• A recent article by Decuypere et al in AJKD explores the role of autophagy in kidney ischemia-reperfusion injury and therapy. (ajkdblog.org)
  • PURPOSE: To investigate blood creatinine and renal histology in rats anesthetized with S(+)-ketamine (keta) or dexmedetomidine (dex) and submitted to kidney ischemia/reperfusion injury (IRI). (unesp.br)
  • The extent of reperfusion injury is directly proportional to preservation time in cold storage, and research has shown that with static storage methods, heart storage time will not exceed six hours. (gotomydoctor.com)
  • In the United States alone, there are an estimated 300,000 laparotomies performed annually for SBO, and about one third of these obstructions are complicated by intestinal ischemia, with significantly higher morbidity and mortality resulting. (crashingpatient.com)
  • Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy? (jneurosci.org)
  • Prenatal hypoxia-ischemia to the developing brain has been strongly implicated in the subsequent development of the hypertonic motor deficits of cerebral palsy (CP) in premature and full-term infants who present with neonatal encephalopathy. (jneurosci.org)
  • Hypoxic-ischemic brain injury results in cerebral palsy (CP), mental retardation, or learning disabilities in surviving children ( Robertson and Finer, 1985 ). (jneurosci.org)
  • Hypoxia-ischemia (H-I) is also associated with subsequent cerebral injury in a disproportionately high percentage of the survivors of premature birth ( Volpe, 2001 ). (jneurosci.org)
  • Most previous studies have employed models of cerebral hypoxia-ischemia in postnatal animals. (jneurosci.org)
  • Glibenclamide has been shown to improve outcomes in cerebral ischemia, traumatic brain injury, and subarachnoid hemorrhage (SAH). (thejns.org)
  • Similar results were found for analyses considering the dichotomized 6-month mRS score (favorable score 0-2), as well as for the secondary outcomes of discharge mRS score (either ordinal or dichotomized), mortality, and delayed cerebral ischemia. (thejns.org)
  • Mortality and delayed cerebral ischemia rates were also similar compared with placebo. (thejns.org)
  • When cerebral perfusion is jeopardized, a definitive corrective procedure is advised at a time when the patient is in a relatively stable condition. (nih.gov)
  • Patients with occlusive lesions of all four cervical arteries usually have severe cerebral ischaemia and their distal runoff is usually unable to be visualized on angiography. (nih.gov)
  • Ischemic cerebrovascular disease refers to cerebral blood supply disorders that occur on the basis of cerebrovascular lesions or hemodynamic disorders, resulting in a series of neurological deficits. (ijpsonline.com)
  • In contrast, all group D rats died of cerebral ischemia. (silverchair.com)
  • Hyperthermia, hypotension, cerebral ischemia and edema, hepatic and renal failure, increased levels of both nitric oxide metabolites (NO x - ) and dihydroxybenzoic acid (DHBA) in plasma, hyperkalemia, respiratory alkalosis, and metabolic acidosis and hypoxia are all observed in vehicle-treated heatstroke animals. (tmu.edu.tw)
  • Most result from middle cerebral artery occlusion (MCAO) causing damage to striatum and cortex resulting in long-term disability. (cdc.gov)
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
  • For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
  • One of the original studies performed by Schneider et al in 1985 found that supplementation with D-ribose after cardiac ischemia resulted in a significant shorter duration of diastolic recovery time vs. the control group (2.8 days vs. 9.4 days). (drandrewneville.com)
  • Antenatal hypoxia-ischemia at preterm gestation results in hypertonia and abnormalities in motor control. (jneurosci.org)
  • These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia. (jneurosci.org)
  • In the present study, a new neurobehavioral battery of tests was used to characterize the motor performance of newborn pups after sustained hypoxia-ischemia to the preterm rabbit fetus at 67-70% gestation. (jneurosci.org)
  • Autophagy is a process that relies on lysosomal pathways for the degradation of cytoplasmic proteins and organelles and plays an important role in the pathology of brain injury such as hypoxia ischemia[ 3 ]. (ijpsonline.com)
