Results live mutants. Medical search. Frequent questions

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant. (jci.org)
We recently described transgenic mice that express point-mutant human K18 (Ku, N.-O., S. Michie, R.G. Oshima, and M.B. Omary. (jci.org)
Here we show that mutant K18 expressing transgenic mice are highly susceptible to hepatotoxicity after acute administration of acetaminophen (400 mg/Kg) or chronic ingestion of griseofulvin (1.25% wt/wt of diet). (jci.org)
The predisposition to hepatotoxicity results directly from the keratin mutation since nontransgenic or transgenic mice that express normal human K18 are more resistant. (jci.org)
Our results indicate that hepatocyte intermediate filament disruption renders mice highly susceptible to hepatotoxicity, and raises the possibility that K18 mutations may predispose to drug hepatotoxicity. (jci.org)
Injecting the virus into the brains of mice that make mutant huntingtin improves their ability to move their limbs, although it does not prolong their lives. (scienceblog.com)
Although other researchers have shown that various intrabodies can protect cells from mutant huntingtin, the Emory team was the first to examine the effects of an intrabody in living mice, says senior author Xiao-Jiang Li, PhD, professor of human genetics at Emory University School of Medicine. (scienceblog.com)
Even though the intrabody only travels within the cytoplasm, it still alleviated the motor problems of mice that make mutant huntingtin when injected into the striatum, the scientists found. (scienceblog.com)
Embryonic lethality of mutant mice deficient in the p116 gene. (nih.gov)
Furthermore, the results of studies using HGF‑overexpressing mice have indicated the therapeutic potential of HGF for various types of disease and injury. (spandidos-publications.com)
Double negative thymocytes were isolated from C57BL/6J mice and transduced with retroviral vectors containing mutant hIL7R plus hTLX3 , or the genes alone. (confex.com)
Mice injected with muthIL7R-hTLX3 cells, but not the controls ( wthIL7R-hTLX3 or mutIL7R alone ) developed leukemia approximately 3 weeks post injection, characterized by GFP expressing T-cells in blood, spleen, liver, lymph nodes and bone marrow. (confex.com)
Phenotypic analysis revealed a higher CD4-CD8- T cell population in the blood, bone marrow, liver and spleen compared in the mutant hIL7R + hTLX3 mice compared with mice injected with mutant IL7R alone indicating that the resulting leukemia from the combination mutant hIL7R plus hTLX3 shows early arrest in T-cell development. (confex.com)
We also screen mutants directly in mice for those unable to colonize or persist in the normal target organs (liver, kidney and spleen). (hopkinsmedicine.org)
To evaluate their potential during hepatic gene therapy, C57BL/6 mice were administered with wild-type or optimal mutant AAVrh.10 and the luciferase transgene expression was documented by serial bioluminescence imaging at 14, 30, 45, and 72 days post-gene transfer. (nih.gov)
Using rats and mice genetically modified to carry normal or disease-mutant versions of human SOD1, a team of researchers led by Timothy M. Miller, M.D., Ph.D., Washington University, St. Louis, MO, discovered that newer versions of the drug may be more effective at treating ALS than the earlier one that had been tested in a phase 1 clinical trial. (nih.gov)
For instance, injections of the newer versions were more efficient at reducing normal, human SOD1 mRNA levels in rats and mice and they helped rats, genetically modified to carry a disease-causing mutation in SOD1, live much longer than previous versions of the drug. (nih.gov)
Injections of the new drugs also delayed the age at which mice carrying a disease-mutant SOD1 gene had trouble balancing on a rotating rod and appeared to prevent muscle weakness and loss of connections between nerves and muscles, suggesting it could treat the muscle activation problems caused by ALS. (nih.gov)

These findings may contribute to the development of therapies for the liver disorders and HCC associated with pre-S2 deletion mutations among HBV carriers. (tmu.edu.tw)
We are now sudying in the clinic three highly innovative RAS(ON) Inhibitors derived from our pioneering tri-complex inhibitor platform that we believe have complementary profiles - RMC-6236 (RAS MULTI ) for patients with cancers caused by a wide range of RAS mutations, and the mutant-selective compounds RMC-6291 (KRAS G12C ) and RMC-9805 (KRAS G12D ) for patients with cancers harboring selected mutations. (kdvr.com)
Credit: Courtesy of wikimedia Scientists had previously found that mutations in the Indy (I'm not dead yet) gene in male Drosophila from a particular genetic background result in flies with doubled lifespan. (the-scientist.com)
The results showed that patients carrying TDP-43 mutations with a longer half-life developed the disease at an earlier age. (medicalxpress.com)
on the other hand, mutations in mutants 53,54. (bioskinrevive.com)
The results, published in the Journal of Clinical Investigation, suggest the newer version of the drug may be effective at treating an inherited form of the disease caused by mutations in SOD1. (nih.gov)
and (4) the appearance of mutations in SARS-CoV-2 proteins, which raise the specter of vaccine escape mutants. (cdc.gov)

