• BLAST is more time-efficient than FASTA by searching only for the more significant patterns in the sequences, yet with comparative sensitivity. (wikipedia.org)
  • Input sequences (in FASTA or Genbank format), database to search and other optional parameters such as scoring matrix. (wikipedia.org)
  • When confronted with the task of finding homology to large numbers of sequences, database searching tools such as Blast and Fasta generate prohibitively large amounts of information. (aaai.org)
  • A BLAST search enables a researcher to compare a subject protein or nucleotide sequence (called a query) with a library or database of sequences, and identify database sequences that resemble the query sequence above a certain threshold. (wikipedia.org)
  • It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
  • He has contributed significantly to the state-of-the-art by frequently presenting novel ideas, methods and results and have pioneered several important proof-of-concepts relevant for the project, including the conceptualization of DNA, RNA and protein variation to Variation Ontology (Vihinen, Genome Res . (lu.se)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • METHODS: To identify expressed TNFSF genes, we searched a computer database of ~50,000 rainbow trout expressed sequence tags generated at the National Center for Cool and Cold Water Aquaculture. (usda.gov)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • In bioinformatics, BLAST (basic local alignment search tool) is an algorithm and program for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences. (wikipedia.org)
  • The sequences were analyzed in silico by BLAST searching for homologies with other DNAs deposited in the local and public data bases. (who.int)
  • In case of homologies identified with the other Leishmania species, these sequences were compared to L. major and/or L. tropica using MEGA software. (who.int)
  • Our proposed framework consists of two main parts: homology analysis, where we compute the Betti number of the target topological space, and Shapley value calculation, where we decompose the topological features of a complex built from data points to individual points. (mit.edu)
  • Given a henselian pair (R,I) of commutative rings, we show that the relative K-theory and relative topological cyclic homology with finite coefficients are identified via the cyclotomic trace K→TC. (ku.dk)
  • We deduce that the cyclotomic trace is an equivalence in large degrees between p-adic K-theory and topological cyclic homology for a large class of p-adic rings. (ku.dk)
  • This is indeed a problem about a basic question in evolutionary analyses, that is, the statement of homology. (bvsalud.org)
  • au: Bourbaki & ti: Algebra Search for au thor and ti tle . (zbmath.org)
  • This is also important in order to hypothesize primary homologies ( sensu de Pinna, 1991, 1997), that is, topographical similarities based on Remane's criteria of homology (adapted to the behavioural domain - see Greene, 1994). (bvsalud.org)
  • BLAST, which The New York Times called the Google of biological research, is one of the most widely used bioinformatics programs for sequence searching. (wikipedia.org)
  • When performing a BLAST on NCBI, the results are given in a graphical format showing the hits found, a table showing sequence identifiers for the hits with scoring related data, as well as alignments for the sequence of interest and the hits received with corresponding BLAST scores for these. (wikipedia.org)
  • If one is attempting to search for a proprietary sequence or simply one that is unavailable in databases available to the general public through sources such as NCBI, there is a BLAST program available for download to any computer, at no cost. (wikipedia.org)
  • We identified zebrafish and Fugu TNFSF 13b homologues by genomic DNA database searches and determined that the predicted proteins share 68% and 76% sequence identity with trout TNFSF 13b. (usda.gov)
  • Areas covered include sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)
  • We describe the predatory sequence of P. phalangioides when using gumfoot lines, and discuss possible behavioural homologies between pholcids and araneoids. (bvsalud.org)
  • Dr. Seymour continued, "Also at WORLD, we presented the details of our optimized gene therapy development candidate for MLD, which showed the ability to cross the blood-brain-barrier following a single I.V. administration in the murine disease model and resulted in levels of enzyme activity predicted to lead to efficacy in vivo. (advfn.com)
  • Therefore, the present study proposes the three‑dimensional structure of the helicase/protease enzyme of SPONV through homology modeling, using the crystal structure of the Dengue virus‑4 helicase/protease of the same viral family as a template. (spandidos-publications.com)
  • Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
  • The results will be compared between the species and their different types of ligules, being subsequently confronted with the available data in the literature and discussed inside Poaceae. (fapesp.br)
  • Because many laboratories use tests that do not routinely distinguish Mycobacterium tuberculosis from closely related species, these laboratories report culture results as being positive or negative for " Mycobacterium tuberculosis complex. (cdc.gov)
  • These 7 species are approximately identical in DNA homology studies. (cdc.gov)
  • The results illuminate the molecular mechanism of a critical biochemical step in the licensing of eukaryotic replication origins. (imperial.ac.uk)
  • It groups beta-lactamases by class on the basis of molecular homology. (msdmanuals.com)
  • A region of the genome of BVDV recovered from PI crias was sequenced to determine genetic homology. (avma.org)
  • Infections in 3 of the 4 herds with PI crias were linked as evidence by the genetic homologies of viruses. (avma.org)
  • Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today the presentation of preclinical data that supports the targeted, prophylactic immunosuppression regimen in the ongoing pheEDIT gene editing clinical trial in adults with phenylketonuria (PKU) and juMPStart gene therapy trial in adults with Hunter syndrome (MPS II). (advfn.com)
  • RESULTS: Here, we report the characterization of a cDNA, 1RT126I22, which contains a TNF homology domain. (usda.gov)