  • Recent studies have reported that dexamethasone worsens neuronal injury after brain ischemia. (silverchair.com)
  • The logistic regression curve demonstrated a close relationship between duration of ischemic depolarization and neuronal damage and showed a rightward shift by lowering the brain temperature. (elsevierpure.com)
  • The results also indicate that the neureprotective effect at 31°C is about three times greater than that at 34°C and that neuronal cells can withstand 2.9 times longer duration of ischemia at 31°C than at 37°C. (elsevierpure.com)
  • While anticonvulsants reduce the duration or frequency of seizures by suppressing neuronal excitation or excitability, real antiepileptogenic agents would act by blocking the initial epileptogenic process or by altering the epileptic disease state after the seizure onset [11]. (jle.com)
  • The postoperative outcomes included length of stay (LOS), creatinine variation (Modification of Diet in Renal Disease group), Clavien complications and pathological results. (bjuinternational.com)
  • We recorded perioperative and postoperative data, including operative time, estimated blood loss, and duration of hospital stay. (ectrx.org)
  • Tubed fasciocutaneous flaps (e.g., from the anterolateral thigh or radial forearm) are most commonly used, because they permit good postoperative speech and result in low systemic morbidity. (thieme-connect.de)
  • The ischemic time seems to be a very important factor affecting the likelihood of postoperative complications, especially for free flaps. (thieme-connect.de)
  • Initial attempts to perform lung transplantation (LTx) were marred by technical limitations that often resulted in early postoperative death. (ersjournals.com)
  • However, postoperative parameters including MV duration, ICU stay and hospital LOS appeared to be no significant decrease as a result of the dexmedetomidine use. (medscape.com)
  • RESULTS: Forty-eight patients were included in the study: 24 with IBD and 24 with IIA occlusion. (lu.se)
  • 1 (4%) patient developed bowel ischemia on both groups, with 1 in the IIA occlusion group needing resection. (lu.se)
  • Mesenteric vessel occlusion has long been the sole cause of acute mesenteric ischemia. (springeropen.com)
  • To this end we analyzed the proteomic profile of cortex and striatum at 2 and 12 h following occlusion via isobaric tag for relative and absolute quantification (iTRAQ) with liquid chromatography-tandem mass spectrometry (LCMS/ MS). Our proteomic analysis identified several key proteins altered by ischemia in a time-related fashion as well as by repeated sleep restriction exposure. (cdc.gov)
  • [ 1 ] This results in ischemic injury and infarction. (medscape.com)
  • In the early stage of ischemia and hypoxia, cells will increase the energy supply to the ischemic area, especially the functional area of the ischemic penumbra, by regulating glycolysis. (ijpsonline.com)
  • Onset times of ischemic depolarization were 1.3 ± 0.2, 1.6 ± 0.4, and 2.4 ± 0.7 mins at 37°C, 34°C, and 31°C, respectively. (elsevierpure.com)
  • On a very basic level, and obstruction that results in, or is caused by, twisting of the mesenteric vasculature (volvulus, internal hernia, or adhesion-related mesenteric restriction) can, and often does, result in ischemic bowel. (crashingpatient.com)
  • The term 'ischemic' specifies that the symptoms result from an obstruction in blood flow, and 'attack' refers to an isolated event. (harvard.edu)
  • Although risk factors of occlusive acute mesenteric ischemia are well known, triggering factors of nonocclusive mesenteric ischemia (NOMI) remain unclear. (springeropen.com)
  • MRLs can be derived for acute, intermediate, and chronic duration exposures for inhalation and oral routes. (cdc.gov)
  • Citation: Rezaeian S, Hamzeh B, Darbandi M, Najafi F, Shakiba E, Pasdar Y. Factors associated with chronic headache among adults: results from a Ravansar noncommunicable disease cohort study. (who.int)
  • Notably, chronic and severe headaches account for affected by age, sex, race, geography and socioeconomic a significant share of headache-related productive time status, and varies according to the population being evaluated ( 6,7 ). (who.int)