In group III, the iron articles Furosemide in choriocarcinoma hypodermal tumors is certainly significantly less than that in spleen or liver ( 0.05). (fabretp.org)
[ 12 ] In his review of liver tumors and tumorlike liver lesions, Edmondson included a report of a 14-year-old girl with an unusually long survival following hepatic resection for liver cancer. (medscape.com)
And what we end up seeing from a practical perspective is when these patients with low-grade tumors are treated with radiation therapy, as they live for a number of years we can see that there is diffuse atrophy and wear and tear on the white matter tract in the brain, and that's something we desperately want to prevent in this patient. (medscape.com)
Adjuvant chemoradiotherapy has become the standard of care for patients with IDH-mutant grade 3 gliomas and patients with IDH-mutant grade 2 tumors who are thought to be a high risk for early progression. (medscape.com)
Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)

By removing this enzyme other proteins fail to work properly and the resulting mutant has the wrong shape to burrow through the stomach wall of the female Anopheles mosquito and pass on the disease to humans. (nottingham.ac.uk)
Mutant proteins have a region consisting of the same amino acid (glutamine) many times, called poly-glutamine, which makes the proteins clump together inside brain cells. (scienceblog.com)
Our goal here was to create a tool that could distinguish between the accumulation of mutant proteins in the nucleus and the cytoplasm," he says. (scienceblog.com)
Recent evidence indicates that altered degradation rate of mutant proteins represents a pathogenic mechanism underlying genetic diseases. (frontiersin.org)
Accelerated disease onset with stabilized familial Amyotrophic Lateral Sclerosis (ALS)-linked mutant TDP-43 proteins. (medicalxpress.com)
The dual mutant, however, displays a lot longer and unregulated telomeres, indicating that both proteins take part in choice regulatory systems 32,34. (bioskinrevive.com)

We are trying to identify virulence genes (genes that evolved in response to the host environment) by screening transposon mutants of C. glabrata for mutants that are specifically altered in adherence to epithelial cells, in survival in the presence of macrophages and PMNs. (hopkinsmedicine.org)
The SIR complex: Due to the heterochromatic nature of telomeres, in many organisms genes located close to telomeres undergo silencing (also called mutants). (bioskinrevive.com)
By CRISPR-Cas9 genome editing, the researchers developed mutant plants that didn't contain functional TPC1, TPC2, or TPC3 genes and double mutant plants that lack functions of both TPC2 and TPC3 genes. (sciencedaily.com)

In particular, the presence of pre-S2 deletion mutants is an important risk factor associated with cirrhosis and HCC. (tmu.edu.tw)
Excessive alcohol consumption causes alcoholic liver disease, which progresses from fatty liver to alcoholic steatohepatitis, cirrhosis, and ultimately hepatocellular carcinoma (HCC). (nature.com)
The more typical form of hepatocellular carcinoma is often associated with active hepatic inflammation, hepatitis B or C viral infection, alcohol-related liver disease, nonalcoholic fatty liver disease (NAFLD), cirrhosis from any other cause, or dietary aflatoxin B1. (medscape.com)
cirrhosis and liver cancer and require medical care. (cdc.gov)

The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)

The results of the detected gene sequencing in all of the infected patients in the latest outbreak were highly homologous, all from variants detected in India, Chen said. (globaltimes.cn)
Studies addressing the combinations of mutant IL7Ra plus TLX3 overexpression indicates in vitro growth advantage, suggesting this gene as potential collaborative candidate. (confex.com)
In the current study we evaluated the importance of a polyamine (nitrogenous compound) biosynthetic gene, spermidine synthase (Spds) that is required to produce the polyamine spermidine (Spd), which is critical for living cells to survive. (usda.gov)
The results presented here show that targeting A. flavus Spds gene through RNAi approach in future might be effective in reducing both fungal growth and aflatoxin contamination in maize. (usda.gov)
Complementation of the 'spds mutant with a wild type (WT) A. flavus Spds gene restored the WT phenotype. (usda.gov)
The mutant that lacked a functional TPC1 gene showed no SV channel activity. (sciencedaily.com)
Inherited copper deficiency occurs in male infants who inherit a mutant X-linked gene. (msdmanuals.com)

