid metabolism in JAR and JEG-3 cells. (ewha.ac.kr)

Luteolin has also been looked at as a possible treatment for Autism spectrum disorder, Alzheimer's disease, Parkinson's disease, multiple sclerosis, diabetes-associated cognitive decline, brain injury from trauma and many more. (nstchemicals.com)
As a result, the growth rate of the nutrient solution treatment group was faster than that of the control group. (kspbtjpb.org)

Over time, this can result in gradual accumulation of senescent cells. (neurohacker.com)

The experimental results show that OPD can interfere with the ferroptosis caused by OPD', and then have a protective effect on H9c2 cells. (bvsalud.org)

Luteolin may help reduce neuroinflammation and cognitive dysfunction or brain-fog. (meresearch.org.uk)

Studies on flies and rodents suggest that cutting intake of one particular amino acid, called methionine, lengthens life to a similar degree as calorie restriction . (qualitycounts.com)
Our previous studies have suggested that acupuncture at Shenmen (HT7) points modulates mesolimbic reward system in order to suppress drug‐induced addiction behaviours. (researchgate.net)
Until carefully controlled, well-designed human efficacy and safety studies are performed, ALSUntangled does not support the use of luteolin or any luteolin-containing products in patients with ALS. (alstuttu.org)

Since these two types are practically difficult to distinguish, aging can be referred to as a biological-psychological process during the final stages of individual growth and development, which is the inevitable result of a combination of many pathological, physiological, and psychological processes. (frontiersin.org)

Neurons are the building blocks of the nervous system and their impairment of their functions could result in neurodegenerative disorders. (mdpi.com)
As we get older, healthy creation and removal functions tend to shift in ways that result in gradual increases in the proportion of senescent cells in some, often many different tissues-removal functions fall behind. (neurohacker.com)

Moreover, incubation of mouse chondrogenic ATDC5 cells in the presence of luteolin clearly decreases the release of aggrecan fragments mediated by aggrecanases under the same conditions in which aggrecanolysis mediated by MMPs is detected. (heightquest.com)

Anatomy26

Organisms19

Diseases14

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes37

Technology, Industry, Agriculture1

Information Science1

Health Care3

Flavonoids10

Flavonoid6

Inhibits1

Inhibit6

Apigenin and luteolin7

Inhibition2

Quercetin inhibited3

Oxidative stress1

Anti-inflammatory2

Antioxidant3

Inhibitory5

Anticancer properties1

Pharmacological2

Rosmarinic acid1

Signaling pathway1

Apoptosis1

Glutathione3

Nitric4

Compounds2

Collectively2

Celery4

Proliferation1

Proteins3

PI3K-AKT1

Testosterone levels2

Beneficial1

Kinase1

Effects5

Induce1

Asthma1

Significantly3

Strongly1

Findings suggest1

Efficiently1

Properties2

Potential4

Found1

Inhibitors1

Inflammation2

Study suggests2

Therapeutic2

Production1

Naturally2

Investigate1

Treatment2

Accumulation1

Effect1

Cognitive1

Studies3

Pathological1

Functions2

Release1