  • Female sex, low income, divorce and death lost: approximately one-third of chronic headache attacks of spouse are recognized as nonmodifiable risk factors occur on workdays and two-thirds of these result in for chronic headache ( 8 ). (who.int)
  • When the twist is sufficient to obstruct arterial inflow (and prevent venous blood return), testicular ischemia results, most likely as a consequence of increased intratesticular pressure. (medscape.com)
  • Let me say a quick word about the pathophysiology of bowel ischemia in the setting of bowel obstruction. (crashingpatient.com)
  • As an obstruction progresses, the bowel proximal to the point of obstruction becomes progressively more dilated over time as the succus and GI secretions accumulate. (crashingpatient.com)
  • This latter type of bowel ischemia is the reason behind the traditional dictum in surgical training to "Never let the sun rise or set on a complete bowel obstruction. (crashingpatient.com)
  • In one study, more than 50% of bowel obstructions with ischemia were misdiagnosed. (crashingpatient.com)
  • If you notice your cat hasn't had a bowel movement, it's time to act. (bestiepaws.com)
  • Preproliferative retinopathy-This may include cotton wool spots, (areas of retinal ischaemia /infarction), venous abnormalities. (ukessays.com)
  • Conduction abnormalities may result in delayed conduction or block, but may also contribute to the formation of ectopy (premature or ectopic depolarizations). (vin.com)
  • 8 Damage subsequently results from autoimmunity-induced inflammation or tissue deposition of immune complexes. (lww.com)
  • Diagnosing whether or not a diabetic foot ulcer is infected can be difficult, especially in the presence of limb ischemia or peripheral neuropathy, the researchers note, but it is generally agreed that this decision should be based on signs or symptoms of inflammation or purulence. (medscape.com)
  • Initial stroke severity, degree of successful revascularization, and the side of ischemia were found to independently predict the functional outcome at 3 months after treatment. (ajnr.org)
  • The median time to healing of the index ulcer was 4.5 months, while median time to amputation, if this occurred, was 2.0 months, and for revascularization, it was 3.0 months. (medscape.com)
  • Background: Laparoscopic live donor nephrectomy is becoming increasingly popular as it has been shown to minimize donor morbidity, length of hospital stay and length of time to return to work. (elsevierpure.com)
  • We here summarize clinical data of all 4 known human VSBV-1 encephalitis cases and describe the distribution of VSBV-1 in different brain areas as determined by real-time reverse transcription PCR (RT-PCR) and immunohistochemical (IHC) analysis in the initial encephalitis cluster. (cdc.gov)
  • We focus on the characterization of the central nervous system (CNS) immunologic response to VSBV-1 by IHC analyses of immune cells in the brain of all patients, as well as by examination of cerebrospinal fluid (CSF) reactions over time during the disease. (cdc.gov)
  • Brain histopathology was assessed at the time of ischemia-related death or after the examination at 48 h. (silverchair.com)
  • In the current study, dexamethasone administration before brain ischemia resulted in a worsening of postischemic outcome that was relate to drug-induced hyperglycemia. (silverchair.com)
  • During these initial stages, progressive brain alterations result in lowered seizure thresholds which eventually cause spontaneous seizures [13, 18]. (jle.com)
  • A person who has a TIA has had ischemia but has 'ducked the bullet' because there was no lasting damage to the brain. (harvard.edu)
  • Because it can be difficult to distinguish problems resulting from reduced blood flow versus other brain disruptions, don't ignore the incident or attempt self-diagnosis. (harvard.edu)
  • Myocarditis may result from infectious or noninfectious causes. (msdmanuals.com)
  • The most severe cerebrospinal fluid and histologic changes occurred in the patient with the highest viral load, shortest duration of disease, and most medical preconditions. (cdc.gov)
  • or = 24h post-ischemia were included in the histologic analysis. (silverchair.com)
  • Measurements and Main Results: DC potentials were measured in the CA1 region, where histologic evaluation was performed 7 days later. (elsevierpure.com)