We found 187 (74.0%) patients had cirrhotic liver associated with hepatocellular carcinoma. (who.int)

More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. (medscape.com)
Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug, and one-third of all drugs withdrawn from the market are withdrawn for liver injury. (medscape.com)
The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure. (medscape.com)
This resulted in more than 50 cases of severe hepatic injury, and the drug was withdrawn in 1998. (medscape.com)
The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis. (nih.gov)
Their hepatic transduction was further verified by a quantitative PCR analysis of AAV copy number in the liver tissue. (nih.gov)

The fact remains that there are many 'mutant' strains of DNA found in the human genome which have a higher purpose that science does not readily acknowledge. (bibliotecapleyades.net)

Inflammation is the first innate immune response to infection or irritation resulting from leukocyte ( neutrophils , mast cells , etc.) accumulation and their secretion of inflammatory, biogenic chemicals such as histamine , prostaglandin , and pro-inflammatory cytokines . (wikidoc.org)
Here, we capture the dynamics of developmental BBB leakage using live imaging, revealing a combination of steady accumulation in the parenchyma and sporadic bursts of tracer leakage. (elifesciences.org)
Wilson Disease Wilson disease results in accumulation of copper in the liver and other organs. (msdmanuals.com)

Mutant AAVrh.10 vectors were generated by site directed mutagenesis of the predicted targets. (nih.gov)
These mutant vectors were first tested for their transduction efficiency in HeLa and HEK293T cells. (nih.gov)

Hepatotoxicity was manifested by a significant difference in lethality, liver histopathology, and biochemical serum testing. (jci.org)

Here, live respiratory epithelial cells were inoculated with broth-grown or biofilm bacteria of different M-types, as well as with isogenic mutants lacking common virulence factors. (lu.se)

Polyamines (PAs) are ubiquitous polycations that influence normal growth, development, and stress responses in living organisms and have been shown to play a significant role in fungal pathogenesis. (usda.gov)
This contrasts using the series regularity seen in various other organisms, such as for example and mutants present elongated telomeres. (bioskinrevive.com)
2 − 6 These nuclease-resistant polymers persist in live organisms for days and are typically designed to recognize 25-base sequences that span intron-exon junctions or translational start sites. (cdc.gov)

An ASNA1 point mutant identified using CRISPR-mediated mutagenesis abolishes both the cytoprotective effect of Retro-2 against ricin and its inhibitory effect on ASNA1-mediated ER-targeting. (elifesciences.org)

This increased stability also made the mutant TDP-43 molecules more toxic to the cells. (medicalxpress.com)
Molecules such as phosphatidylinositol-3,5-bisphosphate and nicotinic acid adenine dinucleotide phosphate, that activate the TPCs of mammalian cells, failed to affect the ion channel activity in isolated vacuoles of the mutant plants. (sciencedaily.com)
MRD measurements at different pH values show that ionization of Glu-66 or Lys-66 is not accompanied by penetration of long-lived water molecules. (lu.se)
As a result, molecules that are normally broken down and their byproducts build up in the body, damaging tissues and leading to lactic acidosis and other chemical imbalances. (medlineplus.gov)
The brain is especially affected by the buildup of molecules and the lack of cellular energy, resulting in the neurological problems associated with dihydrolipoamide dehydrogenase deficiency. (medlineplus.gov)

While we have shown that mutant IL7Ra is sufficient to transform an immortalized thymocyte cell line, mutation of IL7Ra alone was insufficient to cause transformation of primary T cells, suggesting that additional genetic lesions may be present contributing to initiate leukemia. (confex.com)
Here, we characterized the role of the acquired EGFR G724S mutation that was diagnosed in osimertinib-resistant lesions of four individual EGFR 19del -mutant LADC patients. (nature.com)

An addition to the existing requirements was made by introducing a new molecular technique, called mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC), for the quality control of the vaccine. (who.int)
This is the first of a new generation of tests for the molecular consistency of production of live virus vaccine. (who.int)