  • the completely developed leaves, using metodologies like optical microscopy and scanning electron microscopy, searching for a more robust characterization of the character (caracterização do character? (fapesp.br)
  • A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
  • the advantages of using a murine model included small size, easy breeding, short time between generations, production of identical offspring, and the fact that much of their genome has been mapped for homologies with the human genome. (cdc.gov)
  • Quasi* map* py: 1989 The resulting documents have p ublication y ear 1989 . (zbmath.org)
  • [ 1 ] Acquired FXIII deficiencies, which result from autoantibodies against FXIII subunits, are extremely rare but may produce severe bleeding diatheses. (medscape.com)
  • 3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)
  • That's scale - the amount of data I can afford to carry with me has changed dramatically, and as a result, my expectations about what's normal have changed. (scienceblogs.com)
  • Conclusions and Clinical Relevance -Results confirmed the importance of BVDV infections in alpacas in the United States and highlighted the importance of determining the BVDV infection status of animals before they are commingled to limit exposure of herds to BVDV infection. (avma.org)
  • Abstracts of all articles retrieved in the electronic search were evaluated for their relevance. (bvsalud.org)
  • Homology also shared additional details of the optimized, in vivo gene therapy candidate HMI-204 for metachromatic leukodystrophy (MLD) during the 19th Annual WORLDSymposium™ Meeting. (advfn.com)
  • The results obtained with in vitro and in vivo models provided evidence for greater passage of aprotinin across the BBB than of holo-transferrin. (aspetjournals.org)
  • Various software resources are also required to enable users to conveniently connect their experimental results with publicly, and application specific, bioinformatics databases and tools. (lu.se)
  • Enter search terms to find related medical topics, multimedia and more. (msdmanuals.com)
  • The results found relevant by the system are presented in a very concise and clear way, so that the homology can be assessed with minimum effort. (aaai.org)
  • RESULTS: It was found that the fluorescence expression level decreased and the ß-tubulin structure of SANCs was damaged after H/R treatment. (bvsalud.org)
  • Different immunoreactivity results were found in the studies. (bvsalud.org)
  • These tasks were approached with computational methods: homology modeling, docking, ligand-based pharmacophore modeling and virtual screening. (helsinki.fi)
  • and probable cases of primary structural homology. (fapesp.br)
  • We conducted a systematic review of the literature, using expanded search parameters. (researchgate.net)
  • review of the literature, using expanded search parameters. (researchgate.net)
  • For a result to be included in the search result, is it required to fit all added including parameters (in at least one group) and not fit all parameters in one of the excluding groups. (diva-portal.org)
  • A distinct group of 22q13 monosomies has been reported that result from the formation of a ring chromosome which combines loss of some long arm material with loss of part of the short arm, with no clinical consequences. (bmj.com)
  • This system with the two main parts and their groups makes it possible to combine two (or more) distinct searches into one search result, while being flexible in removing results from the final list. (diva-portal.org)
  • Advanced search is divided into two main parts, and one or more groups in each of the main parts. (diva-portal.org)
  • The main parts are the "Search for" (including) and the "Remove from search" (excluding) part. (diva-portal.org)
  • Empirical studies show that when the zero-dimensional Shapley homology is used on neighboring graphs, samples with higher influence scores have a greater impact on the accuracy of neural networks that determine graph connectivity and on several regular grammars whose higher entropy values imply greater difficulty in being learned. (mit.edu)
  • These results show that engineered acetogens enable sustainable, high-efficiency, high-selectivity chemicals production. (nature.com)
  • This set of rules proved to be robust for most cases and gives high fidelity separation between real homologies and spurious matches. (aaai.org)
  • However, some cases result in more severe disease, including febrile syndrome, Vascular leakage (shock) or neurological impairments. (spandidos-publications.com)
  • Research to practice potential : results of this study will emphasize importance of cleaning turnout gear, and proper handling of AFFF waste. (cdc.gov)
  • We are pleased to share our work outlining the impact immunosuppression regimens had on outcomes following AAVHSC dosing in NHPs, as it contributes to a key area of research in the gene therapy and gene editing field," stated Albert Seymour, Ph.D., President and Chief Executive Officer of Homology Medicines. (advfn.com)
  • the amount of information that we use on a daily basis has increased dramatically, and the amount of dramatic, fundamental change that has resulted is both amazing, and amazingly unnoticed by most people. (scienceblogs.com)
  • The docking results revealed that the compounds orientate differently in the enzymes. (helsinki.fi)
  • However, with the appearance of isolates resistant to these compounds, it is necessary to search for new alternatives to control this pathogenic fungus. (bvsalud.org)
  • Table representation of search results timeline featuring number of search results per year. (nih.gov)
  • so: Eur* J* Mat* Soc* cc: 14 Search for publications in a particular so urce with a Mathematics Subject C lassification c ode ( cc ) in 14 . (zbmath.org)
  • The homology model of 11β-HSD2 was constructed using SwissModeler and it showed satisfying superimposition both with is template 17β-HSD1 and 11β-HSD1. (helsinki.fi)
  • The interaction pair for this hydrogen bond donor feature was not observed in the homology model. (helsinki.fi)
  • Subcellular Distribution and Chemical Forms of Cadmium in the Medicine Food Homology Plant Platycodon grandiflorum (Jacq. (techscience.com)
  • is a renowned medicine food homology plant, reports of excessive cadmium (Cd) levels are common, which affects its safety for clinical use and food consumption. (techscience.com)
  • Results: In this study, a total of 4311 under-five admitted with suspected bacterial meningitis from 2012 to 2021 were enrolled. (bvsalud.org)