  • Presence of limb ischemia, multiple foot ulcers, and a longer ulcer duration were most predictive of poor 12-month outcomes. (medscape.com)
  • METHODS: In a telephone survey, a random sample of Iranian drivers were asked to report their age, gender, vehicle age, whether their vehicles were equipped with anti-lock braking system (ABS), average daily drive time (DDT), whether they smoked cigarette or waterpipe, whether they had diabetes mellitus (DM), number of traffic crashes during the last calendar year and whether the crash involved a pedestrian or another vehicle. (who.int)
  • Current methods of cold static storage have reached their limits in storage time due to the extent of ischemia-reperfusion (I/R) injury induced during static cold storage. (gotomydoctor.com)
  • Moreover, strategies for successful treatment of most tachyarrhythmias are based on addressing either the substrate (e.g., relieve the ischemia), suppress the trigger (e.g., treat APCs and VPCs), and influence the modulators (e.g., correct electrolyte imbalances), or address all three. (vin.com)
  • Anti-seizure properties of potential AEDs can be tested by measuring the ability of drugs to suppress SE initiation, duration, or seizure intensity following administration of convulsant agents. (jle.com)
  • Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
  • And if a patient has an obstruction associated with ischemia, why does it matter whether there is anything passing out the rectum? (crashingpatient.com)
  • and (3) normoglycemic, dexamethasone- and insulin-treated rats (group DI) received the same treatment as group D, plus an intravenous insulin infusion shortly before ischemia. (silverchair.com)
  • Hence, duration of low flow state and catecholamine infusion are established risk factors of NOMI. (springeropen.com)
  • Streptokinase infusion initially yielded conflicting results until the Gruppo Italiano per la Sperimentazione della Streptochinasi nell'Infarto Miocardico (GISSI) trial in 1986, which validated streptokinase as an effective therapy and established a fixed protocol for its use in AMI. (medscape.com)
  • This is a technique where one or two renal arteries are ligated for a period of time (30 min to 1 hour), and then released causing AKI. (ajkdblog.org)
  • This report was undertaken to tion, duration of renal failure and having study the pattern of ARF in hospitalized pa- concomitant liver disease were included tients in southern Saudi Arabia. (who.int)
  • Dexmedetomidine is widely used for perioperative anesthesia/analgesia, and may have a more profound renal protection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury. (medscape.com)
  • If effective decompression (either with surgery or with NG tube) does not occur promptly (typically around 6 hours or so), the ischemia may be irreversible, and the chance of intestinal perforation increases dramatically. (crashingpatient.com)
  • For optimal results in cases of trauma, cold should be applied before significant edema and hemorrhage occur. (diagnose-me.com)
  • RESULTS: Blood creatinine was significantly higher at T2 in both groups, but dex group results were lower than those of keta group. (unesp.br)
  • Proliferative retinopathy-This indicates severe ischaemia of the retina leading to new vessel formation in the optic disc or in the periphery of the retina or iris. (ukessays.com)
  • Conclusions: Recipient outcome is not compromised and excellent results can be achieved with living donor kidney transplantation using laparoscopically procured kidneys. (elsevierpure.com)
  • Immediate access to suitable equipment, drugs and staff for emergency treatment must be ensured because, rare cases of serious reactions, at times with a lethal outcome, have been reported after the use of local anaesthetics, even without a case history of individual hypersensitivity. (janusinfo.se)
  • At the same time, there have contribution of patients' background characteristics been 277,318 cases and 4,349 COVID-19-related to the clinical presentation, severity, and outcome deaths in Ethiopia since the first case was confirmed of the disease [3-22]. (bvsalud.org)
  • The operative data included operative duration, warm ischaemia time (WIT) and estimated blood loss (EBL). (bjuinternational.com)
