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  • 2019
  • Our anticipated near-term transition to a clinical stage company with the potential for initial safety and efficacy data by the end of 2019 makes this a significant year for Homology. (einpresswire.com)
  • The lower net loss per share in the 2019 period is reflective of the increase in the Company's outstanding shares as a result of its initial public offering in April 2018. (einpresswire.com)
  • The Company recognizes revenue over time consistent with the pattern of performance of research and development activities under the collaboration agreement as a result of adopting Accounting Standards Codification 606, Revenue from Contracts with Customers (ASC 606) on January 1, 2019, using the full retrospective transition methodology. (einpresswire.com)
  • Homology Medicines, Inc. (FIXX), a genetic medicines company, announced that it achieved all corporate goals for 2018, positioning the Company to start a Phase 1/2 clinical trial of the Company's first gene therapy program in adults with phenylketonuria (PKU), with initial data expected in 2019. (yahoo.com)
  • genes
  • Together, these results suggested that HvPIP2;5 overexpression enhanced stress tolerance to high salt and high osmotic stresses by increasing activities and/or expression of ROS scavenging enzymes and osmoprotectant biosynthetic genes. (frontiersin.org)
  • Our results show that it is possible to identify genes that are specifically and reproducibly associated with specific stages of atherosclerosis by using whole-mount human atherosclerotic specimens. (ahajournals.org)
  • This approach resulted in the identification of 30 additional MADS box genes. (biomedcentral.com)
  • Ours analyses indicate that only few members of type I genes in grapevine have homology in other species and that species-specific clades appeared both in the Mα and Mγ subclasses. (biomedcentral.com)
  • Amino
  • These results suggest a clear structure-function correlation for metallic-like conductivity that can be attributed to overlapping π-orbitals of aromatic amino acids. (asm.org)
  • This alternative model predicted that aromatic amino acids in G. sulfurreducens pili are packed within 3 to 4 Å, consistent with the experimental results. (asm.org)
  • Medicines
  • The Qatar Investment Authority, created to handle the windfall from the country's gas and oil exports, has invested in companies including Foursquare Labs Inc., biotech firm Rubius Therapeutics Inc., Homology Medicines Inc., Thoughtspot Inc. and Grail Inc., said the people, asking not to be identified because the deals are private. (yahoo.com)
  • evolutionary
  • Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. (cambridge.org)
  • strains
  • They exhibit less than 5% DNA-DNA homology with the type strains of Porphyromonas gingivalis (strain ATCC 33277), Porphyromonas endodontalis (strain ATCC 35406), and Porphyromonas asaccharolytica (strain ATCC 25260), which were isolated from humans, or with the type strains of Porphyromonas salivosa (strain NCTC 11632) and Porphyromonas circumdentaria (strain NCTC 12469), which were isolated from cats. (google.com)
  • Genotyping of parasite isolates of this and another patient with malaria admitted 16 days before revealed homology between the two strains. (biomedcentral.com)
  • observation
  • CMG}} __NOTOC__ ==Overview== In [[biology]], homology refers to the general and quite ancient observation of ''similarity of form seen in the biological world'' of animals or plants. (wikidoc.org)
  • genetic
  • Homology closed out the year by nominating development candidates for two additional programs focused on pediatric rare genetic diseases, both of which have entered into IND-enabling studies. (yahoo.com)
  • whereas
  • Exposure also results in an associated proportional loss of S107-μ transcripts and clan III V H -encoded circulating IgM and Ab responses whereas other responses are unaffected ( 5 , 6 ). (rupress.org)
  • structures
  • Homology of structures in evolution == Shared ancestry can be [[evolution]]ary or developmental. (wikidoc.org)
  • Direct measurement of multiple physical properties of Geobacter sulfurreducens pili have demonstrated that they possess metallic-like conductivity, but several studies have suggested that metallic-like conductivity is unlikely based on the structures of the G. sulfurreducens pilus predicted from homology models. (asm.org)
  • ancestor
  • Deep homology is real, as real as the bilaterian ancestor was alive some 600Mio years ago, that is the conclusion of this eminently readable, informative and entertaining book. (cambridge.org)
  • similarity
  • The percentage of identical residues ( percent identity ) or the percentage of residues conserved with similar physicochemical properties ( percent similarity ), e.g. leucine and isoleucine , is usually used to "quantify the homology. (wikipedia.org)
  • pathways
  • Reduction of hemes in MtrF lowered the E m values, resulting in switching to alternative downhill ET pathways that extended to the flavin binding sites. (pnas.org)
  • data
  • Additionally, Homology presented other data demonstrating its AAVHSC vectors have tropism to key tissues, including the ability to cross the blood-brain-barrier and transduce the central nervous system following intravenous administration as well as the retina following a single local injection. (homologymedicines.com)
  • models
  • A homology model of the G. sulfurreducens pilus was constructed with a Pseudomonas aeruginosa pilus model as a template as an alternative to previous models, which were based on a Neisseria gonorrhoeae pilus structure. (asm.org)
  • Year
  • Non-clinical tolerability and efficacy results of HMI-102 as well as the translatability of weight-based dosing from murine to non-human primate, support initiation of the pheNIX trial this year. (einpresswire.com)
  • model
  • Thus, the predictions of homology modeling are highly sensitive to assumptions inherent in the model construction. (asm.org)
  • available
  • Poster and Powerpoint presentations of the results are available below, along with the consensus peptide identifications for all spectra. (abrf.org)
  • present
  • As a result of conducting diligent research in order to accomplish the above-mentioned objects, the present inventors have succeeded in constructing cDNA libraries from both clinical tissues of human hepatoblastoma and normal liver. (google.com)
  • initial
  • The increase of $2.5 million was primarily due to increased personnel costs as a result of new hires, increased facility costs including rent expense, and costs associated with expanded operations in support of the Company's recent initial public offering and financial reporting requirements. (homologymedicines.com)
  • Initial results from this study were presented at the annual conference on 2-5 March 2013. (abrf.org)
  • significant
  • Comparing the result of this optimization strategy with the previous optimization research works was shown that significant save in use of nutrients is possible by using this medium. (springer.com)
  • therefore
  • Antigenic challenge can result, therefore, in either positive selection due to proliferation and pro-survival affects or negative selection due to functional inactivation, deletion, or induction of BCR editing. (rupress.org)
  • analysis
  • The results revealed that biosurfactant produced by this strain was lipopeptide-like surfactin based on FTIR analysis. (springer.com)