We sought to determine whether combination of mutant hIL7Ra plus TLX3 overexpression is sufficient to generate T-cell leukemia in vivo . (confex.com)

Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the brain cells of people with Huntington's. (scienceblog.com)
Li says finding an antibody that prefers to bind mutant, aggregated protein could also prove useful in the study of other neurodegenerative disorders, such as Alzheimer's disease or Creutzfeldt-Jakob disease. (scienceblog.com)
Preclinical and early phase clinical data suggested efficacy of depatuxizumab mafodotin (depatux-m), an antibody drug conjugate (ADC) comprised of a monoclonal antibody that binds activated EGFR (overexpressed wild-type and EGFRvIII-mutant) linked to a microtubule-inhibitor toxin in EGFR-amp GBMs. (bvsalud.org)

The result was a new type of enzyme that digests plastic more efficiently than the original. (livescience.com)
While the newcomer mutant enzyme works somewhat more quickly than PETase does, its more important feature lies in its ability to consume another type of plastic: polyethylene furandicarboxylate (PEF), "literally drilling holes through the PEF sample," study co-author Gregg Beckham, a senior engineer at the National Renewable Energy Laboratory (NREL), said in a statement issued by NREL. (livescience.com)
The new findings suggest that it may be possible to solve the global problem of plastic pollution by introducing human-engineered improvements to an enzyme that is already adept at consuming plastics (such as the mutant PETase) - and further work with this enzyme (and its mutant cousins) could make them even more efficient plastic eaters, the study authors reported. (livescience.com)

Liver problems can also occur in dihydrolipoamide dehydrogenase deficiency, ranging from an enlarged liver (hepatomegaly) to life-threatening liver failure. (medlineplus.gov)

Our data provide a mechanistic basis for the osimertinib-induced selection of EGFR G724S -mutant clones and a rationale to treat these patients with clinically approved second-generation EGFR inhibitors. (nature.com)

As a result, randomly modified designs (i.e., mutants) are introduced into populations of reproducers. (bibliotecapleyades.net)

Liver-specific TBC1D15 deficiency or non-p-NUMB expression reduced TIC numbers and HCC development. (nature.com)

REDWOOD CITY, Calif., Sept. 19, 2023 (GLOBE NEWSWIRE) -- Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, today announced the first patient was dosed in its Phase 1/1b monotherapy clinical trial of RMC-9805, an oral, covalent, mutant-selective KRAS G12 D (ON) Inhibitor designed to treat patients with cancers driven by the KRAS G12 D mutation. (kdvr.com)
With this strong clinical portfolio, as well as a rich collection of additional mutant-selective drug candidates and research-stage assets, we believe our pipeline has the potential to change the standard of care for patients living with a wide range of RAS-addicted cancers including NSCLC, pancreatic cancers and colorectal cancers. (kdvr.com)
and the ability of the company to change the standard of care for patients living with a wide range of RAS-addicted cancers. (kdvr.com)
Clinical results show that patients treated with osimertinib respond in up to 71% in the background of an acquired EGFR T790M mutation 11 , 12 . (nature.com)
These and other results were the basis for a current phase 1 clinical trial testing the next generation drug in ALS patients ( NCT02623699 ). (nih.gov)
RESULTS: Forty-eight patients were enrolled with 33 completing ≥2 cycles of therapy and evaluable for DLT. (bvsalud.org)
CHICAGO - Patients with a certain type of brain tumor could soon be treated with an oral targeted drug instead of undergoing more toxic chemotherapy and radiation, say researchers reporting new results that could potentially change the treatment landscape. (medscape.com)
The results of this study really suggest that in selected patients with IDH mutant low-grade gliomas we can potentially delay the use of these toxic chemotherapies and radiation, maybe for years if not many years, and as a result delay the long-term toxicities of those therapies in a group of patients who typically are experiencing long-term survival," Lesser added. (medscape.com)

But their investigation had an unlikely result - they introduced a mutation to PETase. (livescience.com)
The genetic mutation is theorized to cause an imbalance between free radical production and removal, resulting in the subsequent neuronal degeneration and neurotransmitter decline. (medscape.com)
The frameshift mutation results in the formation of a truncated protein which cannot fold properly, promoting aggregation, and subsequent deposition in tubular cells. (medscape.com)