  • Congenital heart defects with left-to-right shunting and unrestricted pulmonary blood flow (PBF) due to a drop in pulmonary vascular resistance result in pulmonary overcirculation. (medscape.com)
  • Blood creatinine was measured before ischemia (T1) and 48h after reperfusion (T2), when L nephrectomy was performed. (unesp.br)
  • CONCLUSION: S(+)-ketamine plus IRI were aggressive to rat kidneys, according to histological changes, and dexmedetomidine may have not totally protected the kidneys from these injuries, despite the better results of blood creatinine. (unesp.br)
  • The results indicate that IL-1ra therapy may restore tissue blood flow and homeostatic function, and limit multiorgan dysfunction and death in heatstroke. (tmu.edu.tw)
  • It leads to the death of myocyte cells due to loss of blood flow, anemia, and ischemia [ 3 ]. (scitechnol.com)
  • Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. (theodora.com)
  • Cardiac Arrest Cardiac arrest is the cessation of cardiac mechanical activity resulting in the absence of circulating blood flow. (msdmanuals.com)
  • Some medical conditions, particularly fractures, lacerations, costoclavicular syndrome, connective tissue diseases, vascular disorders such as Buerger's disease, generalized atherosclerosis, or a long history of high blood pressure, may result in the same signs and symptoms as primary Raynaud's phenomenon. (cdc.gov)
  • In view of the definition for AKI using conventional tests such as the blood urea nitrogen, serum creatinine levels, urine output quantity and creatinine clearance rate, it may result in delay in the timely detection of kidney injury and can lead to false-negative results, and dexmedetomidine for the prevention of AKI may be more effective than the current results. (medscape.com)
  • Over time, the condition may lead to loss of the testis. (medscape.com)
  • The condition may result in loss of the testis. (medscape.com)
  • Levels of significant exposure for each route and duration are presented in tables and illustrated in figures. (cdc.gov)
  • An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
  • MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)
  • However, existing data are insufficient to recommend a safe duration and intensity of exposure or specific work practices that will prevent the occurrence of vibration syndrome. (cdc.gov)
  • Through research, NIOSH is seeking additional information about the relationship between exposure duration and vibration syndrome, as well as effective control technologies to prevent vibration syndrome. (cdc.gov)
  • Duration of symptoms was from 10 days to 8 years with a mean of 32 months. (nih.gov)
  • The duration of symptoms is less than 48 hours in approximately 80% of adults but tends to be longer in elderly persons and in those with perforation. (medscape.com)
  • The log-rank test shows that having moderate and se- vere disease, one or more symptoms at presentation, and presenting with respiratory and constitutional symptoms seems to extend the time needed to achieve viral clearance. (bvsalud.org)
  • At the same time, the ice enhances the flow of nutrients into the area, aids in the removal of metabolites (waste products), increases strength, and promotes healing. (diagnose-me.com)
  • The timing of dexmedetomidine administration in relation to cardiac surgery is emerging as an important consideration. (medscape.com)
  • This can be accomplished with a balloon atrial septostomy or an operative atrial septectomy at the time of PAB. (medscape.com)
  • Results: The mean operative time was 144.35 ± 22.79 minutes, and the mean warm ischemia time was 184.35 ± 4.97 seconds. (ectrx.org)
  • SE is defined as long-duration seizures, typically lasting for more than 30 min [20]. (jle.com)
  • Cerebrospinal fluid analyses over time demonstrated increasing protein concentrations and cell counts, paralleled by pathologic lactate elevations in all patients. (cdc.gov)
  • Patients with an infected diabetic foot ulcer have a far worse prognosis than previously thought, with 15% of patients dying within a year, less than half of the ulcers healing in the same time period, and one in seven individuals having all or part of their foot amputated, results from a new UK study reveal. (medscape.com)
  • Moreover, she noted that amputations are costly, in terms of the time patients have to spend in the hospital, the cost of hospital care, rehabilitation and prostheses, etc, and the postamputation care required. (medscape.com)