The combination mutant hIL7R wild type and hTLX3 was also tested. (confex.com)

Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. (medscape.com)
Over 3 years, more than 90 cases of hepatotoxicity were reported, resulting in withdrawal of this drug. (medscape.com)

HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)

If therapy with [HA466 trade name] is discontinued, consideration should be given to the long half-life of efavirenz (see section 5.2) and long intracellular half-lives of tenofovir and lamivudine. (who.int)

Notably, the DNAJB1-PRKACA fusion was not detected in any of the matched nontumor liver tissue samples. (medscape.com)

It then takes just 30 minutes for the sporozoites to find and enter liver cells. (nottingham.ac.uk)
These merozoites burst out of the liver, into the blood stream and invade red blood cells where the parasite multiplies again. (nottingham.ac.uk)
Li and his colleagues showed that cultured cells that make both the intrabody and mutant huntingtin are able to get rid of the mutant protein faster and have fewer clumps of huntingtin. (scienceblog.com)
resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver . (wikidoc.org)
Then, by patch-clamp electrophysiology analyses, they measured the ionic currents in isolated vacuoles from the living cells of M. polymorpha plants. (sciencedaily.com)
Liver problems are likely also related to decreased energy production in cells. (medlineplus.gov)

The manic state that is at the ancient root of the word "maniac" might result from a screwed up body clock, new findings in mutant rodents suggest. (sott.net)
Based on their findings, Quintanilla et al suggest the possibility that the effects of mutant HD can be reduced by increasing the availability and activity of PGC-1 α, a co-activator involved in mitochondrial function and glucose, lipid, and energy homeostasis, the function of which seems to be disrupted by mutant HD interactions that interfere with signaling pathways. (medscape.com)

In the United States, approximately 2000 cases of acute liver failure occur annually and drugs account for over 50% of them (39% are due to acetaminophen, 13% are idiosyncratic reactions due to other medications). (medscape.com)
The boxed warning emphasizes the risk for severe liver injury and acute liver failure, which may be fatal. (medscape.com)

Humans have loaded down the planet with an estimated 9 billion tons (8.3 billion metric tons) of plastic, half of which has been produced since 2004, Live Science previously reported . (livescience.com)
Over the years, the Turtles long to live with and like humans their age, much to Splinter's dismay. (wikipedia.org)
He then reveals that he plans to use the stolen technology to mutate every animal on Earth and create a world where mutants have dominance over humans. (wikipedia.org)
Darwin once called humans living, self-replicating machines. (bibliotecapleyades.net)
Data demonstrated that humans are less sensitive to the effect that causes developmental toxicity in rabbits and the PBPK model incorporated this information, resulting in a higher HEC for the developmental endpoint than for the nasal endpoint. (cdc.gov)

Fibrolamellar carcinoma (FLC) is a primary liver cancer that occurs in adolescents and young adults without underlying liver disease. (medscape.com)
dence rate of liver cancer varies widely mortality while hospitalized (hospital stay ranged from 1 week to 6 months. (who.int)

antiviral therapy and viral immune escape may cause and select for these HBV mutants. (tmu.edu.tw)

Results from more found the combination can not to lose muscle mass during cutting. (tools4thegarden.co.uk)
They found that the mutated versions of TDP-43 were far more stable than the normal form, with half-lives up to four times that of the normal protein. (medicalxpress.com)

Osimertinib treatment resulted in a partial response (54% reduction based on RECIST 1.1) (Supplementary Fig. 1B , 1D ). (nature.com)

This population typically has liver disease as the primary symptom. (medlineplus.gov)

Together these results provide a better understanding of the potential mechanisms of uptake and survival of various phenotypes of GAS bacteria relevant for colonization and recurrent infection. (lu.se)

Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. (scienceblog.com)
New research by Koji Yamanaka and colleagues from the Laboratory for Motor Neuron Disease at the RIKEN Brain Science Institute has now revealed that increased stability of mutant TDP-43 is associated with earlier onset of ALS. (medicalxpress.com)
In some affected people, liver disease, which can begin anytime from infancy to adulthood, is the primary symptom. (medlineplus.gov)
Results from the pivotal phase 3 INDIGO trial show that the drug was associated with a significant delay in time to disease progression when compared with placebo. (medscape.com)
The results show that "treatment with an oral precision medicine therapy can produce a reduction in the risk of tumor progression by 61%, so that is, we think, a significant sign of efficacy that has potential to change the landscape in this disease," he commented. (medscape.com)
Over -fetoprotein level was tested using the liver disease. (who.int)

More importantly, the mutant AAVrh.10 vector was able to partially evade neutralizing antibodies (~27-64 fold) in pre-immunized animals. (nih.gov)
The results are quite striking and they're statistically highly significant, and more importantly, they're clinically very, very significant," he continued. (medscape.com)

Because early diagnosis and treatment seem to result in a better prognosis, the disorder is ideally detected before age 2 weeks. (msdmanuals.com)

Drugs are an important cause of liver injury. (medscape.com)
Why was it important that you washed your hands after handling the live toad? (eduref.org)

quantitative RT-PCR result and the On admission, small, bilateral H275Y phenotype of oseltamivir- lung contusions, right pneumothorax, resistant pandemic (H1N1) 2009. (cdc.gov)

The liver problems are usually associated with recurrent vomiting and abdominal pain. (medlineplus.gov)

A 75-year-old female patient, surnamed Guo, living in Guangzhou's Liwan district was the first patient to be detected, but it didn't make her the original source of infection, as local health officials had said she may have become infected due to accidental exposure. (globaltimes.cn)
Down-regulation of Spds in the mutant altered overall nitrogen metabolism and significantly reduced fungal growth, pathogenicity, and the production of aflatoxins during maize seed infection. (usda.gov)

Taken together, because resistin is reputed to contribute to insulin resistance, results such as those mentioned suggest that resistin may be a link in the well-known association between inflammation and insulin resistance. (wikidoc.org)

By and liver lacerations were shown on the time these laboratory results were computed tomographic scan. (cdc.gov)

Whole-genome sequencing revealed that the fusion resulted from a ∼400-kilobase (kb) deletion on chromosome 19 (chr19). (medscape.com)

Given these results, it's clear that significant potential remains for improving its activity further," study co-author Nicholas Rorrer, a postdoctoral researcher at NREL, said in the NREL statement. (livescience.com)
New England Journal of Medicine study that and the visible results it will offer burners and HGH to lose weight. (tools4thegarden.co.uk)
Quintanilla et al published the results of a study that focused on the contribution of mitochondrial dysfunction and transcriptional dysregulation to the pathogenesis of HD and the possibility of therapeutic intervention. (medscape.com)

Starting from 10 pm on Monday, passengers leaving Guangzhou must present a negative nucleic acid test result taken within 72 hours, according to a latest notice issued by Guangzhou's COVID-19 epidemic prevention and control office on Sunday. (globaltimes.cn)
As these data have been included and considered in a result of the sparse and inconsistent evidence the present volume. (who.int)

The Food and Drug Administration (FDA) concluded that the overall risk of liver toxicity from pemoline outweighs the benefits. (medscape.com)

Symptoms result from the selective loss of neurons, mostly in the caudate nucleus and putamen. (medscape.com)

Solo project of Þorsteinn Magnússon,guitarist of the legendary band Þeyr and session guitarist for the band Psychic TV on their Those Who Do Not LP. Released his only album LIF under his alias Stanya through Gramm Records in 1982.A dark ritualistic masterpiece with experimental edges bleding the dark long night of Iceland ,with all the legends of icelanding tradition living here. (blogspot.com)

the mutant virus was carrying bc.ca without antiviral treatment. (cdc.gov)

Anatomy23

Organisms25

Diseases1

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes98

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care3

Mice18

Mutations7

Tumors5

Proteins6

Genes3

Cirrhosis4

Spleen1

Gene7

Hepatocellular carcinoma1

Hepatic6

Strains1

Accumulation3

Vectors2

Lethality1

Epithelial cells1

Organisms3

Point-mutant1

Molecules5

Lesions2

Vaccine2

Vivo1

Antibody3

Enzyme3

Hepatomegaly1

Inhibitors1

Populations1

Expression1

Patients8

Mutation3

Wild-type1

Hepatotoxicity2

Organs1

Intracellular1

Tissue1

Cells6

Findings2

Acute2

Humans5

Cancer2

Immune1

Found2

Partial1

Typically1

Survival1

Disease6

Importantly2

Prognosis1

Important2

Quantitative1

Abdominal pain1

Infection2

Suggest1

Shown1

Deletion1

Study3

Present2

Risk1

Symptoms1

Long1

Virus1