  • The median follow-up duration was 17 months (interquartile range 2-39) for the IBD group, with a primary patency of 60±14% at 3 years that went up to 92±8% with reinterventions (8 reinterventions in 6 patients). (lu.se)
  • Iliac branch devices are shown to be a valid alternative in highly selected cases, with good midterm results, even if reinterventions are required in a significant proportion of patients. (lu.se)
  • Our results suggest that atherosclerosis is not a risk factor for NOMI in critically ill patients. (springeropen.com)
  • Results Of 1826 SLE patients, 88.8% were female, 48.8% Caucasian, mean±SD age 35.1±13.3 years, disease duration 5.6±4.2 months and follow-up 6.6±4.1 years. (bmj.com)
  • While offering a vital therapeutic option for patients with advanced lung disease, LTx remains fraught with complications that threaten both the quality and duration of the recipient's life. (ersjournals.com)
  • Cette étude a permis de déterminer la fréquence et l'étiologie de l'insuffisance rénale aiguë chez des patients hospitalisés en Arabie saoudite sur une période de 2 ans. (who.int)
  • 2. Patients who at the time of admission to the intensive care unit are in multiple organ dysfunction. (who.int)
  • CIGB-500 Group (Experimental): 10 mg of the product will be received every 12 hours for 7-10 days (until completing a maximum of 20 administrations of the product), always in an intravenous bolus of 3 minutes (±20 seconds) duration. (who.int)
  • Nonetheless, the post-transplant course is often marked by complications that threaten both the quality and duration of the recipient's life. (ersjournals.com)
  • Shift work is a risk factor for stroke as well as other circulatory diseases and is known to interfere with circadian rhythms, sleep quality and duration. (cdc.gov)
  • Ischemia is the most common cause of cardiovascular disease and myocardial damage in the developed world. (southcarolinablues.com)
  • Whilst the effects of some of these prob- lems might be minimised with concerted effort (given their widespread prevalence), the limitations resulting from interspecies differences are likely to be technically and theoretically impossible to overcome. (drugstorepdfsearch.com)
  • The emphasis on early application of currently available preventive measures or treatments has resulted in the widespread use of the document. (cdc.gov)
  • Results from the largest-ever recurrent stroke prevention trial, PRoFESS (Prevention Regimen For Effectively avoiding Second Strokes), were presented today at the XVII European Stroke Conference (ESC) in Nice, France. (webwire.com)
  • Conventional flank incision donor nephrectomy causes cosmetic blemishes and induces paresthesia that results from a large skin incision and wide muscle division and subsequent nerve damage. (ectrx.org)
  • Plasma glucose concentration immediately before ischemia was as follows: group P = 129 +/- 8 mg/dl (mean +/- SD), group D= 344 +/- 29 mg/dl, and group DI = 123 +/- 17 mg/dl. (silverchair.com)
  • 1. The objective is to evaluate the relationship between concentration of NaHS and its effect on viability by performing a dose-response test in order to evaluate the concentration of NaHS with the most beneficial results to tissues. (gotomydoctor.com)
  • Absorption --After single oral-dose administration, the maximum observed plasma concentration (C max ) of tadalafil is achieved between 30 minutes and 6 hours (median time of 2 hours). (theodora.com)
  • Results: The Median time to viral clearance was 16 days. (bvsalud.org)
  • The duration, frequency, and type of heat application may differ depending on the quality of the pain and the depth of the tissue being targeted. (wikipedia.org)
  • [6] A March 2021 Los Angeles Times cover story illustrated the efficacy of ECMO in an extremely challenging COVID patient. (wikipedia.org)
  • 3. Pregnancy or lactation at the time of inclusion in the study (referred). (who.int)
  • In contrast, automatic SVT is characterized by "warm-up" (relatively slowly rising heart rate over a time period of several heart beats) and 'cool down' phenomena (gradual decrease of heart rate at termination of the arrhythmia). (vin.com)
  • Mean duration of warm ischaemia time was 206 ± 79 s. (elsevierpure.com)